• 대한한방내과학회지
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• 제37권1호
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• pp.77-89
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• 2016

Objectives: The aim of this study was to develop a standard instrument of pattern identification and evaluation for chemotherapy-induced peripheral neuropathy (CIPN).Methods: The advisory committee for this study was organized by 12 professors of traditional Korean medicine from the Korean Association of Traditional Oncology. The items and structure of the instrument were designed based on a review of previous publications. We revised the instrument in consultation with the advisory committee and received additional advice via email.Results: We divided the symptoms and signs of CIPN into four pattern identifications: wind arthralgia (風痺), cold arthralgia (寒痺), dampness arthralgia (濕痺), and arthralgia of the deficiency type (虛痺). We obtained the mean weights to reflect the standard deviations from each symptom of the four pattern identifications, which were scored on a 5-point scale by the advisor committee. After we obtained the answers to discrimination between variable symptoms (變症) and ordinary symptoms (素症) from the 12 experts, we gained the final weight from the combination of the ratio of pattern identification to the number of total answers of the advisory committee and the mean weight.Conclusions: The Instrument on Pattern Identification and Evaluation for CIPN was developed through a discussion between 12 experts. There was a limitation that the validity and reliability of this instrument have not been proven. However, the significance of this study was that it is the first Instrument on Pattern Identification and Evaluation aimed at assessing CIPN in traditional Korean medicine.

• 대한한방내과학회지
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• 제37권6호
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• pp.961-977
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• 2016

Objectives: This study was designed to analyze the treatment effects of Eunhwayeongyo-tang through retrospective chart reviews. We also checked the correlation between each pair of variables of the symptoms and curative rates of patients with cough. Methods: Thirty-three patients with cough who had satisfied the selection criteria were retrospectively reviewed through their basic medical records, nasal endoscopy, and questionnaires about cough on their first and second visits. The questionnaires used were "The questionnaire on clinical symptoms of cough & sputum", Leicester Cough Questionnaire Korean Version (LCQ-K), Total Nasal Symptom Scores (TNSS), Visual Analog Scale (VAS), and "Cold-heat patterns". The improvement rate, calculated by "The questionnaire on clinical symptoms of cough & sputum" was considered to be clinically effective if reduction of symptoms scored more than 30%. The state of nasopharyngeal mucosa was assessed to categorize the cold-heat patterns of the upper respiratory tract and for diagnosis. Results: According to this study, cough and sputum improved by $57.22{\pm}37.76%$. Most patients (76%) improved significantly after $12.18{\pm}6.59days$ of taking Eunhwayeongyo-tang. The cure rates of 26 patients among the 33 patients were judged as effective. All the mean scores of the questionnaires and the anterior nasal cavity states were significantly improved on the patients' second visits. After $18.39{\pm}15.68days$, 30 patients were completely cured and ended treatment. The nasopharyngeal mucosa states of all patients were categorized as heat patterns. Conclusions: The conditions of the patients with nasopharyngitis significantly improved after taking Eunhwayeongyo-tang. All of the patients had pharyngitis or rhinitis. The cold-heat pattern of nasopharyngeal mucosa was a significant indicator of upper respiratory inflammation diagnosis.

• 한국의사학회지
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• 제29권2호
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• pp.35-47
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• 2016

"JeSeBoGam (濟世寶鑑)" was a medical document authored by Moon Gi-hong during the Japanese colonial rule in 1933, and the author acted as a Korean medicine doctor, an acupuncturist, a medicine practitioner and an apothecary. Since its first publication in 1933, it has been published three times in 1966 and 1975, from the Japanese colonial period to the liberation period. "JeSeBoGam" is largely divided into Preface part, "List of drugs according to symptoms [隨症用藥目錄]", "JeSeBoGam-Gap (濟世寶鑑甲)", and the Appendix includes "Key points for diagnosing the disease [察病要訣]" "Key points of acupuncture and pulse [脈訣]" "Key points of acupuncture and moxibustion treatment [針灸訣]" in the back of the book. In 1933, there are attached exam books and license application forms related to Korean medicine doctor and pharmacist, so strict regulations on them during the Japanese occupation period can be confirmed. "JeSeBoGam-Gap" contains 208 prescriptions from 143 prescriptions taken from "BangYakHapPyeon" and 65 prescriptions from other books. It divided into Gap (甲) Eul (乙) Byung (丙) Jung (丁). These prescriptions were placed in "List of drugs according to symptoms [隨症用藥目錄]" according to a symptom 1,286 times. Considerable parts of organization and prescription drug composition of "JeSeBoGam" are closely related with "BangYakHapPyeon", but there were adjustments in all medicinal ingredients and capacity for the rest of them except 23 prescription drugs. Compared to "BangYakHapPyeon", there was a tendency to substitute the basic prescription in "JeSeBoGam" for prescriptions used for the same disease. Though only 65 prescriptions were taken from books other than "BangYakHapPyeon", 575 times were reflected in "List of drugs according to symptoms [隨症用藥目錄]", and the rate of utilization is high compared with the number of prescriptions of "BangYakHapPyeon". It is thought that the circumstances of the Japanese occupation period, limits in medicinal ingredients composition due to regional characteristics, and changes in a patient's condition and the treatment method might have an influence on the author's drug use tendency. "JeSeBoGam" is similar to "BangYakHapPyeon" in composition, but it is a new practical medical book in which the author's clinical records are concentrated.

• 식물병연구
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• 제13권3호
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• pp.211-215
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• 2007

2003년부터 2006년까지 4년 동안 경남 거제시 일운면 지세포 마을의 유카리나무 재배농가에서 잎과 줄기 및 가지에 이상증상이 심하게 발생하였다. 병징은 처음 잎과 줄기에 갈색 또는 암갈색의 작은 둥근 반점으로 나타나고 심하면 잎과 줄기가 말라 죽는다. 균총은 감자한천배지에서 회색이고 균사생육 적온은 $30^{\circ}C$였다. 분생포자의 모양은 단세포로 원통형이며 크기는 $9{\sim}22{\times}3{\sim}6{\mu}m$였다. 부착기의 모양은 원통형 또는 난형으로 암갈색을 띠고 크기는 $6{\sim}18{\times}4{\sim}10{\mu}m$였다. 자낭각의 모양은 구형이고 검은색으로 크기는 $76{\sim}274{\mu}m$였다. 자낭은 바나나 또는 원통형이며 크기는 $42{\sim}76{\times}8{\sim}12{\mu}m$였다. 자낭포자는 방추형 또는 원통형으로 가운데 부분이 약간 굽었으며 크기는 $10{\sim}23{\times}4{\sim}6{\mu}m$였다. 분리된 병원균을 접종하였을 때 자연 감염된 병징과 유사한 병증상을 발생시켰다. 이상의 결과로 보아 본 병해를 Glomerella cingulata(무성세대: Colletotrichum gloeosporioides)에 의한 유카리나무 탄저병으로 명명할 것을 제안한다.

• 식물병연구
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• 제22권4호
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• pp.293-296
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• 2016

2016년 6월 말 경기도 안성시의 유기농 답전윤환 시험연구포장의 수수 5개 품종에서 줄기썩음병 증상이 관찰되었다. 초기 병징은 줄기의 표면에 적색의 병반이 형성되고 내부에 흑갈색의 반점이 존재하였다. 이후 진전되면 병반 표면에 연한 오렌지색의 포자가 형성되었다. 병원균을 분리하여 배양하면 균총은 백색에서 연한 오렌지색 또는 연노란색을 나타내고 소형분생포자는 $5-19{\times}2-4{\mu}m$의크기로 1-2개의격막을, 대형 분생포자는 $29-52{\times}3-4{\mu}m$로 4-6개의 격막을 갖고 있었다. 병원균의 분생포자 현탁액으로 수수유묘에 분무접종 3일 후 줄기에 진한 적색의 병반이 형성되었고 병의 진전에 따라 줄기가 고사하여 식물체는 쓰러졌다. 분리된 균주의 균학적 특징, 병원성, rDNA ITS 영역의 염기서열을 기초로 병원균은 F. thapsinum으로 동정되었고, 수수의 줄기썩음병으로 명명하였다.

• Korean Journal of Acupuncture
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• 제23권4호
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• pp.1-14
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• 2006

Objectives : Investigate the situation of Joseon Dynasty's Acupuncture and Moxibustion. Methods : the Acupuncture and Moxibustion methods in UiRimCh'walYo (${\ulcorner}$醫林撮要$\lrcorner$ 'Essentials of Oriental Medical Doctors') were studied. Results and Conclusions : First of all, the Acupuncture and Moxibustion methods in UiRimCh'walYo are narrated according to specific symptoms like diarrhea and stomachache, and not organized by the origin of illness or some abstract nature of a disease. In addition, it excluded complicated Acupuncture and Moxibustion methods, only adopting a couple of Acupuncture Bleeding methods and Moxibustion methods to simplify the technique as much as possible. Secondly, the Acupuncture and Moxibustion methods in UiRimCh'walYo, along with those in DongUiBoCam and Ch'imGuYoGyol introduce ways to perform moxibustion on the Umbilical Middle and Elixir Field. By focusing on the similarities between the three comtemporary medical works, it is possible to assume the existence of a unique acupuncture method using moxibustion on the Umbilical Middle and Elixir Field. Thirdly, the Acupuncture and Moxibustion methods in UiRimCh'walYo didn't go into detailed differentiation of symptoms and just concisely described one or two treatment methods for each symptom and simplified the prescription down to the core acupuncture points. This shows that the Acupuncture and Moxibustion methods in UiRimCh'walYo didn't seek its own cure but was edited in order to act as an appendix to Herbal Medicine. When integrating the conclusions above, it can be said that UiRimCh'walYo strived to use acupuncture and moxibustion simply and effectively inside the Oriental medicine's large boundaries of Herbal Medicine and Acupuncture and Moxibustion. Harmony with Herbal Medicine, an easy-to-find organization, and simple, easy-to-do prescription are what UiRimCh'walYo was about.

• Asian Pacific Journal of Cancer Prevention
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• 제16권15호
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• pp.6673-6679
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• 2015

Background: Male breast cancer is a rare neoplasm, and its treatments are based on those of female breast cancer. This study aimed to analyze 20 years of male breast cancer clinical characteristics and treatment results from the Middle Black Sea Region of Turkey. Materials and Methods: A retrospective analysis of 16 male breast cancer patients treated in our tertiary hospital between 1994 and 2014 was performed. Epidemiologic data, tumor characteristics, and treatments were recorded and compared with 466 female breast cancer ((premenopausal; n = 230) + (postmenopausal n = 236)) patients. The 5-year disease-free and overall survival rates were calculated. Results: Male breast cancer constituted 0.1% of all malignant neoplasms in both sexes, 0.2% of all malignant neoplasms in males, and 0.7% of all breast cancers. The mean patient age in this study was $59.8{\pm}9.5$ (39-74) years. The mean time between first symptom and diagnosis was $32.4{\pm}5.3$ (3-60) months. Histology revealed infiltrative ductal carcinoma in 81.3% of patients. The most common detected molecular subtype was luminal A, in 12 (75%) patients. Estrogen receptor rate (93.8%) in male breast cancer patients was significantly higher than that in female breast cancer (70.8% in all females, p = 0.003; 68.2% in postmenopausal females, p = 0.002) patients. Most of the tumors (56.3%) were grade 2. Tumor stage was T4 in 50% of males. The majority (56.3%) of the patients were stage III at diagnosis. Surgery, chemotherapy, radiotherapy and endocrine-therapy were applied to 62.5%, 62.5%, 81.2% and 73.3%, respectively. Loco-regional failure did not occur in any of the cases. All recurrences were metastastic. The 5-year disease-free and overall survival rates in male breast cancer patients were 58% and 68%, respectively. Conclusions: Tumors found in male breast cancer patients were similar in size to tumors found in females, but they advanced to T4 stage more rapidly because of the lack of breast parenchymal tissues. The rate of estrogen receptor expression tended to be higher in male breast cancer patients than in female breast cancer patients. Metastasis is the most important problem in initially non-metastatic male breast cancer patients.

• 한국응용곤충학회지
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• 제48권4호
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• pp.479-484
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• 2009

2008년 6월 15일 경북 상주의 상주둥시 감나무 (Diospyrosi kaki)에서 매미충이 채집되었다. 매미충은 감나무 잎에 심각한 피해를 주고 있었으며 Zorka속의 신종으로 확인되었다. 피해 잎은 앞면쪽에 1 mm 이하의 흰색 반점이 엽맥 주위부에 형성되었고, 피해가 심해지면 잎 전체에 반점이 형성되었다. 엽당 4마리 밀도로 접종 시 4일 후부터 피해 흔적이 확인되었다. 2008년과 2009년 6월에서 8월 사이 6개도 11개 시 군 감나무 과원에서 Zorka sp.에 의한 피해지역을 조사하였다. 조사과원 중 15.4%인 22개 과원에서 피해가 확인되었다. 충북 영동지역에서는 40.7%의 과원이 피해를 받고 있었고, 전북 완주지역에서는 33.3%가 피해를 받고 있었다. 반면 남부지역인 경남과 제주지역에서는 피해 과원이 없었다. 피해과원이 많았던 충북 영동지역의 경우 11개 피해 과원 중 9개 과원이 포도밭과 인접해 있었다.

• 식물병연구
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• 제19권2호
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• pp.124-127
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• 2013

시설재배단지에서 파프리카의 열매에 검은 괴저 반점 증상이 발생하였다. 이 증상주를 전자현미경, 지표식물 검정 및 RT-PCR 분석 결과, 원인 바이러스로 PMMoV로 동정되었다. 신엽에서 병징은 약한 모틀 증상, 과경과 과일에 검은 반점이 보였지만, 성숙한 잎에서는 증상이 나타나지 않았다. PMMoV의 분리주들에 대한 Tobamovirus pathotype(P)의 판별 고추계통에 접종한 결과, 모두 $P_{1.2.3}$으로 확인되었다. 분리한 PMMoV를 건전 파프리카 유묘에 기계적 접종을 통하여 이 바이러스의 병원성을 증명하였다. PMMoV 분리주들의 외피단백질 유전자의 상동성은 96-99%였다. $P_{1.2}$인 PMMoV-P2 분리주의 외피단백질 아미노산 배열 139번째가 Met인 반면, 파프리카 분리주 모두 이 위치가 Asn으로 확인되었다. 본 논문은 파프리카에서 PMMoV pathotype $P_{1.2.3}$의 동정에 관한 우리나라 최초 보고이다.

• 한국전자통신학회논문지
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• 제11권7호
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• pp.707-716
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• 2016

본 연구는 ICT 시대에서 미숙아 어머니의 퇴원 교육 요구도와 미숙아 어머니가 인지한 간호사의 교육수행 정도를 알아보고 관련 있는 요인들을 파악하고자 실시되었다. 대상자는 G광역시 2차 진료기관인 K종합병원의 신생아 중환자실에 입원한 미숙아 어머니 중에서 연구에 동의한 54명이며, 자기 기입식 설문을 통해 조사하였다. 퇴원 교육 요구도와 간호사의 교육수행 정도에 유의한 차이를 보인 영역은 '이상증상 확인과 관리'($0.55{\pm}0.97$, p=0.001), '배설관리'($0.45{\pm}1.11$, p=0.004), '성장발달'($0.41{\pm}1.08$, p=0.007)이었다. 퇴원교육 요구도는 분만형태(질식분만: $4.41{\pm}0.47$, 제왕절개: $4.03{\pm}0.47$, p=0.040)와 출생순위(첫째: $4.37{\pm}0.53$, 둘째: $4.25{\pm}0.51$, 셋째이상: $3.75{\pm}0.72$, p=0.031)에 따라 유의한 차이를 보였다. 미숙아 어머니가 인지한 간호사의 교육수행도는 조력자의 유무(있음: $4.15{\pm}0.66$, 없음: $3.48{\pm}0.67$, p=0.002)에 따라 유의한 차이를 보였다. 그러므로 이런한 결과를 기반으로 미숙아 어머니의 퇴원 교육 요구도에 근거한 실질적으로 도움이 되는 ICT 기반하의 퇴원교육 프로그램 개발 연구를 제안한다.