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Thermodynamics-Based Weight Encoding Methods for Improving Reliability of Biomolecular Perceptrons (생체분자 퍼셉트론의 신뢰성 향상을 위한 열역학 기반 가중치 코딩 방법)

  • Lim, Hee-Woong;Yoo, Suk-I.;Zhang, Byoung-Tak
    • Journal of KIISE:Software and Applications
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    • v.34 no.12
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    • pp.1056-1064
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    • 2007
  • Biomolecular computing is a new computing paradigm that uses biomolecules such as DNA for information representation and processing. The huge number of molecules in a small volume and the innate massive parallelism inspired a novel computation method, and various computation models and molecular algorithms were developed for problem solving. In the meantime, the use of biomolecules for information processing supports the possibility of DNA computing as an application for biological problems. It has the potential as an analysis tool for biochemical information such as gene expression patterns. In this context, a DNA computing-based model of a biomolecular perceptron has been proposed and the result of its experimental implementation was presented previously. The weight encoding and weighted sum operation, which are the main components of a biomolecular perceptron, are based on the competitive hybridization reactions between the input molecules and weight-encoding probe molecules. However, thermodynamic symmetry in the competitive hybridizations is assumed, so there can be some error in the weight representation depending on the probe species in use. Here we suggest a generalized model of hybridization reactions considering the asymmetric thermodynamics in competitive hybridizations and present a weight encoding method for the reliable implementation of a biomolecular perceptron based on this model. We compare the accuracy of our weight encoding method with that of the previous one via computer simulations and present the condition of probe composition to satisfy the error limit.

Practical approaches to becoming the logistics hub of Northeast Asia (동북아 물류중심국가 추진전략에 관한 연구)

  • Oh, Moon-Kap
    • Journal of Distribution Science
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    • v.11 no.6
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    • pp.31-40
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    • 2013
  • Purpose - The Northeast Asian Logistic Hub strategy was established to create a national competitive advantage in northeast Asia. Countries in this region are competing fiercely to become the central base distribution port as the volume of container shipping continues to increase due to the northeast Asian (especially Chinese) economic growth. The primary method by which shippers are improving their customer service and distribution is enhancing profits by minimizing call ports on the key route through strategic affiliations and the use of large vessels. Each nation is planning large-scale investments in the construction of sea ports that can accommodate large vessels. This paper proposes ways by which the logistical strategies of domestic corporations can keep pace with changes in government policy concerning the Northeast Asian Business Hub policy. It examines the logistics system in the Northeast Asian region, analyzes the government's Northeast Asian Business Hub policy, and suggests logistical strategies for domestic corporations through an analysis based on a questionnaire designed to grasp domestic firms' needs and goals. Research design, data and methodology - The purpose of this study is to determine how shipping companies establish partnerships with third-party logistics providers and draws out the implications of the results. The survey methods used were personal interviews and questionnaires distributed to a sample population through e-mail, fax, mail, and telephone. A total of 600 questionnaires were distributed, of which 165 were returned. Among these, ten were excluded due to insufficient content; ultimately, 155 were used for the sample. The statistical data collection process was analyzed through data coating and a statistical package program. Results - This study argues that greater flexibility in policies, administration, and systems will be needed to significantly improve established business practices. In this dissertation, we primarily identify that in order to become a center of northeast Asian logistics, Korea must adopt a new paradigm and abandon the existing systems that are based on the economic and social systems that have stemmed from bureaucracy, inflexibility, chauvinism, and equalitarianism. Flexible policies, administration, and systems will be necessary to improve business practices. Domestic corporations must establish a strategic logistics hub and related network while simultaneously pursuing value-added logistics businesses by increasing their manpower and building a logistics information system. This will strengthen their competitive edge and lead to system improvements. Conclusions - Domestic corporations must adopt a new paradigm and use more reasonable business laws, systems, and policies that are based on market-driven flexibility and transparency. Moreover, social norms and regulations should be established to help ensure political and social security. Korea must also develop a culture of tolerance for foreign companies. Finally, the paradigm defining the policy governing the development of the capital city and its satellite cities in this context must be changed.

Music Recommendation System in Public Space, DJ Robot, based on Context-awareness and Musical Properties (상황인식 및 음원 속성에 따른 공간 설치형 음악 추천 시스템, DJ로봇)

  • Kim, Byung-O;Han, Dong-Soong
    • The Journal of the Korea Contents Association
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    • v.10 no.6
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    • pp.286-296
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    • 2010
  • The study of the development of DJ robots is to meet the demands of the music services which are changing very rapidly in the digital and network era. Existing studies, as a whole, develop music services on the premise of personalized environment and equipment, but the DJ robot is on the premise of the open space shared by the public. DJ robot gives priority to traditional space and music. Recently as the hospitality and demand for cultural contents of South Korea expand to worldwide, industrial use of the contents based on traditional or our unique characteristics is getting more and more. Meanwhile, the DJ robot is composed of a combination of two modules. One is to detect changes in the external environment and the other is to set the properties of the music by psychology, emotional engineering, etc. DJ robot detect the footprint of the temperature, humidity, illumination, wind, noise and other environmental factors measured, and will ensure the objectivity of the music source by repeated experiments and verification with human sensibility ergonomics based on Hevner Adjective Circle. DJ robot will change the soundscape of the traditional space being more beautiful and make the revival and prosperity of traditional music with the use of traditional music through BGM.

Sitagliptin and Vildagliptin Use Evaluation among Dipeptidyl Peptidase 4 Inhibitors in Adult Koreans with Type 2 Diabetes Mellitus (한국인 제2형 당뇨병 환자에 대한 디펩티딜 펩티다제 4 억제제 중 Sitagliptin과 Vildagliptin의 약물 사용 평가)

  • Park, Hyun-Jung;Lee, Ok-Sang;Lim, Sung-Cil
    • YAKHAK HOEJI
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    • v.56 no.2
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    • pp.136-143
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    • 2012
  • Type 2 Diabetes Mellitus (T2DM) is characterized by high blood glucose in the context of insulin resistance and relative insulin deficiency. Diabetes is often initially managed by increasing exercise and dietary modification. As the condition progresses, medications may be needed such as oral sulfonylurea or others. Recently, dipeptidyl peptidase 4 (DPP- 4) Inhibitor is new drug which can control blood glucose by increasing the active levels of incretin hormone in the body. However, researches have been carried out for mostly Caucasian and Japanese, not for Koreans at all. Therefore, this study was to evaluate the efficacy and safety of DPP-4 inhibitor (Sitagliptin, Vildagliptin) in patients with T2DM in Koreans. This study was carried out retrospectively with reviewing of medical records from the 141 patients who received sitagliptin or vildagliptin over 24 week periods from January 2009, to December 2009. Information including demographics, concomitant medication, disease duration, and exercise was evaluated. $HbA_{1c}$, random blood glucose, post prandial 2 hour glucose, blood pressure, AST, ALT, serum creatinine, total cholesterol, triglyceride levels were also collected at baseline and endpoint (at 24 weeks). In each post-treatment group, $HbA_{1c}$, random blood glucose and post prandial 2 hour glucose levels were decreased significantly from baseline in the sitagliptin group (-0.82%, -28.76 mg/dl, -46.65 mg/dl) and vildagliptin group(-1.22%, -27.96 mg/dl, -67.2 mg/dl). Greater $HbA_{1c}$ mean reductions from baseline to 24 weeks were seen in patients with higher baseline values (>7.0%), with shorter disease durations (${\leq}1$ year) compared with those with lower baseline values (<7.0%), with longer disease durations (>1 year) in both sitagliptin and vildagliptin groups. The incidences of hypoglycemia, headache and upper respiratory infection were 0%, 8.7%, 5.8% in sitagliptin group and 2.8%, 8.3%, 6.9% in vildagliptin group. In conclusion, our results showed DPP-4 inhibitor provided similar efficacy compared with sulfonylurea after 24 weeks of treatment and were safer than sulfonylurea in hypoglycemia for Korean T2DM. Also vildagliptin was associated with significant improvement in $HbA_{1c}$ reduction in Korean patient with subgroup (body mass index<25 $kg/m^2$, metformin dose${\geq}$1000 mg, p<0.05) compared to sitagliptin. Therefore, even though DPP-4 inhibitor use for Korean needs to be studied more consistently in the future, DPP-4 inhibitor is a safe and effective drug for Korean T2DM based on our result.

Analysis of PLAN Modernization Trend and Prospects for Balance of U.S-China Naval power in the East Asia (중국해군(PLAN)의 현대화 추세와 동아시아 지역의 미·중 해군력 균형 전망)

  • Kwon, Jeong Wook
    • Strategy21
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    • s.43
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    • pp.5-28
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    • 2018
  • The tensions between the U.S and China, which form the two pillars of the G2 era, seem to have persisted even after the Trump administration inaugurated. The strong confrontation between the two in recent foreign security issues may drive to develop an inadvertent military conflict, and it is high likely to occur in the maritime are. The purpose of this study is not only to analyze the balance of modernized naval forces in the PLAN through naval strategy changes and weapons system modernization trend, but also to predict the impact of the geographical proximity difference on the balance of naval forces in the disputed areas. It examined the impact of distance and geography on naval power by assessing the modernization pattern of the PLAN and capabilities in the context of two scenarios at different distances from China by 2020: one centered on Taiwan and the other on the Spratly Islands. The PLAN's strategy had impact on operational concept and forces construction. First, from the viewpoint of operation operational concept, it can be seen that the passive defense is changing into active defense. Second, in terms of power construction, it can threaten the surface and submarines of U.S power from a distance. And they generated follow three features; The ocean is not the focus of Chinese submarines, Horizontal and vertical expansion of Chinese naval vessels, The improvement of the suppression ability as the Chinese naval modernization ratio increases. The strength of the PLAN is dominant over the U.S in terms of reserves, and it can complement the qualitative deterioration by utilizing nearby bases in the vicinity of the mainland, such as the Taiwan Strait. However, due to the shortage of aircraft carriers, there is a possibility that it will take some time to secure the advantage of air and ocean in the amphibious operation. Therefore, as the dispute is prolonged, China may fail to achieve its original goal. In addition, the lack of cutting edge Commanding Ships may bring to weaken the C2 capabilities. At results, it is expected that PLAN will not be able to have a superiority in the short term due to lagging behind U.S advanced technology. Nevertheless, PLAN has strengthened its naval power through modernization sufficiently and it is highly likely to use force. Especially, it is more likely in the region where the naval power operation like the Taiwan Strait is possible with the almost equality to that of the United States. China will continue to use its naval forces to achieve a rapid and decisive victory over U.S in the close area from the land.

A Study on the Development of Services Supporting Personal Relationship Management - focusing on relationship management using mobile phones (인간 관계관리 지원 서비스 개발을 위한 연구 - 휴대전화를 이용한 관계 관리를 중심으로)

  • Kim, Ju-Yong;Lee, Chang-Hee;Lee, Se-Young;Lee, Jun-Ho
    • 한국HCI학회:학술대회논문집
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    • 2008.02b
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    • pp.239-244
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    • 2008
  • We lead a life in our community, beginning a new relationship with a stranger or maintaining or stopping existing relationships. Relationships with others are sustained through social activities based on communication. Generally speaking, by exchanging feelings and information through communication, relationships are formed and continued, and strengthened through active communication As a result of the development of technologies and information technology over the recent 10 years, a mobile phone has stood as a communication channel, and now it has become such a universal, and highly intimate and important means of communication that almost all the Koreans use more often than wired phones. Today, people have their communication channel available for others, by using a mobile phone at any time and anywhere. Like this, mobile phones have been playing a key role in helping people maintain, repair and strengthen their personal relationship, but from the perspective of personal relationship management, they still remain as an aid to help communication, failing to provide a positive help for actual relationship management. This study was designed to provide services supporting user's personal relationship management, focusing on the use of mobile phones as a major tool of communication, aiming to enable users to understand current state of their relationship and make relationship management efforts, or communication behaviors, by informing who needs communication, on the basis of data on mobile phone calls. To this end, the study established a method to extract intimacy between users and callers and develop a prototype of services supporting personal relationship management, using relationship characteristics in terms of mobile communication.

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Factors Contributing to the Quality of Life of the Urban Homeless (도시 노숙자의 삶의 질 예측요인)

  • Yoon, Kyeong-A;Rho, Byeong-Il
    • Korean Journal of Social Welfare
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    • v.57 no.1
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    • pp.219-243
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    • 2005
  • Homeless people have remained one of the most disadvantaged groups in Korea. Therefore this study aims at examining how the homeless evaluate their quality of life and which factors influence their quality of life. The subjects of this study were 185 homeless adults residing on the street, in the shelter, and in substandard housing in Daejeon Metropolitan City. With a view to collecting the data effectively, different approaches have been taken for each type of homelessness in this study. By using the Korean Version of WHOQOL-BREF(brief version of WHO quality of life measure), this study has examined the current circumstance of the homeless and identified the predictors of their quality of life. The results of this study reconfirm low quality of life of homeless people. Also the results of this study indicate that the important factors influencing their quality of life are age, receipt of public assistance, perceived health status, alcohol use, alcohol addiction, housing type, and recognition by others. Predictors of each domain of quality of life differ to some extent. Statistically significant predictors of physical health are receipt of public assistance, perceived health status, and housing type. Psychological health is significantly influenced by age, receipt of public assistance, perceived health status, housing type, and recognition by others. Significant predictors of social relations are alcohol use, housing type, and recognition by others. Environment is significantly influenced by perceived health status, housing type, and recognition by others. On the basis of the findings of this empirical analysis, some measures conducive to the improvement of quality of life of homeless people are suggested. Only a few studies have been conducted to delve into the quality of life of the displaced group in Korea. In such a context, the significance of this study lies in identifying the circumstances of the homeless as a basic work for upgrading their quality of life on the one hand, and in empirically testing the major predictors of each domain of their quality of life on the other.

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Politics of Knowledge of Asbestos Activism in South Korea: Settled Dust Analysis and the Controversies over Asbestos Pollution Measurement (한국석면운동의 지식 정치: 먼지 분석법과 석면오염 측정 논란을 중심으로)

  • Kang, Yeonsil
    • Journal of Science and Technology Studies
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    • v.18 no.1
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    • pp.129-175
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    • 2018
  • This paper examines asbestos activism in South Korea by focusing on the politics of knowledge between the asbestos activist group and regulatory agency on the risk of asbestos exposure. Asbestos activism has contributed to establishing asbestos pollution an important safety and public health agenda in South Korea. Asbestos pollution investigation is key to core argument of the activism that asbestos pollution is pervasive especially in urban environment and a serious environmental health problem with its worst consequences has not yet seen. A distinctive characteristic of such asbestos investigation is the use of "settled dust analysis," non-standard, non-legislated analysis method. In this paper, literary technologies used in asbestos investigation report written by activists and controversies over asbestos pollution measurement in Samsung's head office building. Asbestos activists successfully concentrated media's attention on their argument and mobilize resources needed to make policy decisions, by using settled dust analysis data. Regulatory agency and expert group, however, neither saw settled dust analysis nor activists argument persuasive enough to make policy changes, base on their evaluation on the use of standards and evidentiary context for analyzing measured data. While its explanatory power is partially acquired, through the dispute between asbestos activists and regulatory agencies unspoken assumptions of regulatory science was revealed and became the matter of social debate. Settled dust analysis captures the characteristic of asbestos analysis which combined social movement and science to challenge the regulatory agency and expert group.

Extraction of the Tree Regions in Forest Areas Using LIDAR Data and Ortho-image (라이다 자료와 정사영상을 이용한 산림지역의 수목영역추출)

  • Kim, Eui Myoung
    • Journal of Korean Society for Geospatial Information Science
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    • v.21 no.2
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    • pp.27-34
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    • 2013
  • Due to the increased interest in global warming, interest in forest resources aimed towards reducing greenhouse gases have subsequently increased. Thus far, data related to forest resources have been obtained, through the employment of aerial photographs or satellite images, by means of plotting. However, the use of imaging data is disadvantageous; merely, due to the fact that recorded measurements such as the height of trees, in dense forest areas, lack accuracy. Within such context, the authors of this study have presented a method of data processing in which an individual tree is isolated within forested areas through the use of LIDAR data and ortho-images. Such isolation resulted in the provision of more efficient and accurate data in regards to the height of trees. As for the data processing of LIDAR, the authors have generated a normalized digital surface model to extract tree points via local maxima filtering, and have additionally, with motives to extract forest areas, applied object oriented image classifications to the processing of data using ortho-images. The final tree point was then given a figure derived from the combination of LIDAR and ortho-images results. Based from an experiment conducted in the Yongin area, the authors have analyzed the merits and demerits of methods that either employ LIDAR data or ortho-images and have thereby obtained information of individual trees within forested areas by combining the two data; thus verifying the efficiency of the above presented method.

Analyzing the Importance and Priority of Safety Information in Walking Tourism: Focusing on Open Data Utilization (도보여행 안전정보의 유형별 중요도 및 우선순위 도출: 오픈데이터 활용을 중심으로)

  • Ham, Juyeon;Choi, Sujeong;Koo, Chulmo
    • Knowledge Management Research
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    • v.19 no.1
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    • pp.59-77
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    • 2018
  • The tourism industry is now changing to smart tourism, which maximizes tourists' overall tourism experience with the use of advanced mobile technologies and emphasizes the utilization of tourism information. Despite the quantitative expansion of the tourism industry, there is a lack of academic and practical discussion on tourism safety. Especially, in the context of walking tourism, tourists are more likely to be exposed to natural or social disasters and emergencies. Therefore, it is necessary to build a system that can provide walking tourists with safety information not only on dangerous factors which are anticipated to be confronted during a walking trip in advance but also on specific dangers in real time. Under the circumstances, this study seeks to identify the types of tourism safety information that can be offered by using publicly available open data, drawing on the safety information framework on the walking tourism that is presented in Choi et al. (2017)'s study. More specifically, this study focuses on the use of open data which is provided by the Korean government. Furthermore, this study verifies the types of safety information that are most urgently needed in walking travel situations. Specifically, this study aims to derive the importance and priority of each type of safety information for a walking trip by applying the analytic hierarchy process (AHP) analysis. For this, we collected 35 questionnaires from walking tour operators (practitioners) and walking tourists. The main results are as follows. First, natural disaster information is the most important factor in the top-level factor of safety information for walking tourists, followed by social disaster, life safety, and exhibition (security crisis) information. Second, information on natural disasters, environmental pollution, and weather is considered to be important at the sub-level factor. Lastly, the noteworthy result of this study is that the importance of each type of safety information varies depending on the walking tour operators (practitioners) and the walking tourists. That is, there is a recognition difference between the operator (practitioner) and the user in the importance and priority of the safety information of the walking trip. Therefore, it is necessary to develop policies and services reflecting the opinions of potential users when providing safety information so that the most importantly recognized information can be provided first.