Korean Journal of Biological Psychiatry (생물정신의학)

The Korean Society of Biological Psychiatry (대한생물정신의학회)
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Depression in Schizophrenia Patients with Tardive Dyskinesia

지연성 이상운동이 있는 조현병 환자의 우울증

  • Cha, Seongjae (Department of Psychiatry, Gongju National Hospital) ;
  • Oh, Keun (Department of Psychiatry, Gongju National Hospital) ;
  • Kim, Misuk (Department of Psychiatry, Gongju National Hospital) ;
  • Park, Seon-Cheol (Department of Psychiatry, Inje University Haeundae Paik Hospital) ;
  • Kim, Young Hoon (Department of Psychiatry, Gongju National Hospital)
  • 차성재 (국립공주병원 정신건강의학과) ;
  • 오근 (국립공주병원 정신건강의학과) ;
  • 김미숙 (국립공주병원 정신건강의학과) ;
  • 박선철 (인제대학교 해운대백병원 정신건강의학과) ;
  • 김영훈 (국립공주병원 정신건강의학과)
  • Received : 2018.06.08
  • Accepted : 2018.10.10
  • Published : 2018.11.30
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Abstract

Objectives This study aimed to investigate the relationship between depressive and anxiety symptoms and tardive dyskinesia (TD) and reveal the association of cognitive function and TD in patients with schizophrenia. Methods We recruited 30 schizophrenia patients with TD and 31 without TD from a national mental hospital in South Korea. To assess depressive and anxiety symptoms, the Beck Depression Inventory-II (BDI-II) and the Beck Anxiety Inventory (BAI) were conducted. Using the five-factor structure of the BDI-II and BAI, somatic anxiety, cognitive depression, somatic depression, subjective anxiety, and autonomic anxiety were assessed. Computerized neurocognitive function test (CNT) was performed to assess levels of cognitive functions. We compared the clinical characteristics, levels of cognitive functions, and depressive and anxiety symptoms between schizophrenia patients with TD and without TD. Chi-square test, Fisher's exact test, independent t-test and Mann Whitney U test were conducted to compare two groups. Pearson correlation analysis was conducted to evaluate relationships among the abnormal involuntary movement scale (AIMS), BDI-II, BAI, somatic anxiety, cognitive depression, somatic depression, subjective anxiety, and autonomic anxiety. Results The subjects with TD had significantly lower score on the cognitive depression than those without TD (t = -2.087, p = 0.041). There were significant correlations between the AIMS score and the BDI-II score (r = -0.386, p = 0.035) and between the AIMS score and cognitive depression score (r = - 0.385, p = 0.035). Conclusions Our findings suggest the inverse relationship between severities in TD and depression and support the assumption that there is an inverse relationship between the pathophysiology of TD and depression.

Keywords

References

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