Toxicological Research

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
권호 표지

FERTILITY STUDY (SEGMENT 1) OF RECOMBINANT GRANULOCYTE-MACROPHAGE COLONY STIMULATING FACTORS (LBD-005) IN RATS

  • Kim, Sung-Hoon (Toxicology Research Center Korea Research Institute of Chemical Technology) ;
  • Chung, Moon-Koo (Toxicology Research Center Korea Research Institute of Chemical Technology) ;
  • Roh, Jung-Koo (Toxicology Research Center Korea Research Institute of Chemical Technology)
  • Published : 1992.06.01
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Abstract

The recombinant glycoprotein, LBD-005 (Lucky R & D Center, Biotechnology)stimulates the growth of stem cells and activates the development of the hematopoietic cell in a similar manner to the naturally occurring GM-CSF. This test was conducted to investigate if LBD-005 had any effect on fertility in male and female rats. Sprague-Dawley rats(88 of each sex) bred at KRICT, were dosed subcutaneously, at a volume of 2ml/kg body weight with LBD-005 at 0, 250, 500 or 1, 000mg/kg body weight. The male rats were dosed, from 6 weeks of asge, for 60 days prior to mating.

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