• Advances in nano research
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• 제14권3호
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• pp.247-259
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• 2023

Muscle strength and hypertrophy are equivalent when low-intensity resistance exercise is paired with blood flow restriction. This paper deals with the impact of physical exercise in the form of body activities on drug delivery using nanodevices. The body's actions impact the blood flow since the nano drug delivery devices are released into the bloodstream, and physical exercise and all the activities that change the blood flow influence the stability of these nanodevices. The nanodevice for the drug delivery purpose is modeled via nonuniform tube structures based on the high-order beam theory along with the nonlocal strain gradient theory. The nanodevice is made by a central nanomotor as well as two nanoblade in the form of truncated conical nanotubes carrying the nanomedicine. The mathematical simulation of rotating nanodevices is numerically solved, and the effect of various parameters on the stability of nanodevices has been studied in detail after the validation study.

• 보건의료산업학회지
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• 제14권2호
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• pp.1-14
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• 2020

Objectives : The purpose of this study was to test fitness of the structured model of SNS activities for health information. Methods : A structured questionnaire were administered to 500 subjects. A structural equation model was applied to collected data. Results : The response rate was 73.9%. The respondents mostly used Facebook and KakaoStory. They spent 70 minutes per day and 21~30% of this usage was taken by health information. In the variances, those who has religion more actively exchanged information about diseases and medical institutions. The goodness-of-fit of the model was .81(GFI) and .90(CFI). The main path was bridging capital -> bonding capital -> credibility -> SNS activities for health information. The path from quality of sharing information to SNS activities was not significant. It could be explained by the restriction of digital literacy. Conclusions : SNS activities for health information were determined by credibility, currency and bonding social capital. Bridging social capital, indirectly, influenced SNS activities through bonding social capital. Thus building bonding social capital would be a critical success factor for SNS.

• 지역사회간호학회지
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• 제29권4호
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• pp.520-529
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• 2018

Purpose: The purpose of this study is to identify factors influencing activities-specific balance confidence in community-dwelling older adults. Methods: This is secondary analysis of data from an intervention study for improving cognitive function. The data were collected from March 2 to September 30, 2017 at a senior center. Data of 131 older adults were included for this secondary analysis, and were analyzed by using t-test, ANOVA, and multiple regression. Results: The mean score of activities-specific balance confidence is 65.08 out of a possible range of 0-100. The significant factors affecting activities-specific balance confidence among old adults include 'more than 85 years old', 'waist circumference', 'depressive symptoms', 'activity restriction due to fear of falling', and 'self-rated health' which explained 52.8% of the variance. Conclusion: The study results indicate that psychologic factors as well as physical condition should be considered for interventions to increase activities-specific balance confidence.

• 생명과학회지
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• 제28권8호
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• pp.931-937
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• 2018

뇌공등에 함유되어있는 트립톨라이드는 뛰어난 항염증, 항산화 효능을 가지고 있음이 보고되었다. 예쁜꼬마선충을 이용한 이전 연구에서 트립톨라이드의 섭취가 개체의 항스트레스 효능을 높이고, 수명을 연장시킴이 밝혀졌다. 본 연구에서는 트립톨라이드에 의한 수명연장에 관여하는 세포 내 기전과 트립톨라이드가 노화관련 질환인 당뇨병과 알츠하이머병에 미치는 영향을 평가하였다. 트립톨라이드는 인슐린/IGF-1-like 신호전달 저하에 의한 수명연장 돌연변이인 age-1과 미토콘드리아 전자 전달계 저하에 의한 수명연장 돌연변이인 clk-1의 수명을 유의적으로 증가시킨 반면, 식이제한 유도 돌연변이인 eat-2의 수명에는 유의적인 변화를 유도하지 못했다. 또한 박테리아 희석을 이용한 식이제한에 의해 연장된 수명을 추가적으로 더 연장시키지 못했다. 트립톨라이드 섭취는 고농도의 당 섭취에 의한 체내 독성과 사람 아밀로이드 베타 형질전환 유전자로 인한 체내 독성을 유의적으로 저하시켰다. 이러한 결과들은 트립톨라이드에 의한 수명연장이 식이제한에 의한 수명연장 기전과 중복되며, 트립톨라이드가 노화관련 질환을 저해하는 효능이 있음을 보여준다. 따라서, 트립톨라이드는 식이제한 효능을 대체할 수 있는 식의약품 개발에 활용될 수 있다.

• 가족자원경영과 정책
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• 제12권3호
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• pp.23-43
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• 2008

This research investigates the effect of leisure activities on lifestyle satisfaction of senior citizens. The target of this research is 202 people over 60 years of age who live in Seoul. Collected data was analyzed using frequency, percentage, average, T-test, one-way ANONA, and logistic regression analysis. SPSS and the Excel PC Program were used for the analysis. The following is the summary of the result of this research. First - in terms of participation in leisure activities: more active participation is observed with the elderly who have a spouse than with those who do not in every kind of leisure activity (except for the pastime activities). Second - all of the variables indicating the level of satisfaction from activities of the seniors who have a spouse are by far higher than those of the elderly who have no spouse. Third - the leisure activities and the satisfaction from the activities prove affective variables on whether they have a spouse or not. Notably, the religious leisure activities are enjoyed more by those senior citizens who are married. Comparatively, the unmarried senior citizens participate more actively in recreational and pastime leisure activities. This study suggests various practical means to promote leisure activities to the elderly and to raise the level of satisfaction received from those activities, as well as to help those who are concerned with understanding and improving lifestyle satisfaction of the elderly population. Nonetheless, this analysis is limited due to the restriction on the number of objects and samples studied. Therefore, studies to analyze leisure activities by regions in order to account for a more balanced set of systematical tools should follow.

• 한국식품영양과학회지
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• 제23권5호
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• pp.743-749
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• 1994

{\beta}-carotene$은 비타민 A 활성형인 retinol로 전환되어 그 기능을 수행하는 영양소로 알려져있지만 {\beta}-carotene$ 자체로서의 생리적, 영양학적 중요성이 부각되고 있다. 본 연구에서는 {\beta}-carotene$을 수준별로 공급하여 체내의 지질대사와 항산화 효소의 활성에 미치는 영향을 살펴보고자 계획되었으며 얻어진 결과는 다음과 같다. 간 미토콘드리아에서의 과산화지지르이 함량은 제한군과 과잉 공급군이 다른 처리군들에비해서 상대적인 증가를 보였고 BC 2군에서 가장 낮은 값을 나태내었다. SOD의 활성은 {\beta}-carotene$ 제한군이 공급군에 비해서 유의적으로 증가하여 SOD 활성에 대한 {\beta}-carotene$의 조절효과를 보여주었고 catalase와 GSH-Px의 활성에 대한 {\beta}-carotene$의 조절효과를 보여주었고 catalase와 GSH-Px의 활성은 과잉 공급군의 경우 가장 낮은 값을 보여주었다. {\beta}-carotene$ 공급에 따른 지질 함량의 변화는 간의 경우에 총지질 함량은 {\beta}-carotene$ 공급에 따라 감소하였고 중성지질은 전 군에서 유의적인 차이가 보이지 않았으며 인지질은 BC 2군과 BC 3군에서 유의적으로 낮은 값을 보였다. 콜레스테롤 함량은 BC 1군에서 가장 낮은 값을 보였다. 혈장에서는 {\beta}-carotene$ 공급이 증가함에 따라 중성지질의 함 은 증가하는 경향이었고 HDL-콜레스테롤은 BC 4군에서 가장 낮은 값을 나타내었다. HDL-콜레스테롤 함량비는 {\beta}-carotene$ 공급에 따라 증가되었으나 과잉공급군에서 제한군과 같은 수준으로 감소되었다. 이상의 결과에서와 같이 12,000mg의 {\beta}-carotene$을 급여한 군에서는 지질대사 관련효소 활성도와 체내 지질함량이 적정량을 급여한 군에 비해 크게 변화하였으나 10~1,200mg을 급여한 실험군들 사이에서는 큰 차이를 나타내지 않아 {\beta}-carotene$의 정량적 평가를 위한 지속적인 연구가 필요하다고 본다.하다고 본다.

• 대한치과기공학회지
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• 제30권2호
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• pp.105-119
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• 2008

This study explored the status of free time activities among the dental technicians who are working at Seoul, Gyonggido, and Gangwondo. On the basis of this research, we aim to present needs and applicable solutions to improve the working conditions and enhance the quality of life through more effective time management in free time activities that lead to their self development and far more enriched life. 500 subjects were randomly chosen and the questionary sheets were provided. Among them, 305 sheets were returned to be analysed through SPSS Win 10.0 software and the results are as follows; First, mean in the satisfaction of leisure activities was 3.44(SD=.73). Mean in sub categories was as follows; psychological factor(M=3.65, SD=.71), social factor(M=3.54, SD=.75), rest factors(M=3.52, SD=.63), physical factor(M=3.43, SD=.88), other factors(M=3.40, SD=.66), circumstantial factor(M=3.33, SD=.63), educational factor(M=3.24, SD=.73). Second, the most relevant sub categories in the satisfaction of leisure activities were social, educational, physical, and other circumstantial factors by sequence. Factors that affect leisure activities satisfaction were career and status of health, which shows statistical significance(p<.001). That is to say, contention of this study is that the general characteristics are closely related with and affect the types and the level of satisfaction in leisure activities of the subjects. Considering these results, the dental businesses and the associations of dental technicians should recognize the needs to improve the time management through more efficient cooperations between dentists and back office dental team, systemized working time, and introduction of incentive system among others. On the basis of this appreciation, the dental business should provide more time and various opportunities with the dental technicians. Dental technicians also need to reconsider their appreciations of leisure activities, that is, leisure activities are not just spending time doing something but they refresh them and enable them to be more active and faithful to home and work.

• 대한물리치료과학회지
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• 제26권3호
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• pp.15-22
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• 2019

Background: The purpose of this study is to explore the effect of the functions of GMFM and ICF-CY on the activities and participation of ICF-CY sub-items. Design: Cross-sectional study. Method: This study compared and analyzed 95 children with cerebral palsy [type of CP: spasticity 86 (90.5%), hypotonia 4 (4.2%), mixed 5 (5.3%); type of palsy: quadriplegia 13 (13.7%), diplegia 71 (74.7%), hemiplegia 11 (11.6%)] using sub-items of functions, activities and participation from GMFM and ICF-CY. Result: The results show that the activities and participation of ICF-CY (9 sub-items) have significant effect on the functions of GMFM and ICF-CY (8 sub-items) (p<0.05). Conclusion: It is intended to provide data to establish practical therapeutic goals and interventions for functions, activities and participation, which are sub-categories of ICF-CY in cerebral palsy.

• 한국지역사회생활과학회지
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• 제19권1호
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• pp.87-99
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• 2008

The purpose of this study was to examine the effects of child rearing behavior and child rearing involvement on elementary school children's stress. The subjects were 201 children selected from 2 elementary schools and their parents. Data was collected using the children's stress index, the child rearing behavior questionnaire, and the child rearing involvement questionnaire, and was statistically analyzed using t-test, one-way ANOVA (Duncan test), correlation analysis and multiple regression analysis. The study showed that there were some significant differences in children's stress according to the child's gender, grade, and scholastic achievement. Correlation analysis indicated that the child's stress and the mother's child rearing behavior had significant correlation, especially the warmth acceptance behavior of the mother indicated negative high correlation. Also, the child's stress and father's child rearing behavior had significant correlation, especially the rejection restriction behavior of the father indicated positive high correlation. Correlation analysis indicated that the child's stress and the mother's child rearing involvement had significant correlation, especially the family activities involvement of the mother indicated negative high correlation. As well, the child's stress and the father's child rearing involvement had significant correlation, especially the day to day guidance involvement of the father indicated negative high correlation. It was also found that rejection restriction behavior of the father, permissiveness non-intervention behavior of the father, day to day guidance involvement of the father, family activities involvement of the father, and warmth acceptance behavior of the mother were all significant predictors of the elementary school child's stress.

• Toxicological Research
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• 제24권4호
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• pp.245-251
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• 2008

Dietary restriction (DR) is the most efficacious intervention for retarding the deleterious effects of aging. DR increases longevity, decreases the occurrence and severity of age-related diseases, and retards the physiological decline associated with aging. The beneficial effects of DR have been mostly studied in non-neuronal tissues. However, several studies have showed that DR attenuate neuronal loss after several different insults including exposure to kainate, ischemia, and MPTP. Moreover, administration of the non-metabolizable glucose analog 2-deoxy-D-glucose (2DG) could mimic the neuroprotective effect of DR in rodent, presumably by limiting glucose availability at the cellular level. Based on the studies of chemically induced DR, it has been proposed that the mechanism whereby DR and 2DG protect neurons is largely mediated by stress response proteins such as HSP70 and GRP78 which are increased in neurons of rats and mice fed a DR regimen. In addition, DR, as mild metabolic stress, could lead to the increased activity in neuronal circuits and thus induce expression of neurotrophic factors. Interestingly, such increased neuronal activities also enhance neurogenesis in the brains of adult rodents. In this review, we focus on what is known regarding molecular mechanisms of the protective role of DR in neurodegenerative diseases and aging process. Also, we propose that DR is a mild cellular stress that stimulates production of neurotrophic factors, which are major regulators of neuronal survival, as well as neurogenesis in adult brain.