Journal of Yeungnam Medical Science
- Volume 31 Issue 2
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- Pages.148-151
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- 2014
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- 2799-8010(eISSN)
DOI QR Code
Delayed presentation of aggravation of thyrotoxicosis after radioactive iodine therapy at Graves disease
그레이브스병에서 방사성요오드 치료 후 발생한 갑상샘항진증 악화의 지연된 발현
- Lee, Ji-Hyun (Department of Internal Medicine, Myongji Hospital) ;
- Na, Hyun-Jin (Department of Internal Medicine, Myongji Hospital) ;
- Park, Jin-Woo (Department of Internal Medicine, Myongji Hospital) ;
- Lee, Cheol-Ho (Department of Internal Medicine, Myongji Hospital) ;
- Han, Hyun-Jeong (Department of Internal Medicine, Myongji Hospital) ;
- Kim, Tae-Ho (Department of Internal Medicine, Catholic Kwandong University College of Medicine) ;
- Kim, Se-Hwa (Department of Internal Medicine, Catholic Kwandong University College of Medicine)
- 이지현 (명지병원 내과) ;
- 나현진 (명지병원 내과) ;
- 박진우 (명지병원 내과) ;
- 이철호 (명지병원 내과) ;
- 한현정 (명지병원 내과) ;
- 김태호 (가톨릭관동대학교 의과대학 내과학교실) ;
- 김세화 (가톨릭관동대학교 의과대학 내과학교실)
- Received : 2013.09.11
- Accepted : 2014.01.08
- Published : 2014.12.31
Abstract
Radioactive iodine (RAI) therapy is widely used for the treatment of Graves disease. After RAI therapy, 44% become hypothyroid and up to 28% remain hyperthyroid. The development of thyrotoxicosis after RAI therapy is believed to be mediated by 2 different mechanisms: a transient increased release of thyroid hormone due to radiation thyroiditis and the rare development of Graves disease due to the formation of antibodies to the thyroid-associated antigens released from the damaged follicular cells. A 55-year-old woman was hospitalized with severe headache, weight loss, and palpitation. She received a dose of 7 mCi of RAI (I-131) about 6 weeks earlier. Thyroid function test showed 7.98 ng/dL free T4, >8 ng/mL T3, <