• Journal of Preventive Medicine and Public Health
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• 제19권2호
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• pp.233-243
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• 1986

Our study was designed to identify the difference in the mental health status among hospitalized patients due to occupational diseases and accidents and pre-employment physical examinees, and to identify the relationship between mental health status and socio-demographic variables, and to provide information useful to non-psychiatric clinicians in caring of such patients. Samples were comprised of 189 pneumoconiotic patients, 132 industrial accident-induced patients and 122 pre-employment physical examinees who were interviewed with 90-item symptom cheklist (SCL-90). The following results were obtained: 1) Mean scores of symptom dimension on socio-demographic subgroup showed higher tendencies in older aged, male, lower educated, miner, married, mining residence, and pneumoconiotic patients. 2) Mean scores of total samples on all symptom dimensions were as follows in the order of their magnitudes; Depression, Somatization, Obsessive-compulsive, Anxiety, Psychoticism, Interpersonal sensitivity, Phobic-anxiety, Hostility, and Paranoid ideation. 3) The highest mean scores on each socio-demographic subgroup were as follows; Depression in younger aged and Somatization in older aged; Depression in male Somatization in female; Somatization in lower educated and depression in higher educated; Somatization in miners and depression in non-miners; Somatization in married and Depression in unmarried; Depression in all kind of residences; Somatization in patients and Depression in pre-employment physical examinees(normal). 4) In consequence of stepwise multiple regression, the important socio-demographic variables were age, occupation, diagnostic classification, and residence. Age was the most imprtant variable in Somatization, Depression, Obsessive-compulsive, Anxiety, Phobic anxiety, Paranoid ideation, and Psychoticism. Occupation was the most important one in Interpersonal sensitivity and Hostility and also had significant realtionships with all symptom dimensions.

• 한국멀티미디어학회논문지
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• 제24권4호
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• pp.583-592
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• 2021

Obsessive-compulsive disorder (OCD) is a mental disorder in which a person repeated a particular thought or feels. The domain of beliefs and guilt predicted OCD symptoms. Although there were some neuroimaging studies investigating OCD symptoms, resting-state functional magnetic resonance imaging (rs-fMRI) study investigating intra-network functional connectivity associated with guilt for OCD is not reported yet. Therefore, in the current study, we assessed the differences between intra-network functional connectivity of healthy control group and OCD group using independent component analysis (ICA) method. In addition, we also aimed to investigate the correlation between changed functional connectivity and guilt score in OCD. Total 86 participants, which consisted of 42 healthy control volunteers and 44 OCD patients, acquired rs-fMRI data using the 3T MRI. After preprocessing the fMRI data, a functional connectivity was used for group independent component analysis. The results showed that OCD patients had higher score in emotion state in beliefs and lower functional connectivity in fronto-parietal network (FPN) than control group. A decrease of functional connectivity in FPN was negatively correlated with feelings of guilt in OCD. Our results suggest excessive increase in guilt negatively affect to process emotional state and behavior or cognitive processing by influencing intrinsic brain activity.

• 대한치과교정학회지
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• 제53권1호
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• pp.3-15
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• 2023

Objective: Body dysmorphic disorder (BDD) is a form of obsessive-compulsive disorder that may be negatively associated with the self-image. It might be associated with orthodontic treatment demand and outcome, and therefore is important. Thus, this study was conducted. Methods: The Yale-Brown Obsessive-Compulsive Scale modified for Body Dysmorphic Disorder (BDD-YBOCS) questionnaire was used in 699 orthodontic patients above 12 years of age (222 males, 477 females), at seven clinics in two cities (2020-2021). BDD diagnosis and severity were calculated based on the first 3 items and all 12 items of the questionnaire. The dental health component of the index of orthodontic treatment need (IOTN-DHC) was assessed by orthodontists. Multivariable and bivariable statistical analyses were performed on ordinal and dichotomized BDD diagnoses to assess potentially associated factors (IOTN-DHC, age, sex, marital status, education level, and previous orthodontic consultation) (α = 0.05). Results: IOTN-DHC scores 1-5 were seen in 13.0%, 39.9%, 29.8%, 12.4%, and 4.9% of patients. Age/sex/marital status/education were not associated with IOTN-DHC (p > 0.05). Based on 3-item questionnaire, 17.02% of patients had BDD (14.02% mild). Based on 12-item questionnaire, 2.86% had BDD. BDD was more prevalent or severer in females, married patients, patients with a previous history of orthodontic consultation, and patients with milder IOTN-DHCs (p < 0.05). Conclusions: IOTNDHC was negatively/slightly associated with BDD in orthodontic patients. Being female and married may increase BDD risk.

• 대한불안의학회지
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• 제20권1호
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• pp.27-34
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• 2024

Objective : Cognitive fusion, or believability, in acceptance and commitment therapy (ACT), refers to the tendency to become entangled in one's thoughts or feelings. It is an important factor in the development and maintenance of anxiety disorders. However, there is a lack of validated self-report measures for cognitive fusion and defusion, particularly for individuals with anxiety. To address this gap, this study aimed to evaluate the Korean Version of Believability of Anxious Feelings and Thoughts Questionnaire (K-BAFT). Methods : A total of 608 university students and 85 patients with obsessive-compulsive disorder (OCD) took part in this study. They were asked to complete various psychological measures, including the K-BAFT, other measures of ACT processes, and symptom scales. The researchers then analyzed the psychometric characteristics of the K-BAFT. Results : The results of the exploratory and confirmatory factor analyses indicated that the three-factor structure of the K-BAFT, which was reported in the original study, was also found in the university sample. Additionally, both the student and the OCD group demonstrated strong internal consistency (α=0.86 and 0.91, respectively). In the university sample, the K-BAFT showed a strong correlation with the Cognitive Fusion Questionnaire (r_s=0.53, p<0.001). However, it had a weak correlation with symptoms scales for depression, anxiety, and stress (all r_s<0.32). Furthermore, the OCD group had higher scores on the K-BAFT compared to the university sample. Conclusion : K-BAFT is considered to be a reliable and valid self-report tool for measuring cognitive fusion with anxious thoughts and feelings.

• 생물정신의학
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• 제6권2호
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• pp.240-245
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• 1999

Object : This study was designed to evaluate the effects of olanzapine on the schedule-induced polydipsia(SIP) which is one of animal model of obsessive-compulsive disorder in rats. We administered olanzapine as a serotonin and dopamine blocking agent, fluoxetine as a selective serotonin reuptake inhibitor, and haloperidol for the dopamine antagonist to rats which showed schedule-induced polydipsic behavior. Methods : Spraque-Dawley rats weighing 200-250gm were individually housed and maintained and allowed free access to water. The rats were placed on a restricted diet. To induce polydipsia, rats were placed in the cage where a pellet dispenser automatically dispensed 90mg pellets on a fixed-time 60 seconds(FT-60s) feeding schedule over 150 minute test session per day. Water was available at all times in the cage. After 4 weeks of daily exposure to the FT 60s feeding schedule, experimental rats met a predetermined criterion for polydipsic behavior(greater than 3 times of water per session on average). 5 groups of rats were administered olanzapine(3mg/kg, i.p), olanzapine(10mg/kg, i.p), fluoxetine(5mg/kg, i.p.), haloperidol(0.1mg/kg, i.p.), and vehicle(1cc/kg, i.p.) for 3 weeks. The rats were tested once a week to access schedule induced polydipsic behavior. Water bottles were weighed before and after the 150-minute test session. The chronic effects of administration of experimental drugs on schedule induced polydipsic behavior were analyzed with ANOVA and Scheffe test as a posthoc comparison. In order to measure water consumption in non-polydipsic food-deprived rats, a separate group of rats(N=8) were individually housed and given a single bolus(14.5gm) of food per day which maintained them at their average body weight. Results and Conclusion : The results were as follows ; 1) After 4 weeks of scheduled feeding procedure, the experimental group showed significant differences than the bolus control in the amount of water consumption as compared with their average water intakes for 4 weeks. At the same periods, there were no differences between the experimental group and the bolus control in the body weight. 2) The fluoxetine group showed significant decrease in the amount of water intake over the 3 weeks of drug treatment as compared with their average amount of polydipsic water intakes. The olanzapine 3mg group showed significant decrease in the amount of water intake at 3rd weeks of drug treatment as compared with their average amount of polydipsic water intakes. The olanzapine 10mg group showed significant decrease in the amount of water intake at 2nd and 3rd weeks of drug treatment as compared with their average amount of polydipsic water intakes. However, the haloperidol group and the vehicle control group showed no changes of amounts of water intake for 3 weeks of treatment as compared with their average amount of polydipsic water intakes. 3) The fluoxetine group showed significantly lower amounts of water intake than the haloperidol group at 2nd weeks of drug treatment. And also the fluoxetine group showed significantly lower amounts of water intake than the haloperidol group and the vehicle control at 3rd weeks of drug treatment. The olanzapine 3mg group and the olanzapine 10mg group showed significantly lower amounts of water intake than the haloperidol group and the vehicle control at 3rd weeks of drug treatment. Above findings suggest that the fixed time feeding procedure for schedule-induced polydipsia as an animal model of obsessive compulsive disorder was effective to the evaluation of pharmacological challenge study. The authors assume that the serotonin hypothesis and the serotonin-dopamine interaction hypothesis are preferred to the dopamine hypothesis in the biological etiology of obsessive-compulsive disorder.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제17권1호
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• pp.10-18
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• 2006

연구목적 : 본 연구는 청소년들의 인터넷 중독과 우울, 충동성, 강박성과의 연관성을 알아보고자 하였다. 연구방법 :경기도 남양주시 소재의 인문계 고등학교 1, 2학년 학생 1410명(남자 611, 여자 799)을 대상으로 하였다. 인터넷 사용 형태에 관한 설문과 인터넷 중독여부는 Young의 인터넷 중독척도(Internet Addiction Scale, IAS)를 사용하였고, 우울증상의 평가는 Beck 우울 척도(Beck Depression Inventory, BDI)를 사용하였다. 충동성 측정을 위하여 Barratt의 충동성 척도(Barratt Impulsiveness Scale, BIS)를 사용하였으며, 강박성은 모즐리 강박 척도(Maudsley obsessive compulsive inventory, MOCI)를 사용하여 평가하였다. 본 연구에서 인터넷 중독 척도 상위 25%를 중독군으로 하위 25%를 비중독군으로 분류하였다. 결 과 : 1) 남학생이 여학생보다 인터넷 중독 점수에서 유의미하게 높았고, 중독군에 포함되는 비율도 더 높았다. 2) 중독군이 비중독군보다 하루 평균 인터넷 사용시간이 유의미하게 많았고, 사용분야에서는 게임에 몰두하는 경향이 있었다. 두 군 간의 인터넷 사용기간의 차이는 없었다. 3) 인터넷 중독군이 비중독군에 비해 우울정도, 충동성, 강박성 점수가 유의미하게 더 높게 나타났다. 4) 인터넷 중독 점수는 우울정도, 충동성, 강박성 점수들과 각각 의미 있는 상관관계를 보였다. 결 론 : 우울정도, 충동성, 강박성 모두 인터넷 중독을 설명하는 변인이었으며, 그 중 충동성의 직접효과가 인터넷 중독을 가장 잘 설명하는 변인이었다. 청소년에서 높은 충동성이 인터넷 중독의 위험 인자가 될 수 있음을 시사한다. 침전물이 전반적으로 관찰되었다. Tensile strength는 NaOCl군에서 다른 군에 비해 유의성 있는 증가를 보였으며 (p < 0.05). elongation rate는 3 종의 소독제 모두 대조군에 비해 유의성 있는 증가를 보였으나 (p < 0.05), 특히 ChloraPrep군에서 가장 큰 증가를 보였다. 본 연구 결과 3 종의 소독제 모두 근관충전 전 가타파차 콘의 rapid sterilization을 위해 유용하게 사용할 수 있음을 시사한다.

• 대한핵의학회:학술대회논문집
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• 대한핵의학회 2000년도 2nd Korea-China Congress of Nuclear Medicine and 39th Annual Spring Meeting if the Korea SOciety Nuclear Medicine
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• pp.59.2-59.2
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• 2000

• 생물정신의학
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• 제9권1호
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• pp.3-7
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• 2002

Genes involved in the serotonin system are good candidates for the pathogenesis of mood disorder and mood-related disorders, such as eating disorder, obsessive-compulsive disorder, alcoholism, and suicide. Serotonin type 2A(5-HT2A) receptor gene promoter polymorphism(-1438A/G) has been reported. In this article, authors reviewed the literatures regarding association studies between -1438A/G and mood disorder and mood-related disorders. There are controversial results with limited data to date. Further researches on the -1438A/G in psychiatric disorders are required.

• 생물정신의학
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• 제4권2호
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• pp.155-161
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• 1997

Serotonin has been implicated in the etiology of many disease states and may be particularly important mental illness, such as depression, anxiety, schizophrenia, sleep disorders, suicide, eating disorders, obsessive compulsive disorders, migraine and others. Many currently used treatments of these disorders are thought to act by modulating serotonergic function. The identification of many serotonin subtypes, most of which have been shown to have functional activity and differential distribution, has stimulated considerable effort into synthesizing selective ligands(drugs) to help understand their significance. This should understand the role of serotonin in mental disorders and these new drugs can be studied alone and in combination with other treatments in order to clarify the parameters of drug use for the clinical effect.

• Journal of Nutrition and Health
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• 제27권1호
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• pp.71-78
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• 1994

Recently the incidence of hemorrhoids has been increased. There were various factors related to hemorrhoids, the amount of fiber intake was known as one of them. And so we performed this case-control study to investigate the association of hemorrhoids and fiber intake. The data was obtained by the combination of self-administered questionnaire and personal interview. The study population was consisted of matched 156 pairs, the cases were selected from S-hospital in Seoul, the age and sex matched control from the general population. The statistical analysis was performed by matched-analysis. The results summarized as follow : 1) As socio-economic status were low, the odds ratio of hemorrhoids were high. 2) There was significant association between hemorrhoids and regularity of eating time rather than regularity of defecation. 3) The odds ratio of hemorrhoids was 3 times higher in the presence of constipation. 4) The incidence of hemorrhoids was influenced by psychological characteristics such as somatization, obsessive-compulsive, depression, and anxiety. 5) Fiber intake was significantly lower in the cases compared to the controls. When the constipation was controlled, the fiber intake was still lower in the cases. These data provide additional evidence that the fiber intake was related to hemorrhoids.