• Proceedings of the Optical Society of Korea Conference
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• 1989.02a
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• pp.225-229
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• 1989

Taking the normal mode transmission direction perpendicular to the substrate, an alternative equivalent network formulation is developed for the analysis of optical strip waveguides. All kinds of mode couplings between the normal modes are included in this formulation. Compared to the previous equivalent network formulations, the calculations are simplified especially when the thickness of the uniform slab is thin enough such that no well guided modes are available along the uniform slab waveguide.

• Journal of the Korean Geotechnical Society
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• v.29 no.6
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• pp.77-86
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• 2013

Embankments on soft ground experience significant deformation during time-dependent consolidation settlement, as well as an initial undrained settlement. Since infinitesimal strain theory assumes no configuration change and minute strain during deformation, finite strain analysis is required for better prediction of geotechnical problems involving large strain and geometric change induced by imposed loadings. Updated Lagrangian formulation is developed for time-dependent consolidation combining both force equilibrium and mass conservation of fluid, and mechanical constitutive equation is written in Janumann stress rate. Numerical convergence during Newton's iteration in large deformation analysis is improved by Nagtegaal's approach of considering the effect of rotation in mechanical constitutive relationship. Numerical simulations are conducted to discuss numerical reliability and applicability of developed numerical code: deformation of cantilever beam, two-dimensional consolidation. The numerical results show that developed formulation can efficiently describe large deformation problems. Proposed formulation is expected to facilitate the upgrading of a numerical code based on infinitesimal strain theory to that based on finite strain analysis.

• Computational Structural Engineering
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• v.10 no.1
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• pp.201-211
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• 1997

A clearly consistent finite element formulation for geometrically non-linear analysis of space frames is presented by applying incremental equilibrium equations based on the updated Lagrangian formulation and introducing Vlasov's assumption. The improved displacement field for symmetric cross sections is introduced based on inclusion of second order terms of finite rotations, and the potential energy corresponding to the semitangential rotations and moments is consistently derived. For finite element analysis, elastic and geometric stiffness matrices of the space frame element are derived by using the Hermitian polynomials as shape functions. A co-rotational formulation in order to evaluate the unbalanced loads is presented by separating the rigid body rotations and pure deformations from incremental displacements and evaluating the updated direction cosines of the frame element due to rigid body rotations and incremental member forces from pure deformaions. Finite element solutions for the spatial buckling and post-buckling analysis of space frames are compared with available solutions and other researcher's results.

• Analytical Science and Technology
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• v.36 no.1
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• pp.32-43
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• 2023

This study reports for the first time about a stability indicating RP-HPLC method for qualitative and quantitative determination of acalabrutinib in bulk and dosage form and in presence its impurities 1, 2 and 3. The chromatographic separation was carried on Zorbax XDB-C18 (250×4.6 mm; 5 µ id) as stationary phase, Phosphate buffer pH 6.4 and methanol 80:20 (v/v) as mobile phase at a flow rate of 1.0 mL/min, UV detection was carried at wavelength of 238 nm and the analysis was completed with a run time of 15 min. In these conditions the retention time of acalabrutinib and its impurities 1, 2 and 3 was observed to be 3.50, 4.83, 8.40 and 9.93 min respectively. The method was validated for system suitability, range of analysis, precision, specificity, stability and robustness. Spiked recovery at 50 %, 100 % and 150 % was carried for both standard and impurities and the acceptable % recovery of 98-102 was observed for acalabrutinib and both impurities studied and the % RSD in each spiked level was found to be less than 2. Stability tests were done through exposure of the analyte solution to five different stress conditions i.e expose to 1N hydrochloric acid, 1 N sodium hydroxide, 3 % peroxide, 80 ℃ temperature and UV radiation at 254 nm. In all the degradation condition, standard drug acalabrutinib was detected along with both the impurities studied and the degradation products were successfully separated. In the formulation analysis there is no other chromatographic detection of other impurities and formulation excipients. Hence the developed method was found to be suitable for the quantification of acalabrutinib and can separate and analyse impurities 1 and 2.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.37 no.4
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• pp.367-371
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• 2009

Analysis on optimality of the proportional navigation guidance(PNG) law is presented in this paper. While most of previous studies on optimality of PNG were relied on the linear formulation, this paper is based on the nonlinear formulation. The analysis shows that PNG is an optimal solution minimizing a range-weighted control energy, where the weighting function is an inverse of $\alpha$ power of the distance-to-target. We show that the navigation constant N is related to $\alpha$ directly. And also the conditions required to ensure the analysis result are investigated.

• Wind and Structures
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• v.11 no.4
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• pp.303-321
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• 2008

When first commissioned, the 1.6 km span 275kV Severn Crossing Conductor experienced large amplitude vibrations in certain wind conditions, but without ice or rain, leading to flashover between the conductor phases. Wind tunnel tests undertaken at the time identified a major factor was the lift generated in the critical Reynolds number range in skew winds. Despite this insight, and although a practical solution was found by wrapping the cable to change the aerodynamic profile, there remained some uncertainty as to the detailed excitation mechanism. Recent work to address the problem of dry inclined cable galloping on cable-stayed bridges has led to a generalised quasi-steady galloping formulation, including effects of the 3D geometry and changes in the static force coefficients in the critical Reynolds number range. This generalised formulation has been applied to the case of the Severn Crossing Conductor, using data of the static drag and lift coefficients on a section of the stranded cable, from the original wind tunnel tests. Time history analysis has then been used to calculate the amplitudes of steady state vibrations for comparison with the full scale observations. Good agreement has been obtained between the analysis and the site observations, giving increased confidence in the applicability of the generalised galloping formulation and providing insight into the mechanism of galloping of yawed and stranded cables. Application to other cable geometries is also discussed.

• International Journal of Aerospace System Engineering
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• v.3 no.1
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• pp.10-16
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• 2016

A trigonometric Layerwise higher order shear deformation theory (TLHSDT) is developed and implemented for free vibration and buckling analysis of laminated composite and sandwich plates by analytical and finite element formulation. The present model assumes parabolic variation of out-plane stresses through the depth of the plate and also accomplish the zero transverse shear stresses over the surface of the plate. Thus a need of shear correction factor is obviated. The present zigzag model able to meet the transverse shear stress continuity and zigzag form of in-plane displacement continuity at the plate interfaces. Hence, botheration of shear correction coefficient is neglected. In the case of analytical method, the governing differential equation and boundary conditions are obtained from the principle of virtual work. For the finite element formulation, an efficient eight noded $C^0$ continuous isoparametric serendipity element is established and employed to examine the dynamic analysis. Like FSDT, the considered mathematical model possesses similar number of variables and which decides the present models computationally more effective. Several numerical predictions are carried out and results are compared with those of other existing numerical approaches.

• Structural Engineering and Mechanics
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• v.67 no.4
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• pp.317-326
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• 2018

The iterative decomposition coupling formulation of the precise integration finite element method (FEM) and the time domain boundary element method (TD-BEM) is presented for elstodynamic problems. In the formulation, the FEM node and the BEM node are not required to be coincident on the common interface between FEM and BEM sub-domains, therefore, the FEM and BEM are independently discretized. The force and displacement converting matrices are used to transfer data between FEM and BEM nodes on the common interface between the FEM and BEM sub-domains, to renew the nodal variables in the process of the iterations for the un-coincident FEM node and BEM node. The iterative coupling formulation for elastodynamics in current paper is of high modeling accuracy, due to the semi-analytical solution incorporated in the precise integration finite element method. The decomposition coupling formulation for elastodynamics is verified by examples of a cantilever bar under a Heaviside-type force and a harmonic load.

• 한국전산유체공학회:학술대회논문집
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• 2006.10a
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• pp.31-35
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• 2006

The delta-formulation of the Navier-Stokes equations has been popularly used in the aerodynamics area. Implicit algorithm can be easily implemented in that by using Taylor series expansion. This formulation is extended for an unsteady analysis by using a dual-time integration. In the meanwhile, the incompressible flows with heat transfers which occur in the area of thermo-hydraulics have been solved by a segregated algorithm such as the SIMPLE method, where each equation is discretised by using an under-relaxed deferred correction method and solved sequentially. In this study, the dual-time delta formulation is implemented in the segregated Navier-Stokes solver which is based on the collocated cell-centerd scheme with un unstructured mesh FVM. The pressure correction equation is derived by the SIMPLE method. From this study, it was found that the Euler dual-time method in the delta formulation can be combined with the SIMPLE method.

• Biomolecules & Therapeutics
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• v.26 no.2
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• pp.218-223
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• 2018

The liver is an essential organ for the detoxification of exogenous xenobiotics, drugs and toxic substances. The incidence rate of non-alcoholic liver injury increases due to dietary habit change and drug use increase. Our previous study demonstrated that Ecklonia stolonifera (ES) formulation has hepatoprotective effect against alcohol-induced liver injury in rat and tacrine-induced hepatotoxicity in HepG2 cells. This present study was designated to elucidate hepatoprotective effects of ES formulation against carbon tetrachloride ($CCl_4$)-induced liver injury in Sprague Dawley rat. Sixty rats were randomly divided into six groups. The rats were treated orally with ES formulation and silymarin (served as positive control, only 100 mg/kg/day) at a dose of 50, 100, or 200 mg/kg/day for 21 days. Seven days after treatment, liver injury was induced by intraperitoneal injection of $CCl_4$ (1.5 ml/kg, twice a week for 14 days). The administration of $CCl_4$ exhibited significant elevation of hepatic enzymes (like AST and ALT), and decrease of antioxidant related enzymes (superoxide dismutase, glutathione peroxidase and catalase) and glutathione. Then, it leaded to DNA damages (8-oxo-2'-deoxyguanosine) and lipid peroxidation (malondialdehyde). Administration of ES formulation inhibited imbalance of above factors compared to $CCl_4$ induced rat in a dose dependent manner. Real time PCR analysis indicates that CYP2E1 was upregulated in $CCl_4$ induced rat. However, increased gene expression was compromised by ES formulation treatment. These findings suggests that ES formulation could protect hepatotoxicity caused by $CCl_4$ via two pathways: elevation of antioxidant enzymes and normalization of CYP2E1 enzyme.