• 혜화의학회지
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• 제8권1호
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• pp.689-710
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• 1999

Bobitang(BBT) is one of the most important prescription that has been used in oriental medicine(dongyibogam) for recovering spleen condition. The study was done to evaluate effects of BBT water extract on the spleen lipid peroxide content and metabolic enzyme system changes. After pretreatment of BBT I (100mg/kg), BBT II(250mg/kg), BBT III(350mg/kg), BBT IV(500mg/kg) for 1 week, lipid peroxide content and metabolic enzyme system changes of the spleen was measured in 8 months rats. The results were obtained as follows : 1. The content of spleen lipid peroxide was significantly decreased in all experimental groups as compared with control, and best in BBT III IV treated groups. 2. The activity of spleen superoxide generation was significantly decreased in all experimental groups as compared with control, and best in BBT IV III treated groups. 3. The activity of cytochrome P-450 and aminopyrine demethylase wasn't significant change. 4. The activity of aniline hydroxylase was significantly decreased in BBT IV II treated groups, xanthine oxidase was significantly decreased in all experimental groups, aldehyde oxidase was significantly decreased in BBT IV treated group as compared with control. 5. The activity of antioxidant enzymes as superoxide dismutase, catalase, glutathione peroxidase was significantly increased in all experimental groups as compared with control. 6. The activity of glutathion S-transferase was significantly increased in all experimental groups, the concentration of spleen glutathione was significantly increased in BBT IV treated group as compared with control. 7. The activity of ${\gamma}$ -glutamylcystein synthetase was significantly increased in BBT III IV I treated groups as compared with control, the activity of glutathione reductase wasn't significant change. From the above results, BBT is cosidered to have effect of remove peroxide content and free radical that was made during ageing process. It is expected that treatment of BBT can be applied in future clinical study of delaying the ageing process.

• 재활간호학회지
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• 제5권2호
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• pp.193-204
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• 2002

This study was a quasi-experimental study of nonequivalent control group pretest- posttest design to investigate the effect of aerobic walking exercise program on the physical & psychological functions of home stayed stroke patients. The data were collected during the period of May 20th to August 15th, 2001. The subjects for this study were 40 hemiplegic stroke patients with the experimental group consisting of 19 patients and the control group being composed of 21 patients. The patients selected for this study were: (a)living in J city who had been diagnosed with stroke and at home after being discharged from the hospital, (b)suffering from stroke for 6 months to 5 years, (c)without recognition disorder with the MMSE-K score above 25, (d)below 2 on the modified Ashworth scale, (e)free from heart and pulmonary disease (f)able to walk beyond 15 minutes for themselves. The aerobic walking exercise program for the experimental group was aerobic exercise and education and supportive care. The aerobic exercise was 8 weeks' period, three times a week, 35 to 50 minutes a day. And the education and supportive care was consisted of one home visiting and 2 times telephoning a week. The data were analysed by $X^2$-test, paired t-test and unpaired t-test and ANCOVA through SAS/PC program. The results of the study were as follows: 1. There was insignificant difference in the gait length experimental and control group. There was significant difference in the gait speed between the two groups. 2. There was significant difference in the dynamic valance between the two groups. 3. There was significant difference in ADL score between the two groups. 4. There was no significant difference in the depression between the two groups. As shown above, the results of 8 weeks' the aerobic walking exercise program for home stayed stroke patients produced positive effects on gait speed, dynamic valance, ADL score. And this program was expected that it was more effective in different intervention period, verified program. Also it was needed follow study.

• 한국수정란이식학회지
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• 제9권1호
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• pp.117-125
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• 1994

In vitro development of parthenogenetic embryo was examined after ethanol treatment of follicular oocytes matured in vitro for 42, 48, 54 and 60h in the pig. The follicular oocytes were matured in TCM 199 containing 15% FCS and gonadotrophins in an atmosphere of 39 $^{\circ}C$ 5% $CO_2$. The cumulus-free oocytes were activated by 10% ethanol treatment in M2+4mg /ml BSA for 10 min. The ethanol-activated oocytes were washed and further cultured in TCM199+20%FCS containing granulosa cell monolayer. Maturation rates at 42, 48, 54 and 60h of IVM were 75.0, 86.5, 81.6 and 87.9%, respectively. Thus the oocytes maturated in vitro for longer periods did not improve nuclear maturation much. Pronuclear formation rates at 18h post-activation in ethanol-activated oocytes were 21.9, 25.0, 47.4 and 32.6%. The cytoplasmic maturation leading to pronuclear formation upon activation increased when the I VM period was extended from 42 to 54h. When the activated oocytes were cultured for 96~120h to analyse early development of the activated oocytes, the rates of embryonic development upto $\leq$ 5~8 cell were 5.3, 5.8, 12.0 and 11.7% among the cultured embryos. The result indicate that earlier development of activated porcine occyte is dependent on the duration of oocyte maturation, and that better development could be obtained from the oocyte matured for 54h.

• Biomolecules & Therapeutics
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• 제17권2호
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• pp.168-174
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• 2009

Epilepsy is one of the most common neurological disorders, and topiramate (TPM) is one of the most effective drugs that can render patients seizure-free. The focus of the present study was to evaluate the immunological safety of TPM in a mouse model. We examined the in vitro effect of TPM on immune functions of BV2 microglial cells, RAW 264.7 macrophages, B cells, T cells, and dendritic cells. We also examined the in vivo effect of TPM on mouse immune organs, such as lymph node, spleen, and thymus. When cells were directly treated with TPM at concentrations from 1 to $30{\mu}g/ml$, TPM did not affect nitrite production by BV2 cells and macrophages, proliferation of B cells and T cells, or maturation of dendritic cells. In addition, TPM did not change the weight and cellularity of lymph nodes, spleen, and thymus in vivo at doses from 3 to 100 mg/kg injected i.p. into mice once a day for 4 consecutive days. These data showed that TPM, which is widely used as an anti-epileptic drug, is immunologically safe.

• Journal of Yeungnam Medical Science
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• 제31권2호
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• pp.148-151
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• 2014

Radioactive iodine (RAI) therapy is widely used for the treatment of Graves disease. After RAI therapy, 44% become hypothyroid and up to 28% remain hyperthyroid. The development of thyrotoxicosis after RAI therapy is believed to be mediated by 2 different mechanisms: a transient increased release of thyroid hormone due to radiation thyroiditis and the rare development of Graves disease due to the formation of antibodies to the thyroid-associated antigens released from the damaged follicular cells. A 55-year-old woman was hospitalized with severe headache, weight loss, and palpitation. She received a dose of 7 mCi of RAI (I-131) about 6 weeks earlier. Thyroid function test showed 7.98 ng/dL free T4, >8 ng/mL T3, < $0.08{\mu}IU/L$ thyroid stimulating hormone, and high titer thyroid stimulating immunoglobulin (TSI) (85.8 IU/L). She improved with propylthiouracil, propranolol, and steroid treatment. The TSI, however, was persistently elevated for 11 months.

• 한국식품영양학회지
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• 제34권5호
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• pp.423-429
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• 2021

Barley's nutritional value as a health food is increasing due to its excellent nutritional functionality. In this study, the levels of β-glucan, total polyphenols, and total flavonoids were analyzed in the ethanol extracts of different barley cultivars (Hinchalssal, Heuksoojeongchal, Betaone, Ganghochung, and Saechalssal). Also, the free radical scavenging abilities of 2,2-diphenyl-1-picryl-hydrazil (DPPH) and 2,2'-azino-bis-3-ethylbenzo-thiaxoline-6-sulfonic acid (ABTS) were measured to determine their antioxidant activity. The results confirmed that Betaone extract contained highly activefunctional components and exhibitedantioxidant activity. Next, we evaluated the hepatoprotective and inhibitory effects of reactive oxygen species (ROS) generated by barley ethanol extracts after inducing oxidative stress with tert-butyl hydroperoxide (tBHP) in HepG2 cells. Hinchalssal and Saechalssal extracts showed the most significant cytoprotective effect and also reduced ROS production significantly. These results suggest that Hinchalssal, Saechalssal, and Betaone represent potential natural antioxidant and hepatoprotective agents.

• 한국건축시공학회지
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• 제19권1호
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• pp.39-46
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• 2019

본 연구에서는 비압축성 Navier-Stokes 방정식을 적용한 ISPH 기법을 이용하여 3차원 유동 수치해석 모델을 개발하였다. 수치해석을 위해 MATLAB을 사용하여 ISPH 프로그램을 구현하였다. ISPH의 커널 함수로 piecewise cubic spline 함수를 사용하였다. 벽 경계조건으로 고정 가상 입자를 사용하였으며, 가상 밀도를 적용하여 자유 표면 경계 부근의 입자들을 결정하였다. 수치해석 모델과 코드의 정도를 확인하기 위해 $T_{500}$ 시험, 슬럼프 플로우 시험, L-box 시험의 수치해석 결과와 실험 결과를 비교하였다. 수치해석 결과 고유동 콘크리트의 점성계수 및 항복응력 변화에 따른 유동 현상의 특성을 잘 묘사하였으며, 기존의 실험값과 비교적 잘 일치함을 확인할 수 있었다.

• 한국정보통신학회:학술대회논문집
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• 한국정보통신학회 2014년도 춘계학술대회
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• pp.429-431
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• 2014

라즈베리 파이는 영국 라즈베리 파이(Paspberry Pi) 재단에서 만든 초소형/초저가 PC이며 교육용 프로젝트의 일환으로 개발되었다. RCA 연결 잭을 가지고 있으며 2012년 3월에 출시되어 1시간만에 모두 매진되기도 했다. 라즈베리 파이는 리눅스 커널 기반 운영체제를 사용하여 Raspbian이라는 라즈베리 파이에 최적화된 데비안 계열의 무료 운영체제를 주로 사용하고 있다. 현재 라즈베리 파이는 큐비 보드와 함께 IoT 분야에서 상당히 각광받고 있으며 큐비 보드보다 많은 자료를 보유하고 있다. 아두이노는 상당히 쉬운 접근을 허용하지만 avr의 접근성 및 코드 연계등이 불가능하여 모든 커스터마이징을 라이브러리로만 해결해야하는 단점이 존재한다. 라즈베리파이는 라즈비안을 사용하며 가격이 저렴하지만 입출력이 작은 한계점이 존재한다. 그래서 이 둘의 결합을 위해 GPOI를 사용한 하드웨어 제어를 생각하게 되었다. 본 논문에서는 GPIO를 사용한 RaspberryPi 보드를 제어하기 위해 Cooking Hacks 실드를 사용하여 입출력이 부족한 라즈베리 파이 확장을 확인하였고 잘 동작됨을 검증하였다.

• Nuclear Engineering and Technology
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• 제53권1호
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• pp.282-293
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• 2021

This paper examines gamma-ray shielding properties of SBC-Bx glass system with the chemical composition of 40SiO₂-10B₂O₃-xBaO-(45-x)CaO- yZnO- zMgO (where x = 0, 10, 20, 30, and 35 mol% and y = z = 6 mol%). Mass attenuation coefficient (µ/ρ) which is an essential parameter to study gamma-ray shielding properties was obtained in the photon energy range of 0.015-15 MeV using PHITS Monte Carlo code for the proposed glasses. The obtained results were compared with those calculated by WinXCOM program. Both the values of PHITS code and WinXCOM program were observed in very good agreement. The (µ/ρ values were then used to derive mean free path (MFP), electron density (N_eff), effective atomic number (Z_eff), and half value layer (HVL) for all the glasses involved. Additionally, G-P method was employed to estimate exposure buildup factor (EBF) for each glass in the energy range of 0.015-15 MeV up to penetration depths of 40 mfp. The results reveal that gamma-ray shielding effectiveness of the SBC-Bx glasses evolves with increasing BaO content in the glass sample. Such that SBC-B35 glass has superior shielding capacity against gamma-rays among the studied glasses. Gamma-ray shielding properties of SBC-B35 glass were compared with different conventional shielding materials, commercial glasses, and newly developed HMO glasse. Therefore, the investigated glasses have potential uses in gamma shielding applications.

• 한국콘텐츠학회논문지
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• 제21권10호
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• pp.645-655
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• 2021

본 연구는 간호대학생의 심리특성을 파악하기 위해 에니어그램 성격유형 설문지와 자유만다라 그리기를 이용하여 2020년 10월 16일부터 11월 13일까지 4주간 충남 일개 간호대학 재학생 127명을 대상으로 시도된 서술적 조사연구이다. 수집된 자료는 SPSS 25.0 version을 이용하여 χ² test, t-test, ANOVA 및 Scheffé test를 이용하여 분석하였다. 만다라는 Fincher(1991), Kellogg(1977), 정여주(2001)의 만다라 분석방식과 평가 기준 등을 참고하였고 분석기준 구성체계의 적절성과 명확성을 논의하기 위해 총 3인이 평가기준 항목 및 그림을 보며 논의하는 과정을 거쳤다. 연구결과, 압도색의 경우 사고형에서, 명암의 경우 본능형에서, 일원상의 만다라 형태의 경우 사고형과 감정형에서 유의미한 차이를 보였다. 본 연구결과를 통해 신입생 시기부터 간호교육 과정에서 자신의 성격유형을 이해하고, 강점과 약점을 파악하여 보완해 갈 수 있는 과정을 연계하여 제공하도록 하여야 할 것이다.