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Kinetics of IL-23 and IL-12 Secretion in Response to Toxoplasma gondii Antigens from THP-1 Monocytic Cells

  • Quan, Juan-Hua;Zhou, Wei;Cha, Guang-Ho;Choi, In-Wook;Shin, Dae-Whan;Lee, Young-Ha
    • Parasites, Hosts and Diseases
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    • v.51 no.1
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    • pp.85-92
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    • 2013
  • IL-23 and IL-12 are structurally similar and critical for the generation of efficient cellular immune responses. Toxoplasma gondii induces a strong cell-mediated immune response. However, little is known about IL-23 secretion profiles in T. gondii-infected immune cells in connection with IL-12. We compared the patterns of IL-23 and IL-12 production by THP-1 human monocytic cells in response to stimulation with live or heat-killed T. gondii tachyzoites, or with equivalent quantities of either T. gondii excretory/secretory proteins (ESP) or soluble tachyzoite antigen (STAg). IL-23 and IL-12 were significantly increased from 6 hr after stimulation with T. gondii antigens, and their secretions were increased with parasite dose-dependent manner. IL-23 concentrations were significantly higher than those of IL-12 at the same multiplicity of infection. IL-23 secretion induced by live parasites was significantly higher than that by heat-killed parasites, ESP, or STAg, whereas IL-12 secretion by live parasite was similar to those of ESP or STAg. However, the lowest levels of both cytokines were at stimulation with heat-killed parasites. These data indicate that IL-23 secretion patterns by stimulation with various kinds of T. gondii antigens at THP-1 monocytic cells are similar to those of IL-12, even though the levels of IL-23 induction were significantly higher than those of IL-12. The detailed kinetics induced by each T. gondii antigen were different from each other.

Dual trigger in normally-responding assisted reproductive technology patients increases the number of top-quality embryos

  • Sukur, Yavuz Emre;Ulubasoglu, Hasan;Ilhan, Fatma Ceylan;Berker, Bulent;Sonmezer, Murat;Atabekoglu, Cem Somer;Aytac, Rusen;Ozmen, Batuhan
    • Clinical and Experimental Reproductive Medicine
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    • v.47 no.4
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    • pp.300-305
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    • 2020
  • Objective: The feasibility of a gonadotropin-releasing hormone agonist (GnRHa) trigger in normal responders is still a matter of debate. The aim of this study was to compare the number of mature oocytes, the number of good-quality embryos, and the live birth rate in normal responders triggered by GnRHa alone, GnRHa and human chorionic gonadotropin (hCG; a dual trigger), and hCG alone. Methods: A retrospective cohort study was conducted at the infertility clinic of a university hospital. Data from 200 normal responders who underwent controlled ovarian hyperstimulation and intracytoplasmic sperm injection with a GnRH antagonist protocol between January 2016 and January 2017 were reviewed. The first study group consisted of patients with cycles triggered by GnRHa alone. The second study group consisted of patients with cycles triggered by both GnRHa and low-dose hCG (a dual trigger). The control group consisted of patients with cycles triggered by hCG alone. Results: The groups were comparable in terms of demographics and cycle characteristics. The numbers of total oocytes retrieved and metaphase II oocytes were similar between the groups. The total numbers of top-quality embryos were 3.2±2.9 in the GnRHa group, 4.4±3.2 in the dual-trigger group, and 2.9±2.1 in the hCG group (p=0.014). The live birth rates were 21.4%, 30.5%, and 28.2% in those groups, respectively (p=0.126). Conclusion: In normal responders, a dual-trigger approach appears superior to an hCG trigger alone with regard to the number of top-quality embryos produced. However, no clinical benefit was apparent in terms of live birth rates.

A Study on the Implementation and Performance Analysis of Software Based GPS L1 and Galileo E1/E5a Signal Processing (소프트웨어 기반의 GPS L1 및 갈릴레오 E1/E5a 신호 처리 구현 및 성능에 관한 연구)

  • Sin, Cheon-Sig;Lee, Sang-Uk;Yoon, Dong-Won;Kim, Jae-Hoon
    • Journal of Advanced Navigation Technology
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    • v.13 no.3
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    • pp.319-326
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    • 2009
  • In this paper, the key technologies of Navigation receiver for GNSS sensor station are presented as a development result of a GNSS ground station in ETRI. A wide-band antenna and RF/IF components and SW signal processing unit to cover the GPS and Galileo signals for GNSS receiver are developed and its performance is verified by using GPS live signal and GNSS RF signal simulator from SpirentTM. We also gather GIOVE-A signal by using H/W antenna and RF/IF units in IF-level as sampling frequency and bit number, 112MHz and 8bits, respectively by using the developed wide-band antenna and RF/IF components. Data acquisition is done by using commercial data acquisition device from National Instrument TM. The gathered data is fed into SW receiver to process Galileo E1 to verify Galileo signal processing by Galileo live signal from GIOVE-A.

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Comparison and Examination of the Measured Data With the Data from Other Company for the Conductor and Sheath Temperatures of Live 6 kV CV Single Core Cables (활선 6 kV CV 단심 케이블의 도체 및 표면온도 측정 데이터에 관한 타사 데이터와의 비교검토)

  • Um, Kee-Hong
    • The Journal of the Institute of Internet, Broadcasting and Communication
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    • v.17 no.3
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    • pp.197-201
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    • 2017
  • The demand for electric power is increasing every year in Korea. All the systems adopted at power stations in order to generate and transmit electric power should operate in perfect condition or reliability. The device for transmitting the generated high-voltage electric power is 6 kV CV single core cables. The manufacturing companies of the cables makes an official announcement that the operating lifetime of their cables is about 30years. But from the moment of operation the deterioration precesses of worsening the characteristics of cables starts. Since the reliability for the status of installed cables in deterioration has not been diagnosed, the cables can be broken at any unexpected moments. In order to prevent the abrupt cable accident by systematically monitoring the cable status, we have invented the first device in Korea. We have installed our device at Korea Western Power Co. Ltd. in order to diagnose the live cables. In this paper, we present our research results of measured temperatures of inner conductor and surface and the compared results of those data with other cable company. We also show that our results agree with those made by other company.

Meaning of Happiness Based on ERG Theory in Middle-Aged Korean Women (ERG 이론에 근거한 한국 중년여성의 행복에 관한 구성요인 도출 연구)

  • Shin, Hee-Jin;Kim, Jeung-Im
    • Women's Health Nursing
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    • v.25 no.3
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    • pp.315-328
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    • 2019
  • Purpose: The purpose of this study was to explore the components and nature of happiness in middle-aged women in Korea. Methods: Thirty middle-aged women living in metropolitan Seoul and Gyeonggi and Chungcheong provinces agreed to participate in this study. The data were collected through in-depth interviews with the participants in one-on-one settings. The data were analyzed qualitative using Colaizzi's method of phenomenology. Results: The three theme clusters were extracted from the raw data, along with 13 themes and 138 meaningful sentences and phrases. The three happiness theme clusters in middle-aged women were "live healthy for stability," "rule one's mind for harmony," and "activate hopes for self-esteem." The first theme cluster included healthy life, economic stability, physical youth, and positive thought. The second theme cluster included that harmonious family, ruling of mind, my position as invisible person in social relationships, and precious relationships to support. The last theme included the center of one's life is oneself, a sense of accomplishment, self-improvement, recognition of one's worth and rest for one self. The three theme clusters were associated with the existence, relatedness, and growth (ERG) of ERG areas, respectively. Conclusions: We conclude that the core components of happiness in middle-aged women are to live healthy and mind-ruled and activate hope. The nature of happiness is egocentric stability in middle-aged women. The results suggest that theme clusters might be used to develop a scale for measuring happiness in middle-aged women. This will be helpful to assess the psychosocial status of middle-aged women in Korea.

Extraction of Geometric Primitives from Point Cloud Data

  • Kim, Sung-Il;Ahn, Sung-Joon
    • 제어로봇시스템학회:학술대회논문집
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    • 2005.06a
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    • pp.2010-2014
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    • 2005
  • Object detection and parameter estimation in point cloud data is a relevant subject to robotics, reverse engineering, computer vision, and sport mechanics. In this paper a software is presented for fully-automatic object detection and parameter estimation in unordered, incomplete and error-contaminated point cloud with a large number of data points. The software consists of three algorithmic modules each for object identification, point segmentation, and model fitting. The newly developed algorithms for orthogonal distance fitting (ODF) play a fundamental role in each of the three modules. The ODF algorithms estimate the model parameters by minimizing the square sum of the shortest distances between the model feature and the measurement points. Curvature analysis of the local quadric surfaces fitted to small patches of point cloud provides the necessary seed information for automatic model selection, point segmentation, and model fitting. The performance of the software on a variety of point cloud data will be demonstrated live.

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Characteristic Measurement by a Real-time Data Acquisition System in Overhead Contact Wire (실시간 계측시스템을 이용한 전차선로 특성 측정)

  • Na, Hae-Kyung;Park, Young;Cho, Yong-Hyeon;Lee, Ki-Won;Park, Hyun-Jun;Oh, Su-Young;Song, Joon-Tae
    • Journal of the Korean Institute of Electrical and Electronic Material Engineers
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    • v.20 no.3
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    • pp.281-285
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    • 2007
  • Facilities of electric railway should be maintained only at night and it is necessary to maintain by human power because facilities are installed at a high place. This paper presents the development and application of a real-time data acquisition system for the characteristics measurement of overhead contact wires in electric railway. The system is designed to perform in the telemetry environments that developed to store data by wireless in a live wire state of 25 kV power source. The field test results show that the proposed technique and the developed system can be practically applied to measure characteristics of temperature, displacement, and strain on overhead contact lines.

The Effect of Dating on the Psychological Well-Being of Elderly Koreans: Focusing on the Single Elderly (노인의 이성교제가 심리적 복지감에 미치는 영향 -이성교제를 하는 홀로된 노인을 대상으로 -)

  • 이예종;장진경
    • Journal of the Korean Home Economics Association
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    • v.40 no.7
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    • pp.141-156
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    • 2002
  • The purpose of this study was to examine the dating of the elderly, focusing on the necessity of dating, intimacies with a data, and difficulties on the process of dating, and to explore the effect of those variables on the psychological well- being of the elderly. The data were collected from 162 elderly who were more than 60 year ages, currently data with oppoaite sex, lived in Seoul. The major findings from this study were as follows; (1) The necessity of dating showed a significant difference in their age, religion, health, family closeness. (2)The intimacies with a data showed a significant difference in their econmic provider. (3) The difficulties on the process of dating showed a significant difference in their gender, age, health, the eldest son who live together. (4) The psychological well-being of the elderly showed a significant difference in the intimacies with opposite-sex friend, family closeness, residing with the couple of the eldest son, health, use of social education /welfare service, and erligon.

Adaptation Process of Mothers-in-law of Vietnamese Women Married to Korean Men (베트남 출신 며느리를 맞은 농촌 지역 시어머니의 적응과정)

  • An, Hyo Ja;Cho Chung, Hyang-In
    • Journal of Korean Academy of Nursing Administration
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    • v.20 no.1
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    • pp.22-34
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    • 2014
  • Purpose: This study was conducted to generate a grounded substantive theory of the adaptation process of mothers-in-law of Vietnamese women married to Korean husbands. Methods: Thirteen women who had Vietnamese daughters-in-law were interviewed. Data were transcribed verbatim and analyzed using a grounded theory method. Results: Eight categories with 19 sub-categories were extracted from 268 concepts. The identified phenomenon was 'overcoming differences' and the core category was 'trying one's best to live together with daughter-in-law'. The 9 categories were grouped into 3 stages for the adaptation process: encountering, struggling, and living together. Conclusion: The results indicate that when individuals from different cultural and personal backgrounds have to live together there is a continuing negotiation process towards meeting each other's needs. Health professionals can assist this adaptation process by providing these women with insights into various ways of meeting each other's need while they are struggling.

Attitudes and Preferences for Elderly Assisted Living according to Socio-economic Status (사회계층별 노인생활지원주택에 대한 태도와 선호)

  • 홍형옥;지은영
    • Journal of Families and Better Life
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    • v.20 no.2
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    • pp.83-95
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    • 2002
  • The objectives of this study were 1) to analyze the attitudes about Elderly Assisted Living(EAL), 2) to consider the policy implications for elderly communal housing according to socio-economic status(income, occupation and education). The survey was undertaken from August to September, 2000 in Seoul and Kyunggi-Do(Ilsan, Bundang). The data were analyzed by SPSS Window program. The major findings were as follows: Most of the respondents prefered to live in EAL(over 56%), under 10 units and desired to be serviced(housework.leisure medical program.meal service). The upper class respondents preferred high-rise apartment style inner city or suburban and prefered paid services in EAL. They would willingly to pay over 800,000 won for living expenses and more than 200 million won for buying their own EAL. The middle class respondents prefered 5 stories multi-family house style with common facilities as a number. And they prefered to common facilities opening to public if the quality of facilities were better. The low class respondents prefered 5 stories multi-family house style and prefered to live within 30 minutes apart from their families and friends. They would pay under 300,000~600,000won for monthly living expenses and under 100 million won for their own EAL.