• Archives of Pharmacal Research
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• 제26권5호
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• pp.358-366
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• 2003

Some N-p-substituted phenyl uracil-5-sulphonamide derivatives have been synthesized to be evaluated as molluscicides against Biomphalaria alexandrina snails, the intermediate host of Schistosoma mansoni. Schistosoma mansoni infected mice were treated with hemolymph obtained from pre-treated Biomphalaria alexandrina snails with the products 4a, 10a, 10b and 4b or obtained from non-treated snails. The selection of the concentration based on the predetermined dose which caused mortality of less than 50% of snails/24 h. $LC_{50}$ of compounds 4a, 10a, 10b and 4b was 50, 100, 200 and 50 ppm respectively. The result showed that immuno-stimulatory effect of treated hemolymph with compounds 4a, 10a and 4b was related to significant protective effects (44.4, 34.6 and 50.4% reduction in worm burden respectively). In addition, mean total worm burdens were significantly reduced in non treated hemolymph by 33.8%. The effect of hemolymph obtained from treated or non treated snails on S. mansoni adult worms antigens was studied by indirect immunofluorescence technique using chronic mouse sera (CMS). The results indicated that there was a strong reaction with epitopes in gut epithelium, tubercles, teigument and subtegumental musculature of untreated and treated S. mansoni adult worms antigens. Therefore, treatment of hemolymph obtained from pre-treated snails with compounds 4a, 10a, and 4b can stimulate specific immune response and induce protective effects against S. mansoni infection.

• 한국문헌정보학회지
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• 제45권1호
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• pp.149-167
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• 2011

이 연구는 독서치료 수퍼비전 활동이 치료 효과 증진에 기여를 할 것이라는 생각에서 시작되었다. 치료사에게 있어 치료 효과를 거둔다는 것은 단순한 치료 작업 이상이다. 그러나 현장에서 활동하고 있는 치료사들은 치료라는 말이 주는 부담감을 갖고 있는 것은 물론, 자신이 실행하고 있는 치료에 대한 확신이 부족하다. 이러한 상황들은 독서치료가 치료로서의 가치를 입증 받지 못하는 현상으로 나타나고 있어, 독서치료전문가로 활동하는 연구자에게도 개선해 나갈 필요가 있음을 느끼게 해주었다. 이러한 필요성에 의해 시작된 연구가 치료 효과 증진을 위한 독서치료 수퍼비전 실행 연구이다. 이 연구는 연구 과정에 대한 '방법적' 접근을 강조하여 해석적 실행연구의 형태로 진행을 했다. 연구 과정에서 나타나는 수퍼바이지의 문제점을 관찰하고 개선점을 마련함으로써 각 치료들이 더욱 효과적일 수 있도록 함은 물론, 연구자와 연구 참여자 모두 성장을 기할 수 있도록 하는데 그 목적이 있다.

• Archives of Pharmacal Research
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• 제18권3호
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• pp.159-163
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• 1995

Previously, we have reported that methylene blue (MB) induces cytotoxicity in human brain tumor cells through the generation of free radicals. In this study the effect of deferoxamine (DFO), an iron chelator, on MB-induced cytotoxicity was investigated using SK-N-MC human neuroblastoma and U-373 MG human astrocytoma cells as model cellular systems. The cytotoxic effect of MB was potentiated by DFO. The potentiation effect of DFO was significantly blocked by either stoichiometric amounts of ferric ion, various antioxidants, hydroxyl radical scavengers or intracellular $Ca^{2+}$ release blockers. These results suggest that hydroxyl radical and intracellular $Ca^{2+}$ may act as important mediators of the enhanced cytotoxicity by MB and DFO. These results further suggest that the combined treatment with MB and DFO may be useful for the therapeutical applications of human brain tumors.

• 동의생리병리학회지
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• 제16권4호
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• pp.774-781
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• 2002

This study was carried out to test the recuperative effect of 2 types of sample drugs for 3 degree burn. The burn injury was made by iron plate heated in the boiling water. The Sprague Dawley rats were shaven with a razor preliminarily and burned by direct contact method for 10 seconds. The experimental groups were classified with 5 each-normal, control, MEBO ointment, sample A, sample B. The effect of the sample drugs were decided by histological results after 3 week application. The results were as following. The 3 treatment groups recovered the burn injury faster than control group. The recuperative effect precedes about 4-5 days at the time of 15th day and 1 week at the time of 3rd week. The therapeutical procedure of 3 treatment groups was similar with naked eye and with microscopic histology in the 1 st, 2nd and 3rd specimens. So there weren't significant differences in curative effect in 3 treatment groups of this experiment. But a regeneration of hair follicle was noted in Sample B uniquely. These results suggested that 3 burn remedies have similar effect of therpy, but sample B containing yolk sac oil has slightly better effect in part of hair regeneration.

• 한방비만학회지
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• 제6권2호
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• pp.43-49
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• 2006

Objective : This study was conducted to offer basic materials for the clinical study of Chi acupuncture (carboxytherapy). Methods : Recent clinical studies were reviewed for carboxytherapy (carbon dioxide therapy) and the ancient and present texts were reviewed for Chi acupuncture. Results and Conclusions : Chi acupuncture is oriental medical therapeutic treatment using carboxytherapy. Chi acupuncture refers to the transcutaneous administration of CO2 gas for therapeutical purposes relating to obesity, cellulites, local circulation and skin irregularity. Recent studies have demonstrated the effects of this therapy on adipose tissue by showing vasomotor effects, increasing local circulation and inducing a partial increase in tcPO2. Chi acupuncture influences the microcirculation and likely has a positive effect upon the physiological oxidative lipolytic process.

• 대한후두음성언어의학회지
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• 제11권1호
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• pp.32-38
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• 2000

Background and Objectives : Voice therapy has been used as a viable adjuvant to surgery and pharmacological therapy fir the management of voice disorders. The singing voice features a special brand of emotion, intensity, and energy so successful therapeutical approach requires the doctor is able to involve himself into the physical and psychic condition and artistic usage of the voice. The purpose of this study was to evaluate the effect and utility of singing therapy as an initial treatment for classically trained singers with voice disorders. Material and method : Twenty-one male and fifty-five female classic singers with voice disorders were treated with singing therapy. At first, abdominal breathing, resonant phonation, and relaxation method was trained, then after accessing each patient's singing abilities, treatment methods for each specific problems was applied. The results were compared according to age, sex, treatment duration, part, laryngeal pathology, patient subjective evaluation, perceptual evaluation of voice, and maximal phonation time. Results : Patients subjective evaluation, perceptual evaluation, pathologic findings of larynx, maximal phonation time showed superior results after singing therapy. Conclusion : Singing therapy changes the mode of respiration and phonation and enhances the vocal function and improves the laryngeal pathology, The result of this study indicate that singing therapy is an effective treatment method that laryngologists can use for classical singers with voice disorders.

• 한방안이비인후피부과학회지
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• 제22권1호
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• pp.181-194
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• 2009

Objectives : This clinical research was conducted to test Patients with Tinea Pedis by using functional soap Gaia 1400, containing medicinal herbs Methods : Total 24 patients who visited Oriental Medical Ophthalmology & Otolaryngology & Dermatology of Dongguk Ilsan Hospital from June 17th, 2008 to November 11th, 2008. They used functional soap daily during 8 weeks. We Observed change of erythema, scaling, vesicle, pustule, exudate, crust and pruritus after 4weeks and 8 weeks. Also Clinical evaluation I, II were used to evaluate the effects of Gaia 1400. Results : 1. There were no significant differences on sex, age and onset. 2. Statistically. After treatment(4,8weekes) Tinea Pedis symptoms score showed significant effect on Tinea Pedis. And the score of using Gala 1400 after 8 weeks is lower than 4 weeks. 3. After 8weeks of treatment, Gaia 1400 showed meaningful effect on Clinical global evaluation I, II. 4. Tinea Pedis Exacerbated in a case after using Gaia 1400 and in the 4 cases Skin dryness Incerased. Conclusion : Considering the above results, we can speculate that functional soap Gaia 1400, containing medicinal herb has some therapeutical effects in mitigating the symptoms of Tenia Pedis.

• 동의신경정신과학회지
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• 제33권1호
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• pp.113-122
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• 2022

Objectives: To report the effect of Korean medicine on a patient with insomnia from severe hot flashes. Methods: The patient suffered from extreme hot flashes for months. Symptoms were so severe that the patient attempted suicide. After starting psychiatric medication, symptoms persisted and hospitalization began. During hospitalization, herbal medicine, acupuncture, and psychotherapy were conducted. For evaluating therapeutical effect, Digital Infrared Thermal Imaging was performed twice during the treatment process. It was divided into major facial area and back area. The facial area was divided into two small units to measure the difference in temperature between two points. The back area was measured in the same way. Results: The temperature difference between the two points decreased over time and the patient's subjective symptoms reduced. Conclusions: Korean medicine therapy can improve symptoms of patients with insomnia accompanied by hot flashes.

• 한국문헌정보학회지
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• 제47권1호
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• pp.149-173
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• 2013

성장기 자녀의 정신적 건강에 가장 큰 영향을 미치는 것은 부모의 태도와 관심으로, 부모와 자녀의 상호관계가 좋을수록 자녀에게 긍정적인 영향을 미치게 된다. 이 연구는 부모와 자녀의 상호작용 증진에 미치는 독서치료의 효과를 밝히는데 목적이 있다. 연구 목적을 달성하기 위하여 실행연구 방법을 바탕으로 부모-자녀 대상의 독서치료 프로그램을 1차 및 2차로 나누어 총 25회에 걸쳐 수행하면서 매 과정을 상세히 관찰하고 기술하였다. 연구 결과 독서치료 프로그램이 부모-자녀 상호작용 증진에 도움이 되는 것으로 밝혀졌다.

• 대한상한금궤의학회지
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• 제8권1호
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• pp.155-164
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• 2016

Objective : The purpose of this paper is to report the improvement of patient with panic disorder treated by herb medication based on Shanghanlun disease pattern identification diagnostic system. Methods :, The patient with panic disorder was diagnosed according to 'Disease Pattern Identification Diagnostic System based on Shanghanlun Provisions'. The changing symptom of panic disorder was estimated by BAI(Beck Anxiety Inventory). Results : The patient was diagnosed with yin-yang-yi-cha-hou-lao-fu bing, number 397 provision, and took Jukyeopseokgo-tang herb medication about 113 days. The BAI score changed 37 to 12. Conclusions : The therapeutic intervention and herb medication showed a therapeutical effect on the patient. The anxiety and helplessness of the patient was improved. This patient's panic disorder was associated with poor sleep patterns and sensitivity to minor things and controled by Jukyeopseokgo-tang. The relationships between poor sleep patterns and 陰陽易差後勞復病, shortness of breath when sensitive to minor things and 少氣 need further study.