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4-WEEK SUBCUTANEOUS TOXICITY STUDY OF RECOMBINANT GRANULOCYTE-MACROPHAGE COLONY STIMULATING FACTOR (LBD-005) IN RATS

  • Kim, Hyoung-Chin;Boohyon Kang;Han, Sang-Seop;Park, Jung-Koo
    • Toxicological Research
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    • v.8 no.1
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    • pp.49-61
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    • 1992
  • Recombinant granulocyte-macrophage colony stimulating factor was subcutaneously administered to both sexes of Sprague-Dawley rats at the doses of 0, 0.5, 1 and 2mg/kg of body weight five days per week for 4 weeks to evaluate the subchronic toxicity. There were decreased 1 and 2 mg/kg. In the serum, changes were decreased alkaline phostatase(ALP) in the female groups dosed at 1 and 2mg/kg, and increased glutamic oxaloacetic transaminiase (GOT)in the male groups dosed at 0.5 and 2.0mg/kg.

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ACUTE TOXICITY STUDY OF RECOMBINANT GRANULOCYTE-MACROPHAGE COLONY STIMULATING FACTOR (LBD-005) IN RATS

  • Kim, Hyoung-Chin;Boohyon Kang;Ha, Chang-Soo;Han, Sang-Seop
    • Toxicological Research
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    • v.8 no.1
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    • pp.41-48
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    • 1992
  • The actue toxicity of a recombinant granulocyte macrophage colony-stimulating factor (code name: LBD-005) was evaluated in both sexes of Sprague-Dawley rats, 4 weeks old, by the oral, subcutaneous and intravenous routes of administration. LBD-005 in the acute toxicity study in the rats was not considerde to induce any toxicological effect on the rats in mortalities, clinical findings, body weights and gross findings. It is suggested that $LD_{50}$ values in rats would be >48 mg/kg in the oral route and >12 mg/kg in the subcutaneous or intravenous route.

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Single Oral Toxicity of Jeju Citrus Rind Pectin in Spraque-Dawley Rats

  • Shim, Kyoo-Jung;Choung, Se-Young
    • Biomolecules & Therapeutics
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    • v.11 no.2
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    • pp.109-111
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    • 2003
  • The single oral toxicity of Jeju citrus rind pectin (Jeju pectin) was studied in Spraque-Dawley rats of both sexes. In this study, rats were administrated orally with dosages of 100, 250 and 500 mg/kg of Jeju pectin. We daily examined number of deaths, clinical signs, body weights and gross findings for 14 days after Jeju pectin administration. When we administered different doses of 100, 250 and 500 mg/kg. We found no rats died in both sex after administration. Some clinical signs (decrease locomotor activity, salivation, soft stool, prone position, lacrimation, crouching position, convulsion, ataxic gait, incontinence of mine) were also observed during the experimental period.

Contribution to the Knowledge of the Tribe Alyssontini Dalla Torre (Hymenoptera: Crabronidae: Bembicinae) of the Korean Peninsula

  • Kim, Jeong-Kyu
    • Animal Systematics, Evolution and Diversity
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    • v.36 no.1
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    • pp.1-6
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    • 2020
  • With the discovery of Didineis sibirica and Alysson moticola in South Korea, the tribe Alyssontini Dalla Torre of the Korean Peninsula is supplemented. The genus Didineis Wesmael is reported for the first time in the Korean Peninsula. It is easily separated by the following combination of characteristics from the genus Alysson, another member of Alyssontini occurring in the Far East. In both sexes, fore wing media diverging much before cu-a; metapleuron much less half as long as high; metasomal tergum 2 without pale spots. In males, the last antennal segment is strongly incurved and opposed by a projection from antennal segment 12. Alysson monticola is also new to Korea. Of the Far Eastern species with triangular propodeal enclosure, this species is unique with extended inter-antennal marking. In this study, list of all the known Korean species of the tribe, diagnostic characteristics and digital images are provided.

New Combination of Pararrhynchium paradoxum koreanum (Hymenoptera: Vespidae: Eumeninae)

  • Kim, Jeong-Kyu
    • Animal Systematics, Evolution and Diversity
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    • v.36 no.1
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    • pp.81-84
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    • 2020
  • An eumenid subspecies Pararrhynchium paradoxum koreanum Giordani Soika, 1986 is newly combined to the genus Pseudepipona de Saussure, 1856. Although tegula of this subspecies is similar to one of Allodynerus, shape of scutellar crest and related structures in both sexes and peculiar shape of mandible in male are critically justifiable for the genus Pseudepipona. This form is a discrete species in the genus, thus named as Pseudepipona koreanum (Giordani Soika, 1986) n. comb. The original description of this species was based on the sole male specimen and hardly diagnostic, just providing coloration compared with the nominotypical subspecies of P. paradoxum. A redescription of males and description of the hitherto unknown female are provided.

Localized Pleural Fibrous Mesothelioma - Report of 3 Cases - (국소형 흉막 중피세포종: 3례 보고)

  • 이석열
    • Journal of Chest Surgery
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    • v.24 no.6
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    • pp.595-604
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    • 1991
  • Pleural mesothelioma is usually divided into two forms of localized and diffuse type. Localized pleural fibrous mesothelioma is uncommon mesodermal neoplasm, which may occurs in both sexes and at the age of 50 years. This type of mesothelioma is usually asymptomatic and detected on routine chest X-ray and made fibrous tissue and shows of collagen fibers microscopically. Most localized fibrous mesothelioma arises from the visceral pleura and is well encapsulated and pedunculated mass. CT findings included well delineated, often lobulated, non-calcified soft tissue masses in close relation to a pleural space, associated pleural thickening, and absence of chest wall invasion and a peripheral or fissure location. Three cases of localized pleural fibrous mesothelioma diagnosed by resectional surgery were reported with the review of literature.

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New Limoniinae crane flies (Diptera: Limoniidae) of Korea

  • Podenas, Sigitas;Byun, Hye-Woo
    • Journal of Species Research
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    • v.3 no.2
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    • pp.167-182
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    • 2014
  • Korean species of Achyrolimonia, Dicranoptycha and Helius crane flies (Diptera: Limoniidae) are taxonomically revised. Identification keys, redescriptions and illustrations of all species and both sexes, if they were found in Korea, are presented. Genus Achyrolimonia is new record for the Korean peninsula, genera Dicranoptycha and Helius are new records for South Korea, species Helius (Helius) obliteratus (Alexander, 1920) is new record for the Korean peninsula and new record for the continent. Illustrations of females of D. diacantha Alexander, 1938 and H. gracillimus Alexander, 1938 are provided and female of D. prolongata Alexander, 1938 is described and illustrated for the first time.

A ROENTGENOGRAPHIC STUDY OF THE RANGE OF CONDYLAR MOVEMENT IN CHILDREN WITH YOUNG PERMANENT DENTITION (초기(初期) 영구치열시기(永久齒列時期)의 정상아동(正常兒童)의 하악골운동시(下顎骨運動時) 하악과두(下顎顆頭)의 이동범위(移動範圍)에 관(關)한 방사선학적(放射線學的) 연구(硏究))

  • Goo, Young-Jae;Lee, Keung-Ho
    • Journal of the korean academy of Pediatric Dentistry
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    • v.10 no.1
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    • pp.57-65
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    • 1983
  • The purpose of this study was to investigate the range of condylar movement of children with young permanent dentition. Materials included 33 roentgenograms of 4 serial projections of TMJ by modified transcranial projection with Accurad 100. Four serial projections were taken in the centric occlusion, rest position, 1 inch open, and maximum open position. The results obtained from this study were as follows. 1. The condyle was located anteriorly in articular fossa at centric occlusion. 2. The condyle was moved forwardly and downwardly during mandibular movement from centric occlusion to maximum open position. 3. The pattern of condylar movement was similar in both sexes, but there were no sex differences in distance of condylar movement.

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Redescription of Free-Living Marine Nematode, Dracograllus filipjevi Allen and Noffsinger, 1978 (Nematoda: Draconematidae) from Korea

  • Rho, Hyun-Soo;Kim, Dong-Sung;Kim, Won
    • Ocean Science Journal
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    • v.41 no.3
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    • pp.163-173
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    • 2006
  • A draconematid nematode species, Dracograllus filipjevi Allen and Noffsinger, 1978, is described from the washings of shallow littoral coralline algae at Guryongpo in the eastern coast of Korea. This species is recognized by the following characteristics: larger body size, number of posterior sublateral adhesion tubes (9 in male and 12-13 in female) and subventral adhesion tubes (8-9 in male and 9-10 in female), the absence of cephalic acanthiform setae on rostrum, the presence of longitudinally areolated body cuticle with dot-like punctations, the presence of some cuticular collar in swollen pharyngeal region, the shape of amphidial fovea (large, elongate, and loop-shaped in both sexes), the absence of preanal corniform setae, and the absence of lateral differentiation on narrow body region. Morphological features of the species using differential interference contrast photomicrographs are described in detail in the present work. The is the first report of D. filipjevi in Korea.

Proposals for Fashion Technology in the Standardization of Research Methods - Centered on Scientific Approaches to Body Type Research Methods -

  • Shim, Boo-Ja
    • Journal of Fashion Business
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    • v.5 no.5
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    • pp.7-15
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    • 2001
  • As a means of achieving fashion technology and scientification, this research on the standardization proposals of body type research methods has the following conclusions: 1. As human body displays different characteristics according to races, regions, sexes, and ages, clothing products (unlike other industrial goods) cannot be subject to global standardization. As a result, clothing size standardization can be desirably regionalized, for example, as Asian, European countries, etc. 2. In order to share human-body-concerned information among nations, programs for raw data exchange need to be urgently developed. 3. Top priority is databasing all raw data at home and abroad. 4. So that the findings of body type research can be practically applied to the concerned industry, industry-academy cooperation and information exchange are a must. While researchers have to heighten the precision of their studies, industrial partners ought to focus on the invaluable importance of academic research. 5. The scientific body type analysis, the basis of fashion technology, as well as the development of its application technology and software are ultimately and urgently required.

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