• Asian Pacific Journal of Cancer Prevention
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• v.15 no.23
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• pp.10463-10468
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• 2015

Opisthorchis viverrini (Ov) infection is the major etiological factor for cholangiocarcinoma (CCA), especially in northeast Thailand. We have previously reported significant involvement of PI3K/AKT/PTEN and $Wnt/{\beta}$-catenin in human CCA tissues. The present study, therefore, examined the expression and activation of PI3K/AKT/PTEN and $Wnt/{\beta}$-catenin signaling components during Ov-induced cholangiocarcinogenesis in a hamster animal model. Hamsters were divided into two groups; non-treated and Ov plus NDMA treated. The results of immunohistochemical staining showed an upregulation of PI3K/AKT signaling as determined by elevated expression of the $p85{\alpha}$-regulatory and $p110{\alpha}$-catalytic subunits of PI3K as well as increased expression and activation of AKT during cholangiocarcinogenesis. Interestingly, the staining intensity of activated AKT (p-AKT) increased in the apical regions of the bile ducts and strong staining was detected where the liver fluke resides. Moreover, PTEN, a negative regulator of PI3K/AKT, was suppressed by decreased expression and increased phosphorylation during cholangiocarcinogenesis. We also detected upregulation of $Wnt/{\beta}$-catenin signaling as determined by increased positive staining of Wnt3, Wnt3a, Wnt5a, Wnt7b and ${\beta}$-catenin, corresponded with the period of cholangiocarcinogenesis. Furthermore, nuclear staining of ${\beta}$-catenin was observed in CCA tissues. Our results suggest the liver fluke infection causes chronic inflammatory conditions which lead to upregulation of the PI3K/AKT and $Wnt/{\beta}$-catenin signaling pathways which may drive CCA carcinogenesis. These results provide useful information for drug development, prevention and treatment of CCA.

• Journal of the Korean Mathematical Society
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• v.34 no.3
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• pp.673-693
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• 1997

In this work, the irreducible complex representations of degree 4 of $B_4$, the braid group on 4 strings, are classified. There are 4 families of representations: A two-parameter family of representations for which the image of $P_4$, the pure braid group on 4 strings, is abelian; two families of representations which are the composition of an irreducible representation of $B_3$, the braid group on 3 strings, with a certain special homomorphism $\pi : B_4 \longrightarrow B_3$; a family of representations which are the tensor product of 2 irreducible two-dimensional representations of $B_4$.

• Research in Plant Disease
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• v.10 no.4
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• pp.217-226
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• 2004

One hundred isolates of Magnaporthe grisea from Korea and China were characterized for pathogenicity using eight Korean differential varieties(KDV), six Chinese differential varieties(CDV) and six near isogenic lines(NILs) developed in China. The restriction length polymorphism of M. grisea isolates from each country also was analyzed using MGR586 as a probe. One hundred Korean isolates classified into 17 races on KDV were grouped into 29 pathotypes on Chinese near isogenic lines(NILs). Virulence of 46% of Korean isolates against all the six Chinese NILs indicated that the current six Chinese NILs alone was not enough to be used as differential varieties in Korea. Especially, susceptibility of the BL1 carrying resistance gene Pi-b to 70% of tested Korean isolates suggested that BL1(Pi-b) may not be a useful resistance source to Korean blast. Based on the virulence assays of M. grisea populations from each country were divided into two groups. About 50% of Chinese isolates showed similarity to the 30% of the Korean isolates. Especially, the isolates from northern part of China, where Japonica rice cultivars were grown, showed high similarity to the Korean isolates, while isolates from southern part of China, where Indica rice were mainly grown, showed low similarity to Korean isolates. The genome RFLPs of Korean isolates were quite different from those of southern part of China using MGR586 as a probe. These data indicated that the physiological and genetical characteristics of M. grisea population might be determined by strong interaction with cultivated rice.

• Journal of Photoscience
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• v.2 no.2
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• pp.89-93
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• 1995

Solvatochromic effects and hydrogen bonding interactions of 4-hydroxy-4'-nitrostilbene(NSOH) were investigated. Electronic transition energies of NSOH have good correlation with Taft's $\pi$$^*$. The hydrogen bonding interactions can be accounted by analysis with equation of $\Delta$E= $\Delta$E$_0$ + s($\pi$$^*$ + d$\delta$) + a$\alpha$ + b$\beta$. From UV-visible absorption maximum energies, $\Delta$E = 81.2 kcal/mole - 6.66($\pi$$^*$ - 0.20$\delta$) - 0.66$\alpha$ - 1.93$\beta$ (corr.=0.970) was obtained, and from fluorescence intensity maximum energies, $\Delta$E= 70.07 kcal/mole - 21.6($\pi$$^*$ - 0.11d) - 1.74$\alpha$ - 2.73$\beta$ (corr.=0.947) was obtained. The micropolarity estimated at the solubilization sites is close to the polarity of water. The apparent Taft's $\pi$$^*$ values of solubilization sites are close to 1. Howcver, the solubilization sites for the fluorescent NSOH is rather nonpolar. Both NSOH and NSO$^-$ can be solubilized in CTAB and CTAC micelles and NSOH is the only species that can be solubilized in SDS and Brij-35 micelles.

• Proceedings of the KIEE Conference
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• 2005.10a
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• pp.155-157
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• 2005

This paper shows how to design a MPPT control of PV system using neural network PI self tuning. The conventional self-tuning methods have the voltage control problem of nonlinear PV system which can't adapt against any kinds of noise or operation circumstances. In this paper, supposed to solve these problem to PI parameters controller algorithm using ANN. In the proposed algorithm, the parameters of the controller were adjusted to reduce by on-line system the error of the output voltage of DC-DC chopper. In this process, EBPA NN was constituted to an output error value of a DC-DC chopper and conspired an input and output. The performance of the self-tuning controller is compared with that of the PI controller tuned by conventional method. The effectiveness of the proposed control method is verified thought the Matlab Simulink.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.24 no.12
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• pp.1120-1127
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• 2013

In this paper, novel chip-on-chip(CoC) flip-chip bump structures using chip-on-wafer(CoW) process technology are proposed, designed and fabricated, and their microwave frequency responses are analyzed. With conventional bumps of Cu pillar/SnAg and Cu pillar/Ni/SnAg and novel Polybenzoxazole(PBO)-passivated bumps of Cu pillar/SnAg, Cu pillar/Ni/SnAg and SnAg with the deposition option of $2^{nd}$ Polyimide(PI2) layer on the wafer, 10 kinds of CoC samples are designed and their frequency responses up to 20 GHz are investigated. The measurement results show that the bumps on the wafers with PI2 layers are better for the batch flip-chip process and have average insertion loss of 0.14 dB at 18 GHz. The developed bump structures for chips with fine-pitch pads show similar or slightly better insertion loss of 0.11~0.14 dB up to 18 GHz, compared with that of 0.13~0.17 dB of conventional bump structures in this study, and we find that they could be utilized in various microwave packages for high integration density.

• Journal of the Institute of Electronics Engineers of Korea TC
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• v.39 no.2
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• pp.92-100
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• 2002

The 16-port feed waveguide array with inductive walls analyzed by Galerkin's method of moments are proposed for the DBS reception system mounted on vehicle. First of all, in order to verify the validity of electromagnetic analysis and design for a $\pi$-junction feed waveguide, it is designed and fabricated at DBS band. The measurement results of a $\pi$-junction feed waveguide agree well with the theoretical ones. Based on this design method, an array design for WR-90 standard waveguide is conducted. Since the width of a $\pi$-junction feed WR-90 standard waveguide is larger than a guided wave length in an array design, the difference of amplitude and phase of 8-port array are calculated 2.3 dB and 62 degrees, respectively. The bandwidth with return loss of -20 dB below is about 220 MHz and it doesn't satisfy DBS band. To solve this problem, we propose a novel design that the width of a $\pi$-junction feed waveguide equals to a guided wave length. By the proposed novel design for 8-port feed waveguide array, the difference of amplitude and phase are decreased 1 dB and 13 degrees, respectively. The broad bandwidth of 700 MHz is also realized. The size of 16-port waveguide away compared with WR-90 array is reduced about 10 cm. The measured antenna gain for the fabricated 16-port feed waveguide array is observed 24 dBi above at DBS band.

• Journal of IKEEE
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• v.13 no.4
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• pp.103-109
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• 2009

We report an efficient jitter reduction technique in an analog fier-optic link employing a Mach-Zehnder modulator followed by an erbium-doped fiber amplifier. By adjusting the modulator-bias to $0.089V_{\pi}$, we could increase the RF gain up to 10.65 dB for 10 GHz RF signal and reduce the random jitter by 46.5%, max, at an input optical power of -0.11 dBm to the EDFA.

• Journal of Advanced Marine Engineering and Technology
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• v.37 no.1
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• pp.105-113
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• 2013

In this work, using a ${\pi}$-type multiple coupled microstrip line structure (MCMLS) and RCR (Resistor Capacitor Resistor) structure, we fabricated ultra-compact and high isolation Wilkinson power divider on GaAs MMIC (Monolithic Microwave Integrated Circuit). The line length of the Wilkinson power divider was reduced to about ${\lambda}$/46, and its size was 0.304 [$mm^2$], which is 12.1 % of conventional one. Compared with conventional Wilkinson power divider, isolation characteristic of the proposed Wilkinson power divider was highly improved by using RCR insertion method. The proposed Wilkinson power divider showed good RF performances in C/X band.

• Journal of Advanced Navigation Technology
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• v.13 no.5
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• pp.662-668
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• 2009

Design of IPI(Inverted PI) feeding internal antenna for the gain improvement of mobile phone was proposed. IPI feeding structure affects on both low radiation resistance of antenna and increase current for the internal antenna such as IFA(Inverted F Antenna). By these facts, antenna fed by IPI can get the gain improvement with increasing radiation efficiency. For the verification, we applied IPI feeding structure to conventional quad band IFA. Measurement shows that IPI-IFA has 0.3~2.0[dB] higher gain than conventional IFA on GSM/DCS/USPCS/WCDMA band.