• 인터넷정보학회논문지
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• 제17권6호
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• pp.25-31
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• 2016

최근 무선통신 기술이 급속도로 발전하면서 스마트 센서를 이용한 사물통신 (Machine-to-Machine, M2M)과 사물인터넷 (Internet of Things, IoT) 등의 신규 서비스들이 창출되고 있다. 본 논문에서는 사용자들이 스마트폰이나 태블릿PC 등의 사용자 장비 (User Equipment, UE)를 이용하여 사물인터넷 디바이스 (IoT Device, IoTD)를 제어하는 환경에서, 스몰셀 기지국(Small-cell Access Point, SAP)을 도입하여 IoTD를 개인화하는 방법을 제안한다. 이를 위해, 먼저 UE, IoTD, 그리고 SAP 로 구성되는 시스템 아키텍처를 소개한다. 이후, IoTD의 프로파일 등록 절차와 댁내 외 UE의 IoTD를 제어 절차로 구성되는 IoTD 개인화 방법을 제안한다. 마지막으로 시뮬레이션을 통해 제안하는 방법의 시스템 성능을 분석하였고, 전형적인 방법보다 제안하는 방법이 패킷 지연시간, 패킷 손실률, 그리고 정규화된 수율 측면에서 성능이 향상됨을 알 수 있었다.

• 생물정신의학
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• 제11권1호
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• pp.54-60
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• 2004

Objectives:Tardive dyskinesia(TD) is a serious side effect associated with long-term antipsychotic treatments. Some candidate genetic polymorphisms were reported to be associated with TD and possible involvement of serotonergic receptors in the pathophysiology of TD has been suggested. In the present study, we investigated the association between $5-HT_6$ receptor gene polymorphism and TD with schizophrenia. Methods:To investigate the relationship between $5-HT_6$ receptor gene polymorphism and TD, 60 patients with TD were compared with 60 patients without TD. The 267C/T allele of $5-HT_6$ receptor gene was genotyped by means of polymerase chain reaction method. TD was evaluated using the Abnormal Involuntary Movement Scale(AIMS). Results:The patients with the three 267C/T genotype showed no significant differences in age, gender, and duration of illness. No significant difference in genotype frequencies was observed between schizophrenic patients with and without TD. In addition, there was no difference in allele frequencies. Further analysis with an measure of AIMS scores showed that these scores were not significantly influenced by the $5-HT_6$ receptor gene polymorphism. Conclusion:These results suggest that 267C/T polymorphism of $5-HT_6$ receptor gene is not significantly associated with susceptibility to TD in schizophrenia.

• 미생물학회지
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• 제31권3호
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• pp.208-213
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• 1993

The structural and functional roles of IGS element of T4 td intron in thymidylate synthase activity in vivo were investigated Site-directed mutagenesis was employed to crete mutations of IGS element of T4 td intron, When a U-G pari was changed to a U-C pari in the 5' splice site of P1 stem of td intron, the activity of thymidylate synthase was completely abolished whereas the wild type retained the normal activity of enzyme. When U at 12 position within IGS element was changed to C, the activity of thymidylate synthase was approximately 32% of that of the wild type. Comparison of enzyme activities suggests that IGS element within P1 structure is an essential requirement for splicing of td gene in vivo.

• 생물정신의학
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• 제10권2호
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• pp.133-140
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• 2003

Objective:Some candidate gene polymorphisms were reported to be associated with tardive dyskinesia (TD). The aim of this study was to investigate the association of the 5-$HT_{2A}$ receptor gene polymorphisms with TD in Korean schizophrenic subjects. Method:Subjects were of 59 schizophrenic patients with TD and 60 schizophrenic patients without TD for studying of 5-$HT_{2A}$ receptor gene polymorphisms. TD was evaluated using the Abnormal Involuntary Movement Scale(AIMS). Genomic DNA was amplified by PCR and digestion with MspI and BsmI. Result:There were no statistically significant differences in the demographic variables, such as age, male to female percentage, duration of illnesses and duration of antipsychotic drug exposure between the TD group and control group. 1) T102C polymorphisms and TD Comparing the TD group and control group, the 102T/C allele was associated with a significantly increased risk for TD (${\chi}^2$=5.560, df=1, p=0.018). 2) Three AIMS categories of TD and T102C genotype. There were statistically significant differences in the three AIMS categories(${\chi}^2$=6.835, df=2, p=0.033). Conclusion:These result suggest 102T/C genotypes of the 5-$HT_{2A}$ receptor gene are related to the development of TD. The 102T/C genotypes were associated with significantly higher AIMS orofacial dyskinesia scores. These findings suggest that the 5-$HT_{2A}$ receptor gene is significantly associated with susceptibility to TD in patients with chronic schizophrenia.

• International Journal of Oral Biology
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• 제33권2호
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• pp.45-50
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• 2008

Treponema denticola is the best studied oral spirochete and numerous studies have shown that it is strongly associated with periodontitis and expresses several putative virulence factors. In this study, we report on a surface protein of T. denticola, Td92, which is homologous to Tp92 of Treponema pallidum, an agent of syphilis. Immunofluorescence assay and immunogold labeling with anti-Td92 Ab revealed that Td92 had surface-exposed epitopes. And Td92 was capable of binding to fibronectin and KB cells, an oral epithelial cell line. In addition, Td92 could enter the KB cells. These results indicate that Td92 is a fibronectin-binding protein which can bind to and internalize into the host cells, facilitating the virulence of T. denticola.

• 한국식생활문화학회지
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• 제19권4호
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• pp.419-428
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• 2004

다시마 분말 첨가식이가 당뇨쥐의 당질과 지질대사 및 항산화효소계에 미치는 영향을 규명하기 위하여 SD계 횐쥐에 17% 다시마 분말을 급여하여 7주간 실험 사육한 후 혈청의 포도당 및 지질농도와 주요장기의 항산화효소의 활성도를 관찰하였다. 다시마 당뇨군(TI)에서 다사마 섭취는 당뇨에 의한 체중감소 현상을 보였다. 당뇨군의 혈당 농도는 다시마 섭취에 의한 혈당강하 효과는 3주째에 나타났다. 당뇨에 의한 산화적 스트레스로 인해 증가한 GST 활성도가 다시마 섭취로 인해 정상 수준으로 저하됨으로써 다시마의 섭취가 당뇨시 산화적 반응에 대한 방어기전을 제공할 수 있음을 유추할 수 있었다. 또한 중성지방이 감소하고 HDL-콜레스테롤의 증가하는 경향으로 심혈관계와 관련되는 당뇨합병증의 억제 가능성을 제시하였다.

• 한국정보디스플레이학회:학술대회논문집
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• 한국정보디스플레이학회 2002년도 International Meeting on Information Display
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• pp.325-328
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• 2002

We developed a high performance 2.2" active matrix OLED display for IMT-2000 mobile phone. Scan and Data driver circuits were integrated on the glass substrate, using low temperature poly-Si(LTPS) TFT CMOS technology. High efficiency EL materials were employed to the panel for low power consumption. Peak luminescence of the panel was higher than 250cd/$m^2$ with power consumption of 200mW.

• 생물정신의학
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• 제25권4호
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• pp.110-117
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• 2018

Objectives This study aimed to investigate the relationship between depressive and anxiety symptoms and tardive dyskinesia (TD) and reveal the association of cognitive function and TD in patients with schizophrenia. Methods We recruited 30 schizophrenia patients with TD and 31 without TD from a national mental hospital in South Korea. To assess depressive and anxiety symptoms, the Beck Depression Inventory-II (BDI-II) and the Beck Anxiety Inventory (BAI) were conducted. Using the five-factor structure of the BDI-II and BAI, somatic anxiety, cognitive depression, somatic depression, subjective anxiety, and autonomic anxiety were assessed. Computerized neurocognitive function test (CNT) was performed to assess levels of cognitive functions. We compared the clinical characteristics, levels of cognitive functions, and depressive and anxiety symptoms between schizophrenia patients with TD and without TD. Chi-square test, Fisher's exact test, independent t-test and Mann Whitney U test were conducted to compare two groups. Pearson correlation analysis was conducted to evaluate relationships among the abnormal involuntary movement scale (AIMS), BDI-II, BAI, somatic anxiety, cognitive depression, somatic depression, subjective anxiety, and autonomic anxiety. Results The subjects with TD had significantly lower score on the cognitive depression than those without TD (t = -2.087, p = 0.041). There were significant correlations between the AIMS score and the BDI-II score (r = -0.386, p = 0.035) and between the AIMS score and cognitive depression score (r = - 0.385, p = 0.035). Conclusions Our findings suggest the inverse relationship between severities in TD and depression and support the assumption that there is an inverse relationship between the pathophysiology of TD and depression.

• Journal of Microbiology
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• 제33권2호
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• pp.160-164
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• 1995

The splicing activity of T4 phage td intron RNA has been examined with various Mg$^{2+}$ ions such as MGCl$_{2}$, MgS $O_{4}$ and magnesium acetate using various splicing conditions such as different incubation time and temperature. The maximum splicing of td intron RNA occurred at the concentration of 5 mM MgCl$_{2}$. Raising the Mg$^{2+}$ concentration up to 15 mM appeared to promote P2 delection mutant to overcome the loss of some splicing activity. In both wild type and mutant, a complete hydrolysis of RNA occurred at 30 mM MgCI$_{2}$ MgS $O_{4}$ and magnesium acetate exhibited the rate and pattern of RNA splicing identical to MGCI$_{2}$. The optimal splicing conditions involve the incubation of RNA with 5 mM MgCI$_{2}$ at 58 .deg.C for 15 min. The results suggest that Mg$^{2+}$ may play a key role in the catalytic mechanism of td intron RNA.n RNA.

• 미생물학회지
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• 제35권4호
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• pp.253-257
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• 1999

Cadaverine, putrescine, spermidine과 spermine이 spectinomycin에 의한 T4 파지 thymidylate synthase 유전자(td) intron의 splicing 억제에 미치는 영향을 조사하였다. Polyamine이 존재하지 않는 상태에서 7mM spectinomycin은 splicing rate를 약 40% 감소시켰다. 사용한 농도 범위(0.1~5mM)에서 cadaverine은 splicing rate를 감소시켰으나, putrescine은 0.5mM 농도에서 약 13% 정도의 splicing rate를 증가시켰다. Spermidine은 0.5mM 농도에서 약 11% 정도의 splicing rate를 증가시켰으며, sperimine은 0.01mM 농도에서 약 16% 정도의 splicing rate을 증가시켰다. 시험한 polyamine 중에서 특히 sperimine은 가장 낮은 농도에서 spectinomycin에 의한 억제반응을 극복하는 최고의 활성효과를 나타냈다. 이와 같은 억제 회복 효과는 polyamine에 의한 td intron 리보자임의 구조적 안정성에 기인하는 것으로 추정된다.