• Structural Engineering and Mechanics
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• 제70권6호
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• pp.781-791
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• 2019

Earthquakes most often induce damage to structures, resulting in the degradation or deterioration of integrity. In this paper, based on the experimental study on 5 RC frames with different span length and different layout of buckling-restrained braces, the seismic damage evaluation law of RC frame with buckling-restrained braces was analyzed, and then the seismic damage for different specimens was calculated using different damage models to study the damage evolution. By analyzing and comparing the observation in test and the calculated results, it could be found that, damage evolution models including Gosain model, Hwang model as well as Ou model could better simulate the development of damage during cyclic loading. Therefore, these 3 models were utilized to analyze the development of damage to better demonstrate the evolution law for structures with different layout of braces and under different axial compression ratios. The results showed that from all layouts of braces studied, the eccentrically braced frame behaved better under larger deformation with the damage growing slowly. It could be deduced that the link beam benefited the seismic performance of structure and alleviated the damage by absorbing high values of energy.

• International Journal of Computer Science & Network Security
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• 제21권1호
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• pp.107-118
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• 2021

The term Internet of Things (IoTs) refers to the future where things are known daily through the Internet, whether in one way or another, as it is done by the method of collecting various information from various sensors to form a huge network through which people, things and machines are helped to make a link between them at all time and anywhere. The IoTs is everywhere around us such as connected appliances, smart homes security systems and wearable health monitors. However, the question is what if there is a malfunction or outside interference that affects the work of these IoTs based devises? This is the reason of the spread of security causes great concern with the widespread availability of the Internet and Internet devices that are subject to many attacks. Since there aren't many studies that combines requirements, mechanisms, and the attacks of the IoTs, this paper which explores recent published studies between 2017 and 2020 considering different security approaches of protection related to the authentication, integrity, availability and confidentiality Additionally, the paper addresses the different types of attacks in IoTs. We have also addressed the different approaches aim to prevention mechanisms according to several researchers' conclusions and recommendations.

• IMMUNE NETWORK
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• 제21권3호
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• pp.20.1-20.18
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• 2021

The gut is an important organ with digestive and immune regulatory function which consistently harbors microbiome ecosystem. The gut microbiome cooperates with the host to regulate the development and function of the immune, metabolic, and nervous systems. It can influence disease processes in the gut as well as extra-intestinal organs, including the brain. The gut closely connects with the central nervous system through dynamic bidirectional communication along the gut-brain axis. The connection between gut environment and brain may affect host mood and behaviors. Disruptions in microbial communities have been implicated in several neurological disorders. A link between the gut microbiota and the brain has long been described, but recent studies have started to reveal the underlying mechanism of the impact of the gut microbiota and gut barrier integrity on the brain and behavior. Here, we summarized the gut barrier environment and the 4 main gut-brain axis pathways. We focused on the important function of gut barrier on neurological diseases such as stress responses and ischemic stroke. Finally, we described the impact of representative environmental sensors generated by gut bacteria on acute neurological disease via the gut-brain axis.

• Ocean Systems Engineering
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• 제14권1호
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• pp.1-16
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• 2024

This paper investigates the impact of local joint flexibility (LJF) on the fatigue life of jacket-type offshore platforms. Four sample platforms with varying geometric properties are modeled and analyzed using the Opensees software. The analysis considers the LJF of tubular joints through the equivalent element and flexible link approaches, and the results are compared to rigid modeling. Initially, modal analysis is conducted to examine the influence of LJF on the frequency content of the structure. Subsequently, fatigue analysis is performed to evaluate the fatigue life of the joints. The comparison of fatigue life reveals that incorporating LJF leads to reduced fatigue damage and a significant increase in the longevity of the joints in the studied platforms. Moreover, as the platform height increases, the effect of LJF on fatigue damage becomes more pronounced. In conclusion, considering LJF in fatigue analysis provides more accurate results compared to conventional methods. Therefore, it is essential to incorporate the effects of LJF in the analysis and design of offshore jacket platforms to ensure their structural integrity and longevity.

• 디지털융복합연구
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• 제19권11호
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• pp.351-357
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• 2021

분산 환경에서 다양하게 사용되고 있는 IoT 장치는 의료·환경·교통·바이오·공공장소 등 사용 분야가 다양해지면서 IoT 장치에서 송·수신되는 데이터의 중요도가 점점 증가하고 있다. 본 논문에서는 IoT 데이터의 신뢰성을 보장하기 위한 방법으로 수 많은 데이터들을 다양한 중요 속성별로 분류·처리하도록 오토인코더 기반의 IoT 연계 처리 기법을 제안한다. 제안 기법은 오토인코더 기반의 IoT 연계 처리를 위해서 IoT 데이터를 특성별로 블록체인으로 묶어 처리하도록 IoT 데이터별로 상관관계 지수를 사용한다. 제안 기법은 IoT 데이터의 신뢰성을 보장하기 위해서 상관관계 지수에 적용된 블록체인 기반의 n-계층 구조로 확장 운영한다. 또한, 제안 기법은 IoT 데이터의 상관관계 지수에 따라 IoT 수집 데이터에 가중치를 적용하여 IoT 데이터를 선택할 수 있을 뿐만 아니라 실시간으로 IoT 데이터의 무결성을 검증하는 비용을 낮출 수 있다. 제안 기법은 n-계층 구조로 IoT 데이터를 확장할 수 있도록 IoT 데이터의 처리 비용을 유지한다.

• Asian Pacific Journal of Cancer Prevention
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• 제16권7호
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• pp.2883-2887
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• 2015

Background: The calcium-binding S100A4 protein is involved in epithelial to mesenchymal transition, oncogenic transformation, angiogenesis, cytoskeletal integrity, mobility and metastasis of cancer cells. This study aimed to clarify the roles of S100A4 in genesis and progression of glioma. Materials and Methods: S100A4 expression was examined by real-time RT-CPR and Western blot in glioma and paired normal brain tissue (n=69), and compared with clinicopathological parameters of tumors. In addition, glioma U251 cells transfected with an S100A4-expressing plasmid were examined for proliferation by MTT, apoptosis by Annexin V-FITC, and migration and invasion with Transwell chambers. Results: Increased S100A4 mRNA expression was found in gliomas, compared with paired non-tumor tissue (p<0.001). Gradual elevation of overexpression of S100A4 was observed with increasing glioma grade (p<0.001). Astrocytoma showed lower S100A4 mRNA expression than oligodendrogliomas, with glioblastomas having highest values (p<0.001). Similar results were obtained for S100A4 protein, a positive link being found between mRNA and protein expression in gliomas (p<0.001). There was higher growth, lower apoptosis, stronger migration and invasion of S100A4 transfectants than control and mock transfected cells (p<0.001). Conclusions: These findings indicate that up-regulated S100A4 expression is positively linked to pathogenesis, progression and histogenesis of glioma by modulating proliferation, apoptosis, migration and invasion.

• 대한의생명과학회지
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• 제15권1호
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• pp.1-8
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• 2009

Human genomic DNA is continuously attacked by oxygen radicals originated from cellular metabolic processes and numerous environmental carcinogens. 2-deoxyribonolactone (dL) is a major type of oxidized abasic (AP) lesion implicated in DNA strand scission, mutagenesis, and formation of covalent DNA-protein crosslink (DPC) with DNA polymerase (Pol) ${\beta}$. We show here that human DNA polymerase (Pol)${\iota}$ and mitochondrial $Pol{\gamma}$ give rise to stable DNA-protein crosslink (DPC) formation that is specifically mediated by dL lesion. $Pol{\gamma}$ mediates DPC formation at the incised dL residue by its 5'-deoxyribose-5-phosphate (dRP) lyase activity, while $Pol{\gamma}$ cross links with dL thorough its intrinsic dRP lyase and AP lyase activities. Reactivity in forming dL-mediated DPC was significantly higher with $Pol{\gamma}$ than with $Pol{\iota}$. DPC formation by $Pol{\gamma}$, however, can be reduced by an accessory factor of $Pol{\gamma}$ holoenzyme that may attenuate deleterious effects of crosslink adducts on mitochondrial DNA. Comparative kinetic analysis of DPC formation showed that the rate of DPC formation with either $Pol{\iota}$ or $Pol{\gamma}$ was lower than that with $Pol{\beta}$. These results revealed that the activity of catalytic lyase in DNA polymerases determine the efficiency of DPC formation with dL damages. Irreversible crosslink formation of such DNA polymerases by dL lesions may result in a prolonged strand scission and a suicide of DNA repair proteins, both of which could pose a threat to the genetic and structural integrity of DNA.

• Journal of Communications and Networks
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• 제18권3호
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• pp.327-332
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• 2016

The routing protocol for low-power and lossy networks (RPL) is an internet protocol based routing protocol developed and standardized by IETF in 2012 to support a wide range of applications for low-power and lossy-networks (LLNs). In LLNs consisting of resource-constrained devices, the energy consumption of battery powered sensing devices during network operations can greatly impact network lifetime. In the case of inefficient route selection, the energy depletion from even a few nodes in the network can damage network integrity and reliability by creating holes in the network. In this paper, a composite energy-aware node metric ($RER_{BDI}$) is proposed for RPL; this metric uses both the residual energy ratio (RER) of the nodes and their battery discharge index. This composite metric helps avoid overburdening power depleted network nodes during packet routing from the source towards the destination oriented directed acyclic graph root node. Additionally, an objective function is defined for RPL, which combines the node metric $RER_{BDI}$ and the expected transmission count (ETX) link quality metric; this helps to improve the overall network packet delivery ratio. The COOJA simulator is used to evaluate the performance of the proposed scheme. The simulations show encouraging results for the proposed scheme in terms of network lifetime, packet delivery ratio and energy consumption, when compared to the most popular schemes for RPL like ETX, hop-count and RER.

• 한국정보통신학회:학술대회논문집
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• 한국정보통신학회 2017년도 추계학술대회
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• pp.346-348
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• 2017

기술 발전 속도가 증가되고, 고성능의 디지털 기기가 확산되고 있다. 기존 유선 환경에 최적화 되어 제한적으로 활용되던 PC와 같은 유선 디지털 기기에서 시 공간의 제약에서 벗어나, 언제 어디서나 효율적인 업무 수행이 가능한 스마트워크로 전환되고 있다. 유선환경에 비해 단말기 분실, 도난 및 파손 등 물리적 위협과 도난, 서비스 거부, 비인가 접근 등 기술적 위협 등 다양한 보안 위협에 대해 무결성과 가용성을 확보할 수 있는 시스템 보안설계가 필요하다. 본 논문 연구에서는 스마트워크의 네트워크시스템, 유 무선 링크시스템, 디지털 스마트기기를 분석한다. 현재 업무에 사용되고 있는 스마트워크 유선시스템과 향후 무선시스템을 위한 보안설계 방안을 연구한다. 본 연구는 안전한 스마트워크 구축에 기초자료로 활용될 것이다.

• 한국정보통신학회논문지
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• 제11권4호
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• pp.696-706
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• 2007

다중처리기 SoC(MPSoC) 플랫폼은 SoC 설계 분야에 새로운 여러가지 혁신적인 트랜드를 가지고 있다. 급격히 십억 단위의 트랜지스터 집적이 가능한 시대에 게이트 길이가 $60{\sim}90nm$ 범위를 갖는 서브 마스크로 기술에서 주요문제점들은 확장되지 않는 선 지연, 신호 무결성과 비동기화 통신에서의 오류로 인해 발생한다. 이러한 문제점들은 미래의 SoC을 위한 NOC 구조의 사용에 의해 해결될 수 있다. 대부분의 미래 SoC들은 칩 상에서 통신을 위해 네트워크 구조와 패킷 기반 통신 프로토콜을 사용할 것이다. 이 논문은 NOC 구조를 위한 칩 통신에서 교착상태가 발생되지 않는 것을 보장하기 위해 적극적 turn prohibition을 갖는 적응적 wormhole 라우팅에 대해 기술한다. 또한 5개의 전이중, flit-wide 통신 채널을 갖는 간단한 라우팅 구조를 제시한다. 메시지 지연에 대한 시뮬레이션 결과를 나타내고 같은 연결비율에서 운영되는 다른 기술들의 결과와 비교한다.