• 한국학교수학회논문집
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• 제4권2호
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• pp.61-74
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• 2001

The purposes of this study are to develop the mathematical performance assessment tasks and to apply them to the middle school students. And I also intend to know the students' inclination and learning attitude to mathematics. In order to satisfy this study, I developed the performance assessment tasks and the standard program of marking about the mathematical function and statistics for the first grade students at middle school. After examining the students' basic investigation, their inclination and learning attitude to mathematics, I applied these developed tasks to them After that I put both classes and performance assessment into operation in all 15 periods. I set up two classes of the first grade students (49 students) at J middle school in Kongju, Chungcheongnam-do as a model group. The results of this study are as follows: First, owing to the developed performance assessment tasks of function and statistics, the teachers can operate the assessment system as a process of teaching and learning. Second, because of the application of mathematical performance assessment tasks, we can change the students' inclination and learning attitude to mathematics affirmatively. And by using these tasks, we can help the students to think mathematically. In this way, the students will be able to realize the real value of mathematics and have a growing interest in mathematics through all these meaningful processes. Judging from this study, we can elevate the students' abilities of problem solving and reasoning and improve teaching-learning method by applying the performance assessment tasks to them. Thanks to these tasks, the students will be changed affirmatively in their inclination and learning attitude to mathematics. I think that these tasks are very good assessment method which can call forth curiosity and interest. Besides, they can also help the students realize the real value of mathematics.

• Clinics in Shoulder and Elbow
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• 제21권2호
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• pp.95-100
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• 2018

Background: The purpose of this study was to evaluate the clinical outcomes and complications of hook plate fixation in acromioclavicular (AC) joint dislocations and distal clavicle fractures. Methods: We retrospectively reviewed a series of 60 consecutive patients with hook plate fixation for AC joint dislocation (group I) and distal clavicle fracture (group II). Groups I and II had 39 and 21 patients, respectively. Clinical results were evaluated using the pain visual analogue scale (VAS), simple shoulder test, and Constant-Murley scores. In addition, subacromial erosion and stiffness were evaluated as complications. Results: At the removal, the pain VAS was $2.69{\pm}1.30$ and $4.10{\pm}2.14$ in groups I and II, respectively, which were significantly different (p=0.003). The simple shoulder test score was $9.59{\pm}1.60$ and $7.81{\pm}2.67$ in groups I and II, respectively, which were also significantly different (p=0.002). Subacromial erosion was significantly more frequent in group II (14/21 patients, 66.7%) than in group I (15/39 patients, 38.5%) (p=0.037), and stiffness was also higher in group II (17/21 patients, 81.0%) than in group I (22/39 patients, 56.4%), but it was not significant. Conclusions: Hook plate fixation showed good clinical and functional results for the treatment of acute unstable AC joint dislocation and distal clavicle fracture. But, in distal clavicle fractures, there are more subacromial erosion and stiffness compare with acute unstable AC joint dislocation.

• Journal of Periodontal and Implant Science
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• 제51권4호
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• pp.276-284
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• 2021

Purpose: The aim of this randomized clinical trial was to assess whether chemical cleansing using a sulfonic/sulfuric acid gel solution (HBX) as an adjunct to scaling and root planing (SRP) resulted in a decrease in residual plaque and calculus in deep periodontal pockets compared to SRP alone. Methods: Fifty-six patients with 56 hopeless posterior teeth, scheduled for extraction due to severe periodontitis, were enrolled in this study. Each tooth was randomly assigned to 1 of the 2 experimental procedures. The test teeth were subjected to the irrigation of the subgingival area with HBX for 2 minutes, followed by SRP with hand and ultrasonic instruments for 14 minutes, and then extracted. The control teeth received only mechanical instrumentation before extraction. Residual biofilm was evaluated on photographs and measured as total area and percentage of root surface covered by remaining plaque (RP) or calculus (RC) after treatment. Results: The initial pocket depth (PD) and total subgingival root surface area were similar between the 2 treatment groups. After treatment, the total subgingival root area covered by RP and RC was statistically significantly larger (P<0.001) in the control group than in the test group. The test teeth showed a lower percentage of RP, but a higher percentage of RC than the control teeth (both P<0.001). Complete calculus removal was achieved in 42% of the control teeth surfaces and in 25% of the test teeth surfaces for a PD of 4 mm. Conclusions: The additional chemical cleansing with HBX resulted in a statistically significant improvement in bacterial plaque removal during SRP of deep pockets, but it was not effective in reducing calculus deposits.

• 한국ITS학회 논문지
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• 제20권3호
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• pp.86-99
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• 2021

본 연구는 V2I통신을 이용하여 교차로 등의 사각지대로 인해 발생할 수 있는 충돌 사고를 예방하기 위한 충돌 방지체계를 제안한다. 교차로의 인프라에 위치한 Vision센서와 LiDAR센서가 물체를 인식하고 사고 위험이 있는 차량에게 경고함으로써 사고를 미연에 방지한다. 딥러닝 기반의 YOLOv4를 이용하여 교차로에 진입하는 물체를 인식하고 LiDAR 센서와의 Calibration을 통해 대상 물체와의 맨하탄 거리값을 이용하여 충돌 예상시간과 제동거리에 대한 가중치를 계산하고 안전거리를 확보한다. 차량-인프라간 통신은 ROS통신을 이용하였으며 충돌 경고 외에도 진입 물체의 Class, 거리, 진행속도 등의 다양한 정보를 차량에 전달함으로써 사고를 미연에 방지하고자 하였다.

• Clinical and Experimental Pediatrics
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• 제46권7호
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• pp.687-694
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• 2003

목 적 : 급성 허혈성 신손상 후 손상된 세뇨관 상피세포의 재생은 순환하거나 국소적으로 생성된 성장인자나 cytokine, 생리적 인자 및 주위 환경들의 조절에 의해 매개되는 것으로 알려져 있다. 따라서 급성 허혈성 신손상 후 신기능 회복에 따른 혈중 IGF-I의 변화와 전체 신장조직과 각 부위에 따른 IGF-I, -II, VEGF, $TGF-{\beta}1$, CTGF의 mRNA 발현의 변화를 알아보는데 연구의 목적이 있다. 방 법 : 체중이 250-300 g의 백서를 대상으로 급성 허혈성 신손상을 시켜 유발된 급성 신부전 모델을 이용하여 급성 신부전의 진행과정에 따라 혈청 IGF-I치와 여러 성장인자 발현의 변화를 측정하였다. 급성 신부전 진행은 혈청 크레아티닌을 측정하여 평가하였고 혈청 IGF-I 농도는 iodinated IGF-I과 polyclonal anti-IGF-I 항체를 이용한 방사면역 측정법을 이용하여 측정하였다. 신장에서 성장인자의 발현은 RT-PCR을 이용하였고 신장조직에서의 RNA 추출은 통상적인 방법에 준하였다. 신장에서의 IGF-I과 CTGF의 분포는 anti-IGF-I 항체와 anti-CTGF 항체를 이용한 면역조직화학법을 이용하였다. 결 과 : 1) 양측 신동맥을 결찰한 후 1일째부터 체중 감소와 혈청 크레아티닌치의 증가가 관찰되었는데 이러한 변화는 3일째에 가장 현저하였다. 혈청 IGF-I은 신손상 후 1일 째 현저하게 감소하였고 신손상 3일째에 더 증가되었다가 5일째부터는 신손상 전으로 회복되었다. 2) 신기능 회복에 따른 성장인자의 변화는 거의 유사하였다. IGF-I, IGF-II, $TGF-{\beta}1$ 및 VEGF의 mRNA 발현은 허혈성 신손상 후 1일째에 현저하게 감소하였고 신손상 3일째에는 신손상 전에 비해 증가하였으며 7일째에는 거의 신손상 전의 수준으로 회복되었다. 3) IGF-I과 IGF-II는 정상 신장에서는 주로 수질부 특히 바 깥쪽 수질부에서 발현되었고 허혈성 신손상 1일째에 현저하게 감소하였다가 3일째에는 정상 수준으로 회복되었다. $TGF-{\beta}1$은 정상에서 신수질부에서 주로 발현되었고 1일째는 현저하게 감소하였다가 회복되는 소견을 보였다. CTGF와 VEGF는 정상 신장의 수질부와 피질부 모두에서 발현되었으며 신손상 1일째에 현저하게 감소되었다가 3일째부터 정상 수준으로 회복되는 소견을 보였다. 4) 정상 백서의 신장에서 IGF-I은 주로 피질부위의 신세뇨관에 분포하였고 사구체에서는 발견되지 않았는데 급성 허혈성 신손상 후 1일째 신장의 피질부위에서는 IGF-I가 현저히 감소되었다. CTGF는 정상 백서의 신장에서는 주로 혈관에 분포하는 소견을 보였는데 신손상 3일째에는 세뇨관에서 현저한 증가가 관찰되었다. 결 론: 이번의 연구로 저자들은 IGF-I, IGF-II, $TGF-{\beta}1$, CTGF, VEGF 등과 같은 성장인자가 급성 허혈성 신손상 후 신기능과 세뇨관세포의 회복과정에 발현의 변화가 초래된다는 사실을 알 수 있었다. 따라서 신기능 회복을 촉진시키기 위해 여러 성장인자를 급성신부전 치료제로 사용할 수 있을 것으로 생각되고 이에 대한 연구가 더 필요할 것으로 생각된다.

• The Korean Journal of Physiology and Pharmacology
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• 제17권4호
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• pp.315-320
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• 2013

Here, we show that radicicol, a fungal antibiotic, resulted in marked inhibition of inducible nitric oxide synthase (iNOS) transcription by the pancreatic beta cell line MIN6N8a in response to cytokine mixture (CM: TNF-${\alpha}$, IFN-${\gamma}$, and IL-$1{\beta}$). Treatment of MIN6N8a cells with radicicol inhibited CM-stimulated activation of NF-${\kappa}B$/Rel, which plays a critical role in iNOS transcription, in a dose-related manner. Nitrite production in the presence of PD98059, a specific inhibitor of the extracellular signal-regulated protein kinase-1 and 2 (ERK1/2) pathway, was dramatically diminished, suggesting that the ERK1/2 pathway is involved in CM-induced iNOS expression. In contrast, SB203580, a specific inhibitor of p38, had no effect on nitrite generation. Collectively, this series of experiments indicates that radicicol inhibits iNOS gene expression by blocking ERK1/2 signaling. Due to the critical role that NO release plays in mediating destruction of pancreatic beta cells, the inhibitory effects of radicicol on iNOS expression suggest that radicicol may represent a useful anti-diabetic activity.

• Biomolecules & Therapeutics
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• 제25권6호
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• pp.641-647
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• 2017

Galangin (3,5,7-trihydroxyflavone) is a polyphenolic compound abundant in honey and medicinal herbs, such as Alpinia officinarum. In this study, we investigated the anti-inflammatory effects of galangin under in vitro and in vivo neuroinflammatory conditions caused by polyinosinic-polycytidylic acid (poly(I:C)), a viral mimic dsRNA analog. Galangin suppressed the production of nitric oxide, reactive oxygen species, and pro-inflammatory cytokines in poly(I:C)-stimulated BV2 microglia. On the other hand, galangin enhanced anti-inflammatory interleukin (IL)-10 production. Galangin also suppressed the expression of pro-inflammatory markers in poly(I:C)-injected mouse brains. Further mechanistic studies showed that galangin inhibited poly(I:C)-induced nuclear factor (NF)-${\kappa}B$ activity and phosphorylation of Akt without affecting MAP kinases. Interestingly, galangin increased the expression and transcriptional activity of peroxisome proliferator-activated receptor (PPAR)-${\gamma}$, known to play an anti-inflammatory role. To investigate whether PPAR-${\gamma}$ is involved in the anti-inflammatory function of galangin, BV2 cells were pre-treated with PPAR-${\gamma}$ antagonist before treatment of galangin. We found that PPAR-${\gamma}$ antagonist significantly blocked galangin-mediated upregulation of IL-10 and attenuated the inhibition of tumor necrosis factor (TNF)-${\alpha}$ and IL-6 in poly(I:C)-stimulated microglia. In conclusion, our data suggest that PI3K/Akt, NF-${\kappa}B$, and PPAR-${\gamma}$ play a pivotal role in mediating the anti-inflammatory effects of galangin in poly(I:C)-stimulated microglia.

• 대한화학회지
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• 제55권1호
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• pp.112-123
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• 2011

화학은 단계별로 개념이 연계 발전되는 학문 체계를 가지므로 고등학교의 화학 I II의 교육 내용은 대학 일반화학과 연계성 측면에서 매우 중요하다. 현재 고등학교 학생들은 심화 선택 최상위 과목인 화학II를 배우지 않고도 이공계 대학에 진학하는 것이 가능하다. 따라서 이러한 학생들이 일반화학을 수강하면서 얼마나 어려움을 겪는지 알아보기 위해 일반화학과 고등학교 화학교재의 내용 연계성 및 학생들의 인식을 조사했다. 연구 결과, 화학I에서는 일반화학 필수 개념의 약 27%밖에 소개하고 있지 않지만, 화학II에서는 약 62%의 내용이 일반화학과 연계되었다. 전남 M대학의 학생들 중 화학II를 배우지 않은 약 70%의 학생들은 일반화학을 배울 때 상대적으로 더 어려워했고, 학업성취도도 상대적으로 낮았을 뿐 아니라, 화학에 대해 흥미도도 낮게 조사되었다.

• 대한수학회지
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• 제54권4호
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• pp.1265-1279
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• 2017

In order to study the structure of arbitrary split Leibniz triple systems, we introduce the class of split Leibniz triple systems as the natural extension of the class of split Lie triple systems and split Leibniz algebras. By developing techniques of connections of roots for this kind of triple systems, we show that any of such Leibniz triple systems T with a symmetric root system is of the form $T=U+{\sum}_{[j]{\in}{\Lambda}^1/{\sim}}I_{[j]}$ with U a subspace of $T_0$ and any $I_{[j]}$ a well described ideal of T, satisfying $\{I_{[j]},T,I_{[k]}\}=\{I_{[j]},I_{[k]},T\}=\{T,I_{[j]},I_{[k]}\}=0 \text{ if }[j]{\neq}[k]$.

• Bulletin of the Korean Chemical Society
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• 제25권9호
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• pp.1397-1402
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• 2004

The vibrational predissociation of triatomic, i.e., atom-diatom, van der Waals complexes in transient electronic excited state has been widely investigated. The predissociation rates or lifetimes are major concerns of the previous studies. Experimentally rotational state distributions of diatomic product are hardly investigated and few theoretical stuides on rotational state distributions have appeared in literature. In this work, choosing the frequently studied $I_2(B)-Ne$ complex as an example, we investigate the change of rotational state distributions of $I_2(B)-Ne$ produced from predissociation of the various initial states of $I_2(B)-Ne$. The present study on the rotational distributions indicates that rotational state distributions depend significantly on the predissociation energy and the van der Waals vibrational modes of $I_2(B)-Ne$. That is, the initial state dependency of rotational state distributions is extensively discussed.