• Molecular & Cellular Toxicology
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• v.4 no.2
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• pp.157-163
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• 2008

Formation of ${\beta}$-amyloid $(A{\beta})$ fibrils has been identified as one of the major characteristics of Alzheimer's disease (AD). Inhibition of $A{\beta}$ fibril formation in the CNS would be attractive therapeutic targets for the treatment of AD. Several small compounds that inhibit amyloid formation or amyloid neurotoxicity in vitro have been known. Citrate has surfactant function effect because of its molecular structure having high anionic charge density, in addition to the well-known antibacterial and antioxidant properties. Therefore, we hypothesized that citrate might have the inhibitory effect against $A{\beta}$ fibril formation in vitro and have the protective effect against $A{\beta}$-induced neurotoxicity in PC12 cells. We examined the effect of citrate against the formation of $A{\beta}$ fibrils by measuring the intensity of fluorescence in thioflavin-T (Th-T) assay of between $A{\beta}_{25-35}$ groups treated with citrate and the control with $A{\beta}_{25-35}$ alone. The neuroprotective effect of citrate against $A{\beta}$-induced toxicity in PC12 cells was investigated using the WST-1 assay. Fluorescence spectroscopy showed that citrate inhibited dose-dependently the formation of $A{\beta}$ fibrils from ${\beta}$-amyloid peptides. The inhibition percentages of $A{\beta}$ fibril formation by citrate (1, 2.5, and 5 mM) were 31%, 60%, and 68% at 7 days, respectively in thioflavin-T (Th-T) assay. WST-1 assay revealed that the toxic effect of $A{\beta}_{25-35}$ was reduced, in a dose-dependent manner to citrate. The percentages of neuroprotection by citrate (1, 2.5, and 5 mM) against $A{\beta}-induced$ toxicity were 19%, 31 %, and 34%, respectively. We report that citrate inhibits the formation of $A{\beta}$ fibrils in vitro and has neuroprotective effect against $A{\beta}$-induced toxicity in PC12 cells. Neuroprotective effects of citrate against $A{\beta}$ might be, to some extent, attributable to its inhibition of $A{\beta}$ fibril formation. Although the mechanism of anti-amyloidogenic activity is not clear, the possible mechanism is that citrate might have two effects, salting-in and surfactant effects. These results suggest that citrate could be of potential therapeutic value in Alzheimer's disease.

• The Korean Journal of Petroleum Geology
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• v.9 no.1_2 s.10
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• pp.16-23
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• 2001

The study area in the East Sea is located on the northeastern margins of the Ulleung Basin near the Kita-Yamato Bank. The research area provides the important clue to the development of Miocene basins which are characterized by the normal faults and volcanic activities related to rifting in the continental crust. Kita-Yamato Bank is a small sediment-filled graben which was formed by failed rifting in the Early Miocene. The basins rapidly vary the bathymetry, depth of acoustic basement and thickness of sedimentary layer. The tension in the study area caused the extensional lithospheric deformation before/during the Early Miocene. In consequence, tectonic forces resulted in the depression or subsidence of basement from continental rifting in the Kita-Yamato Bank followed by the opening of the Ulleung Basin, and caused the onset of graben or half-graben structure bounded by large blocked syn-rift faults. Afterward no significant tectonic deformation exists, with the consequence that post-rift normal faults with small heave were formed and reactivated by the resultant forces such as tectonic subsidence, sediment loading and volcanic activity. The Cenozoic sediment layer has a maximum thickness of 1.0 s along the center of the graben or half-graben, which overlies the consolidated acoustic basement. Seismic units V and IV supposed to be syn-rift sedimentary rocks are deformed by both the volcanic activities and numerous basement-involved normal faults induced from extension. In the uppermost layer, slump scars resulted from the slope failure are recognized.

• Korean Journal of Remote Sensing
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• v.30 no.6
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• pp.731-742
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• 2014

In this study, we developed a new algorithm which can construct model buildings used as a surface boundary in numerical models using GIS with latitudinal and longitudinal information of building vertices. The algorithm established the outer boundary of a building first, by finding segments passing neighboring two vertices of the building and connecting the segments. Then, the algorithm determined the region inside the outer boundary as the building. The new algorithm overcame the limit that the algorithm developed in the previous study had in constructing concave buildings. In addition, the new algorithm successfully constructed a building with complicated shape. To investigate effects of the modification in building shape caused by the building-construction algorithm on flows and pollutant dispersion around buildings, a computational fluid dynamics model was used and three kinds of building type were considered. In the downwind region, patterns in flow and pollutant dispersion were little affected by the modification in building shape caused. However, because of reduction in air space resulted from the building-shape modification, vortex structure was not resolved or smaller vortex was resolved near the buildings. The changes in flow pattern affected dispersion patterns of scalar pollutants emitted around the buildings.

• Korean Journal of Remote Sensing
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• v.36 no.5_4
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• pp.1195-1207
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• 2020

With the development of GeoWeb technology, 2D/3D spatial information services through the web are also has been used increasingly in the application of disaster management. This paper is suggested to construct a web-based 3D geo-spatial information mapping platform to visualize various spatial information collected at the disaster site in a web environment. This paper is presented a web-based geo-spatial information mapping service plan for the various types of 2D/3D spatial data and large-volume LiDAR point cloud data collected at the disaster accident site using HTML5/WebGL, web development standard technology and open source. Firstly, the collected disaster site survey 2D data is constructed as a spatial DB using GeoServer's WMS service and PostGIS provided an open source and rendered in a web environment. Secondly, in order to efficiently render large-capacity 3D point cloud data in a web environment, a Potree algorithm is applied to simplifies point cloud data into 2D tiles using a multi-resolution octree structure. Lastly, OpenLayers3 based 3D web mapping pilot system is developed for web visualization of 2D/3D spatial information by implementing basic and application functions for controlling and measuring 3D maps with Graphic User Interface (GUI). For the further research, it is expected that various 2D survey data and various spatial image information of a disaster site can be used for scientific investigation and analysis of disaster accidents by overlaying and visualizing them on a built web-based 3D geo-spatial information system.

• Korean Security Journal
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• no.36
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• pp.293-316
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• 2013

Today's high-rise buildings are increasing concern about the safety and evacuation of people related to the fire and threat from outside. Terrorism breaking out in high-rise buildings, a symbol of the national economy results in a number of casualties, economic loss, social fear and damage to national status. That's why high-rise building has also emerged as a target of major terrorist attacks, compared to other types of buildings. We have 54 high-rise buildings in 15 regions over the country. The Ministry of Land, Infrastructure and Transport and Seoul Metropolitan Government have offered the guidelines to prevent terrorist attacks toward high-rise buildings. Since the 9/11 terrorist attacks, the U.S. Federal Emergency Management Agency (FEMA) has developed and taken advantage of the Risk Management Manual Series. According to this manual, pre-assessment is conducted for the prevention of terrorism and particularly in FEMA 455, risk of the surrounding areas, vulnerability, possibility from terrorist attacks are checked. After the check, experts classify the risk of terrorist attacks toward the high-rise buildings and according to the risk classification, architects, security experts and structure engineers can carry out terrorism prevention program for high-rise buildings. The U.K. NaCTSO has also offered the terrorism prevention guidelines. Therefore, the Ministry of Land, Infrastructure and Transport and Seoul Metropolitan Government should make more concrete guidelines for high-rise buildings such as what U.S. FEMA and U.K. NaCTSO implement, including prior evaluation technique for terrorism risk.

• Journal of Science of Art and Design
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• v.3
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• pp.87-144
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• 2001

This study looks into historical genealogy of autonomy in art criticism on modernism and presents the view of the judgment and correction about that. A matter of autonomy in art appeared in the attempt to totally reconsider and upset the theory of 'Mimesis' or 'Representation' which was the basis of traditional aesthetic theory. In the traditional theory of representation, they assumed primary image exists first and then tried to obtain visual similarity to it through art works. However, in the theory of autonomy in modernism, they maintained the reduction to pure form' or medium', regarding what art works represents and how similar to primary image are not the true essence of art. In the early 20th century, C. Bell laid the foundation stone of the theory of Formalism', providing that a matter of autonomy is significant form', which is the combination of lines and colors Aesthetic autonomy theory came to a climax by C. Greenberg, who systemized art criticism on modernism in the middle 20th century. According to his theory, the pursuit of the essence of form resulted in the specificity of medium' and flatness. They thought that the autonomy of art would be achieved by eliminating outward social factors from art works. This theory ended by Minimalism preventing the instructive function of art work and only emphasizing its material property. Since the middle 20th century, the autonomy theory was confronted with the limit and intense attack because it resulted in this fixed canon and materialism, so they began laying emphasis on those extrinsic factors around art works such as human life, society, history, and so on. This study focuses on arguing and complementing the limit of autonomy such as the adhesive and fixed canon, and then defining the more dynamic area of it. For this, first, I introduced the view of T. J. Clark and T. Crow who criticized the aesthetic autonomy theory. They denied the transcendental structure of form, and found form only in the association with substantial life and society. And they insisted the dynamism of form by emphasizing form as a result of negation insisted by avant-garde. Second, I researched the view of A. C, Danto and M. Fried, who complemented the traditional autonomy theory. They made autonomy emerge from the fixation of form like flatness through connecting essentialism with historical view. In conclusion, I insist that autonomic position of art make it possible to connect or mediate between material form and human or social elements. Therefore, autonomy should not be reduced to the axis of form or that of society but make interaction between two heterogeneous axes.

• Korean Journal of Applied Biomechanics
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• v.13 no.3
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• pp.253-264
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• 2003

This study aims at finding the structure of spike technique by analysing comparatively the spike action by excellent and by non-excellent players throughout the section from a flying jump to the time of landing for the correct analysis of spike action and tries to help athletes and coaches to execute a scientific training. For the objected person of this study, six of H College athletes three of excellent athletes and three of non-excellent athletes, presently registered as athlete with the Korea Volleyball federation) were chosen, and the factors of analysis were analysed upon performance time of action by section, human body centered displacement, change of articulation angle, speed change of articulation of the upper limbs, uniformity of the articulation of the upper limbs upon impact, etc. The conclusion of this study is as follow: 1. In the time required for taking action, it shows to take $1.067{\pm}0.057$ seconds for the group of excellent athletes and $1.034{\pm}0.033$ seconds for the group of non-excellent athletes. Although there was not big difference between two groups in the performance time of action, it showed that the group of excellent athletes takes longer compared to the group of non-excellent athletes. And it was found by the result of this study that the group of excellent athletes stays longer in the duration of flight. 2. In the displacements of horizontal movement and vertical movement, it was found that the group of excellent athletes have moved more than the group of non-excellent athletes in the horizontal movement of the center of human body 3. In the angles of wrist and knee, it was found that the excellent athletes have shown little than the non-excellent athletes in the entire sections, but that in the angle of elbow, the non-excellent athletes have shown bigger than the excellent athletes.. 4. In the speed of the articulation of the upper limbs upon impact, it was found that the group of excellent athletes have shown bigger than the group of non-excellent athletes, and that in the maximum value of the articulation of the upper limbs, the maximum value for the hand was indicated upon impact and that forearm and upper arm have shown the maximum value just before the impact. 5. In the uniformity of articulation of the upper limbs at the time of impact, the group of excellent athletes showed bigger than the group of non-excellent athletes in all the articulations.

• Journal of Korean Society of Steel Construction
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• v.17 no.6 s.79
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• pp.673-679
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• 2005

According to continuous welded rails on a bridge, temperature changes bring about the expansion of the bridge deck,adding axial forces on the track. Moreover, the ballast on the bridge deck expansion joint is moved due to the bridge deck. The longer the bridge deck is, the greater the influence will be, loosening the ballast, causing track irregularities, and deteriorating passenger comfort. Considering the structure of the bridge itself and tolerance for track irregularities caused by the loosened ballast on the bridge, the maximum length of the deck should be less than 80 m, which is the same as the standard of French railways. In this study, the interaction between the expansion related to the bridge length and the irregularity in the longitudinal level, referring to measurements and maintenance work performed in high-speed railways, was analyzed. This research shows that the installation of a sliding plate or a vertical ballast stopper is not a good option, since it is difficult. On the other hand, the installation of a ZLR fastener or gluing is easy, but its influence is insignificant. In conclusion, switch tie tamping or manual tamping is more effective than other methods of what?

• Journal of Korean Society of Steel Construction
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• v.14 no.6
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• pp.735-746
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• 2002

The task of plastic theory is twofold: first, to set up relationships between stress and strain that adequately describe the observed plastic deformation of metals, and second, to develop techniques for using these relationships in studying of the mechanics of metal forming processes, and the anlaysis and design of structures. One of the major problems in the theory of plasticity is to describe the behavior of work-hardening materials in the plastic range for complex loading histories. This can be achieved by formulating constitutive laws either in the integral or differential forms. To adequately predict the response of steel members during cyclic loading, the hardening rule must account for the features of cyclic stress-strain behavior. Neithe of the basic isotropic and kinematic hardening rules is suitable for describing cyclic streess-strain behavior, although a kinematic hardening rule describes the nearly linear portions of the stabilized hystersis loops. There is also a limited expansion of the yield surface as predicted by the isotropic hardening rule. Strong ground motions or wind gusts affect the complex and nonproportional loading histories in the inelastic behavior of structues rather than the proportional loading. Nonproportional loading is defined as externally applied forces on the structure, with variable ratios during the entire loading history. This also includes the rate of time-dependency of the loads. For nonproportional loading histories, unloading may take place along a chord instead of the radius of the load surface. In such cases, the shape of the stress-strain curve has to be determined experimentally for all non-radial loading conditions. The plasticity models including two surface models ae surveyed based on a yield surface and a bound surface that represent a state of maximum stress. This paper is concerned with the improvement of a plasticity models of the two-surface type for structural steel. This is follwed by an overview of plasticity models on structural steel. Finally the need for further research is identified.

• Journal of Korean Society of Steel Construction
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• v.22 no.1
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• pp.13-20
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• 2010

Seismic risk assessment of railway bridges is an important issue for a transportation network, because loss of functionality of railway bridges could result in severe disruption of the railway line, as no redundant routing systems generally exist. Although many studies have been conducted by numerous researchers regarding fragility analyses of bridge structure, little or no studies have been done for fragility analyses of a class of bridge structures considering their geometric variability. This study performs a fragility analysis for Track-on Steel-Plate-Girder (TOSPG) railway bridges in Korea considering their span variability. Seismic fragility curves are developed for a series of bridges with different spans varying from 2 to 15. At last, the fragility curves for the whole TOSPG bridges in Korea are also developed using the total probability theorem. This study is expected to effectively contribute to the seismic risk assessment of railway lines, where a number of bridges are present.