• 대한전자공학회:학술대회논문집
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• 대한전자공학회 1999년도 하계종합학술대회 논문집
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• pp.239-242
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• 1999

In this paper, we report the process/device design of high-speed, high-voltage SOI smart power IC for mobile communication system, high-speed HDD system and the electronic control system of automobiles. The high voltage LDMOS with 70V breakdown voltage under 0.8${\mu}{\textrm}{m}$ design rule, the high voltage bipolar with 40V breakdown voltage for analog signal processing, the high speed bipolar with cut-off frequency over 20㎓ and LDD NMOS for high density were proposed and simulated on a single chip by the simulator DIOS and DESSIS. And we extracted the process/device parameters of the simulated devices.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2007년도 제38회 하계학술대회
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• pp.555-556
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• 2007

This paper proposes a new concept's IDSFHA(Intelligent Digital Switchgear For Home Automation) which can obtain the safety, the reliability and the easy to correspond to the request of the general electric customer or electric power company under the ubiquitous-based home automation environments The IDSFHA is designed by analyzing their requirement functions, a 32-bit micro processor is adopted as main controller to support efficiently the designed functions. The single phase power IC(ADE7753) is utilized to collect the electric power information, and makes it possible to communicate as internet among the IDSFHA and their using the ethernet convertor. In the proposed IDSFHA, the several functions are implemented such as the earth leakage level display and waveform transmitting, the electric power using fee display, voltage management, load management and load control function. Finally, the prototype of the IDSFHA is made experimently based on the designed results.

• Journal of Semiconductor Engineering
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• 제1권3호
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• pp.81-87
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• 2020

An instrumentation amplifier (IA) and an analog-to-digital converter (ADC) are essential circuit blocks for accurate and robust sensor readout systems. This paper introduces recent advances in radiation-hardening by design (RHBD) techniques applied for the sensor readout integrated circuits (IC), e.g., the three-op-amp IA and the successive-approximation register (SAR) ADC, operating against total ionizing dose (TID) and singe event effect (SEE) in harsh radiation environments. The radiation-hardened IA utilized TID monitoring and adaptive reference control to compensate for transistor parameter variations due to radiation effects. The radiation-hardened SAR ADC adopts delay-based double-feedback flip-flops to prevent soft errors which flips the data bits. Radiation-hardened IA and ADC were verified through compact model simulation, and fabricated CMOS chips were measured in radiation facilities to confirm their radiation tolerance.

• 전력전자학회논문지
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• 제19권1호
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• pp.91-97
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• 2014

Recently, the LED(Light Emitting Diode) is expected to replace conventional lamps including incandescent, halogen and fluorescent lamps for some general illumination application, due to some obvious features such as high luminous efficiency, safety, long life, environment-friendly characteristics and so on. To drive the LED, a single stage PFC(Power Factor Correction) flyback converter has been adopted to satisfy the isolation, PFC and low cost. The conventional flyback LED driver has the serious disadvantage of high 120Hz output current ripple caused by the PFC operation. To overcome this drawback, a new PFC flyback with low 120Hz output current ripple is proposed in this paper. It is composed of 2 power stages, the DCM(Discontinuous Conduction Mode) flyback converter for PFC and BCM(Boundary Conduction Mode) boost converter for tightly regulated LED current. Since the link capacitor is located in the secondary side, its voltage stress is small. Moreover, since the driver is composed of 2 power stages, small output filter and link capacitor can be used. Especially, since the flyback is operated at DCM, the PFC can be automatically obtained and thus, an additional PFC IC is not necessary. Therefore, only one control IC for BCM boost converter is required. To confirm the validity of the proposed converter, theoretical analysis and experimental results from a prototype of 24W LED driver are presented.

• 한국운동역학회지
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• 제32권1호
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• pp.9-16
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• 2022

Objective: The purpose of this study was to investigate how the chronic ankle instability affects postural control during forward jump landing. Method: 20 women with chronic ankle instability (age: 21.7 ± 1.6 yrs, height: 162.1 ± 3.7 cm, weight: 52.2 ± 5.8 kg) and 20 healthy adult women (age: 21.8 ± 1.6 yrs, height: 161.9 ± 4.4 cm, weight: 52.9 ± 7.2 kg) participated in this study. For the forward jump participants were instructed to stand on two legs at a distance of 40% of their body height from the center of force plate. Participants were jump forward over a 15 cm hurdle to the force plate and land on their non-dominant or affected leg. Kinetic and kinematic data were obtained using 8 motion capture cameras and 1 force plates and joint angle, vertical ground reaction force and center of pressure. All statistical analyses were using SPSS 25.0 program. The differences in variables between the two groups were compared through an independent sample t-test, and the significance level was to p < .05. Results: In the hip and knee joint angle, the CAI group showed a smaller flexion angle than the control group, and the knee joint valgus angle was significantly larger. In the case of ankle joint, the CAI group showed a large inversion angle at all events. In the kinetic variables, the vGRF was significantly greater in the CAI group than control group at IC and mGRF. In COP Y, the CAI group showed a lateral shifted center of pressure. Conclusion: Our results indicated that chronic ankle instability decreases the flexion angle of the hip and knee joint, increases the valgus angle of the knee joint, and increases the inversion angle of the ankle joint during landing. In addition, an increase in the maximum vertical ground reaction force and a lateral shifted center of pressure were observed. This suggests that chronic ankle instability increases the risk of non-contact knee injury as well as the risk of lateral ankle sprain during forward jump landing.

• Journal of Microbiology and Biotechnology
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• 제29권4호
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• pp.651-657
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• 2019

Although smallpox was eradicated in 1980, it is still considered a potential agent of biowarfare and bioterrorism. Smallpox has the potential for high mortality rates along with a major public health impact, eventually causing public panic and social disruption. Passive administration of neutralizing monoclonal antibodies (mAbs) is an effective intervention for various adverse reactions caused by vaccination and the unpredictable nature of emerging and bioterrorist-related infections. Currently, vaccinia immune globulin (VIG) is manufactured from vaccinia vaccine-boosted plasma; however, this production method is not ideal because of its limited availability, low specific activity, and risk of contamination with blood-borne infectious agents. To overcome the limitations of VIG production from human plasma, we isolated two human single-chain variable fragments (scFvs), (SC34 and SC212), bound to vaccinia virus (VACV), from a scFv phage library constructed from the B cells of VACV vaccine-boosted volunteers. The scFvs were converted to human IgG1 (VC34 and VC212). These two anti-VACV mAbs were produced in Chinese Hamster Ovary (CHO) DG44 cells. The binding affinities of VC34 and VC212 were estimated by competition ELISA to $IC_{50}$ values of $2{\mu}g/ml$ (13.33 nM) and $22{\mu}g/ml$ (146.67 nM), respectively. Only the VC212 mAb was proven to neutralize the VACV, as evidenced by the plaque reduction neutralization test (PRNT) result with a $PRNT_{50}$ of ~0.16 mg/ml (${\sim}1.07{\mu}M$). This VC212 could serve as a valuable starting material for further development of VACV-neutralizing human immunoglobulin for a prophylactic measure against post-vaccination complications and for post-exposure treatment against smallpox.

• Restorative Dentistry and Endodontics
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• 제17권1호
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• pp.153-165
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• 1992

Dental composite resin is a kind of the particle - reinforced composite material, and is widely used in recent dental restoration of anterior and posterior tooth region. The purpose of this study was to investigate the fracture behaviour according to volume fractions and external findings of the filler particles for better interpretation of the fracture characteristics of posterior dental composite resins by analytic method of fracture mechanics. The plane strain fracture toughness($K_{IC}$) and Acoustic Emission were determined with three - point bending test using the single edge notch specimen according to the ASTM - E399, and its analyzed data was compared with filler volume fractions derived from the standard ashing test and scanning electron fractographs of each specimen including the unfilled experimental resin as a control. The results were that the value of fracture toughness of the composite resin material was in the range from 0.85 MPa$\sqrt{m}$ to 1.60 MPa$\sqrt{m}$ and was higher than the value of the unfilled experimental resin, and the fracture behaviours dervied from Acoustic Emission analysis show prominent differences according to the volume fraction and the size of filler particles used in each composite resin. The degree of resistance against crack propagation seems to be increase and the fractographs demonstrate the high degree of surface roughness and irregularity according with the increase of fracture toughness value.

• 전기전자학회논문지
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• 제15권4호
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• pp.319-323
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• 2011

본 논문에서는 Mobile 기기의 다양한 기능을 지원하기 위해 사용되는 내부 회로들의 낮은 전압 레벨을 지원하기위해 가장 널리 사용되는 SMPS(Switch Mode Power Supply)방식의 Buck converter를 설계한다. 제안된 Buck converter는 넓은 부하 영역에서 높은 효율을 가지는 것을 목적으로 일반적인 구동 방식인 PWM (Pulse Width Modulation)Mode의 고 효율 저 리플 특성 구현 외에 PFM(Pulse Frequency Modulation) Mode를 적용하여 낮은부하 조건 혹은 부하를 사용하지 않는 대기 시간에서도 고 효율 저 리플 특성을 가지는 Dual mode synchronous buck converter를 설계한다. 이를 위해 본 논문에서는 부하 변동 시에 PWM - PFM Mode로의 효율적인 변환방법 및 저 리플 특성을 위한 방법을 제안한다. 또한 제안된 IC는 Mobile 기기에 부합하는 입력 전압 범위 2.5V-5V를 가지며, 2.5Mhz의 높은 주파수로 동작하여 리플 특성이 양호하고 집적화가 유리하다. 고효율을 위하여 Synchronous Type 설계 및 Dynamic Control 방식을 적용하였다. 보호 기능으로는 회로 동작의 초기 시에 발생하는 Inrush Current를 방지하기 위한 Soft start function 외에 Current limit, Thermal shutdown function, UVLO 회로가 내장되어 신뢰성을 높였다.

• Bulletin of the Korean Chemical Society
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• 제32권5호
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• pp.1709-1714
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• 2011

KIST301135 was semi-synthetically prepared by the reaction of Staurosporine with triphosgene in anhydrous dichloromethane. The structure of KIST301135 was confirmed by $^1H$ NMR, $^{13}C$ NMR, and high resolution mass spectrum. KIST301135 was initially tested in a single dose duplicate mode at a concentration of 20 nM over a panel of 53 kinases against Staurosporine as a positive control. KIST301135 has showed inhibitions above 75% in only 2 kinases (FLT3 and JAK3 kinases) of the 53 tested kinases, while Staurosporine has showed inhibitions above 80% in about 62% of the tested kinases. KIST301135 was retested at a 5-dose testing mode over the 9 kinases inhibited by percentages over 20 at the single dose testing in order to determine its $IC_{50}$ values. KIST301135 has shown much improved kinase inhibitory selectivity relative to Staurosporine in its potency at JAK3 kinase and CAMK2b kinase.

• Biomolecules & Therapeutics
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• 제23권2호
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• pp.201-206
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• 2015

Scutellaria baicalensis is one of the most widely used herbal medicines in East Asia. Because baicalein and baicalin are major components of this herb, it is important to understand the effects of these compounds on drug metabolizing enzymes, such as cytochrome P450 (CYP), for evaluating herb-drug interaction. The effects of baicalin and baicalein on activities of ethoxyresorufin O-deethylase (EROD), methoxyresorufin O-demethylase (MROD), benzyloxyresorufin O-debenzylase (BROD), p-nitrophenol hydroxylase and erythromycin N-demethylase were assessed in rat liver microsomes in the present study. In addition, the pharmacokinetics of caffeine and its three metabolites (i.e., paraxanthine, theobromine and theophylline) in baicalin-treated rats were compared with untreated control. As results, EROD, MROD and BROD activities were inhibited by both baicalin and baicalein. However, there were no significant differences in the pharmacokinetic parameters of oral caffeine and its three metabolites between control and baicalin-treated rats. When the plasma concentration of baicalin was determined, the maximum concentration of baicalin was below the estimated $IC_{50}$ values observed in vitro. In conclusion, baicalin had no effects on the pharmacokinetics of caffeine and its metabolites in vivo, following single oral administration in rats.