International Journal of Oral Biology

The Korean Academy of Oral Biology (대한구강생물학회)
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Binding of Tp92 homolog of Treponema denticola to fibronectin and epithelial cells

  • Jun, Hye-Kyoung (Department of Oral Microbiology and Immunology, School of Dentistry, Seoul National University) ;
  • Lee, Sung-Hoon (Department of Oral Microbiology and Immunology, School of Dentistry, Seoul National University) ;
  • Lee, Hae-Ri (Department of Oral Microbiology and Immunology, School of Dentistry, Seoul National University) ;
  • Choi, Bong-Kyu (Department of Oral Microbiology and Immunology, School of Dentistry, Seoul National University)
  • Published : 2008.06.30
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Abstract

Treponema denticola is the best studied oral spirochete and numerous studies have shown that it is strongly associated with periodontitis and expresses several putative virulence factors. In this study, we report on a surface protein of T. denticola, Td92, which is homologous to Tp92 of Treponema pallidum, an agent of syphilis. Immunofluorescence assay and immunogold labeling with anti-Td92 Ab revealed that Td92 had surface-exposed epitopes. And Td92 was capable of binding to fibronectin and KB cells, an oral epithelial cell line. In addition, Td92 could enter the KB cells. These results indicate that Td92 is a fibronectin-binding protein which can bind to and internalize into the host cells, facilitating the virulence of T. denticola.

Keywords

References

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