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Propatation and Application of a New HPLC Chiral Stationary Phase Edrived from 2-Amino-1-indanolo

  • Hyeon, Myeong Ho;Jang, Yeong Su;Min, Hye Jeong;Kim, Do Hun;Eom, Bong Ho
    • Bulletin of the Korean Chemical Society
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    • v.22 no.4
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    • pp.401-404
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    • 2001
  • A new chiral stationary phase (CSP) based on (1R,2S)-2-amino-1-indanol, which is expected to be conformationally rigid because of its cyclic nature, was prepared. The new CSP was applied in resolving various $N-acyl-\alpha-arylalkylamines$. The chromatographic resolution results on the new CSP were compared with those on the other CSP based on (1S,2R)-norephedrine, which is believed to be conformationally flexible. Comparison of the chromatographic resolution results on the two CSPs demonstrated that conformationally flexible analytes are resolved better on the conformationally rigid CSP while conformationally rigid analytes are resolved better on the conformationally flexible CSP. From these results it was concluded that conformational rigidity or flexibility of CSPs is the important factor for the chiral recognition.

Relationship between Core competencies, Nursing professionalism and Employment strategies in Nursing students (간호대학생의 핵심역량과 간호전문직관 및 취업전략과의 관계)

  • Han, Young-In
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.17 no.3
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    • pp.144-152
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    • 2016
  • This paper reports a descriptive correlation to explore the relationships among core competencies, nursing professionalism, and employment strategies of nursing students. Data collection was conducted from November 1 to November 28, 2014. A structural questionnaire were completed by 107 nursing students of 4th year in B city and G city. The data was analyzed using the SPSS 22.0 program. The mean value of the study was as follows: core competencies, 3.57; nursing professionalism, 4.22; and employment strategies, 3.69. A positive relationship was observed between the core competencies and nursing professionalism (r=.401, p<.001), core competencies and employment strategies (r=.559, p<.001), and nursing professionalism and employment strategies (r=.465, p<.001). The factors affecting the employment strategies of the study participants were core competencies (${\beta}=.43$, p<.001), nursing professionalism (${\beta}=.28$, p=.001), school score (${\beta}=-.19$, p=.011), which explained approximately 42% (F=24.82, p<.001). Overall, this study indicates that the core competencies and nursing professionalism, employment strategies of Nursing students have a significant positive relationship. Therefore, it is necessary to improve the curriculum, program development and repeat research for improving the core competencies, nursing professionalism, and employment strategies.

The health status, aging anxiety, social networking, generativity, and happiness of late middle-aged adults (중년후기 성인의 건강상태, 노화불안, 사회관계망, 생성감 및 행복)

  • Chang, Hae Kyung
    • The Journal of Korean Academic Society of Nursing Education
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    • v.27 no.4
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    • pp.392-401
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    • 2021
  • Purpose: This study was conducted to identify the relationship of health status, aging anxiety, social networking, generativity, and happiness and to investigate the main factors influencing happiness of late middle-aged adults. Methods: The study collected data from a total of 153 middle-aged men and women aged 50 to 64 years old from a consumer panel of Macromill-Embrain, the biggest online survey provider in Korea. The data were analyzed using descriptive statistics, Pearson's correlation coefficient and a stepwise multiple regression using the SPSS 22.0 program. Results: The subjects' happiness mean score was 16.17±9.29. Statistically significant differences in happiness were found according to education (F=4.38, p=.014), economic status (t=5.13, p<.001), and religion (t=2.18, p=.031). Happiness was correlated significantly with health status (r=.41, p<.001), aging anxiety (r=-.62, p<.001), family support (r=.43, p<.001), friend support (r=.36, p<.001) and generativity (r=.63, p<.001). The factors influencing happiness of late middle-aged adults were generativity (𝛽=.37, p<.001), aging anxiety (𝛽=-.35, p<.001), family support (𝛽=.20, p<.001), and economic status (𝛽=.13, p=.033). The explanatory power of the model was 58.0%. Conclusion: This study will be used as basic data when developing a nursing intervention program for successful aging by identifying factors that affect the happiness of late middle-aged adults.

Isolation and identification of Flavobcterium succinicans from anadromous ayu Plecoglossus altivelis (소하은어의 병소로부터 Flavobcterium succinicans의 분리 및 동정)

  • Lee, Chang-Hoon;Kim, Pil-Youn;Lim, Bong-Soo;Oh, Duck-Chul;Kang, Bong-Jo
    • Journal of fish pathology
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    • v.22 no.3
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    • pp.401-406
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    • 2009
  • On May in 2008, mortality of anadromous Ayu Plecoglossus altivelis was observed on the Gangjeong river in Jeju. Major symptoms of the infected fish were mouth rot and skin ulcer. The causative agent was suspected as gliding bacteria. After culture on Shu-Shott and R2A media, we isolated bacterium belonging to the Flavobacterium from ayu with symptoms. As a result, the bacterium was identified as Flavobacterium succinicans JMFL55 by 16S rDNA sequence alignment with F. succinicans DSM 4002(98.27% similarity, GenBank accession NO. AM230492).

Factors Affecting the Retention Intention of the Emergency Room Nurse to Promote Life Care (응급실 간호사의 라이프케어 증진을 위한 재직의도에 영향을 미치는 요인)

  • Jung, Ji-Hyeon;Park, Huyn-Jung
    • Journal of Korea Entertainment Industry Association
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    • v.15 no.4
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    • pp.287-297
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    • 2021
  • This study was to investigate the relationship of job stress, health status, and health promotion behavior, retention intention and to identify the influencing factors on retention intention of nurse in Emergency Room(ER). The subjects were 155 ER nurses working at 15 general hospital in Gwangju, Korea. The data were collected from October 15, 2020 to November 3, 2020. The result, there were negative correlation between job stress and health promotion behavior(r=-0.310, p=<.000), between job stress and retention intention(r=-0.220, p=.006), between health status, and health promotion behavior(r=-0.448, p=<.000), between health status and retention intention(r=-0.296, p=<.000), but there were positive correlation between job stress and health status(r=0.368, p=<.000), between health promotion behavior and retention intention(r=0.229, p=.004). Factors influencing retention intention were fatige and health status with R2 value 22.7%. Considering these results, it seems that important factors determining the retention intention of nurses in ER are Spiritual health status, heavy workload due to job stress, fatigue and social health status by nurse. Therefore, in order to increase the retention intention of nurse in ER, it is a need for strategies to improve the working environment and develop programs to reduce job stress and fatigue through work adjustment, and to maintain and promote health.

An Experimental Study on Evaperation Heat Transfer and Pressure Drop in Plated cleat Exchangers with Different Chevron Angles (판형열교환기의 세브론각에 따른 증발 열전달특성 및 압력강하에 대한 실험적 연구)

  • Kim, Yun-Ho;Lee, Gyu-Jeong
    • Transactions of the Korean Society of Mechanical Engineers B
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    • v.26 no.2
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    • pp.269-277
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    • 2002
  • Experiments on the evaporation heat transfer and pressure drop in the brazed type plate heat exchangers were performed using refrigerants R410A and R22. To investigate the geometric effect, plate heat exchangers with the same pitch and height but different 45$^{\circ}$, 35$^{\circ}$and 20$^{\circ}$chevron angles are used. Tests were conducted fur the ranges of the mass flux of refrigerant from 13 kg/m$^2$s to 34 kg/m$^2$s, the evaporation temperatures of 15$^{\circ}C$, 1$0^{\circ}C$ and 5$^{\circ}C$, vapor quality from 0.15 to 0.95 and the heat flux from 2.5 kW/m$^2$to 8.5 kW/m$^2$. The evaporation heat transfer coefficients and pressure drops were measured. Most of flow patterns are in the chum flow regime and become close to the annular flow for increasing the mass flux and the vapor quality. The heat transfer coefficient increases with increasing the evaporation temperature at a given mass flux in all plate heat exchangers. Also, the pressure drop increases with increasing the mass flux and the quality and decreasing the evaporation temperature and the chevron angle.

Development of Profile Design Method Based on Longitudinal Strain for Flexible Roll Forming Process (가변 롤 성형 공정시 길이방향 변형률에 근거한 제품 형상 설계 기술 개발)

  • Joo, B.D.;Han, S.W.;Shin, S.G.R.;Moon, Y.H.
    • Transactions of Materials Processing
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    • v.22 no.7
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    • pp.401-406
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    • 2013
  • The use of roll-formed products increases every year due to its advantages, such as high production rates, reduced tooling cost and improved quality. However, till now, it is limited to part profiles with constant cross section. In recent years, the flexible roll forming process, which allows variable cross sections of profiles by adaptive roll stands, was developed. In this study, an attempt to optimize profile design for the flexible roll forming process was performed. An equation that predicts the longitudinal strain for part geometries with variable cross-sections was proposed. The relationship between geometrical parameters and the longitudinal strain was analyzed and investigations on the optimal profile design were performed. Experiments were conducted with a lab-scale roll forming machine to validate the proposed equation. The results show that the profile design method proposed in this study is feasible and parts with variable cross sections can be successfully fabricated with the flexible roll forming process.

Effects of Restricted Feeding on Intake, Digestion, Nitrogen Balance and Metabolizable Energy in Small and Large Body Sized Sheep Breeds

  • Kamalzadeh, A.;Aouladrabiei, M.R.
    • Asian-Australasian Journal of Animal Sciences
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    • v.22 no.5
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    • pp.667-673
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    • 2009
  • Ninety six intact male sheep (12 months old with mean live weight of about 35 kg) were used to assess the effects of restricted feeding on intake, digestion, nitrogen balance and metabolizable energy (ME). The animals were selected from two known Iranian small and large body size breeds: 48 Sangsari (S) and 48 Afshari (A), and were divided into two equal groups: restricted (R) and a control (C). Each group had 48 sheep (24 each breed). The experiment had a duration of 15 and 75 days adaptation and treatment periods, respectively. The animals were individually placed in metabolism cages and fed a diet based on pelleted concentrate mixture consisting of alfalfa, barley grain, cottonseed meal and barley straw. The animals in group C were fed ad libitum, while animals in group R were fed at maintenance level and maintained a relatively constant live weight. During the experiment, the average daily weight gain (ADG) of S and A animals in R group was 0.34 and -0.25 g/d (0.02 and -0.02 $g/kg^{0.75}/d$), respectively. While that of S and A animals in C group was 174.4 and 194.4 g/d (10.16 and 11.48 $g/kg^{0.75}/d$), respectively. Nitrogen (N) was determined by both measured and regression methods. Animals of R group stayed at about zero N balance (0.01 and -0.00 g $N/kg^{0.75}/d$ for S and A animals, respectively). The N retention of animals of both S and A breeds in C group were similar (0.45 and 0.46 g $N/kg^{0.75}/d$, respectively). Digestible organic matter intake (DOMI) and ME requirement for maintenance (MEm) were measured by both constant weight technique and regression method by regressing N balance on DOMI and ME intake on ADG. The measured DOMI during constant weight was 24.61 and 24.27 g $DOMI/kg^{0.75}/d$ and the calculated DOMI from regression equation was 24.24 and 24.22 g $DOMI/kg^{0.75}/d$, for S and A animals, respectively. The measured MEm was 402 and 401 kJ $ME/kg^{0.75}/d$ and the calculated MEm from regression analysis was 398 and 400 kJ $ME/kg^{0.75}/d$ for S and A breeds, respectively. There were no significant differences between both measured and regression techniques. There was no significant difference between S and A breeds for DOMI, N retention, MEm, digestibility and metabolizability values. Digestibility values for OM, GE and CP and metabolizability were significantly (p<0.05) higher in restricted feeding sheep compared with that of sheep fed ad libitum.

Usability Evaluation of Graphic User Interfaces for a Military Computer-Based Training System

  • Kim, Sungho;Lee, Soojung;Lee, Kiwon;Lee, Baekhee;Lee, Jihyung;Park, Seikwon;You, Heecheon
    • Journal of the Ergonomics Society of Korea
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    • v.34 no.5
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    • pp.401-410
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    • 2015
  • Objective: The present study was to improve the graphic user interface (GUI) of a military computer-based training (CBT) system in terms of usability. Background: Existing studies have focused on usability evaluation of a particular GUI type such as sequence, hierarchy, or context type; however, few research has been conducted which identifies preferred GUI features based on a comparative analysis of different GUI types. Method: A comparative evaluation was conducted by 9 CBT design experts using a 7-point scale (1: very low, 4: neutral, and 7: very high) on hierarchy and context GUI types of a military CBT system in terms of 10 usability criteria. Then, preferred features of the hierarchy and context types being accommodated, a new GUI was developed and validated by 22 CBT users. Results: While the hierarchy type was found preferred by 1.6 times in terms of controllability to the context type, the opposite was found in terms of attractiveness, simplicity, and responsiveness by 0.6, 0.8, and 0.8 times, respectively. The proposed GUI was found superior to the hierarchy and context types in terms of accessibility and informativeness by more than 1.5 times, but inferior to the hierarchy and context type in terms of simplicity by 0.6 and 0.9 times, respectively. Conclusion: The new GUI developed by accommodating the preferred features of the hierarchy and context types improves usability in terms of accessibility and informativeness except simplicity. Application: The comparative analysis of various GUIs can be applied to develop an improved GUI in a systematic manner based on preferred features of the existing GUIs.

Evaluation of Tuberculosis Activity in Patients with Anthracofibrosis by Use of Serum Levels of IL-2 $sR{\alpha}$, IFN-${\gamma}$ and TBGL(Tuberculous Glycolipid) Antibody (Anthracofibrosis의 결핵활동성 지표로서 혈청 IL-2 $sR{\alpha}$, IFN-${\gamma}$, 그리고 TBGL(tuberculous glycolipid) antibody 측정의 의의)

  • Jeong, Do Young;Cha, Young Joo;Lee, Byoung Jun;Jung, Hye Ryung;Lee, Sang Hun;Shin, Jong Wook;Kim, Jae-Yeol;Park, In Won;Choi, Byoung Whui
    • Tuberculosis and Respiratory Diseases
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    • v.55 no.3
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    • pp.250-256
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    • 2003
  • Background : Anthracofibrosis, a descriptive term for multiple black pigmentation with fibrosis on bronchoscopic examination, has a close relationship with active tuberculosis (TB). However, TB activity is determined in the later stage by the TB culture results in some cases of anthracofibrosis. Therefore, it is necessary to identify early markers of TB activity in anthracofibrosis. There have been several reports investigating the serum levels of IL-2 $sR{\alpha}$, IFN-${\gamma}$ and TBGL antibody for the evaluation of TB activity. In the present study, we tried to measure the above mentioned serologic markers for the evaluation of TB activity in patients with anthracofibrosis. Methods : Anthracofibrosis was defined when there was deep pigmentation (in more than two lobar bronchi) and fibrotic stenosis of the bronchi on bronchoscopic examination. The serum of patients with anthracofibrosis was collected and stored under refrigeration before the start of anti-TB medication. The serum of healthy volunteers (N=16), patients with active TB prior to (N=22), and after (N=13), 6 month-medication was also collected and stored. Serum IL-2 $sR{\alpha}$, IFN-${\gamma}$ were measured with ELISA kit (R&D system, USA) and serum TBGL antibody was measured with TBGL EIA kit (Kyowa Inc, Japan). Results : Serum levels of IL-2 $sR{\alpha}$ in healthy volunteers, active TB patients before and after medication, and patients with anthracofibrosis were $640{\pm}174$, $1,611{\pm}2,423$, $953{\pm}562$, and $863{\pm}401$ pg/ml, respectively. The Serum IFN-${\gamma}$ levels were 0, $8.16{\pm}17.34$, $0.70{\pm}2.53$, and $2.33{\pm}6.67$ pg/ml, and TBGL antibody levels were $0.83{\pm}0.80$, $5.91{\pm}6.71$, $6.86{\pm}6.85$, and $3.22{\pm}2.59$ U/ml, respectively. The serum level of TBGL antibody was lower than of other groups (p<0.05). There was no significant difference of serum IL-2 $sR{\alpha}$ and IFN-${\gamma}$ levels among the four groups. Conclusion : The serum levels of IL-2 $sR{\alpha}$, IFN-${\gamma}$ and TBGL antibody were not useful in the evaluation of TB activity in patients with anthracofibrosis. More useful ways need to be developed for the differentiation of active TB in patients with anthracofibrosis.