• Title/Summary/Keyword: biased response

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Absorption Coefficients for the Bound-to-continuum Transitions in a Biased Quantum-well Infrared Photodetector

  • Choe Jeong-woo;Hwang Hyung-Joon
    • Journal of the Optical Society of Korea
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    • v.9 no.4
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    • pp.131-134
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    • 2005
  • We have proposed a method to calculate the absorption coefficients for the bound-to-continuum transitions in a strong biased quantum-well infrared photodetector. We have applied this method to a manufactured sample of typical device parameters, and obtained good agreements with experiments. The absorption coefficients evaluated are up to 5,700/cm at some particular operating conditions. We have also been able to make a qualitative explanation for the bias dependence of response.

Molecular Markers in Sex Differences in Cancer

  • Shin, Ji Yoon;Jung, Hee Jin;Moon, Aree
    • Toxicological Research
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    • v.35 no.4
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    • pp.331-341
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    • 2019
  • Cancer is one of the common causes of death with a high degree of mortality, worldwide. In many types of cancers, if not all, sex-biased disparities have been observed. In these cancers, an individual's sex has been shown to be one of the crucial factors underlying the incidence and mortality of cancer. Accumulating evidence suggests that differentially expressed genes and proteins may contribute to sex-biased differences in male and female cancers. Therefore, identification of these molecular differences is important for early diagnosis of cancer, prediction of cancer prognosis, and determination of response to specific therapies. In the present review, we summarize the differentially expressed genes and proteins in several cancers including bladder, colorectal, liver, lung, and nonsmall cell lung cancers as well as renal clear cell carcinoma, and head and neck squamous cell carcinoma. The sex-biased molecular differences were identified via proteomics, genomics, and big data analysis. The identified molecules represent potential candidates as sex-specific cancer biomarkers. Our study provides molecular insights into the impact of sex on cancers, suggesting strategies for sex-biased therapy against certain types of cancers.

The Empathy and Justice Contemplated From the Neuroscientific Perspective in the Age of Social Divisions and Conflicts (분열과 반목의 시대에 신경과학적 관점에서 고찰해보는 공감과 정의)

  • Ji-Woong, Kim
    • Korean Journal of Psychosomatic Medicine
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    • v.30 no.2
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    • pp.55-65
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    • 2022
  • Although humans exist as Homo Empathicus, human society is actually constantly divided and conflicted between groups. The human empathy response is very sensitive to the justice of others, and depending on the level of others' justice, they may feel empathy or schadenfreude to the suffering of them. However, our empathy to others' suffering are not always fair, and have inherent limitations of ingroup-biased empathy. Depending on whether the suffering other persons belongs to an ingroup or an outgroup, we may feel biased empathy or biased schadenfreude to them without even realizing it. Recent advances in information and communication technology facilitate biased access to ingroup-related SNS or ingroup media, thereby deepening the establishment of a more biased semantic information network related groups. These processes, through interacting with the inherent limitation of empathy, can form a vicious cycle of more biased ingroup empathy and ingroup-related activities, and accelerate divisions and conflicts. This research investigated the properties and limitations of empathy by reviewing studies on the neural mechanism of empathy. By examining the relationship between empathy and justice from a neuroscientific point of view, this research tried to illuminate the modern society of division and conflict in a different dimension from the classical perspective of social science.

Modulation of Antibody Responses against Gnathostoma spinigerum in Mice Immunized with Crude Antigen Formulated in CpG Oligonucleotide and Montanide ISA720

  • Intapan, Pewpan M.;Hirunpetcharat, Chakrit;Kularbkaew, Churairat;Yutanawiboonchai, Wiboonchai;Janwan, Penchom;Maleewong, Wanchai
    • Parasites, Hosts and Diseases
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    • v.51 no.6
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    • pp.637-644
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    • 2013
  • This study aimed to investigate the antibody responses in mice immunized with Gnathostoma spinigerum crude antigen (GsAg) incorporated with the combined adjuvant, a synthetic oligonucleotide containing unmethylated CpG motif (CpG ODN 1826) and a stable water in oil emulsion (Montanide ISA720). Mice immunized with GsAg and combined adjuvant produced all antibody classes and subclasses to GsAg except IgA. IgG2a/2b/3 but not IgG1 subclasses were enhanced by immunization with CpG ODN 1826 when compared with the control groups immunized with non-CpG ODN and Montanide ISA or only with Montanide ISA, suggesting a biased induction of a Th1-type response by CpG ODN. After challenge infection with live G. spinigerum larvae, the levels of IgG2a/2b/3 antibody subclasses decreased immediately and continuously, while the IgG1 subclass remained at high levels. This also corresponded to a continuous decrease of the IgG2a/IgG1 ratio after infection. Only IgM and IgG1 antibodies, but not IgG2a/2b/3, were significantly produced in adjuvant control groups after infection. These findings suggest that G. spinigerum infection potently induces a Th2-type biased response.

Design of the Detection Circuitry for the Characteristics of Micromachined Vibrating Gyroscope (미세가공 진동형 자이로스코프의 특성 감지 회로의 설계에 관한 연구)

  • U, Yeong-Sin;Byeon, Gwang-Gyun;Seo, Il-Won;Seong, Man-Yeong
    • The Transactions of the Korean Institute of Electrical Engineers C
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    • v.48 no.10
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    • pp.687-692
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    • 1999
  • A new technique to measure low level capacitance variations of the gyroscope is proposed and verified by computer simulation. It is based on the new CV(capacitance-voltage) converter circuit biased by dc current source and the peak detector without low pass filter. The CV converter biased by dc current source provides good signal-to-noise ratio and this setup of the detection circuitry without low pass filter makes it possible to provide short settling time, that is, higher speed of measurement and wide operation range if only a few parameters are adjusted. The key parameters that affect the performance of the detection circuitry are illustrated and computer simulation results are presented. The demonstrated detection circuitry shows linear response from 10 fF to 130 fF at 10 kHz and shows good linearity.

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Blind Signal Processing for Medical Sensing Systems with Optical-Fiber Signal Transmission

  • Kim, Namyong;Byun, Hyung-Gi
    • Journal of Sensor Science and Technology
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    • v.23 no.1
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    • pp.1-6
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    • 2014
  • In many medical image devices, dc noise often prevents normal diagnosis. In wireless capsule endoscopy systems, multipath fading through indoor wireless links induces inter-symbol interference (ISI) and indoor electric devices generate impulsive noise in the received signal. Moreover, dc noise, ISI, and impulsive noise are also found in optical fiber communication that can be used in remote medical diagnosis. In this paper, a blind signal processing method based on the biased probability density functions of constant modulus error that is robust to those problems that can cause error propagation in decision feedback (DF) methods is presented. Based on this property of robustness to error propagation, a DF version of the method is proposed. In the simulation for the impulse response of optical fiber channels having slowly varying dc noise and impulsive noise, the proposed DF method yields a performance enhancement of approximately 10 dB in mean squared error over its linear counterpart.

Decoupling Control of Levitation and Thrust Motion of The Transverse Flux Linear Induction Motor Using DC-biased Multi Phase Inputs (DC 편의된 다상 입력을 이용한 횡자속 선형 유도 전동기의 부상/추진 독립제어)

  • Jung, Kwang-Suk;Huh, Jin-Hyuk;Baek, Yoon-Su
    • Transactions of the Korean Society of Mechanical Engineers A
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    • v.28 no.11
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    • pp.1733-1740
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    • 2004
  • In the transverse flux linear induction motor(TFLIM) with the general secondary composed of conductor and back-yoke, there exists a magnetized force into the normal direction or the air-gap direction of the thrust motion as well as the thrust force. Therefore, the various methodologies have been tried to use the normal force by the two independent control variables of the multi-phase input. But, as the force depends inevitably and strongly on the thrust force, it is essential to decouple both forces for two control index. In this paper, we suggest a novel approach capable of compensating the couple between both forces and the control index by using the DC-biased multi-phase input, and then realizing the independent control of TFLIM.

Risk Value Calculation Method for Moderate Risk Concentration Type at Qualitative Risk Analysis Phase (정성적 위험분석 단계에서 중간위험 집중형 위험도 산정 방법)

  • Kim, Seon-Gyoo
    • Korean Journal of Construction Engineering and Management
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    • v.16 no.2
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    • pp.38-45
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    • 2015
  • The risk analysis phase of construction risk management process is subdivided into the qualitative risk analysis that plays a major role, and the quantitative risk analysis acting as a supportive role. The traditional calculation method for quantifying a risk value that has been applied so far is an equation to multiply a probability by an impact simply, but its result shows the low risk value biased distribution. Although another equation that shows the high risk biased distribution as an alternative of traditional method was proposed, both of the low or high risk biased equations do not match with the statistical general knowledge that most natural phenomenons are close to the normal distribution. This study proposes a new risk value calculation method that is concentrated to the moderate risk value. Because the risk value distribution by a new method shows a normal shape similar to natural phenomenon, it helps to choose a middle level not biased to the low or high levels when choosing the level of risk response. Furthermore, it could contribute to improve the flexibility and rationality of risk analysis method by providing additional options for the risk value calculation.

A convergence analysis of a PLL for a digital recording channel with an adaptive partial response equalizer (적응 부분응답 등화기를 갖는 디지탈 기록 채널의 PLL 수렴 특성 분석)

  • 오대선;양원영;조용수
    • Journal of the Korean Institute of Telematics and Electronics B
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    • v.33B no.6
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    • pp.45-53
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    • 1996
  • In this paper, the convergence behavior of timing phase when an adaptive partial response equalizer and decision-directed type of a PLL work together in a digital recording channel is described. The phenomena of getting biased in timing phase when the convergence parameter of an adaptive partial response equalizer and timing recovery constant of a PLL are not selected properly is introduced. The phenomena, occurring due to perturbation of timing phase, are analyzed, by computer simulation and the region of ocnvergence for timing phase is discussed. Also, a method to overcome the phenomena using a variable step-size parameter is described.

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A Study on Air Traffic Controllers' Cultural bias and Their Response on Abnormal Situations (항공교통관제사의 문화적 편향(Cultural Bias)에 따른 위기 대응 연구)

  • Kim, Geun-Su;Cho, Sung-Hwan
    • Journal of the Korean Society for Aviation and Aeronautics
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    • v.26 no.4
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    • pp.64-75
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    • 2018
  • A status of air traffic controller is a government officer and air traffic controllers who work at airport are divided by duty rating and work experience. Abiding by law, rules and regulation, air traffic controllers are working together based on mutual trust. This paper's theoretical background is based on cultural bias theory. The theory divide people group into four groups according to cultural bias such as fatalism, hierarchy, individualism and egalitarianism. A research model was designed how such four cultural bias could affect air traffic controller's risk response in case of emergency or abnormal situation during their work. Depend on empirical research, it was found that air traffic controllers perceived they had been more biased to fatalism than hierarchy. The characteristics of fatalism group are as follows: first of all, they follow rigid rules and regulation. However, they have less self-efficacy compared to other government officers. According to structural equation model, air traffic controller's fatalism had a significant negative effect on organizational royalty. Their royalty, however, had a very significant positive effect on planning response and immediate response.