Toxicological Research

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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ACUTE TOXICITY STUDY OF RECOMBINANT GRANULOCYTE-MACROPHAGE COLONY STIMULATING FACTOR (LBD-005) IN RATS

  • Kim, Hyoung-Chin (Toxicology Research Center Korea Research Institute of Chemical Technology) ;
  • Boohyon Kang (Toxicology Research Center Korea Research Institute of Chemical Technology) ;
  • Ha, Chang-Soo (Toxicology Research Center Korea Research Institute of Chemical Technology) ;
  • Han, Sang-Seop (Toxicology Research Center Korea Research Institute of Chemical Technology)
  • Published : 1992.06.01
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Abstract

The actue toxicity of a recombinant granulocyte macrophage colony-stimulating factor (code name: LBD-005) was evaluated in both sexes of Sprague-Dawley rats, 4 weeks old, by the oral, subcutaneous and intravenous routes of administration. LBD-005 in the acute toxicity study in the rats was not considerde to induce any toxicological effect on the rats in mortalities, clinical findings, body weights and gross findings. It is suggested that $LD_{50}$ values in rats would be >48 mg/kg in the oral route and >12 mg/kg in the subcutaneous or intravenous route.

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References

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