• Natural Product Sciences
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• v.13 no.1
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• pp.68-77
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• 2007

The aim of the present study was to examine the effects of green tea extract (CUMS6335) on the release of CA evoked by cholinergic stimulation and direct membrane-depolarization in the perfused model of the adrenal gland isolated from the spontaneously hypertensive rats (SHRs), and to establish the mechanism of action. Furthermore, it was also to test whether there is species difference between animals, and between CUMS6335 and EGCG, one of biologically the most powerful catechin compounds found in green tea. CUMS6335 $(100\;{\mu}g/ml)$, when perfused into an adrenal vein for 60 min, time-dependently inhibited the CA secretory responses evoked by ACh (5.32mM), high $K^+$(56 mM), DMPP $(100\;{\mu}M)$, and McN-A-343 $(100\;{\mu}M)$ from the isolated perfused adrenal glands of SHRs. However, CUMS6335 itself did fail to affect basal catecholamine output. Also, in adrenal glands loaded with CUMS6335 $(100\;{\mu}g/ml)$, the CA secretory responses evoked by Bay-K-8644 $(10\;{\mu}M)$ and cyclopiazonic acid $(10\;{\mu}M)$ were also inhibited in a relatively time-dependent fashion. However, in the Presence of EGCG $(8.0\;{\mu}g/ml)$ for 60 min, the CA secretory response evoked by ACh, high $K^+$, DMPP, McN-A-343, Bay-K-8644 and cyclopiazonic acid were not affected except for last period. Collectively, these results indicate that CUMS6335 inhibits the CA secretion evoked by stimulation of cholinergic (both nicotinic and muscarinic) receptors as well as by direct membrane-depolarization from the perfused adrenal gland of the SHR. It seems that this inhibitory effect of CUMS6335 is exerted by blocking both the calcium influx into the rat adrenal medullary chromaffin cells and the uptake of $Ca^{2+}$ into the cytoplasmic calcium store, which are at least partly relevant to the direct interaction with the nicotinic receptor itself. It seems likely that there is much difference in mode of the CA-releasing action between CUMS6335 and EGCG.

• International Journal of Control, Automation, and Systems
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• v.5 no.2
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• pp.161-169
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• 2007

The PLL equivalent augmented system incorporated with state feedback is proposed in this paper. The optimal value of filter time constant of loop filter in the phase-locked loop control system and the optimal state feedback gain designed by using linear quadratic regulator approach are derived. This approach allows the PLL control system to employ the large value of the phase-frequency gain $K_d$ and voltage control oscillator gain $K_o$. In designing, the structure of phase-locked loop control system will be rearranged to be a phase-locked loop equivalent augmented system by including the structure of loop filter into the process and by considering the voltage control oscillator as an additional integrator. The designed controller consisting of state feedback gain matrix K and integral gain $k_1$ is an optimal controller. The integral gain $k_1$ related to weighting matrices q and R will be an optimal value for assigning the filter time constant of loop filter. The experimental results in controlling the second-order lag pressure process using two types of loop filters show that the system response is fast without steady-state error, the output disturbance effect rejection is fast and the tracking to step changes is good.

• Journal of the Institute of Electronics Engineers of Korea SD
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• v.46 no.7
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• pp.39-46
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• 2009

A fast-switching current-pulse driver for light emitting diode (LED) backlight is proposed. It uses a regulated drain current mirror (RD-CM) [1] and a high-voltage NMOS transistor (HV-NMOS). It achieves the fast-response current-pulse switching by using a dynamic gain-boosting amplifier (DGB-AMP). The DGB-AMP does not discharge the large HV-NMOS gate capacitance of the RD-CM when the output current switch turns off. Therefore, it does not need to charge the HV-NMOS gate capacitance when the switch turns on. The proposed current-pulse driver achieves the fast current switching by removing the repetitive gate discharging and charging. Simulation results were verified with measurements performed on a fabricated chip using a 5V/40V 0.5um BCD process. It reduces the switching delay to 360ns from 700ns of the conventional current-pulse driver.

• Journal of the Institute of Electronics Engineers of Korea TC
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• v.49 no.1
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• pp.85-91
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• 2012

In this paper, we implemented a Ka-band frequency synthesizer for millimeter wave seeker. we designed for high frequency resolution and frequency hopping response time in the digital synthesis method which uses DDS(Direct Digital Synthesizer). but frequency bandwidth was limited low frequency because DDS output frequency was limited 1/2 by system clock. thus, frequency synthesizer was converted to Ka-band using the frequency multiplier ${\times}4$ and local oscillator. proposed frequency synthesizer was bandwidth 500MHz, frequency switching time was $0.7{\mu}s$, spurious level was suppressed below -52dBc. phase noise was -99dBc/Hz at offset 100kHz and flatness was ${\pm}1dB$.

• Journal of the Korean Institute of Electrical and Electronic Material Engineers
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• v.29 no.10
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• pp.601-607
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• 2016

Piezoelectric thick films of soft $Pb(Zr,Ti)O_3$ (PZT) based commercial material (S55) were fabricated using a conventional tape casting method. Ag-Pd electrodes were printed on the piezoelectric film at room temperature and all 5 layered films with a dimension of $12mm{\times}16mm$ were successfully laminated for a multi-layered piezoelectric ceramic actuator. The laminated specimens were co-fired at $1,100^{\circ}C$ for 1 h. A flat layered and dense microstructure was obtained for the $112{\mu}m$ thick piezoelectric actuator after sintering process. Thereafter, a prototype piezoelectric speaker was fabricated using the multi-layered piezoelectric ceramic actuator which can operate as a bimorph. Its SPL (sound pressure level) characteristic was also evaluated for speaker application. Frequency response revealed that the output SPL with a root mean square voltage of 10 V increased gradually to the highest peak of 87.5 dB for 1.5 kHz and exhibited a relatively stable behavior over the measured frequency range (${\leq}20kHz$) at a distance of 10 cm, implying that the fabricated piezoelectric speaker is potential for speaker applications.

• Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
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• v.19 no.1
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• pp.70-79
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• 2005

In this paper, improvement method of control performance by a full-order observer using reduced-order state equation is proposed in the low speed range. Full-order observer using reduced-order state equation is the motor speed and the disturbance torque observer. The proposed algorithm is very stable in the low speed range about 1.9[rpm]. The disturbance torque in the motor drive system degrades speed control performance in the low speed range. The proposed algorithm estimated both motor speed and disturbance torque. The estimated disturbance torque is used as a feedforward value in output of the speed controller, As a result, it improves the response of load torque in the low speed range(1.9rpm).

• Journal of Yeungnam Medical Science
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• v.31 no.1
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• pp.38-42
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• 2014

Cardiovascular beriberi is caused by thiamine deficiency and usually presents as high cardiac output failure associated with predominantly right-sided heart failure and rapid recovery after treatment with thiamine. Because of its rarity in developed countries, the diagnosis can often be delayed and missed. We recently experienced a case of cardiovascular beriberi with pulmonary hypertension which successfully treated with thiamine infusion. A 50-year-old man with chronic heavy alcoholics was refered to our department for dyspnea with mental change. Echocardiography showed marked right ventricular (RV) dilatation and flattening of the interventricular septum with a D-shaped deformation of the left ventricle. Moderate tricuspid valve regurgitation was found and estimated RV systolic pressure was 52 mm Hg. Because of his confused mentality and history of chronic alcohol intake, neurological disorder due to thiamine deficiency was suspected and intravenous thiamine was administered and he continuously received a daily dose of 100 mg of thiamine. Follow up echocardiography showed marked reduction of RV dilatation and improvement of a D-shaped deformation of the left ventricle. He finally diagnosed as cardiovascular beriberi on the basis of dramatic response to intravenous thiamine. Thiamine deficiency can cause reversible pulmonary hypertension, and can still be encountered in the clinical setting. Thus high index of suspicion is critically needed for diagnosis.

• KCID journal
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• v.13 no.2
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• pp.262-273
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• 2006

The Soil and Water Assessment Tool (SWAT) model has been widely used in hydrology and sediment simulation worldwide. In most cases, the SWAT model is first calibrated with adjustments in model parameters, and then the validation is performed. However, very little study regarding the effects on SWAT estimation of subwatershed delineation was performed. Thus, the SWAT model was applied to the Doam-dam watershed with various threshold values in subwatershed delineation in this study to examine the effects on the number of subwatershed delineated on SWAT estimation. It was found the flow effect of subwatershed delineation is negligible. However there were huge variations in SWAT estimated sediment, T-N, and T-P values with the use of various threshold value in watershed delineation. Sometimes these variations due to watershed delineation are beyond the effects of parameter adjustment in model calibration and validation. The SWAT is a semi-distributed modeling system, thus, the subwatershed characteristics are assumed to be the same for all Hydrologic Response Unit (HRU) within that subwatershed. This assumption leads to variations in the SWAT estimated sediment and nutrient output values. Therefore, it is strongly recommended the SWAT users need to use the HUR specific slope length and slope value in model runs, instead of using the slope and the corresponding slope length of the subawatershed to exclude the effects of the number of subwatershed delineated on the SWAT estimation.

• 제어로봇시스템학회:학술대회논문집
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• 2000.10a
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• pp.480-480
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• 2000

In this paper, we proposed a fuzzy-neuro controller to control the speed of wound rotor induction motor with slip energy recovery. The speed is limited at some range of sub-synchronous speed of the rotating magnetic field. Control speed by adjusting resistance value in the rotor circuit that occurs the efficiency of power are reduced, because of the slip energy is lost when it passes through the rotor resistance. The control system is designed to maintain efficiency of motor. Recently, the emergence of artificial neural networks has made it conductive to integrate fuzzy controllers and neural models for the development of fuzzy control systems, Fuzzy-neuro controller has been designed by integrating two neural network models with a basic fuzzy logic controller. Using the back propagation algorithm, the first neural network is trained as a plant emulator and the second neural network is used as a compensator for the basic fuzzy controller to improve its performance on-line. The function of the neural network plant emulator is to provide the correct error signal at the output of the neural fuzzy compensator without the need for any mathematical modeling of the plant. The difficulty of fine-tuning the scale factors and formulating the correct control rules in a basic fuzzy controller may be reduced using the proposed scheme. The scheme is applied to the control speed of a wound rotor induction motor process. The control system is designed to maintain efficiency of motor and compensate power factor of system. That is: the proposed controller gives the controlled system by keeping the speed constant and the good transient response without overshoot can be obtained.

• 제어로봇시스템학회:학술대회논문집
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• 2000.10a
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• pp.395-395
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• 2000

Optimization of existing processes becomes more important than the past as environmental problems and concerns about energy savings stand out. When we can model a process mathematically, we can easily optimize it by using the model as constraints. However, modeling is very difficult for most chemical processes as they include numerous units together with their correlation and we can hardly obtain parameters. Therefore, optimization that is based on the process models is, in turn, hard to perform. Especially, f3r unknown processes, such as bioprocess or microelectronics materials process, optimization using mathematical model (first principle model) is nearly impossible, as we cannot understand the inside mechanism. Consequently, we propose a few optimization method using empirical model evolutionarily instead of mathematical model. In this method, firstly, designing experiments is executed fur removing unecessary experiments. D-optimal DOE is the most developed one among DOEs. It calculates design points so as to minimize the parameters variances of empirical model. Experiments must be performed in order to see the causation between input variables and output variables as only correlation structure can be detected in historical data. And then, using data generated by experiments, empirical model, i.e. response surface is built by PLS or MLR. Now, as process model is constructed, it is used as objective function for optimization. As the optimum point is a local one. above procedures are repeated while moving to a new experiment region fur finding the global optimum point. As a result of application to the pulp digester benchmark model, kappa number that is an indication fur impurity contents decreased to very low value, 3.0394 from 29.7091. From the result, we can see that the proposed methodology has sufficient good performance fur optimization, and is also applicable to real processes.