• Journal of Korean Medicine for Obesity Research
• /
• v.6 no.2
• /
• pp.43-49
• /
• 2006

Objective : This study was conducted to offer basic materials for the clinical study of Chi acupuncture (carboxytherapy). Methods : Recent clinical studies were reviewed for carboxytherapy (carbon dioxide therapy) and the ancient and present texts were reviewed for Chi acupuncture. Results and Conclusions : Chi acupuncture is oriental medical therapeutic treatment using carboxytherapy. Chi acupuncture refers to the transcutaneous administration of CO2 gas for therapeutical purposes relating to obesity, cellulites, local circulation and skin irregularity. Recent studies have demonstrated the effects of this therapy on adipose tissue by showing vasomotor effects, increasing local circulation and inducing a partial increase in tcPO2. Chi acupuncture influences the microcirculation and likely has a positive effect upon the physiological oxidative lipolytic process.

• Journal of Physiology & Pathology in Korean Medicine
• /
• v.22 no.2
• /
• pp.446-452
• /
• 2008

To evaluate the anti-obesity efficacy of Gamitaeeumjowi-tang consisting of Taeeumjowitang and Daehwang. Eleven male(n=4) and female(n=7), obesity patients were recruited by Tenten Diet Network from November 2005 to February 2006. All the subjects were treated with Gamitaeeumjowi-tang 3 times a day for 12 weeks. Weight, BMI, body fat weight, Total cholesterol, LDL, HDL, Triglycerides, GOT, GPT, and CT results were evaluated before and after the 12 week treatment. Weight, BMI, body fat weight, total cholesterol, triglyceride, and subcutaneous fat in upper and lower abdomen all showed significant decrease after 12 weeks of administration. Also Gamitaeeumjowi-tang showed no toxic effects based on liver function test. Taken together, The potentials of Gamitaeeumjowi-tang as a safe and effective treatment for obesity has been recognized through this study. Further large sample sized and double blinded randomized control trials are needed to fully confirm the findings of this study.

• Journal of Korean Medicine for Obesity Research
• /
• v.21 no.2
• /
• pp.105-111
• /
• 2021

This study is reporting the clinical effect of herbal medicine for Class III obesity. A 34-year-old man with body mass index (BMI) 44.1 kg/m² was diagnosed to Class III obesity. We prescribed herbal medicine (Gambi-hwan) for 60 days. Self controlled low calorie diet and slight aerobic exercise were concomitantly performed during the treatment period. Body weight decreased from 152.4 kg to 128.1 kg. BMI decreased from 44.1 kg/m² to 37.0 kg/m². Visceral fat area decreased from 276 cm² to 195 cm². Percent of excess weight loss was 58.40% after treatment. A Class III obesity patient showed significant weight loss with herbal medicine as single Korean medicine treatment.

• Journal of Korean Medicine for Obesity Research
• /
• v.6 no.2
• /
• pp.59-73
• /
• 2006

Objectives: This study was conducted to investigate the effects of Uncoupling protein (UCP) polymorphisms on weight loss. We analyzed associations between polymorphisms of UCP-2, 3 and changes in percentage of obesity phenotypes (Body mass index and percent body fat) after treatment. Materials and Methods: A total of 207 Korean women (BMI over 25) were recruited from the obesity clinic in Kirin Oriental Medical Hospital (Seoul, Korea). All patients were treated with a very low calorie diet and oriental medical therapy for one month. The effect of UCP polymorphisms on changes in obesity-phenotypes were analyzed. For the genotyping of a single nucleotide polymorphism (SNPs), genomic DNA from each subject was extracted from whole blood and genotyped using the TaqMan Method. Associations between changes in percentage of obesity phenotypes (BMI and percent body fat) and UCP polymorphisms were analyzed using age-adjusted general linear model. Results and Conclusions: In this study, AG, GG type of UCP-2 -866A>G, CC, CT type of UCP-2 +4787C>T, CG, GG type of UCP-3 +2564C>G, AG, GG type of UCP-3 +3106A>G, and TC, CC type of UCP-3 +4589T>C played a role as a resistance gene to weight loss.

• Journal of Korean Medicine for Obesity Research
• /
• v.2 no.1
• /
• pp.13-23
• /
• 2002

Background & Methods: In order to study the effect of electro-lipolysis-acupuncture, 57 outpatients who have had herbal medication in Kirin Oriental Hospital were devided to two groups; acupuncture-treated group(46) vs non-acupuncture-treated group(11) Acupuncture-treated group was given electro-lipolysis-acupuncture at least two times a week and administered with herbal diet medication, whereas non-acupuncture-treated group was administered only with herbal diet medication. Results: Mean age, body weight and BMI of these two group at the start point of the treatment were $27.22({\pm}7.64)\;vs \;29.09({\pm}8.73),\;67.76({\pm}9.34)\;vs\;67.00({\pm}10.69),\;and\;26.20({\pm}3.02)\;vs\;26.14({\pm}4.10)$ in the order of acupuncture-treated and non-acupuncture groups. After one month of treatment, change rate of body weight, BMI, total fat, percentage of fat was significantly higher in acupuncture-treated group. Also the change rate of arm circumference, hip circumference and thigh circumference was significantly higher in acupuncture-treated group. The change rate of abdominal circumference and WHR of acupuncture-treated group was higher than that of non-acupuncture-treated group with no statistical significance. The circumference reduction rate according to herbal dieting program was higher in this order, abdomen, arms, chest, thighs and hips. On the other hand, chest circumference change rate over weight loss rate, which is the portion no acupuncture treatment was given to, and AMC change rate was higher in non-acupuncture-treated group. Conclusion: These results imply that herbal dieting program combined with electro-lipolysis-acupuncture is more effective on reducing body fat, size reduction of localized obesity and preservation of muscle than herbal prescription only dieting program.

• Journal of Korean Medicine for Obesity Research
• /
• v.12 no.2
• /
• pp.28-43
• /
• 2012

Objectives: The aim of the study was to investigate the efficacy of Boiogito for obesity. We examined the efficacy of Boiogito for obese patients and we expected the reaction of Boiogito would vary according to the single nucleotide polymorphism(SNPs). Methods: 111 subjects(body mass index${\geq}25m/kg^2$) were recruited and randomized to receive Boiogito(n=55) or Placebo(n=56) for 8weeks. Anthropometric factors, serum lipid profile, glucose, blood pressure(BP), pulse rate, resting metabolic rate and Korean version of obesity-related quality of life(KOQOL) scale measured at baseline and 8weeks. SNPs(${\beta}3$-adrenergic receptor(ADRB3), G protein ${\beta}3$(GNB3), peroxisome proliferator activated receptor gamma 2 gene(PPAR-${\gamma}2$), uncoupling protein(UCP2)) were conducted at baseline. Adverse reactions and safety outcome variables were also checked during trials. Results: Both groups showed significant improvement on obesity after treatment. Boiogito group decreased triglyceride than did control group and improved KOQOL. Boiogito showed a significant higher efficacy in C/T and T/T genotype of GNB3 gene / in Trp64 and Arg64 genotype of ADRB3 gene / in D/D genotype of UCP2 gene / in Pro/Pro genotype of PPAR-${\gamma}$ gene. Conclusions: Boiogito promoted obesity indexes without severe adverse reactions and proved its safety. Pharmacogenetical studies of Boiogito on obesity could be a effective method for the individualized treatment and prevention of obesity.

• Journal of Korean Medicine for Obesity Research
• /
• v.6 no.2
• /
• pp.95-104
• /
• 2006

Objectives : This study was performed to assess the effect onf abdominal obesity treatment on changes in abdominal subcutaneous and visceral fat. Methods : The study was conducted on 61 abdominally obese patients (13 men and 48 women). Measures of body weight, waist circumference, abdominal subcutaneous and visceral fat area by CT scan, and V/S ratio (Viscero-subcutaneous fat ratio) were acquired before and after Kirindiet therapy. Paired t-test and Wilcoxon signed rank tests were used to est the effects of teatment. Results : Following a mean of 68 days of treatment, waist circumference (-15%), abdominal total fat (-40%), subcutaneous fat (-37.9%), visceral fat (-47.8%) and V/S ratio (-11.1%) were significantly reduced (p<0.05). The change in V/S ratio in female patients was not statistically significant (p=0.491) whereas the change in the V/S ratio in male patients was significant indicating a greater loss of visceral fat (p=0.017). Please check that my changes reflect what the study found Conclusions : The reduction in visceral fat was greater than for subcutaneous fat in male patients but not for female patients.

• Journal of Sasang Constitutional Medicine
• /
• v.16 no.1
• /
• pp.100-111
• /
• 2004

Objectives To study on the relation between Sasang constitution and obesity and that of obese patient's clinical symptom. Methods The subjects were 129 female patients to visit to diet. The subjects were 129 female patients to diet who answered questionnaire QSCC II and were diagnosed by the Sasang constitution from May to December in 2001 at Nara oriental medical clinic. Results 1. Of obese patients 79.1% were Taeumin, 11.6% Soeumin, and 9.3% Soyangin. 2. A relation of a grade of obesity and Sasang constitution. 2-1) 45.8% of the obese patients were high level obesity who had over 35% of body fat. Out of these people, 91.5% were Taeumin. 2-2) 40.3% of the obese patients weight hip ratio was between 0.84 to 0.89 and 84.6% of these people were proved to be Taeumin. 2-3) 39.2% of the people who had a minimum weight hip ratio of 0.90 were significantly Taeumin, 6.7% Soeumin and 16.6% Soyangin. 2-4) 65.7% of Taeumin were obese patients. 3. Obesity treatment with constitution. 3-1) 59.8% of Taeumin were Pyo-zng patients. 3-2) As treatment periods tended to increase, Taeumin and Soeumin patients showed a large decling of body fat, whereas Soeumin patients showed the opposite reaction. 3-3) The weight hip ratio was led by Taeumin with 0.03 and then came Soeumin and Soyangin with a 0.02 ratio. As treatment was taken into process longer Taeumin patients showed a great progress in decreasing their weight hip ratios. 4. Costitutional related symptom with Obesity. 4-1) Taeumin was followed by Soyangin and then Soeumin in family history. 4-2) Soeumin was followed by Taeumin, then Soyangin when complain of physical fatigue was taken into consideration. 4-3) The ordinary exercise was led by Soyangin, Taeumin then Soeumin. 4-4) People who receive stress turned out to be 72.9% much higher than the people who don't. 4-5) Overeating due to stress was found in 83.3% of Soyangin.

• Journal of Korean Medicine for Obesity Research
• /
• v.2 no.1
• /
• pp.43-52
• /
• 2002

Purpose & Methods: In order to study obese gene mutation rate in obese Korean patients and to investigate the effect at Chegamuiyiin-tang and electro-lipolysis-acupuncture on obesity treatment. the difference of the reaction to herbal dieting between patients with ${\beta}3$ adrenergic receptor mutation and the patients with wild type ${\beta}3$ adrenergic receptor is observed. Results: Chegamuiyiin-tang and electro-lipolysis-acupuncture treatment are effective on the treatment of obesity in weight reduction. body fat reduction and the circumferences of arm, abdomen, hip and thigh. In the comparison of ${\beta}3$ adrenergic receptor wild type and ${\beta}3$ adrenergic receptor mutation groups, body fat was more reduced with statistical significance, and as for BMI change and body weight change were higher in ${\beta}3$ adrenergic receptor mutation groups with no statistical significance. In the comparison of ${\beta}3$ adrenergic receptor wild type and ${\beta}3$ adrenergic receptor mutation groups among BMI under 25 patients change rate of body weight. BMI, body fact percentage, WHR and body circumference were higher in ${\beta}3$ adrenergic receptor mutation group than in ${\beta}3$ adrenergic receptor wild type group. Conclusion: These results imply that herbal dieting program combined with electro-lipolysis-acupuncture is more effective on reducing body weight and body fat in ${\beta}3$ adrenergic receptor mutation group than wild type group, and that the earlier the treatment is applied, the more effective it is.

• Journal of Korean Medicine for Obesity Research
• /
• v.19 no.1
• /
• pp.56-67
• /
• 2019

Objectives: The purpose of this study is to review clinical studies of herb medicine and acupuncture treatment on obesity in menopausal women. Methods: Key words "Obesity", "Menopause", "Herb medicine", "Acupuncture", "Moxibustion", "Catgut embedding" were searched on 9 database systems (PubMed Central, Cochrane Controlled Register of Trials, Embase, China Academic Journals, Korean Traditional Knowledge Portal, Oriental Medicine Advanced Searching Integrated System, Korean Studies Information Service System, National Digital Science Library, DBpia) on April 30th 2019. Results: 1 case report and 17 clinical trials were collected in accordance with the selection and exclusion criteria. Among the 17 trials, 6 were randomized controlled trials, 1 was controlled clinical trial, and 10 were single-arm trials. The types of intervention were herb medicine, electroacupuncture, acupuncture, auricular acupuncture, warm needle acupuncture, moxibustion, laser acupuncture, and catgut embedding. The study design, study results and method of intervention were analyzed. Conclusions: 1 case report described the effectiveness of pharmacopuncture, 4 trials described the effectiveness of herbal medicine, 2 of electroacupuncture, 1 of laser acupuncture, and 2 of catgut embedding. Among the 17 trials, 2 studies showed that herbal medicine treatment was more effective than no treatment or selective serotonin reuptake inhibitors, and 1 study showed that electroacupuncture was more effective than hormone therapy. All of 18 selected studies reported the effectiveness of weight reduction and abdominal obesity reduction after the traditional Korean medicine treatment for obesity in menopausal women.