• Journal of Pharmaceutical Investigation
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• 제27권4호
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• pp.323-329
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• 1997

Ipriflavone is non-hormonal antiosteoporotic drug which inhibits bone resorption by reducing recruitment and/or differentiation of osteoclasts, and stimulates proliferation and differentiation of osteoblast, and also enhances calcitonin secretion in the presence of estrogen. Although some kinds of immediately-released preparation of ipriflavone are available in commercial market, in present study, we tried to formulate sustained-release tablet using coating method with hydrophobic and hydrophilic coating materials. In vitro dissolution test was applied to evaluate sustained-release patterns of several test preparations (Test tablet A, B and C) designed using different preparation method or different compositions. From the results of dissolution test, test tablet A which showed suitable dissolution profile was selected as the candidate of new product. Pharmacokinetic evaluation of test drug, ipriflavone sustained-release tablets, was conducted in 6 beagle dogs weighing $11.5{\pm}0.5\;Kg$ compared with $Theobon^{\circledR}$ tablet, immediately-released tablet (Kukjae Pharm. Co.) as reference drug. Two products were randomly administered to 6 beagle dogs, and after 1 week, cross-over study was conducted. From the present study, AUC and $T_{max}$ of test product were significantly different from those of reference product (p<0.05), respectively$(AUC\;:\;3646.28{\pm}472.56\;vs\;3646.28{\pm}472.56\;ng{\cdot}hr/ml,\;T_{max}\;:\;4.33{\pm}1.03\;vs\;1.42{\pm}0.38\;hr)$. But $C_{max}$ was not significantly different between two products (p>0.05) $(\;512.52{\pm}48.18\;vs\;443.97{\pm}140.53\;ng/ml)$. From the results of pharmacokinetic evaluations, it was noted that absorption amount of test product was increased, but absorption rate was delayed and $C_{max}$ of two products were not changed. And it was concluded that redesign of the sustained-release preparation which has a lower content of iprifavone rather than test tablet A must be considered.

• 전기학회논문지
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• 제65권9호
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• pp.1590-1596
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• 2016

In this paper, catenary wires were analyzed aging through the experiment about a new product and a test sample in accordance with temperature changes from long-term use. In case of the contact wire, the maximum load was reduced within 7% and the tensile strength showed a reduced within 6.7% compared with a new reference standard $110mm^2$. 19 Strands of messenger wire have a little more than a standard value, but result data on tensile test were less than the reference value about stranded wire. Also parts among 49 strands of dropper was found to be smaller than the reference value and it appeared greatly increasing intensity as toward the center of the strand.

• 한국의류학회지
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• 제13권3호
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• pp.223-241
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• 1989

As a preliminary work for the clothing conformity study, Its theoretical backgrounds were reviewed. In the view of convertibility into clothing conformity, two prevailing conformity types were studied. One is normative-social influence and informational-social influence classified by Deutsch and Gerald. And the other is Kelman's classification which includes compliance, identification and internalization. Reference group, as an object of conformity, was studied. In addition to Engel and Blackwell' s and Assael's classification, the reference groups which were revealed in the studies of consumer behavior and clothing behavior were reviewed. The factors were reviewed which influence conformity and clothing conformity. They were product factor, group factor, situational factor and individual factor.

• Journal of Mechanical Science and Technology
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• 제17권1호
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• pp.77-84
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• 2003

Virtual work in multibody systems is frequently expressed as the inner product of the virtual displacement and the resultant force at the centroid. But provided that the resultant force is converted into the equipollent forces there is no restriction on where the analysis reference point is placed. There are basically three candidate points : the centroid, joint point and the instant global origin. The traditional fully recursive formulation uses the centroid, but the present work verifies that the instant global origin always shows better efficiency (e.g. 86% CPU time of the centroid for quarter car model) and joint point shows the efficiency between that of the centroid and the instant global origin. A discussion on how important it is to define the analysis reference point properly in a fully recursive formulation is also presented.

• Mass Spectrometry Letters
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• 제10권4호
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• pp.112-116
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• 2019

In this study, a chloroform consumer chemical product (CCP) reference material (RM) is successfully developed, with potential to be used in the proficiency testing of hazardous compounds in CCPs for analysis and testing agencies. Validation experiments are rigorously conducted to evaluate whether the RM meets the requirements set by the ISO 13528 and ISO Guide 35, using a reliable GC/MS method for the analysis of chloroform. The obtained calibration plot linearity, limit of detection (LOD), and limit of quantitation (LOQ) are excellent. The developed RM meets the homogeneity and stability requirements; the between-unit (s_bb) and within-unit (s_wb) standard deviations are less than 2.5%, and the stability is found to be guaranteed for 50 days.

• 한국CDE학회논문집
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• 제12권4호
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• pp.245-254
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• 2007

This research proposed feature extraction algorithms as an input of STEP Ap214 data, and feature parameterization process to simplify further design change and maintenance. The procedure starts with suppression of blend faces of an input solid model to generate its simplified model, where both constant and variable-radius blends are considered. Most existing cell decomposition algorithms utilize concave edges, and they usually require complex procedures and computing time in recomposing the cells. The proposed algorithm using reference features, however, was found to be more efficient through testing with a few sample cases. In addition, the algorithm is able to recognize depression features, which is another strong point compared to the existing cell decomposition approaches. The proposed algorithm was implemented on a commercial CAD system and tested with selected industrial product models, along with parameterization of recognized features for further design change.

• Industrial Engineering and Management Systems
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• 제12권2호
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• pp.95-102
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• 2013

It is difficult to determine an appropriate discount price for daily perishable products to increase profit from a long-term standpoint. Even if the discount pricing is efficient to increase profit of the day, consumers memorize the sales price and they might hesitate to purchase the product at a regular price the following day. The authors discussed the inventory clearance pricing for a single period in our previous study by constructing a mathematical model to derive an optimal sales price to maximize the expected profit by considering the reference price effect of demand. This paper extends the discussion to handle the discount pricing for multiple periods. A mathematical analysis is first conducted to reveal the properties on an objective function, which is the present value of total expected profits for multiple periods. An algorithm is then proposed to derive an optimal price for asymmetric consumers. Numerical experiments investigate the characteristics of the objective function and optimal pricings.

• 한국안전학회지
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• 제25권5호
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• pp.27-32
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• 2010

This study is to investigate and compare domestic hazardous toys with harmful substances with foreign toys so that we can find out management criteria for in cognitive infants. Actually, commercially used toys have been collected and tested to find out more effective management standard. it is tried to produce evaluation criteria of environmentally harmful substance but variety of product is needed for overcoming actual barrier due to lot of difficulty huge cost, time, objectiveness. Therefore, This study does not cover all the above. Establishment of evaluation criteria for product harmfulness made by Government or Local government should be continued to improve. Foreign reference material for toy product in Europe, USA, Japan have been investigated and domestic product have been collected and tested for containing heavy metals, formaldehyde, phthalate in the study. All the test have been made in accordance with KSM ISO 2124 to measure heavy metal transfer into body. Toy product used for the study have been purchased in the real market and some of them contains harmful elements with over standard. Post management system such as RAPEX to control periodically should be established for plastic toy with low quality product.

• 한국환경보건학회지
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• 제50권2호
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• pp.138-145
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• 2024

Background: Appropriateness issues have emerged regarding the non-application of hazardous substance safety standards for items classified as 'other textile products'. Objectives: Testing for formaldehyde (HCHO) and risk assessment were conducted on 'other textiles products' to provide reference data for promoting product safety policies. Methods: Testing was conducted on five items (102 products) classified as 'other textile products' according to relevant standards (textile products safety standards), and the risk of each product was assessed using the evaluation methodologies of the European Centre for Ecotoxicology and Toxicology of Chemicals (ECETOC) and European Chemical Agency (ECHA). Results: Out of the 102 products tested, HCHO was detected above the quantification limit in five. Based on these results, the screening risk assessment indicated that three products exceeded the criteria. Upon reassessing the emission and transfer rates of products exceeding the criteria, it was confirmed that there were no instances of exceeding the criteria. Conclusions: Risk assessment results can be used as supporting data for non-application of hazardous substance standards. However, it is deemed necessary to transition towards a management approach based on risks in order to addressing emerging trends such as convergence/new products.

• 한국항해항만학회:학술대회논문집
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• 한국항해항만학회 2002년도 춘계학술대회논문집
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• pp.73-87
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• 2002