Korean Journal of Biological Psychiatry (생물정신의학)

The Korean Society of Biological Psychiatry (대한생물정신의학회)
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Association between Tardive Dyskinesia and 267C/T Polymorphism of $5-HT_6$ Receptor Gene in Schizophrenia

정신분열병환자에서 만발성 운동장애와 $5-HT_6$ 수용체 유전자 다형성(267C/T)과의 관계

  • Han, Sang-Woo (Department of Psychiatry, University of Soonchunhyang, College of Medicine) ;
  • Kim, Dong-Hyeon (Department of Psychiatry, University of Soonchunhyang, College of Medicine) ;
  • Jun, Yong-Ho (Department of Psychiatry, Seoul National University, College of Medicine)
  • 한상우 (순천향대학교 의과대학 정신과학교실) ;
  • 김동현 (순천향대학교 의과대학 정신과학교실) ;
  • 전용호 (서울대학교 의과대학 정신과학교실)
  • Published : 2004.06.30
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Abstract

Objectives:Tardive dyskinesia(TD) is a serious side effect associated with long-term antipsychotic treatments. Some candidate genetic polymorphisms were reported to be associated with TD and possible involvement of serotonergic receptors in the pathophysiology of TD has been suggested. In the present study, we investigated the association between $5-HT_6$ receptor gene polymorphism and TD with schizophrenia. Methods:To investigate the relationship between $5-HT_6$ receptor gene polymorphism and TD, 60 patients with TD were compared with 60 patients without TD. The 267C/T allele of $5-HT_6$ receptor gene was genotyped by means of polymerase chain reaction method. TD was evaluated using the Abnormal Involuntary Movement Scale(AIMS). Results:The patients with the three 267C/T genotype showed no significant differences in age, gender, and duration of illness. No significant difference in genotype frequencies was observed between schizophrenic patients with and without TD. In addition, there was no difference in allele frequencies. Further analysis with an measure of AIMS scores showed that these scores were not significantly influenced by the $5-HT_6$ receptor gene polymorphism. Conclusion:These results suggest that 267C/T polymorphism of $5-HT_6$ receptor gene is not significantly associated with susceptibility to TD in schizophrenia.

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