Toxicological Research

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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A STUDY ON ANTIGENICITY OF GRANULOCYTE-MACROPHAGE COLONY STIMULATING FACTOR(LBD-005) IN MICE AND GUINEA PIGS

  • Park, Jong-Il (Toxicology Research Center Korea Research Institute of Chemical Technology) ;
  • Han, Sang-Seop (Toxicology Research Center Korea Research Institute of Chemical Technology) ;
  • Roh, Jung-Koo (Toxicology Research Center Korea Research Institute of Chemical Technology)
  • Published : 1992.06.01
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Abstract

Antigenicity of Recombinant Granulocyte macrophage colony stimulating factor(LBD-005), a newly developed drug for hematopoietic growth, was investigated in mice and guinea pigs. 1. Mice showed production of antibodies against LBD-005 (100mg/kg) with alumin]m hydroxide gel(alum) as an adjuvant, judged by the heterologous anaphylaxis(PCA) test using rats. On the other hand, antibodies against ovalbumin(OVA) inoculated with alum were definitely detected. 2. In the studies with guinea pigs, both the inoculation of LBD-005 only and of LBD-005 with complete Freund's adjuvant(CFA) as an adjuvant did not produce positive reactions in homologous passive cutaneous anaphylaxis (PCA).

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References

  1. Blood v.76 no.4 High-dose melphalan and granulocyte-macrophage colony stimulating factor for refractory multiple myeloma Barlogie,B.;Jagannath,S.;Dixon,D.O.(et al.)
  2. Blood v.56 no.6 The nature and action of granulocytemecrophage colony stimulating factor Burgress,A.W.;Metcalf,D.
  3. British Medical Bulletin v.45 no.2 Haemopoietic growth factors Dexter,T.M.
  4. Scinece v.226 Purified human graulocyte-macrophage colony stimulations: direct action on neutrophils Gasson,J.C.
  5. Leuk, Res. v.14 no.8 The role of haemopoietic growth factors in bone marrow transplanation Goldsone,A.H.;Khwaja,J.
  6. Int. Arch. Allerge v.39 Effect of combinations of inbred strain, antigen and antigen dose on immune responsiveness and reagin production in the mouse Levine,B.B.;Vaz,N.M.
  7. Blood v.4 no.8 Characterization of the clinical effects after the first dose of bacterially synthesized recombinant human granulocyte-macrophage colony stimulating factor Lieschke,G.J.;Cebon,J.;Morstyn,G.
  8. Blood v.67 no.1 Biologic properties in vitro of a recombinant human granulocyte-macrophage colony stimulating factor Metcalf,D.;Begley,C.G.;Johnson,G.R.;Nicola,N.A.
  9. Life Science v.7;11 Mouse homocytotropic antibodies. Ⅰ. Specific differentiation between mouse 7s, and mouse reagin-like antibodies Mota,I.;Wong,D.;Sadum,E.H.
  10. Life Science v.8 Homologous and heterologous passive cutaneous anaphylactic activity of mouse antisera during the course of immunization Mota,I.;Wong,D.
  11. J. Immunol. v.1115 Reaginic antibody formation in the mouse. Ⅲ. Collaboration between hapten-specitic memory cells and carrier-specific helper cells for secondary anti-hapten antibody formation Okudaira,H.;Ishizaka,K.
  12. Progr. Allerge. v.5 Immediate reactions in the skin of experimental animals provoked by antibody-antigen interaction Ovary,Z.
  13. Passive cutaneous anaphylaxis in immunological methods Ovary,Z.
  14. Scinece v.230 Human recombinant granulocyte-macrophage colony stimulating factor: a multilineage hematopoietin Shieff,C.A.;Emerson,S.G.;Donahue,R.E.(et al.)
  15. 醫學のあゆみ v.100 no.11 藥物の抗原性の 檢討-とくに IgE 抗體生産 檢討のための動物モデルについて- 萩田 忠厚;水道 裕
  16. 藥劑 アレルキ 發生機序 堀內 淑彦