• Journal of Information Technology Applications and Management
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• v.27 no.1
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• pp.59-73
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• 2020

There is a growing interest in convergence. National R & D is also providing various policies and institutional support to promote convergence research. Convergence research, however, does not clearly specify its characteristics at the academic and government levels. This research proceeds with the process of collecting, refining, analyzing, modeling, verifying and visualizing national R & D data through the National Science and Technology Information Service (NTIS). The method is to derive the convergence research characteristics and to derive through text mining, focusing on the unstructured information of national R & D project data. The study confirmed that there was a difference in perception between the definition of converged research and the research site. In order to improve this, the research suggested that convergence among research subjects, collaboration among research topics reflecting various backgrounds and characteristics of researchers, and analysis of characteristics of convergence research using information were suggested in the process of establishing convergence policy.

• The Mathematical Education
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• v.53 no.3
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• pp.357-381
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• 2014

This study analyzed the cases of three teacher communities participating in an innovative professional development program and clarified the characteristics and the process of lessons for mathematics-oriented convergence that were developed and applied during the program. Each of the teacher communities designed and implemented lessons according to the context of each community and the concept of lessons for mathematics-oriented convergence were developed and refined. The lessons developed by the three teacher communities were characterized as convergence problem posing lessons using technology, convergence of various subject content focused on mathematical concepts through team teaching, and convergence lessons according to students' achievement levels. The program contributed to teacher community activities by proving sustainable professional development in the area of convergence education, a connection between the content of their professional development and the context of the field, and opportunities for active participation in the process of developing and implementing the convergence lessons.

• ETRI Journal
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• v.34 no.3
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• pp.439-449
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• 2012

In recent innovation trends, one notable feature is the merging and overlapping of technologies: in other words, technological convergence. A key technological convergence is the fusion of biotechnology (BT) and information technology (IT). Major IT advances have led to innovative devices that allow us to advance BT. However, the lack of data on IT-BT convergence is a major impediment: relatively little research has analyzed the inter-disciplinary relationship of different industries. We propose a systematic approach to analyzing the technological convergence of BT and IT. Patent analysis, including citation and co-classification analyses, was adopted as a main method to measure the convergence intensity and coverage, and two portfolio matrices were developed to manage the technological convergence. The contribution of this paper is that it provides practical evidences for IT-BT convergence, based on quantitative data and systematic processes. This has managerial implications for each sector of IT and BT.

• BMB Reports
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• v.57 no.6
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• pp.281-286
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• 2024

Adult hippocampal neurogenesis plays a pivotal role in maintaining cognitive brain function. However, this process diminishes with age, particularly in patients with neurodegenerative disorders. While small, non-coding microRNAs (miRNAs) are crucial for hippocampal neural stem (HCN) cell maintenance, their involvement in neurodegenerative disorders remains unclear. This study aimed to elucidate the mechanisms through which miRNAs regulate HCN cell death and their potential involvement in neurodegenerative disorders. We performed a comprehensive microarray-based analysis to investigate changes in miRNA expression in insulin-deprived HCN cells as an in vitro model for cognitive impairment. miR-150-3p, miR-323-5p, and miR-370-3p, which increased significantly over time following insulin withdrawal, induced pronounced mitochondrial fission and dysfunction, ultimately leading to HCN cell death. These miRNAs collectively targeted the mitochondrial fusion protein OPA1, with miR-150-3p also targeting MFN2. Data-driven analyses of the hippocampi and brains of human subjects revealed significant reductions in OPA1 and MFN2 in patients with Alzheimer's disease (AD). Our results indicate that miR-150-3p, miR-323-5p, and miR-370-3p contribute to deficits in hippocampal neurogenesis by modulating mitochondrial dynamics. Our findings provide novel insight into the intricate connections between miRNA and mitochondrial dynamics, shedding light on their potential involvement in conditions characterized by deficits in hippocampal neurogenesis, such as AD.

• Composites Research
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• v.31 no.5
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• pp.186-191
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• 2018

Condition and properties of composites with different chemical structure of epoxy matrix were observed after saline solution treatment. Epoxy was used as matrix and the flexibility was controlled by using 2 typed-epoxies and 3 types hardeners (amine, acid anhydride and amide). Saline water treatment was conducted with 6 wt% NaCl solution at $60^{\circ}C$ for 0, 15, and 30 days. Cross section was observed and interfacial and mechanical and properties was evaluated. Amine type exhibited the highest crosslinking density and mechanical and interfacial properties whereas water absorbance was lowest. It is because that the water molecules can be hardly penetrate into the epoxy matrix or the interface between epoxy and glass fiber and it leads to saline water resistance of composites.

• Journal of the Chungcheong Mathematical Society
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• v.28 no.1
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• pp.1-12
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• 2015

We present a local convergence analysis for inexact Newton-like method in a Banach space under weaker Lipschitz condition. The convergence ball is enlarged and the estimates on the error distances are more precise under the same computational cost as in earlier studies such as [6, 7, 11, 18]. Some special cases are considered and applications for solving nonlinear systems using the Newton-arithmetic mean method are improved with the new convergence technique.

• Journal of the Korean Mathematical Society
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• v.49 no.6
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• pp.1097-1110
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• 2012

The convergence properties of extended negatively dependent sequences under some conditions of uniform integrability are studied. Some sufficient conditions of the weak law of large numbers, the $p$-mean convergence and the complete convergence for extended negatively dependent sequences are obtained, which extend and enrich the known results in the literature.

• Journal of applied mathematics & informatics
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• v.40 no.3_4
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• pp.433-444
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• 2022

In the present paper, we introduce some new notions of Wijsman ${\mathcal{I}}$-statistical convergence with the use of Orlicz function, lacunary sequence and triple sequences of sets, and obtain some analogous results from the new definitions point of views.

• Journal of applied mathematics & informatics
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• v.40 no.3_4
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• pp.619-632
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• 2022

In this study, we examine rough ${\Delta}\mathcal{I}$-statistical convergence for difference sequences as an extension of rough convergence. We investigate the set of rough ${\Delta}\mathcal{I}$-statistical limit points of a difference sequence and analyze the results with proofs.

• Molecules and Cells
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• v.38 no.11
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• pp.991-997
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• 2015

Tristetraprolin (TTP) is an AU-rich elements (AREs)-binding protein, which regulates the decay of ARE-scontaining mRNAs such as proto-oncogenes, anti-apoptotic genes and immune regulatory genes. Despite the low expression of TTP in various human cancers, the mechanism involving suppressed expression of TTP is not fully understood. Here, we demonstrate that Resveratrol (3,5,4'-trihydroxystilbene, Res), a naturally occurring compound, induces glioma cell apoptosis through activation of tristetraprolin (TTP). Res increased TTP expression in U87MG human glioma cells. Res-induced TTP destabilized the urokinase plasminogen activator and urokinase plasminogen activator receptor mRNAs by binding to the ARE regions containing the 3' untranslated regions of their mRNAs. Furthermore, TTP induced by Res suppressed cell growth and induced apoptosis in the human glioma cells. Because of its regulation of TTP expression, these findings suggest that the bioactive dietary compound Res can be used as a novel anti-cancer agent for the treatment of human malignant gliomas.