• Toxicological Research
• /
• v.11 no.1
• /
• pp.63-68
• /
• 1995

N-methyl-D-aspartate(NMDA) receptor has been well known as an important mediator of several forms of neural and behavioral plasticity. But different results were reported about the effect of MK-801 or dextromethorphan on opioid dependence. The present studies examined whether NMDA receptor antagonists can alter the opioid dependence and tolerance in rodents. Naloxone precipitated withdrawal symptoms and changes of locomotor activities were observed in MK-801 or dextromethorphan pretreated morphine-dependent rats. Tail-flick assay was used for morphine analgesia and tolerance was found after 4 day's consecutive injections (10 mg/kg, s.c., twice/day) of morphine in mice. Locomotor activity was increased and the withdrawal symptoms were decreased by the pretreatment of MK-801 in morphine-dependent rats. But 0.3 mg/kg i.p. of MK-801 intensified the body weight loss and produced severe ataxia and rotation although some withdrawal signs were attenuated. Morphine induced analgesic tolerance was inhibited by the pretreatment of MK-801 and dextromethorphan. Dextromethorphan was more potent than MK-801 in inhibiting the development of the analgesic tolerance in mice. These results suggest that NMDA system may be involved in opioid withdrawal and analgesic tolerance but appropriate caution should be requested when MK-801 is used in combination with opioid because of untoward neurologic signs.

• Korean Journal of Pharmacognosy
• /
• v.16 no.1
• /
• pp.31-35
• /
• 1985

Intraperitoneal administration of ginseng butanol fraction(GBF) to chronic morphinization in male Sprague-Dawley rats inhibited the development of tolerance to the analgesic effect and hyperthermic action of morphine. Rats were rendered tolerant to morphine by subcutaneous multiple morphine injections for a period of 8 days. The development of tolerance was evidenced by the decreased analgesic response to morphine and inhibition of tolerance by the greater analgesic response. Concomitant administration of morphine with GBF blocked the tolerance to the hyperthermic effect of morphine as evidenced by elevation of body temperature by morphine. Dopamine receptor sensitivity was enhanced in morphine tolerant rats as measured by apomorphine induced in spontaneous motor activity. GBF administration also blocked dopamine receptor supersensitivity induced by chronic morphinization.

• Molecules and Cells
• /
• v.21 no.2
• /
• pp.192-196
• /
• 2006

Salt tolerance was evaluated at the young seedling stage of rice (Oryza sativa L.) using recombinant inbred lines (MG RILs) from a cross between Milyang 23 (japonica/indica) and Gihobyeo (japonica). 22 of 164 MG RILs were classified as tolerant with visual scores of 3.5-5.0 in 0.7% NaCl. Interval mapping of QTLs related to salt tolerance was conducted on the basis of the visual scores at the young seedling stage. Two QTLs, qST1 and qST3, conferring salt tolerance, were detected on chromosome 1 and 3, respectively, and the total phenotypic variance explained by the two QTLs was 36.9% in the MG RIL population. qST1 was the major QTL explaining 27.8% of the total phenotypic variation. qST1 was flanked by Est12~RZ569A, and qST3 was flanked by RG179~RZ596. The detection of new QTLs associated with salt tolerance will provide important information for the functional analysis of rice salt tolerance.

• Analyses & Alternatives
• /
• v.7 no.1
• /
• pp.201-227
• /
• 2023

The purpose of this study is to examine how France became a representative country for far-right European populism, despite its tradition of tolerance. To achieve this goal, we examine, first, how the concept of tolerance developed in France after the 16th century. Through this process, we find that within the political system, the tolerance of the liberal tradition met with universalism, a republican value, and developed into an 'institutional tolerance' that allowed 'differences' from an authoritarian perspective rather than on an equal level. This 'assimilation' policy, reflecting a 'patriarchal' and 'oppressive' institutional tolerance, formed the keynote of the immigration policy of the 20th century, which continued until the 1980s, and shows that the French government did not take practical steps for the social integration of immigrant groups under the republican universal value that does not allow 'differences.' The government came up with an 'integration' immigration policy that embraces cultural 'differences' only after encountering problems with immigrant groups. However, this was not enough to calm the antipathy towards immigrants in French society and the discontent of immigrants in French society. Also, universalism, a republican value with deep roots in France, prevented the French immigration policy from escaping its assimilationist nature even in the 21st century. In the midst of this, far-right parties have gained power by promoting xenophobic sentiments centered on immigration problems. Finally, this study also looks at how far-right populism is currently changing the French political environment.

• Journal of Korean Society for Quality Management
• /
• v.36 no.2
• /
• pp.20-27
• /
• 2008

Tolerance design has been identified as an important research area and a number of models have been proposed in the literature. This paper investigates the effect of limited capacity on tolerance design for products with nominal-the-best type (N-type) quality characteristics. The model is developed under the assumption that the reprocessed and nonreprocessed items are produced by the same manufacturing process and therefore their quality characteristics are identically and independently distributed. Profit models are constructed which involve four price/cost components; selling price, cost incurred by imperfect quality, reprocessing and quality inspection costs. Methods of finding the optimal tolerance limits are presented, and a numerical example is given. Sensitivity analyses are also performed to study the effect of a process standard deviation on this model.

• Transactions of the Korean Society for Noise and Vibration Engineering
• /
• v.12 no.9
• /
• pp.661-667
• /
• 2002

With the increase of storage density, high rotational speed and high access technologies in optical disk drive, mechanical issues, mainly noise and vibration, become critical. Up to now the researches of rubber mount for anti-vibration focused on how to calculate the static and the dynamic stiffness of rubber mount and loaned out consideration of the dimensional tolerance of rubber mount for anti-vibration. This paper presents the effects of dimensional tolerance of rubber mount for anti-nitration on the dynamic characteristics of optical disk drive by finite element analysis and dynamic test. The relation between dimensional tolerance and dynamic characteristics of optical disk drive is observed and discussed.

• Journal of Environmental Science International
• /
• v.11 no.11
• /
• pp.1173-1181
• /
• 2002

The present study was undertaken to investigate the effect of low temperature and salicylic acid(SA) on the chilling tolerance of acclimated and nonacclimated cucumber(Cucurmis sativus L.) seedlings. The acclimation phenomenon was characterized in chilling-sensitive cucumber seedlings and found to have a significant effect on the survival and shoot dry weights. The injuries experienced by the acclimated seedlings in the third leaf stage were on average smaller by half than those experienced by the nonacclimated seedlings. Chilling also caused a large increase in the free proline levels, regardless of the acclimation status. Exogenous treatment with SA(0.5mM) resulted in improved growth and survival of the nonacclimated chilled seedlings, indicating that SA induced chilling tolerance and SA and acclimation had common effects. The application of cycloheximide in the presence of SA restored the acclimation-induced chilling tolerance. The elevated proline level observed in the cold-treated and SA-treated plants was more pronounced in the light than in the dark at a chilled temperature, indicating that endogenous proline may play a role in chilling tolerance by stabilizing the water status in response to chilling. From these results it is suggested that SA provided protection against low-temperature stress by increasing the proline accumulation, and pre-treatment with SA may induce antioxidant enzymes leading to increased chilling tolerance.

• Archives of Pharmacal Research
• /
• v.16 no.3
• /
• pp.237-243
• /
• 1993

These studies were performed to investigate the acting sites of ginseng total saponins (GTS) on the U-50, 488H-induced antinociception and the inhibitory effect of the development of tolerance to U-50, 488H-induced antinociception by GTS were studied. The U-50, 488H-induced antinociception was ntagonized in mice pretreated with GTS intraperitoneally, intracerebrally. These antagonisms were reversed by the pretratment iwth a serotonin precursor, 5-hydroxytrypophan (5-HTP), but not with a noradrenaline precursor, L-dihydroxyphenylalanine (L-DOPA). However, the intraplantar sites. On the other hand, GTS inhibited the development of tolerance to U-50, 488H-induced antinociception was reversed by pretreatment with 5-HTP, but not with L-DOPA. Therefore, the antagonism of U-50, 488H-induced antinociception and the inhibition of the development of tolerance to U-50, 488H-induced antinociception and the inhibition of the development of tolerance to U-50, 488H-induced antinociception by GTS are dependent on serotonegic mechanisms.

• KOREAN JOURNAL OF CROP SCIENCE
• /
• v.40 no.2
• /
• pp.150-156
• /
• 1995

Planting date is the most important factor in determining winter survival of Crop plants. The objective of this study was to explore the effect of planting date on the development of freezing tolerance and winter survival of canola. Six winter cultivars were planted at three different dates during the fall on the Michigan State University Research Farm at East Lansing, MI. Freezing tolerance was determined by ion leakage tests every 15 days after planting until middle of November. Winter survival was evaluated by counting the live plants in the fall and next spring. Planting date as well as cultivar treatment had a significant effect on freezing tolerance and winter survival A different pattern in development of freezing tolerance was observed for different planting dates. There was a high correlation between freezing tolerance and winter survival suggesting that freezing tolerance could be a useful predictor for winter survival.

• Journal of the Korean Institute of Landscape Architecture
• /
• v.31 no.2
• /
• pp.94-101
• /
• 2003

The purpose of this paper is to analyze the correlation between Death Rate of Trees (DRT) and the Physiological Characteristics of Trees(PCT) in POSCO Gwangyang works, which is a reclaimed area. To analyze the DRT, 15 species of deciduous trees were selected, for example Ulmus davidiana var., Zelkova serrata, Melia azedarach var. etc. Though there were numerous factors to affect the growing of trees, 5 PCT were considered to be main factors, soil salt tolerance, wind salt tolerance, water needs, transplanting difficulty, and nutrient needs. According to two kinds of soil-base: mound and pot area, we tested the relationship between 5 PCT and DRT by use of t-test and multiple regression analysis. The results are as follows. 1. The DRT of Acer palmatum, Cornus kousa, Magnolia kobus, Liriodendron tulipifera, and Albizzia julibrissin were high by more than 20%. On the other hand, Chionanthus retusa, Ulmus davidiana var. japonica Celtis sinensis, and Lagerstroemia indica were low by less than 10% in the DRT and are considered to be species suitable for planting in reclaimed areas. 2. The DRT of trees in pot areas was meaningfully higher than in mound areas; for this reason the mound technique is desirable as a soil-base for planting in reclaimed areas. 3. In the pot area, the independent variables, in the order of soil salt tolerance, wind salt tolerance, transplanting difficulty, had an effect on the DRT more significantly than in mount area. On the other hand, wind salt tolerance and soil salt tolerance affected the DRT in mount areas. This means that soil salt tolerance, wind salt tolerance, and transplanting difficulty have to be considered as significant factors to the DRT. Although the researchers tried to interpret how the PCT affected the DRT in order to analyze the relationship between the two in reclaimed areas, it was neglected at an experimental level. Therefore, future research should work on this aspect in detail.