• Preventive Nutrition and Food Science
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• v.2 no.1
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• pp.1-5
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• 1997

Solution Properties of polyelectrolytic biopolymers such as chitosen, pectin, alginate and etc. are significantly influenced by molecular weight and salt concentrations. The effect of NaCI concentration on the hydrodynamic properties of chitosan in dilute region was investigated for chitosans of varying molecular weight. Intrinsic vicosity([η]) of citosans with 5 different molecular weight was determined by glass capillary viscometer, and the viscosity average molecular weight was calculated using Mark-Houwink equation. Intrinsic viscosity decreased with increasing NaCI concentration for all chitosan samples, and it was proportional to the logarithmic NaCI concentration, i.e.,[η]∝log{TEX}$(C_{NaCl})^{$\alpha$}${/TEX}. Decreasing trend of[η] with NaCI concentration became more pronounced with increasing molecular weight. It was also found that the a values, indicating {TEX}$C_{NaCl}${/TEX} dependence of[η], were linearly correlated with the logarithmic molecular weight({TEX}$R^{2}${/TEX}=0.980). The chain stiffness parameters(B) were calculated by B=S./{TEX}$([η]_{0.1})^{1.32}${/TEX}, in which S was obtained from slope of [η] va {TEX}$I^{-1/2}${/TEX}. The B values of chitosan samples were determined to be 0.113~0071 with a average of 0.09.

• Toxicological Research
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• v.33 no.3
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• pp.173-182
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• 2017

In silico methods to predict toxicity include the use of (Quantitative) Structure-Activity Relationships ((Q)SARs) as well as grouping (category formation) allowing for read-across. A challenging area for in silico modelling is the prediction of chronic toxicity and the No Observed (Adverse) Effect Level (NO(A)EL) in particular. A proposed solution to the prediction of chronic toxicity is to consider organ level effects, as opposed to modelling the NO(A)EL itself. This review has focussed on the use of structural alerts to identify potential liver toxicants. In silico profilers, or groups of structural alerts, have been developed based on mechanisms of action and informed by current knowledge of Adverse Outcome Pathways. These profilers are robust and can be coded computationally to allow for prediction. However, they do not cover all mechanisms or modes of liver toxicity and recommendations for the improvement of these approaches are given.

• Journal of Technologic Dentistry
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• v.38 no.3
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• pp.119-125
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• 2016

Purpose: The purpose of this study is to evaluate the marginal gap of all-ceramic crowns fabricated by CEREC$^{(R)}$ in-office CAD/CAM system. Methods: The mandibular first molar was selected as the abutment for the experiments. Thirty working models were prepared. VITA Mark II(VM) and VITA Enamic(VE), LAVA Ultimate(LU) blocks were milled using CEREC MCXL with CEREC 3D system to construct 10 crowns for each groups. To measure marginal gap, milled restorations were examined under digital microscope with scale under 160x magnifications. The results were statistically analyzed using the one-way ANOVA and Tukey's HSD test(${\alpha}=0.05$). Results: There was no significant difference in the marginal gap regarding to ceramic materials(p>0.05). Conclusion: Single crowns fabricated using CEREC in-office CAD/CAM system provided clinically acceptable marginal gap. This confirmed that the type of ceramic material used does not determine the precision of fit of a prosthesis.

• Korean Journal of Health Education and Promotion
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• v.20 no.2
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• pp.179-196
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• 2003

This study was aimed at examining the self-reported health-promoting life- style (HPL) and related factors among teachers assumed to be role models for students. The subjects were 300 teachers who were conviently drawn from nine elementary schools and three high schools. The conceptual framework for this study was based on the Pender's revised Health Promotion Model(1996). Data was collected by a mailed survey (response rate, 62.5％) with structured questionnaire. The score of health-promoting life-style was 2.8(full mark： 5.0), harmonized relationship was the highest(3.2), and professional helath management was the lowest(2.0). The related factors to health-promoting life-styles were age, marital stauts, career, perceived health status, self esteem, intermal locus of control, perceived benefit, perceived barrier, self efficacy, and social support in univariate analysis. In the final regression model, predictors of HPL were social support, self esteem, perceived benefit. self efficacy, and perceived health status after control the effects of demographic characteristics (p＜.0001, R2＝0.494). The results generally supported the Pender Model. It is recommended to develop the health promotion program for teachers based on these results, and to evaluate the effect of that program for teacher.

• Structural Engineering and Mechanics
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• v.53 no.1
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• pp.73-87
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• 2015

In case of aircraft impact on nuclear containment structures, the initial kinetic energy of the aircraft is transferred and absorbed by the outer containment, may causing either complete or partial failure of containment structure. In the present study safety analysis of BWR Mark III type containment has been performed. The total height of containment is 67 m. It has a circular wall with monolithic dome of 21m diameter. Crash analysis has been performed for fighter jet Phantom F4. A normal hit at the crown of containment dome has been considered. Numerical simulations have been carried out using finite element code ABAQUS/Explicit. Concrete Damage Plasticity model have been incorporated to simulate the behaviour of concrete at high strain rate, while Johnson-Cook elasto-visco model of ductile metals have been used for steel reinforcement. Maximum deformation in the containment building has reported as 33.35 mm against crash of Phantom F4. Deformations in concrete and reinforcements have been localised to the impact region. Moreover, no significant global damage has been observed in structure. It may be concluded from the present study that at higher velocity of aircraft perforation of the structure may happen.

• Journal of Applied Reliability
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• v.6 no.1
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• pp.63-91
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• 2006

According to the rapid development of science technologies, a life and development cycle of products are getting shorter and structures and functions become more complex so that the reliability requirement of customers is getting greater for components in the products. However, most domestic mechanical components are manufactured by small and medium-sized companies, who are manufacturing in poor economic and technical condition. Because of this, assessment technologies and equipment to predict and guarantee the reliability are very weak. For this reason, it is the fact that many customers neglect the domestic mechanical components which fail to win the reliability. Korean government has been trying to eliminate the problem by establishing 18 reliability assessment centers in 2000 and performing R-Mark certification promotion and constructions of the foundation for reliability assessment to rebuild the reliability on the domestic components and materials. Korea Institute of Machinery and Materials has been designated as a supervising organization for reliability assessment in the machinery filed for 5 years. In this paper, we would like to introduce effective and systematized 12 steps of reliability substantiation test on mechanical components with know-how we achieved during the period.

• Proceedings of the Korea Water Resources Association Conference
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• 2019.05a
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• pp.123-123
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• 2019

최근 기후변화로 인해 중국, 한국, 일본, 몽골 등을 포함한 동아시아 지역은 태풍, 가뭄, 홍수와 같은 자연재해의 발생 빈도가 증가하고 있는 추세이다. 중국의 경우 2017년 극심한 가뭄으로 1,850만 (ha)의 농작물 피해가 발생하였으며, 몽골 또한 2017년 4월 이후 극심한 가뭄으로 사막화가 급속도로 진행되고 있다. 위성 기반의 강우 자료는 공간과 시간 해상도가 높아짐에 따라 지상관측소 강수량 자료의 대체 수단으로 이용되고 있다. 본 연구에서는 Climate Hazards Groups InfraRed Precipitation with Station (CHIRPS), Precipitation Estimation From Remotely Sensed Information Using Artificial Neural Networks-Climate Data Record (PERSIANN-CDR), Global Precipitation Climatology Centre (GPCC) 강우 위성 자료를 활용하여 기상학적 가뭄지수인 표준강수지수 (Standardized Precipitation Index, SPI)를 산정하였다. 시간 해상도는 월별 영상을 기준으로 2008년부터 2017년까지 지난 10년간의 데이터를 이용하였으며, 각각 격자가 다른 위성영상을 기존 기상관측소와 비교하였다. 피어슨 상관계수 (Pearson Correlation Coefficient, R)를 활용하여 강우 위성 영상과 지상관측소의 상관관계를 분석하고, 평균절대오차 (Mean Absolute Error, MAE), 평균제곱근오차 (Root Mean Square Error, RMSE)를 통해 통계적으로 정확도를 분석하였다. 인공위성 강수량 자료는 미계측 지역이 많은 곳이나 측정이 불가능한 지역에 효율성 측면에서 중요한 이점을 제공할 것으로 판단된다.

• Journal of the FoodService Safety
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• v.2 no.1
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• pp.10-21
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• 2021

According to the analysis which investigated visitors of HACCP system certified stores and non-visitors of such stores on the awareness of HACCP for livestock products, 77.1% (246 pollees) heard of HACCP certification for livestock products, 67.1% (214 pollees) had seen the HACCP certification mark for livestock products, 62.1% (198 pollees) heard of HACCP certification for livestock products in meet retail shops, and 51.4% (164 pollees) were not aware of the recent TV · subway advertisements regarding HACCP certification for livestock products. For every questionnaire on the awareness of HACCP for livestock products, visitors of HACCP system certified stores showed significantly higher response rate than nonvisitors (p<0.01, p<0.001). The majority of pollees (74.9%, 239 pollees) replied that the word HACCP for livestock products brings up the image of safe livestock products, and 37.0% answered that the term HACCP defines 'Hazard analysis critical control point'. Regarding the questions on HACCP system for livestock products, 38.6% showed that they were most curious in terms of the benefits of such system. The demand analysis on HACCP for livestock products for consumer was also conducted. In the analysis, the demand for support of the policy (4.06 points) was higher than demand for education · public promotion of HACCP (4.03 points) and demand for related application (3.90 points).

• Proceedings of the National Institute of Ecology of the Republic of Korea
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• v.3 no.3
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• pp.154-164
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• 2022

Understanding temporal variations in wildlife populations is a prerequisite for conservation planning of wide-ranging species such as tigers (Panthera tigris). We determined the temporal variation in abundance, population growth, and sex ratios at different age and sex stages for a tiger population in Ranthambhore Tiger Reserve, India from November 2007 to February 2011 using motion-sensing cameras. We identified 19 male and 21 female tigers from stripe patterns during 16,110 trap nights within an area covering 233 km². The annual abundance of the population varied from 34.9 (mean)±3.8 (SE) to 23.9±1.5, with a declining trend in the mean annual change of abundance (-12%). The density of adult females remained stable across the study duration, but the densities of adult males and non-breeding tigers fluctuated. The sex ratio was female-biased (0.58 males/female) for breeding tigers and male-biased (1.74 males/female) for non-breeding tigers. Our results reinforce the importance of long-term studies for monitoring the naturally occurring processes in populations to develop population indicators and identify reliable baseline information for conservation and management planning of populations.

• Molecules and Cells
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• v.45 no.7
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• pp.435-443
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• 2022

In response to environmental changes, signaling pathways rewire gene expression programs through transcription factors. Epigenetic modification of the transcribed RNA can be another layer of gene expression regulation. N⁶-adenosine methylation (m⁶A) is one of the most common modifications on mRNA. It is a reversible chemical mark catalyzed by the enzymes that deposit and remove methyl groups. m⁶A recruits effector proteins that determine the fate of mRNAs through changes in splicing, cellular localization, stability, and translation efficiency. Emerging evidence shows that key signal transduction pathways including TGFβ (transforming growth factor-β), ERK (extracellular signal-regulated kinase), and mTORC1 (mechanistic target of rapamycin complex 1) regulate downstream gene expression through m⁶A processing. Conversely, m⁶A can modulate the activity of signal transduction networks via m⁶A modification of signaling pathway genes or by acting as a ligand for receptors. In this review, we discuss the current understanding of the crosstalk between m⁶A and signaling pathways and its implication for biological systems.