• KDI Journal of Economic Policy
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• v.14 no.2
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• pp.77-108
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• 1992

Many economists and policymakers regard the ratio of R&D investment to GNP to be a good indicator of a nation's technological capabilities. Consequently, their major policy recommendation to promote technological development is a rapid expansion in R&D investment. However, a low R&D ratio does not necessarily mean less efforts at technological advancement since the composition of technologies to be developed varies depending upon the stage of economic development. Technology policy to improve the international competitiveness of domestic industries should be based on the stage of economic development and present technological status rather than on a simple comparison with advanced countries. At Korea's stage of development, maximizing the efficiency of R&D investment is more important than enlarging the size of the investment. Strategic alliances between domestic firms and foreign enterprises should be encouraged to save time and costs involved in acquiring new technologies and learning how to use them. The government should establish institutional devices to stimulate private enterprises to internationalize their business activities such as R&D, production, and marketing. The government should also promote the development of domestic and international R&D networks, which can serve as the infrastructure for technological innovations.

• The korean journal of orthodontics
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• v.47 no.1
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• pp.39-49
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• 2017

Objective: This retrospective, cross-sectional study aimed to establish reference data for normal crown and root lengths and the root-crown ratios (R/C ratios) for the mature maxillary and mandibular incisors in a Korean population by using cone-beam computed tomography (CBCT). Methods: We included 672 Korean patients (141 men and 531 women; mean age, $27.2{\pm}7.7years$) who underwent CBCT examinations during various dental treatments. Crown and root lengths and the R/C ratios of the maxillary and mandibular incisors were measured using CBCT data, which were analyzed to detect significant differences between demographic factors as well as sagittal and vertical skeletal or occlusal relationships. Results: Teeth of the same type in each half-arch were symmetrical. The mean R/C ratios varied from 1.1 to 1.2 for the maxillary incisors and from 1.3 to 1.4 for the mandibular incisors. Crown and root lengths were greater in men than in women, regardless of tooth type. Root lengths and R/C ratios for the mandibular incisors were significantly greater in patients with skeletal Class II malocclusion or an excessive overjet than in the other patients. The R/C ratios for the mandibular incisors were lower in patients with an open bite than in those with a normal or deep bite. Moreover, the R/C ratios for the mandibular incisors increased with age. Conclusions: The data obtained in our study can serve as reference values for crown and root lengths and the R/C ratios for the maxillary and mandibular incisors in the Korean population.

• Journal of Microbiology and Biotechnology
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• v.26 no.7
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• pp.1173-1181
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• 2016

Salmonella spp. are gram-negative flagellated bacteria that cause a variety of diseases in humans and animals, ranging from mild gastroenteritis to severe systemic infection. To explore development of a potent vaccine against Salmonella infections, the gene encoding outer membrane protein L (ompL) was inserted into the swinepox virus (SPV) genome by homologous recombination. PCR, western blot, and immunofluorescence assays were used to verify the recombinant swinepox virus rSPV-OmpL. The immune responses and protection efficacy of rSPV-OmpL were assessed in a mouse model. Forty mice were assigned to four groups, which were immunized with rSPV-OmpL, inactive Salmonella (positive control), wild-type SPV (wtSPV; negative control), or PBS (challenge control), respectively. The OmpL-specific antibody in the rSPV-OmpL-immunized group increased dramatically and continuously over time post-vaccination, and was present at a significantly higher level than in the positive control group (p < 0.05). The concentrations of IFN-γ and IL-4, which represent Th1-type and Th2-type cytokine responses, were significantly higher (p < 0.05) in the rSPV-OmpL-vaccinated group than in the other three groups. After intraperitoneal challenge with a lethal dose of Salmonella typhimurium CVCC542, eight out of ten mice in the rSPV-OmpL-vaccinated group were protected, whereas all the mice in the negative control and challenge control groups died within 3 days. Passive immune protection assays showed that hyperimmune sera against OmpL could provide mice with effective protection against challenge from S. typhimurium. The recombinant swinepox virus rSPV-OmpL might serve as a promising vaccine against Salmonella infection.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.4
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• pp.1563-1567
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• 2012

To investigate the relationship between serum miRNA-21 (miR-21) expression in esophageal squamous cell carcinomas (ESCCs) and its clinicopathologic features, a 1:1 matched case-control study including 21 patients with ESCC and 21 age- and gender-matched healthy controls was carried out. Serum specimens were taken from all subjects. Total RNA was extracted and the stem-loop real time polymerase chain reaction was used to measure serum miR-21 in both groups. Clinical parameters were assessed to determine associations with serum miR-21 concentrations. Serum miR-21 expression in ESCC samples was significantly higher than in paired cancer-free samples (P<0.05). Metastasis was associated with mir-21 expression in serum (P<0.05), ESCC patients with metastasis having 8.4-fold higher serum miR-21 concentrations than healthy controls. There were no statistically significant associations between miR-21 expression and clinicopathologic parameters, such as gender (P>0.05), age (P>0.05), tumor location (P>0.05), cell differentiation (P>0.05), TNM staging (P>0.05), whether chemo/radiotherapy had been administered (P>0.05), or whether surgery had been performed (P>0.05). These findings suggest that the detection of microRNA-21 in serum might serve as a new tumor biomarker in diagnosis and assessment of prognosis of ESCCs.

• Journal of Information Management
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• v.37 no.2
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• pp.109-136
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• 2006

The development of Semantic Web basically requires knowledge which is induced by the formalization and semantization of information, and thus ontology should be introduced as a knowledgization tool. URI(Uniform Resource Identifier) is an indispensible scheme to uniquely indicate individuals on ontology. However, it is difficult to find the use cases of identifiers or URIs in real data sets including science & technology publications. This paper describes the method to construct, manage, and serve reference information based on URI which is a crucial component on establishing national R&D reference information ontology. We expect the reference information which was acquired from about 7,000 proceeding papers would be adopted to Semantic Web applications such as researcher network analysis and outcome statistics.

• Mycobiology
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• v.41 no.2
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• pp.86-93
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• 2013

Sequence characterized amplified region (SCAR) markers are one of the most effective and accurate tools for microbial identification. In this study, we applied SCAR markers for the rapid and accurate detection of Phytophthora katsurae, the casual agent of chestnut ink disease in Korea. In this study, we developed seven SCAR markers specific to P. katsurae using random amplified polymorphic DNA (RAPD), and assessed the potential of the SCAR markers to serve as tools for identifying P. katsurae. Seven primer pairs (SOPC 1F/SOPC 1R, SOPC 1-1F/SOPC 1-1R, SOPC 3F/SOPC 3R, SOPC 4F/SOPC 4R, SOPC 4F/SOPC 4-1R, SOPD 9F/SOPD 9R, and SOPD 10F/SOPD 10R) from a sequence derived from RAPD fragments were designed for the analysis of the SCAR markers. To evaluate the specificity and sensitivity of the SCAR markers, the genomic DNA of P. katsurae was serially diluted 10-fold to final concentrations from 1 mg/mL to 1 pg/mL. The limit of detection using the SCAR markers ranged from $100{\mu}g/mL$ to 100 ng/mL. To identify the limit for detecting P. katsurae zoospores, each suspension of zoospores was serially diluted 10-fold to final concentrations from $10{\times}10^5$ to $10{\times}10^1$ zoospores/mL, and then extracted. The limit of detection by SCAR markers was approximately $10{\times}10^1$ zoospores/mL. PCR detection with SCAR markers was specific for P. katsurae, and did not produce any P. katsurae-specific PCR amplicons from 16 other Phytophthora species used as controls. This study shows that SCAR markers are a useful tool for the rapid and effective detection of P. katsurae.

• Journal of The Korean Society of Integrative Medicine
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• v.11 no.3
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• pp.137-145
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• 2023

Purpose : The purpose of this study was to identify the degree of work ethics of an occupational therapist and examine the correlation between work ethics and organizational commitment. In this study, we aimed to investigate the effects of occupational therapists' work ethics on organizational commitment. Through this study, we aim to determine the importance of work ethics and find a way to improve organizational commitment in occupational therapists. Methods : We conducted nationwide surveys on occupational therapists working in hospitals and other institutions from April 24, 2023 to May 30, 2023. We evaluated general characteristics, work ethics, and organizational commitment. General characteristics were analyzed using a frequency analysis. Work ethics and organizational commitment were examined using descriptive statistics. The correlation among work ethics and organizational commitment was analyzed using the Pearson correlation coefficient. Additionally, a multiple regression analysis was conducted to identify factors that affected organizational commitment. Results : The results of this study were as follows. First, the average score of work ethics was 3.32 ± .32. Second, a significant positive correlation was observed between work ethics and organizational commitment (p<.01). And as a result of the correlation between work ethics sub-factors and organizational commitment, wasted time (r=.261, p<.01), centrality of work (r=.366, p<.01), morality/ethics (r=.470, p<.01), leisure (r=.189, p<.05), delay of gratification (r=.410, p<.01), hard work (r=.437, p<.01), self-reliance (r=.233, p<.01) showed a statistically significant correlation. Third, the sub-factors of work ethics that influenced organizational commitment, including morality/ethics (𝛽=.302, p<.01), hard work (𝛽=.271, p<.01), and delay of gratification (𝛽=.205, p<.01) were identified. Conclusion : In conclusion, the results of this study underscore the importance of work ethics in influencing organizational commitment. Through this study, we recognized the importance of work ethics, which may serve as basic data to promote work ethics and improvement of organizational commitment.

• Journal of the Korean Society of Industry Convergence
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• v.27 no.3
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• pp.563-572
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• 2024

Image processing and computer vision technologies are becoming increasingly important in a variety of application fields that require techniques and tools for sophisticated image analysis. In particular, image segmentation is a technology that plays an important role in image analysis. In this study, in order to identify recent research trends on image segmentation techniques, we used the Web of Science(WoS) database to analyze the R&D topography based on the network structure of the author's keyword co-occurrence matrix. As a result, from 2015 to 2023, as a result of the analysis of the R&D map of research articles on image segmentation, R&D in this field is largely focused on four areas of research and development: (1) researches on collecting and preprocessing image data to build higher-performance image segmentation models, (2) the researches on image segmentation using statistics-based models or machine learning algorithms, (3) the researches on image segmentation for medical image analysis, and (4) deep learning-based image segmentation-related R&D. The scientometrics-based analysis performed in this study can not only map the trajectory of R&D related to image segmentation, but can also serve as a marker for future exploration in this dynamic field.

• Journal of Microbiology and Biotechnology
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• v.30 no.10
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• pp.1552-1558
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• 2020

With an increase in the consumption of non-heated fresh food, foodborne shiga toxin-producing Escherichia coli (STEC) has emerged as one of the most problematic pathogens worldwide. Endolysin, a bacteriophage-derived lysis protein, is able to lyse the target bacteria without any special resistance, and thus has been garnering interest as a powerful antimicrobial agent. In this study, rV5-like phage endolysin targeting E. coli O157:H7, named as LysECP26, was identified and purified. This endolysin had a lysozyme-like catalytic domain, but differed markedly from the sequence of lambda phage endolysin. LysECP26 exhibited strong activity with a broad lytic spectrum against various gram-negative strains (29/29) and was relatively stable at a broad temperature range (4℃-55℃). The optimum temperature and pH ranges of LysECP26 were identified at 37℃-42℃ and pH 7-8, respectively. NaCl supplementation did not affect the lytic activity. Although LysECP26 was limited in that it could not pass the outer membrane, E. coli O157: H7 could be effectively controlled by adding ethylenediaminetetraacetic acid (EDTA) and citric acid (1.44 and 1.14 log CFU/ml) within 30 min. Therefore, LysECP26 may serve as an effective biocontrol agent for gram-negative pathogens, including E. coli O157:H7.

• Proceedings of the KIEE Conference
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• 2002.11b
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• pp.127-130
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• 2002

Recently, with the increasing use of power semiconductors and microprocessors which are very sensitive to little change of power quality and for coping positively with anticipating power quality disputes between power providers and consumers which are possible to occur by of power market being formed, the power quality problem has gained preponderance among the contemporary research areas. To serve these purposes, the integrated system has been researched and developed for power quality analysis and monitoring, which provides speedy and powerful functions by the growth of computer hardware and information technology. But the advent of fast and lower price hardware make little difference in an application on many systems. As a result, the key issues of constructing power quality monitoring system are in the management of data obtained, accurate algorithms, graphic representation and user-friendly-environment for easy and clear analysis results. So, in this paper it will be introduced that the standard of user-friendly-GUI(Graphic User Interface) and analysis graphic representation for intuitive understanding of results from power quality analysis based on consideration of several systems currently being in use.