• Journal of Nutrition and Health
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• v.2 no.1
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• pp.35-46
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• 1969

Thirty female and six male rats aged fourty days were divided into two groups in order to feed them by pairfeeding for 50% dietary restriction in the pair group two weeks interval. Each group contains 15 female and three male rats matched each rat between two groups in consideration of body weight. Two female groups, one fed by 50% restricted diet and other Ad Libitum were divided into four groups each by the duration of dietary restriction during pregnancy: First ten days dietary restriction at 50% level, Last ten days dietary restriction at 50% level, Dietary restriction at 50% level for full period, And dietary unrestriction for full period Urinary total nitrogen and creatinine were determined. The birth weights of offsprings were decreased partial and full period dietary restriction of pregnant rats. There was no significant difference in the litter size of progeny due to the maternal diets. The growth was stunted in offsprings from the mothers fed restricted diet at 50% level for full period of pregnancy. No effect in the body weight gain of offsprings was observed in account of partial period of maternal dietary restriction. The urinary nitrogen of offsprings from eight different groups did not show any statistically significant difference.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.15 no.3
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• pp.1375-1381
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• 2014

The purpose of the present study was to test the mediating effect of children's creativity on the relationship among the openness to experience(OE) trait, maternal parenting behaviors, and their subjective well-being. 248 children attending elementary schools in the rural areas of Korea and their mothers were recruited. Results indicated that creativity partially mediated the relations between children's OE and their subjective well-being. However, creativity did not mediate the relations between maternal parenting behaviors and children's subjective well-being. Results of the present study suggest that the OE may influence children's adjustment through creativity. It is also implied that there may be no optimal parenting style which unconditionally promotes children's creativity.

• The Korean Journal of Physiology and Pharmacology
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• v.23 no.6
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• pp.449-458
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• 2019

Retinoblastoma (Rb) is one of the most common eye malignancies occur in childhood. The crucial roles of non-coding RNAs, particularly long non-coding RNAs (lncRNAs) and microRNAs (miRNAs), have been widely reported in Rb progression. In the present study, we found the expression of lncRNA T-cell leukemia/lymphoma 6 (TCL6) was significantly downregulated in Rb tissues and cell lines. Knockdown of lncRNA TCL6 promoted cell proliferation while reduced cell apoptosis in Rb cells. Moreover, lncRNA TCL6 serves as a sponge for miR-21, a previously-reported oncogenic miRNA in Rb, by direct targeting to negatively regulated miR-21 expression, therefore modulating Rb proliferation through miR-21. TCL6 overexpression inhibited Rb cell proliferation while miR-21 overexpression exerted an opposing effect; the effect of TCL6 overexpression was partially attenuated by miR-21 overexpression. PTEN/PI3K/AKT signaling pathway was involved in lncRNA TCL6/miR-21 axis modulating Rb cell proliferation. Taken together, lncRNA TCL6 serves as a tumor suppressor by acting as a sponge for miR-21 to counteract miR-21-mediated PTEN repression.

• The Korean Journal of Physiology and Pharmacology
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• v.27 no.1
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• pp.113-125
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• 2023

It has been reported that stressful events in early life influence behavior in adulthood and are associated with different psychiatric disorders, such as major depression, post-traumatic stress disorder, bipolar disorder, and anxiety disorder. Maternal separation (MS) is a representative animal model for reproducing childhood stress. It is used as an animal model for depression, and has well-known effects, such as increasing anxiety behavior and causing abnormalities in the hypothalamic-pituitary-adrenal (HPA) axis. This study investigated the effect of MS on anxiety or aggression-like behavior and the number of GABAergic neurons in the hippocampus. Mice were separated from their dams for four hours per day for 19 d from postnatal day two. Elevated plus maze (EPM) test, resident-intruder (RI) test, and counted glutamic acid decarboxylase 67 (GAD67) or parvalbumin (PV) positive cells in the hippocampus were executed using immunohistochemistry. The maternal segregation group exhibited increased anxiety and aggression in the EPM test and the RI test. GAD67-positive neurons were increased in the hippocampal regions we observed: dentate gyrus (DG), CA3, CA1, subiculum, presubiculum, and parasubiculum. PV-positive neurons were increased in the DG, CA3, presubiculum, and parasubiculum. Consistent with behavioral changes, corticosterone was increased in the MS group, suggesting that the behavioral changes induced by MS were expressed through the effect on the HPA axis. Altogether, MS alters anxiety and aggression levels, possibly through alteration of cytoarchitecture and output of the ventral hippocampus that induces the dysfunction of the HPA axis.

• The Journal of the Convergence on Culture Technology
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• v.9 no.1
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• pp.95-100
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• 2023

The purpose of this study was to examine the relationship among children's perceived parental attachment, parental happiness, and children's autonomy, and to find out in detail the influence of parental attachment and parental happiness on children's autonomy. Frequency analysis and descriptive statistical analysis were performed on data from the 12th year of the Korean Children's Panel (2019), and Pearson's moment correlation coefficient was calculated for correlation analysis between variables. Multiple regression analysis was conducted to examine the influence of parental attachment and parental happiness on children's autonomy. The research results were as follows. First, parental attachment perceived by children, parental happiness, and children's autonomy were all positively correlated. Second, among the sub-variables of parental attachment, maternal trust, paternal trust, and maternal communication were found to have an influence, and only maternal happiness was found to have an effect on parental happiness. This means that parental attachment acts as a more important variable than parental happiness. Therefore, we need constant attention and effort to support children in a more intimate and stable relationship with their parents so that they can gain life satisfaction through active and proactive choices and decisions.

• Journal of Families and Better Life
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• v.28 no.6
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• pp.95-111
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• 2010

The purposes of this study were to show general trends in the aspects of psychological family environment (parental communication), peer factor, academic performance factor, depression perceived by adolescents and to examine possible changes in such trends in accordance with demographic variables and the family structure environment (parental marital status, family economic status, and parents' education level), and then to determine the effect of these variables on adolescents' depression. The subjects were 1009 middle and high school students in Seoul and Gyeonggi province. The main results were as follows: 1) Paternal communication was significantly lower in technical high school students, divorced/ separated parents, and families of lower economic status. Maternal communication was significantly lower in male students, divorced/sepa-rated parents, and families of lower economic status. Academic performance problems was significantly higher in males, technical high school students, divorced/ separated parents, families of lower economic status, and a less educated father. Peer relations was significantly lower in students of divorced / separated parents, and of families of lower economic status. Depression was significantly higher in technical high school students, divorced / separated parents, and families of lower economic status. 2) In the case of male students, paternal communication had both a direct and an indirect negative effect through peer relations on depression, while academic performance problems had both a direct and an indirect positive effect through peer relations on depression. Both peer relations and maternal communication had a positive and a negative direct effect on depression. School grade had both a direct and an indirect negative effect through paternal communication on depression. Parental marital status(divorced or separated) had both a direct and an indirect positive effect through academic performance problems on depression. Family economic status had only an indirect effect on discussed.

• International Journal of Human Ecology
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• v.15 no.1
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• pp.12-22
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• 2014

The effects of conflicted teacher-child relation on conflicted or passive peer interaction and a moderation effect of mothers' interpersonal relation satisfaction on the associations were assessed. Children from 2- to 6-year-olds (184 girls, 185 boys) mostly from middle socioeconomic-status urban community in Korea and their teachers and mothers participated. Conflicted teacher-child relation predicted conflicted peer interaction but not passive peer interaction. Children, whose relationship with teachers were conflicted, engaged in conflicted play with peers more often than children who were in less conflicted relationship with the teachers. Teachers who were in conflicted relationship with the children, perceived the children having conflicted interaction with peers more often, if mothers of the children were less satisfying in relationship with significant others, especially boys. Children, whose mothers are in less satisfying interpersonal relation with others, were more passive in peer interaction than children whose mothers are in more satisfying interpersonal relationship.

• Korean Journal of Child Studies
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• v.36 no.3
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• pp.19-34
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• 2015

The purpose of this study was to explore the influence of marital satisfaction and depression of adoptive mother on the problem behaviors of adopted children and the mediating effects of parenting competency between them. Contextual variables such as family background and adoption-related characteristics were also included as control variables. The results of multiple regression analysis showed marital satisfaction had significant influence on the problem behavior of adopted child through flexibility of parenting competency, while depression was not significantly related to parenting competency of adoptive mother. Yet, maternal depression had direct influence on the problem behavior of adopted child. Based on the limitations of the study, suggestions for further study were made.

• Journal of the Korean Home Economics Association
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• v.48 no.8
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• pp.67-76
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• 2010

The major purpose of this study was to explore mediating effects of narcissism on the relationship between paternal maternal psychological control, over-expectation, and adolescent aggression. This study's participants were 678 boys and girls selected from second and third graders at middle schools in Busan. The major findings were as follows. First, there were gender differences in paternal psychological control, fathers' over-expectation, mothers' over-expectation, and adolescents' overt aggression. Second, boys' overt aggression indirectly affected fathers' psychological control and mothers' over-expectation through boys' narcissism. Third, girls' relational aggression indirectly affected fathers' psychological control and mothers' over-expectation through girls' narcissism and directly affected fathers' psychological control. Finally, girls' overt relational aggression indirectly affected fathers' and mothers' over-expectation through girls' narcissism.

• Korean Journal of Child Studies
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• v.30 no.5
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• pp.119-135
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• 2009

This study investigated how perceived social support, self-esteem and parenting attitudes of mothers relates to children's social competence and explored the mediating role of parenting attitudes in multicultural families. Participants were 67 immigrant women and their children aged 4-6. Instruments were the Social Support Scale (Park, 1985), Maternal Behavior Instrument (Lee, 1986), Self-Esteem Scale (Rosenberg, 1965) and Social Competence Scale (Doh & Falbo, 1994). Data were analyzed by Pearson's Correlation and Structural Equation Modeling (SEM). Results indicated that social support perceived by mothers related positively to their self-esteem and positive parenting, and to children's social competence. Mothers' self-esteem related positively to their positive parenting and to children's social competence. Maternal parenting behavior mediated the effects of social support and self-esteem on children's social competence.