• Journal of Korean Neurosurgical Society
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• v.66 no.4
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• pp.465-475
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• 2023

Objective : Our objective is to analyze the occurrence, clinical course and risk factors for glioma patients with leptomeningeal metastasis (LM) according to different metastasis patterns and clinical variables. Methods : We retrospectively reviewed data from 376 World Health Organization (WHO) grade II-IV adult glioma patients who were treated in the National Cancer Center from 2001 to 2020. Patients who underwent surgery at other institutions, those without initial images or those with pathologically unconfirmed cases were excluded. LM was diagnosed based on magnetic resonance imaging (MRI) findings or cerebrospinal fluid (CSF) cytology. The metastasis pattern was categorized as nodular or linear according to the enhancement pattern. Tumor proximity to the CSF space was classified as involved or separated, whereas location of the tumor was dichotomized as midline, for tumors residing in the thalamus, basal ganglia and brainstem, or lateral, for tumors residing in the cerebral and cerebellar hemispheres. Results : A total of 138 patients were enrolled in the study. A total of 44 patients (38%) were diagnosed with LM during a median follow-up of 9 months (range, 0-60). Among the clinical variables, tumor proximity to CSF space, the location of the tumor and the WHO grade were significant factors for LM development in univariate analysis. In multivariate analysis, the midline location of the tumor and WHO grade IV gliomas were the most significant factor for LM development. The hazard ratio was 2.624 for midline located gliomas (95% confidence interval [CI], 1.384-4.974; p=0.003) and 3.008 for WHO grade IV gliomas (95% CI, 1.379-6.561; p=0.006). Conclusion : Midline location and histological grading are an important factor for LM in glioma patients. The proximity to the CSF circulation pathway is also an important factor for WHO grade IV glioma LM. Patients carrying high risks should be followed up more thoroughly.

• Journal of the Korean Society of Earth Science Education
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• v.7 no.3
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• pp.338-346
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• 2014

In this study, find out of recognition of the effect of science, society and ethical aspects on natural disasters and understanding degree of knowledge applying for SSI class aimed at elementary pre-service teachers by developing SSI training program of the 'Earth and Space' field. Also, after SSI class application we examined the change perceptions of elementary pre-service teachers. SSI training program was that elementary pre-service teachers participated in the SSI class of a variety of subjects in the field of 'Earth and Space' and directly joined in the decision-making process and reflectional discussion with colleagues as conducted in this class reflective discussion with the pre-primary teachers pre-service teachers. Elementary pre-service teachers were understanding of the nature of the science and to understand in more depth about the SSI class characteristics. This study, second grade 115 people who was taking 'science and teaching materials' course in B National University of Education at B city participated. In order to apply for SSI class, one semester based on 15 weeks until seven weeks were science and teaching materials and based on the nature of science, after 8 weeks we set the theme of the contents related to the Earth and space and give lesson applied for SSI. During 8 weeks, test subjects 4 classes were taking 50 minutes a week 100 minutes. First time has theoretical lessons in topics related to the 'Earth and space' and on the second week, each classes participate in the decision-making processes respectivly by dicussing and debating on the first week's topic as regarding social and moral aspects of it. We obtained the following results. First, elementary pre-service teachers were acquiring the results of 67% in the knowledge aspects of the 'Earth and space'. This result was determined that most of the elementary pre-service teachers were liberal arts in high school. Second, while participating in the SSI class, elementary pre-service teachers were concretely aware of the nature of SSI and the characteristics of the class. Third, the elementary pre-service teacher are thaught that introduction education courses about 'Earth and space' are needed but most of the students responded that this would require a lot of effort of teachers. This was derived from not familiar class form that did not fulfill in the science teaching methods until now.

• Journal of The Korean Association For Science Education
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• v.37 no.4
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• pp.539-552
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• 2017

The purpose of this study is to investigate the trends of model and modeling-related research in science education from 1989 to 2016 in Korea. Eighty-five (85) models and modeling-related journal articles were extracted from the KCI-listed journals and analyzed according to the criteria such as participants, research fields, research design, methods, data collection and elements of metamodeling knowledge. According to research participants, three out of four (3/4) were studied for students and the rest were for teachers. More than half of the studies for students were conducted with middle and high school students. The research fields of models and modeling-related researches in science education were comprised of earth science, chemistry, biology science, physics and science course. With regards to research design, the highest type is qualitative research and followed by hybrid research and quantitative research. According to research methods, the most numerous researches that were analyzed was the effectiveness of program, which was a developed model and modeling-related research. The analysis from the elements of the metamodeling knowledge showed most of model and modeling-related research utilized for the change of scientific concept or understanding.

• Journal of Animal Science and Technology
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• v.57 no.8
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• pp.28.1-28.7
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• 2015

Background: The physiologic characteristics of the cashmere trait and many of the differentially expressed genes relevant to hair cycling have been extensively studied, whereas genes involved in the prenatal development of hair follicles have been poorly investigated in cashmere goats. The aim of this study, therefore, was to quantify the time-course changes in the expressions of $TR{\alpha}$ and CRABPII genes in the fetal skin of Chinese cashmere goats at the multiple embryonic days (E70, E75, E80, E90, E100, E120 and E130) using real-time quantitative PCR (RT-qPCR). Results: RT-qPCR showed that $TR{\alpha}$ was expressed at E70 with relatively high level and then slightly decreased (E75, E80, and E90). The highest expression of $TR{\alpha}$ mRNA was revealed at E130 (P > 0.05). The expression pattern of CRABPII mRNA showed an 'up-down-up' trend, which revealed a significantly highest expression at E75 (P < 0.05) and was down-regulated during E80 to E120 (P < 0.05) and mildly increased at E130, subsequently. Conclusion: This study demonstrated that $TR{\alpha}$ and CRABPII genes expressed in different levels during prenatal development of cashmere. The present study will be helpful to provide the comprehensive understanding of $TR{\alpha}$ and CRABPII genes expressions during cashmere formation and lay the ground for further studies on their roles in regulation of cashmere growth in goats.

• Journal of The Korean Association For Science Education
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• v.39 no.1
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• pp.35-44
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• 2019

Currently, most of the science and engineering students who enter the university are required to take general chemistry and general chemistry experimental subjects. However they have different learning bases about learning basic science subjects. Regarding college entrance examinations, the current system is used for selection, so they have different levels of basic knowledge. But, without considering this situation, all of the students in science and engineering are participating in the same basic science class, some learners are relatively easy to adapt to learning, while others experience extreme difficulties and suddenly give up. This is true. The purpose of this study is to develop a scale to measure the ability to learn general chemistry of freshmen in science and engineering at H University in the Seoul Metropolitan area and to analyze what kind of learning backgrounds are related to learners. The results show that gender and major are not related to general chemistry learning major, and it we found that there is a close relationship to the relationship between their major and chemistry, the level of the chemistry learning in the high school, and the selection of chemistry in college entrance examinations. In addition, it was found that the degree of feeling that pre-learning is beneficial to current learning and that it is common with current learning is also a factor related to general chemistry learning aptitude. Therefore, in this study, we propose two ways of presenting and promoting a guide for learning by majors, and establishing a step-by-step learning system considering the level of students.

• Journal of the Korean earth science society
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• v.28 no.2
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• pp.169-178
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• 2007

In this research we diagnosed the actual status of the 7th National science elective curriculum and suggested a way to select and organize the content of the new science elective curriculum. The first science education reform was grounded in the structuralism where the structure of discipline was valued above everything else. On the other hand, the second science education reform suggested alternative interpretations of students' opportunity to learn, putting a brake on the structuralist thinking. According to the survey result, the majority of the science elective courses are in need for revision because the contents are overcrowded, too difficult in light of students' learning readiness, failed to draw students' interest in science, and are overlapped and repeated among the 10th grade science, high school science I and II. In particular, Earth Science II and physics II are the most unfavorable courses among students. Thus, we recommended a fundamental change be made in the new curriculum in addition to the optimization of the content. In this paper, we suggested 'topic-centered content organization' for the science elective course I, i.e., Physics I, Chemistry I, Biology I and Earth Science I that is designed for both science track and non-science track students. Since curriculum provides students with an 'opportunity to learn', a curriculum study should focus on what the 'opportunity to learn' is that students ought to be offered. Based on the result of this study, we recommended one way to select and organize the content of high school elective curriculum.

• Investigative Magnetic Resonance Imaging
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• v.9 no.1
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• pp.9-15
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• 2005

Purpose : This study attempted to investigate the effects of supply of highly concentrated $(30\%)$ oxygen on human ability of visuospatial cognition using time course data analysis of functional Magnetic Resonance Imaging (fMRI). Materials and Methods : To select an item set in the visuospatial performance test, two questionnaires with similar difficulty were developed through group testing. A group test was administered to 263 college students. Two types of questionnaire containing 20 questions were developed to measure the ability of visuospatial cognition. Eight college students (right-handed male, average age of 23.5 yrs) were examined for fMRI study. The experiment consisted of two runs of the visuospatial cognition testing, one with $21\%$ level of oxygen and the other with $30\%$ oxygen level. Each run consisted of 4 blocks, each containing control and visuospatial items. Functional brain images were taken from 37 MRI using the single-shot EPI method. Using the subtraction procedure, activated areas in the brain during visuospatial tasks were color-coded by t-score. To investigate the time course data in each activated area from brain images, 4 typical regions (cerebellum, occipital lobe, parietal lobe, and frontal lobe) were selected. Results : The average accuracy was $50.63{\pm}8.63$ and $62.50{\pm}9.64$ for $21\%\;and\;30\%$ oxygen respectively, and a statistically significant difference was found in the accuracy between the two types of oxygen (p<0.05). There were more activation areas observed at the cerebellum, occipital lobe, parietal lobe and frontal lobe with $30\%$ oxygen administration. The rate of increase in the cerebellum, occipital lobe and parietal lobe was $17\%$ and that of the frontal lobe, $50\%$. Especially, there were increase of intensity of BOLD signal at the parietal lobe with $30\%$ oxygen administration. The increase rate of the left parietal lobe was $1.4\%$ and that of the right parietal lobe, $1.7\%$. Conclusion : It is concluded that while performing visuospatial tasks, high concentrations of oxygen administration make oxygen administration sufficient, thus making neural network activate more, and the ability to perform visuospatial tasks increase.

• Journal of Korean Academy of Nursing
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• v.6 no.1
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• pp.12-22
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• 1976

Amongst varieties of clinical nursing role, the administration of medication is often highlighted as of prime importance. In order to attain data for the improvement of teaching strategies of medication, diagnostic evaluation of the knowledge level is a necessity. This study was performed from August through December 1975. 449 registered nurses, randomly sampled from general hospitals:16 of Seoul and 7 of Taegu and Pusan, were tested through 54 test questionaries based on 4 practical dimensions of administration of medication. Results are as follows ; 1. Status of respondents: Length of clinical experiences; the average length revealed to be 2 years and 7 months, 72% revealed to have had less than 3 years of experience; 38.6%-less than 1 year, 19 .2%-over 1 year and less than 2 years, and 14, 2%-over 2 years and less than 3 years. Type of Nursing education received ; 9.4% revealed to have graduated technical high school of nursing, 67.5o/o the 3 year diploma school and 21, 7% the baccalaureate degree program. The knowledge Level; Degree of self-satisfaction on knowledge level revealed that;27, 4% responded to "more or less satisfied", 48.8% "more or less un-satisfied" and 19.8% to "not satisfied". The average level of basic knowledge revealed to be moderate by 66.95 points. The level of knowledge of 4 questionnaire categories revealed that; drug action category by average of 66.5 points, methodology category by 65.4 Points, safety measure category by 71.4 points and terminology and concepts category by 64.6 points, Questionnaire items which revealed high points are of;6 of drug action category, 4 of methodology, 4 of safety measure, and 3 of terminology. The items of low points are: 8 of drug action, 3 of methodology, 3 of safety measure and 5 of terminolology categories. 3. The type of nursing education revealed to have no significant influence on the level of knowledge on the administration of medication. 4. The length of clinical experience revealed to have no significant influence on the level of knowledge. 5. 75. l% responded that the actual practice of medication modes are "similar" to that included in the fundamentals of nursing course. 6. In-service education on medication; 54.0% revealed to have some incidental in-service education on medication while 34.0% receive programmed in- service education. 61.8% revealed to have expressed the need of systemic In-service education as one of the means for improvement of medication. 32.7% revealed to obtain information concerning medicine by reading commercial publications on drug package, while only 20.9% by reading specific information channel.

• Journal of the Korean Society of Earth Science Education
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• v.10 no.3
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• pp.308-322
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• 2017

It is the purpose of the study to investigate how high school students understand the concept of carbon cycle according to their spatial perception ability. For this, a total of 30 male students and 33 female students, who belong to the science course of the 2nd grade at a general co-education high school located in a megalopolis of Korea and have finished the class of Earth Science I in the first semester, took part in the spatial perception ability test, and four male students and four female students were selected as members of two groups : one group of higher spatial perception ability and the other group of lower spatial perception ability, and they agreed to participate in the study and have got the test of the carbon cycle concept. The results are as followings. It was found that the students who had higher spatial perception ability recorded more scores in the carbon cycle concept, state change concept, and process concept at the factor of word association and the carbon cycle concept, state change and process concept at the factor of drawing than those who had lower spatial perception ability. Connecting link used in the systemic viewpoint was disclosed like this in the factor of causal map of those who had higher spatial perception ability : one student 2 and another one student 1 and the other two students 0 : and in the factor of drawing three students 1 and the other 0 ; But nothing was found in the factors of causal map and drawing of those who had lower spatial perception ability. In addition, it was also found that those students who had higher spatial perception ability, when compared with those students who had lower spatial perception ability, have understood the fact that carbon moves through the interaction of the earth system's lower parts; Three students, who showed higher spatial perception ability, had a low level of systemic thinking concept, and one student who had higher spatial perception ability and four students who had lower spatial perception ability did not have a systemic thinking concept.

• Journal of Science Education
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• v.46 no.2
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• pp.195-211
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• 2022

In this study, we explored the meaning of astronomical observation activities of five earth science teachers through in-depth interviews. Semi-structured interviews were conducted after providing a questionnaire based on Seidman's three-step process of interview. By analyzing the interview transcript, the educational implications inherent in astronomical observation activities were extracted. Teachers have constructed systematic basis of observation and astronomy in the observational astronomy and laboratory class during their course in the teacher education institute. After they became in-service teachers, practical know-hows of astronomical observation activities in schools were developed with the help of colleagues. By designing and executing astronomical observation activities for students, teachers notice positive changes in the cognitive domain, affective domain, and career perception of the students. Hence, teachers consider that astronomical observation activities have great educational effects. In addition, astronomical activities appear to be very rewarding and satisfying experiences to teachers, by providing opportunities for having pride as an earth science teacher. However, teachers tend to find difficulties in operating astronomical observation activities in fields, due to both internal and external obstacles. It is found that the removal of internal obstacles is more important for teachers to attempt or to continue astronomical observation activities. In this sense, it is necessary to support teachers by providing timely training courses with related content, as well as opportunities to share their experiences within a peer group such as teachers' research society.