• The Journal of Korean Institute of Communications and Information Sciences
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• v.17 no.10
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• pp.1157-1163
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• 1992

The development of adaptive control algorithms for possibly nonminimum phase systems has been hampered by singularities that may arise in the control law. To solve this problem, one securing convergence of the estimates to their true values by inducing persistency of excitation in the plant signals using direct adaptive control method and indirect adaptive control method, and another in which the estimates are adequately modified to meet the controllability requirements using indirect adaptive control method, without persistency of excitation. This paper presents an adaptive scheme that achieves regulation without persistent excitation condition using direct adaptive control method and reduces estimation algorithms with direct estimation of controller parameters without estimation of plant parameters.

• Journal of the Korean Institute of Gas
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• v.18 no.2
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• pp.28-34
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• 2014

In the natural gas pressure regulation station, high pressure natural gas is decompressing using pressure regulation valves. Waste pressure occurred in the pressure regulation process can be recovered through adopting turbo expanders. However, in the waste pressure recovery process, Joule Thompson effect causes below $0^{\circ}C$ and this low temperature freezes outside land of pipeline or generates methane hydrate in the pipeline which can block the pipeline. Therefore, turbo expander systems are accompanying with a boiler for preheating natural gas. Molten carbonate fuel cell (MCFC), one of the high temperature fuel cell, can use natural gas as a direct fuel and is also exhausting low emission gas and generating electricity. In this paper, a thermodynamic analysis on the hybrid MCFC-turbo expander system is conducted. The fuel cell system is analyzed for the base load of the hybrid system.

• Korean Journal of Family Social Work
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• no.56
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• pp.105-133
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• 2017

The purpose of this study was to examine the relationship between family strength and career decision-making difficulties and the mediating effect or career self-regulation. The results of the present study suggested the significance of family strength and career self-regulation in understanding career decision-making difficulties. With 172 Korean college students, there were both significant direct and indirect effects from family strength to career decision-making difficulties. Specifically, the mediation roles of career self-regulation was confirmed. Comparing the partial mediation model with full mediation model, the partial mediation model fits better with the data. These results have significant clinical implication that counseling practitioners need to address the possible influence of family strength on college student's perceived difficulties in career decision-making process and to assist students develop appropriate level of competencies of regulating one's emotion, thoughts, and behavior related to career problems.

• BMB Reports
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• v.42 no.11
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• pp.725-730
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• 2009

Cyclin E1 (CCNE1), a positive regulator of the cell cycle, controls the transition of cells from G1 to S phase. In numerous human tumors, however, CCNE1 expression is frequently dysregulated, while the mechanism leading to its dysregulation remains incompletely defined. Herein, we showed that CCNE1 expression was subject to post-transcriptional regulation by a microRNA miR-16-1. This was evident at protein level of CCNE1 as well as its mRNA level. Further evident by dual luciferase reporter assay revealed that two evolutionary conserved binding sites on 3' UTR of CCNE1 were the direct functional target sites. Moreover, we showed that miR-16-1 induced G0/G1 cell cycle arrest by targeting CCNE1 and siRNA against CCNE1 partially phenocopied miR-16-1-induced cell cycle phenotype whereas substantially rescued anti-miR-16-1- induced phenotype. Together, all these results demonstrate that miR-16-1 plays a vital role in modulating cellular process in human cancers and indicate the therapeutic potential of miR-16-1 in cancer therapy.

• Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
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• v.26 no.12
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• pp.21-27
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• 2012

Korean Industrial Standards for lightning protection system complies with IEC standards. However, the standards are applicable only to buildings and structures more than 20 meters in high. Therefore, it is necessary to determine whether lightning protection system should be installed on structures lower than 20 meters high. This paper proposes an efficient method of assessing risk against lightning of structures lower than 20 meters high. The method suggests simplified lightning protection system and provides selecting an appropriate protection level. The suggested method assumes that structure under assessment has no lightning protection system and there is no person around the structure at the moment of lightning stroke. A simplified method of assessing the risk to human within the structure is developed by adopting the general assessment factor. The selection of a protection level is possible by comparing tolerable risk with physical damage risk caused by a direct lightning. Finally, this paper gives ways to establish surge protection measures when a structure with lightning risk is within a radius of 2km from the assessed structure even if this structure requires no lightning protection system.

• BMB Reports
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• v.47 no.1
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• pp.8-14
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• 2014

Telomerase plays a pivotal role in the pathology of aging and cancer by maintaining genome integrity, controlling cell proliferation, and regulating tissue homeostasis. Telomerase is essentially composed of an RNA component, Telomerase RNA or TERC, which serves as a template for telomeric DNA synthesis, and a catalytic subunit, telomerase reverse transcriptase (TERT). The canonical function of TERT is the synthesis of telomeric DNA repeats, and the maintenance of telomere length. However, accumulating evidence indicates that TERT may also have some fundamental functions that are independent of its enzymatic activity. Among these telomere-independent activities of hTERT, the role of hTERT in gene transcription has been investigated in detail. Transcriptional regulation is a fundamental process in biological systems. Several studies have shown a direct involvement of hTERT in gene transcription. This mini-review will focus on the role of hTERT in gene transcription regulation, and discuss its possible mechanisms.

• Archives of Pharmacal Research
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• v.29 no.3
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• pp.249-255
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• 2006

Ability of iron acquisition of pathogenic microorganisms functions as a virulence factor. Candida albicans, a fungal pathogen that requires iron for growth, is susceptible to growth retardation by high-affinity iron binding proteins such as transferrin. Recently, we reported that C. albicans could utilize the heme as a part of heme-containing proteins dissociated by heme oxygenase, CaHMX1. In search of another pathway that C. albicans can use to bypass the growth regulation produced by iron limitation, this present study examined utilization of non-candidal siderophores such as Desferal and rhodotorulic acid (RA) for acquisition of inorganic iron by the fungus. C. albicans secreting no siderophores was cultured in iron-free (pretreated with apotransferrin for 24 h) (culture medium). Once growth of the yeast reached stasis from iron starvation, a siderophore was added to the culture media. Results showed that cultures containing apotransferrin within a dialysis membrane recovered growth to the level of untreated controls, whereas C. albicans yeast cells in direct contact with soluble iron-free (apo) transferrin recovered growth only partially. When static growth from iron limitation was reached, the addition of siderophore-apotransferrin complex to culture medium also permitted the yeast to recover growth from apotransferrin growth regulation. All the data show that C. albicans can utilize the non-candidal siderophores for iron acquisition under transferrin regulation as can pathogenic bacteria.

• Korean Journal of Child Studies
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• v.31 no.3
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• pp.17-32
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• 2010

In this study, I examined the direct or indirect paths among the intra-personal factors as well as extra-personal factors affecting on children's peer competence. Subjects were 514 5-year-old children, their mothers, teachers. The teachers rated each children using Peer Competence Scale (Park, 2001) and completed emotion regulation and Student-Teacher Relationship Scale. The mothers responded to a questionnaire, including Parental Involvement Checklist (Cohen, 1989), parenting behaviors, and Children's Temperament. The data were used for path analysis with Amos 6.0 program. Results of this study were : (1) Children's temperament have an influence on children's peer competence through children's emotion regulation via mothers' parenting behaviors. (2) Children's temperament have an influence on children's peer competence through teacher-child relationship. (3) Mothers' parenting behaviors have an influence on children's peer Competence through mothers' management strategies of peer relations.

• Archives of Pharmacal Research
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• v.25 no.1
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• pp.93-101
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• 2002

The extract of European mistletoe ( Viscum album, L) has been used in adjuvant chemotherapy of cancer and mistletoe lectins are considered to be major active components. The present work was performed to investigate the effects of Korean mistletoe lectin (Viscum album L. coleratum agglutinin, VCA) on proliferation and apoptosis of human hepatoma cells as well as the underlying mechamisns for these effects. We showed that VCA induced atoptosis in both SK-Hep-1 and Hep 3B (p53-negative) cells through p53- and p21 -independent pathways. VCA induced apoptosis by down-regulation of Bcl-2 and by up-regulation of Bax functioning upstream of caspase-3 in both cell lines. In addition, we observed down-regulation of telomerase activity in both VCA-treated cells. Our results provide direct evidence of the anti-tumor potential of this biological response which comes from inhibition of telomerase and consequent inducing apoptosis. VCA-induced apoptosis is regulated by mitochondria controlled pathway independently of p53. These findings are important for the therapy with preparation of mistletoe because they show that telomerase-dependent mechanism can be targeted by VCA in human hepatocarcinoma. Taken together, our results suggest that the VCA, considered as a telomerase-inhibitor, can be envisaged as a candidate for enhancing sensitivity of conventional anticancer drugs.

• The Transactions of the Korean Institute of Electrical Engineers P
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• v.66 no.2
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• pp.63-68
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• 2017

This paper proposes a new non-isolated DC conversion circuit topology of the voltage source coupled inductor series resonant high-frequency PFM controlled boost chopper type DC-DC power converter using two in one IGBT power module, which can efficiently operate under a principle of zero current soft switching for wide output regulation voltage setting ranges and wide fluctuation of the input DC side voltage as well as the load variation ranges. Its steady state operating principle and the output voltage regulation characteristics in the open-loop-based output voltage control scheme without PI controller loop are described and evaluated from theoretical and experimented viewpoints. Finally, in this paper the computer-aided simulation steady-state analysis and the experimental results are presented in order to prove the effectiveness and the validity of voltage regulation characteristics of the proposed series resonant zero current soft switching boost chopper type DC-DC power converter circuit using IGBTs which is based on simple pulse frequency modulation strategy more than, 20kHz.