• 제목/요약/키워드: Research and Development Project

검색결과 2,899건 처리시간 0.03초

Albumin and Antioxidants Inhibit Serum-deprivation-induced Cell Adhesion in Hematopoietic Cells

  • Han, Mi-Jin;Lim, Sung-Mee;Kim, Yu-Lee;Kim, Hyo-Lim;Kim, Kye-Ok;Sacket, Santosh J.;Jo, Ji-Yeong;Bae, Yoe-Sik;Okajima, Fumikazu;Im, Dong-Soon
    • Biomolecules & Therapeutics
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    • 제16권4호
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    • pp.410-415
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    • 2008
  • Previously, we identified albumin as an inhibitory factor in serum for cell adhesion of T cells such as human Jurkat T and primary cultured human T cells. In the present study, we found that other hematopoietic cell lines including U-937 human monocytes, THP-1 human monocytes, K-562 promyelocytic leukemia cells, and HL-60 human leukemia cells, also adhere to tissue culture flasks when serum is withdrawn, and albumin exerts an inhibitory effect on cell adhesion by those cells, implying that this inhibition is a common phenomenon in hematopoietic cells. Furthermore, we found that cell adhesion is inhibited by antioxidants such as (-)-epigallocatechin- 3-gallate (EGCG), morin, and a-tocopherol. Our results suggest that albumin may inhibit basal cell adhesion of hematopoietic cells and that the oxidative balance in the plasma may be important for cell adhesion of hematopoietic cells in vivo.

IT Service기업의 Software개발 생산성 영향 요인에 관한 실증 연구 : SW개발 방법론 중심으로 (A Study on Factors for Influence SW Development Productivity on The IT Service Company)

  • 송영운;김완기
    • 한국IT서비스학회지
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    • 제13권2호
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    • pp.195-217
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    • 2014
  • This paper has explored when implementing SW development project of the IT service corporations, what factors affect its productivity in SW development methodology. The importance of the AHP analysis surveyed from the experts in IT service companies and related committee, was shown in the order of the following processes : 1) Deployment process 2) Management process 3) Establishment process. It is measured the methodology levels of establishment, deployment and management in each project using the survey results collected from project execution members and analyzed the productivity of projects that have been executed within 2 years. Using project methodology level, productivity correlation analysis, and regression analysis, this study confirms that the methodology deployment level brings positive effects significantly to SW development productivity. The significance of this study would be not only to research and analyze SW development productivity using the real project execution data but also to underline the necessities and the importance of steady research, deployment and support for SW development productivity improvement.

N,N-Dimethyl-D-ribo-phytosphingosine Modulates Cellular Functions of 1321N1 Astrocytes

  • Lee, Yun-Kyung;Kim, Hyo-Lim;Kim, Kye-Ok;Sacket, Santosh J.;Han, Mi-Jin;Jo, Ji-Yeong;Lim, Sung-Mee;Im, Dong-Soon
    • Biomolecules & Therapeutics
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    • 제15권2호
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    • pp.73-77
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    • 2007
  • N,N-Dimethyl-D-ribo-phytosphingosine (DMPH) is an N-methyl derivative of sphingosine. In the present paper, we studied effects of DMPH on intracellular Ca$^{2+}$ concentration, pH, glutamate uptake, and cell viability in human 1321N1 astrocytes. DMPH increased intracellular Ca$^{2+}$ concentration and cytosolic pH significantly in a dose-dependent manner. DMPH also inhibited glutamate uptake by 1321N1 astrocytes. Finally, treatment of cells with DMPH for 24 h reduced viability of cells largely and concentration-dependently. In summary, DMPH increased intracellular Ca$^{2+}$ concentration and pH, inhibited glutamate uptake and evoked cytotoxicity in 1321N1 astrocytes. Our observations with DMPH in the 1321N1 astrocytes would enhance understanding of DMPH actions in the brain.

지방자치단체 환경영향평가 조례 비교 연구 (A Comparative Study on the Local Governments' Environmental Impact Assessment Regulations in Korea)

  • 성현찬;민수현
    • 환경영향평가
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    • 제12권3호
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    • pp.137-150
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    • 2003
  • This study aims to survey whether local governments have legislated laws and regulations on environment impact assessment system, to compare and analyze specific projects and their scale, assessment items, and procedures & discussion process, to identify issues and generate improvement plans, and to suggest a direction for future legislation to local governments that plan to legislate laws and regulations in the future. Major outcome of the study are as follows. First, terminologies used for environment impact assessment by local governments need to be unified. Also, laws and regulations need to be legislated soon. Second, in "urban development project" areas, a total of nine project areas including "quarrying of soil and stone, sand, gravel, and minerals" was essential common projects. A total of six project types were added or newly established compared to national systems. Among them, four project types were added within national-level project areas and two project types were not available under the national-level project areas and newly added due to the nature of local governments. Third, in terms of project scale, scale enhancement of "urban development project" was most common. Analysis showed that in case of clean natural environment such as Cheju Island, it is necessary to consider reinforcing project areas where development activities take place directly in forests or rivers such as "industrial base and complex development", "water resource development", and "development of tourism complex." Fourth, the discussion and review procedures of assessment reports were similar to those at government level. However, in case of Seoul city, it is required to write a "preparation plan" before drafting an assessment report. The city features partial introduction of scoping and screening, which allows to exempt discussion procedures if impact on environment is found to be minimal after drafting the assessment report. In case of national-level, it has a dual system that is split between Ministry of Construction and Transportation and Ministry of Environment. However, in case of environment impact assessment of local governments, it is a single system where city mayors and provincial governors are in charge of both project execution and environmental assessment. Therefore, the most important task is how to satisfy objectiveness and accountability.

PL 리더십 성향과 프로젝트 특성요인이 프로젝트 참여 만족 및 성과에 미치는 영향 (The Effect of PL Leadership and Characteristics of Project on Project Participants' Satisfaction and Performance)

  • 양희동;김명진;강소라
    • Asia pacific journal of information systems
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    • 제20권4호
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    • pp.53-79
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    • 2010
  • The study was originated from recognition that project participants' satisfaction should be Improved to raise project performance and to make progress of a successful project since the above dissatisfaction was operated as a danger factor of the project. The study selected one large-scale sample project and attempted measuring characteristics of the project, participants' satisfaction and project performance with the whole project participants. The study analyzed correlations between individual level (team members) and group level (development team), and examined what effect a sub project manager under complicated hierarchical organization of the large-scale project, namely PL (project leader)'s leadership style had on each individual project participant's satisfaction and what effect project uncertainty in organization/technology environment had on project participants' satisfaction and project performance. The study verified that development team (group) had an effect on team member (individual)-level project participants' satisfaction by disclosing that there was a significant dispersion among groups within project participants' satisfaction by each individual. It is analyzed that it is necessary to make improvement through approach by each pertinent team to raise individual-level project participants' satisfaction. The study also verified PL's ideal leadership under strict methodology and hierarchical control of the large-scale project. Based on the verification of the hypotheses, the results of the analysis were produced as follows. First, the development team affects the satisfaction level that an individual has when he/she participates in a project. This suggests that the satisfaction with project participation should be improved at the team level. In addition, the project management style and leadership orientation of the manager of a sub project who is mostly affected by the team proved to have a direct influence on the satisfaction with project participation and project performances. Second, both the performance-oriented leadership and the relationship-oriented leadership of the PL of the development team were verified to have a significant effect on the satisfaction of the team members associated with project participation. In other words, when the team members recognize that the PL of the development team shows both the performance-oriented leadership and the relationship-oriented leadership, their satisfaction with project participation increases accordingly. Third, it was verified that the uncertainty of the organizational environment significantly affects the satisfaction level when the PL of the development team exerts a relationship-oriented and performance-oriented leadership. The higher the uncertainty of the organizational environment is, the more the satisfaction with project participation decreases whereas the relationship-oriented leadership has a more positive effect on the satisfaction than the performance-oriented leadership style. Fourth, when the PL of the development team exerts the relationship-related and performance-related leadership, the uncertainty of the technological environment has a significant influence on the satisfaction level. The higher the uncertainty of the technological environment is, the more the satisfaction with project participation decreases whereas the performance-oriented leadership has a more positive effect on the satisfaction than the relationship-oriented leadership style. The result of the research on the uncertainty of the project environment suggests that when the development team leader exerts a relationship-oriented and performance-oriented leadership style, the uncertainty of the organizational environment has a significant effect on the satisfaction with project participation; the higher the uncertainty of the organizational environment, the more the satisfaction level decreases, and the relationship-oriented leadership style affects the satisfaction level more positively than the performance-oriented leadership style. In addition, when the development team leader displays a relationship-oriented and performance-oriented leadership style, the uncertainty of the technological environment has a significant effect on the satisfaction with project participation; the higher the uncertainty of the technological environment. the more the satisfaction level decreases. The performance-oriented leadership style as well affects the satisfaction level more positively than the relationship-oriented leadership style. Based on the above results, the research provides the following implications when handling multiple concurrent projects. First, the satisfaction with the participation in the multiple concurrent projects needs to be enhanced at the team (group) level. Second. the manager of the project team, particularly the middle managers should have both a performance-oriented and relationship (task and human)-oriented attitude and exert a consolidated leadership in order to improve the satisfaction of team members with project participation and their performances. Third, as the uncertainty factor of the technological and organizational environment among the characteristics factors of the project has room for methodological improvement depending on one's effort even though there are some complications, we need to continuously prevent and control the risks resulting from the uncertainties of the technological and organizational environment of the project in order to enhance the satisfaction of project participation and project performances. Fourth, the performance (task)-oriented leadership is required when there is uncertainty in a technological environment while the relationship (human)-oriented leadership is required when there is uncertainty in an organizational environment. This research has the following limitations. First, this research intended to select one large-sized sample project and measure the project characteristics, the satisfaction of all the participants associated with project participation, and their performances. Therefore, it is inappropriate to generalize and apply the result of this result onto other numerous projects. Second, as this case study entailed a survey to measure the characteristics factors and performance of the project, since the result value was based on the perception of project team members, the data may have insufficient objectivity. Third, though this research targeted on all the project participants, some development teams did not provide sufficient data and questionnaires were collected from some specific development teams among the 23 development teams, causing a significant deviation in the response rate among the development teams. Therefore, we need to continuously conduct the follow-up researches making comparisons among the multiple projects, and centering on the characteristics factors of the project and its satisfaction level.

프로젝트 위험요인 인식에 관한 비교 연구 - 정보시스템 구현 프로젝트에서 소프트웨어 패키지 적용과 순수 개발하는 경우 - (A Study on Perception of Project Risk Factor - Comparison between Software Package and Development with Program Language in Information System Project -)

  • 박송미;채명신
    • 한국정보시스템학회지:정보시스템연구
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    • 제16권4호
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    • pp.243-268
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    • 2007
  • It is critical to manage risks to complete IS(Information Systems) projects successfully. Identifying risk factors would be the first step for the project risk management. Previous research has discussed the issue with various points of view, such as different risk factors based on project types and roles involved in their projects. This paper empirically explored how people perceive different risk factors by project development methodology, between self-developing IS using programming language like C, Visual Basic and adapting software package already developed by software venders like ERP, CRM packages. There are researches regarding project risk factors for project management in the several point of views. And there are also researches regarding comparison between self-developing and adapting software packages methodology in IS project. However, there are no study on project risk factors comparison between self-developing IS using programming language and adapting software packages already developed by software venders in IS project. This research can be differentiated from previous ones, because it was considered both point of project risk management and development methodology in IS project. This research results implied meaningful messages to enterprise company to be planned IS projects and people who involved in IS projects. They should consider and need to prepare differently according to each development methodology for preventing project risks. It makes them reduce project risks in each case and complete successfully IS projects. Especially, if they have no experiences for implementing software packages, they can forecast the project risks and prepare them in advance.

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IS프로젝트에서 PMS 품질이 성과에 미치는 영향에 대한 연구 (A Study on the Impact of the PMS Quality on Performance in Information Systems Project)

  • 정천수;안현철
    • 지식경영연구
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    • 제13권3호
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    • pp.79-103
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    • 2012
  • Recently because the IS development project is large scale and complicated, the necessity of tools that can manage effectively smooth communications and the harmonized project between the interested parties is exposed. According to this fact, many companies are investing enough to the PMS (Project Management System) for the sake of the systematic management of the IS development project, and also this PMS is emerging as one of the indispensable tools for the successful IS development project by casting off from a auxiliary means for the past project management. However, as had been expected, whether the introduction of the PMS is possible to facilitate communications within a project team, and a main motivation that can derive individual performance and organizational performance that participated in the IS development project is induced or not are not verified still empirically and apparently. With respect to this, a survey was conducted to examine how PMS quality affected user satisfaction, communication, individual performance and project performance. The effects of the data gathered were verified by structural equation model analysis.

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A Study on the Dimension of Quality Metrics for Information Systems Development and Success : An Application of Information Processing Theory

  • An, Joon M.
    • 정보기술과데이타베이스저널
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    • 제3권2호
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    • pp.97-118
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    • 1996
  • Information systems quality engineering is one of the most problematic areas in practice and research, and needs cooperative efforts between practice and theory [Glass, 1996]. A model for evaluating the quality of system development process and ensuing success is proposed based on information processing theory of project unit design. A nomological net among a set of quality variables is identified from prior research in the areas of organization science, software engineering, and management information systems. More specifically, system development success was modelled as a function of project complexity, system development modelling environment, user participation, project unit structure, resource availability, and the level of iterative nature of development methodology. Based on the model developed from the information processing theory of project unit design in organization science. appropriate quality metrics for each variable in the proposed model are matched. In this way, a framework of relevant systems development and success quality metrics for controlling systems development processes and ensuing success is proposed. The causal relationships among the constructs in the proposed model are proposed as future empirical research for academicians and as managerial tools for quality managers. The framework and propositions help quality manager to select more parsimonious quality metrics for controlling information systems development processes and project success in an integrated way. Also this model can be utilized for evaluating software quality assurance programmes, which are developed and marketed by many vendors.

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파이로 프로젝트에 프로젝트 관리 적용 방안 (Application of Project Management on Pyro Project)

  • 김정국;김혁종;고원일;구정회;남효온
    • 시스템엔지니어링학술지
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    • 제13권2호
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    • pp.26-33
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    • 2017
  • Pyro project, one of complex project, is now under research and development. To manage this kind project successfully, it is essential to apply the processes of technical management (TM) based on systems engineering (SE) and project management (PM). In this paper, the project management processes from ISO-21500 standard, PMBOK guide, and PRINCE2 guide were reviewed, and then some common PM for the large national R&D project were selected. An integrated technical management and project management frame work was finally established and suggested for Pyro project.

대형 국가 R&D 프로젝트의 기술관리 프로세스 : 파이로 프로젝트를 중심으로 (Technical Management Processes for Large National R&D Projects : Focused on Pyro Project)

  • 김정국;고원일;구정회;남효온
    • 시스템엔지니어링학술지
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    • 제13권2호
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    • pp.34-41
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    • 2017
  • The Pyro project, one of the large national R&D project to construct Korea Advanced Pyroprocessing Facility (KAPF), which has many goals such as development of pyro technology and process equipment, design of equipment and facility, construction, and test operation, is now under research and development. To reduce uncertainty and risk of such complex project, the technical management processes in systems engineering standards and NASA handbook were reviewed, and then the ten common technical management processes were selected for the large national R&D project to meet its goal successfully. And the essential technical management processes were finally suggested for Pyro project in consideration of current situation of the project.