Molecules and Cells

Korean Society for Molecular and Cellular Biology (한국분자세포생물학회)
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Resveratrol Induces Glioma Cell Apoptosis through Activation of Tristetraprolin

  • Ryu, Jinhyun (Department of Anatomy and Convergence Medical Science, Institute of Health Science, School of Medicine, Gyeongsang National University) ;
  • Yoon, Nal Ae (Department of Anatomy and Convergence Medical Science, Institute of Health Science, School of Medicine, Gyeongsang National University) ;
  • Seong, Hyemin (Department of Anatomy and Convergence Medical Science, Institute of Health Science, School of Medicine, Gyeongsang National University) ;
  • Jeong, Joo Yeon (Department of Anatomy and Convergence Medical Science, Institute of Health Science, School of Medicine, Gyeongsang National University) ;
  • Kang, Seokmin (Department of Anatomy and Convergence Medical Science, Institute of Health Science, School of Medicine, Gyeongsang National University) ;
  • Park, Nammi (Department of Physiology, Institute of Health Sciences, School of Medicine, Gyeongsang National University) ;
  • Choi, Jungil (Gyeongnam Department of Environmental Toxicology and Chemistry, Korea Institute of Toxicology (KIT)) ;
  • Lee, Dong Hoon (Department of Anatomy and Convergence Medical Science, Institute of Health Science, School of Medicine, Gyeongsang National University) ;
  • Roh, Gu Seob (Department of Anatomy and Convergence Medical Science, Institute of Health Science, School of Medicine, Gyeongsang National University) ;
  • Kim, Hyun Joon (Department of Anatomy and Convergence Medical Science, Institute of Health Science, School of Medicine, Gyeongsang National University) ;
  • Cho, Gyeong Jae (Department of Anatomy and Convergence Medical Science, Institute of Health Science, School of Medicine, Gyeongsang National University) ;
  • Choi, Wan Sung (Department of Anatomy and Convergence Medical Science, Institute of Health Science, School of Medicine, Gyeongsang National University) ;
  • Park, Jae-Yong (School of Biosystem and Biomedical Science, College of Health Science, Korea University) ;
  • Park, Jeong Woo (Department of Biological Sciences, University of Ulsan) ;
  • Kang, Sang Soo (Department of Anatomy and Convergence Medical Science, Institute of Health Science, School of Medicine, Gyeongsang National University)
  • Received : 2015.07.14
  • Accepted : 2015.09.07
  • Published : 2015.11.30
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Abstract

Tristetraprolin (TTP) is an AU-rich elements (AREs)-binding protein, which regulates the decay of ARE-scontaining mRNAs such as proto-oncogenes, anti-apoptotic genes and immune regulatory genes. Despite the low expression of TTP in various human cancers, the mechanism involving suppressed expression of TTP is not fully understood. Here, we demonstrate that Resveratrol (3,5,4'-trihydroxystilbene, Res), a naturally occurring compound, induces glioma cell apoptosis through activation of tristetraprolin (TTP). Res increased TTP expression in U87MG human glioma cells. Res-induced TTP destabilized the urokinase plasminogen activator and urokinase plasminogen activator receptor mRNAs by binding to the ARE regions containing the 3' untranslated regions of their mRNAs. Furthermore, TTP induced by Res suppressed cell growth and induced apoptosis in the human glioma cells. Because of its regulation of TTP expression, these findings suggest that the bioactive dietary compound Res can be used as a novel anti-cancer agent for the treatment of human malignant gliomas.

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References

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