• Biomolecules & Therapeutics
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• 제16권3호
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• pp.173-178
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• 2008

Several lines of evidence indicate that scopolamine as a nonselective muscarinic antagonist disrupts object recognition performance and spatial working memory when administered systemically. In the present study, we investigated the different effects of scopolamine on acquisition, consolidation, and retrieval phases of object recognition performance and spatial working memory using the object recognition and the Morris water maze tasks in mice. In the acquisition phase test, scopolamine decreased recognition index on object recognition task and the trial 1 to trial 2 differences on Morris water maze task. In the consolidation and retrieval phase tests, scopolamine also decreased recognition index on object recognition task, where as scopolamine did not exhibited any effects on the Morris water maze task.

• JSTS:Journal of Semiconductor Technology and Science
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• 제16권2호
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• pp.251-254
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• 2016

An energy-efficient object matching accelerator is proposed for mobile object recognition based on matching prediction scheme. Conventionally, vocabulary tree has been used to save the external memory bandwidth in object matching process but involved massive internal memory transactions to examine each object in a database. In this paper, a novel object matching accelerator is proposed based on matching predictions to reduce unnecessary internal memory transactions by mitigating non-target object examinations, thereby improving the energy-efficiency. Experimental results show a 26% reduction in power-delay product compared to the prior art.

• Animal cells and systems
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• 제12권1호
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• pp.11-14
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• 2008

Finding a way to strengthen human cognitive functions, such as learning and memory, has been of great concern since the moment people realized that these functions can be affected and even altered by certain chemicals. Since then, plenty of endeavors have been made to look for safe ways of improving cognitive performances without adverse side-effects. Unfortunately, most of these efforts have turned out to be unsuccessful until now. In this study, we examine the effect of a natural compound, idesolide, on hippocampus-dependent recognition memory. We demonstrate that idesolide is effective in the enhancement of recognition memory, as measured by a novel object recognition task. Thus, idesolide might serve as a novel therapeutic medication for the treatment of memoryrelated brain anomalies such as mild cognitive impairment(MCI) and Alzheimer's disease.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제14권10호
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• pp.4098-4116
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• 2020

Mobile devices such as smartphones are very attractive targets for augmented reality (AR) services, but their limited resources make it difficult to increase the number of objects to be recognized. When the recognition process is scaled to a large number of objects, it typically requires significant computation time and memory. Therefore, most large-scale mobile AR systems rely on a server to outsource recognition process to a high-performance PC, but this limits the scenarios available in the AR services. As a part of realizing large-scale standalone mobile AR, this paper presents a solution to the problem of accuracy, memory, and speed for large-scale object recognition. To this end, we design our own basic feature and realize spatial locality, selective feature extraction, rough pose estimation, and selective feature matching. Experiments are performed to verify the appropriateness of the proposed method for realizing large-scale standalone mobile AR in terms of efficiency and accuracy.

• 동의생리병리학회지
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• 제20권2호
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• pp.471-476
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• 2006

Chongmyung-tang(CMT, 聰明湯), oriental herbal medicine which consists of Polygaglae Radix(遠志), Acori Graminei Rhizoma(石菖蒲) and Hoelen(白茯神) has effect on amnesia, dementia. In order to evaluate effect of CMT on memory and learning in mice, CMT extract was used for studies. This paper describes the effects of CMT extract on memory and learning processes by using the passive and active avoidance performance tests, novel object recognition task and water maze task. The CMT extract ameliorated the memory retrieval deficit induced by ethanol in the passive avoidance responses but did not affect ambulatory activity of normal mice. These results suggest that CMT has an ameliorating effect on memory retrieval impairment. CMT extract decreased spontaneous motor activity(SMA) in the latter sessions of memory registration in active avoidance responses. These results suggest that CMT has partly transquilizing or antianxiety effects. In novel object recognition task to measure visual recognition memory, CMT-administered mice enhanced in long term memory for 1-3 days. In water maze task to measure spatial learning, which requires the activation of NMDA receptors in the hippocampus, spatial learning in CMT-administered mice was faster than in wild-type mice. These results suggest that CMT enhances memory and activates NMDA receptors.

• Toxicological Research
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• 제24권3호
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• pp.183-188
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• 2008

The behavioral phenotypes of out-bred ICR mice were compared with those of in-bred C57BL/6 and BALB/c mice. In particular, this study examined the locomotor activity and two forms of hippocampus-dependent learning paradigms, passive avoidance and object recognition memory. The basal open-field activity of the ICR strain was greater than that of the C57BL/6 and BALB/c strains. In the passive avoidance task, all the mice showed a significant increase in the cross-over latency when tested 24 hours after training. The strength of memory retention in the ICR mice was relatively weak and measurable, as indicated by the shorter cross-over latency than the C57BL/6 and BALB/c mice. In the object recognition memory test, all strains had a significant preference for the novel object during testing. The index for the preference of a novel object was lower for the ICR and BALB/c mice. Nevertheless, the variance and the standard deviation in these strains were comparable. Overall, these results confirm the strain differences on locomotor activity and hippocampus-dependent learning and memory in mice.

• 인지과학
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• 제19권2호
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• pp.125-142
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• 2008

본 연구는 공간-기반 주의(space-based attention)와 대상-기반 주의(object-based attention)가 공간 및 시각 작업기억에 미치는 영향을 살펴보고자 두 가지 주의 자원 양상이 모두 관여하는 공간 스트룹 과제를 이용하여 작업기억의 재인율을 측정하였다. 작업기억과 공간 스트룹 과제의 자극 배열의 유사성 조건은 작업기억 과제 수행 시 공간 시연에 미치는 공간-기반 주의의 영향을 살펴보고자 구성되었으며, 스트룹 조건은 작업기억 과제 수행시 대상에 대한 시연에 미치는 대상-기반 주의의 영향을 살펴보고자 하였다. 그 결과, 공간 작업기억과 공간 스트룹 과제의 자극 배열의 유사성이 높은 조건에서 공간 작업기억의 재인율이 높은 것으로 나타났으며, 스트룹 조건에 따라서는 차이가 없는 것으로 나타났다. 반면, 시각 작업기억의 재인율은 스트룹 일치조건보다 불일치조건에서 더 저조한 것으로 나타났으며, 유사성 조건에 따라서는 차이가 없는 것으로 나타났다. 이러한 결과는 작업기억에서 요구되는 자원의 양상과 선택적 주의 자원의 양상이 동일한 경우에만 선택적 주의가 작업기억에 영향을 준다는 것을 시사하는 것이다.

• Toxicological Research
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• 제31권1호
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• pp.17-23
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• 2015

Excessive manganese (Mn) in the brain promotes a variety of abnormal behaviors, including memory deficits, decreased motor skills and psychotic behavior resembling Parkinson's disease. Hereditary hemochromatosis (HH) is a prevalent genetic iron overload disorder worldwide. Dysfunction in HFE gene is the major cause of HH. Our previous study has demonstrated that olfactory Mn uptake is altered by HFE deficiency, suggesting that loss of HFE function could alter manganese-associated neurotoxicity. To test this hypothesis, Hfe-knockout ($Hfe^{-/-}$) and wild-type ($Hfe^{+/+}$) mice were intranasally-instilled with manganese chloride ($MnCl_2$ 5 mg/kg) or water daily for 3 weeks and examined for memory function. Olfactory Mn diminished both short-term recognition and spatial memory in $Hfe^{+/+}$ mice, as examined by novel object recognition task and Barnes maze test, respectively. Interestingly, $Hfe^{-/-}$ mice did not show impaired recognition memory caused by Mn exposure, suggesting a potential protective effect of Hfe deficiency against Mn-induced memory deficits. Since many of the neurotoxic effects of manganese are thought to result from increased oxidative stress, we quantified activities of anti-oxidant enzymes in the prefrontal cortex (PFC). Mn instillation decreased superoxide dismutase 1 (SOD1) activity in $Hfe^{+/+}$ mice, but not in $Hfe^{-/-}$ mice. In addition, Hfe deficiency up-regulated SOD1 and glutathione peroxidase activities. These results suggest a beneficial role of Hfe deficiency in attenuating Mn-induced oxidative stress in the PFC. Furthermore, Mn exposure reduced nicotinic acetylcholine receptor levels in the PFC, indicating that blunted acetylcholine signaling could contribute to impaired memory associated with intranasal manganese. Together, our model suggests that disrupted cholinergic system in the brain is involved in airborne Mn-induced memory deficits and loss of HFE function could in part prevent memory loss via a potential up-regulation of anti-oxidant enzymes in the PFC.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 1997년도 한국자동제어학술회의논문집; 한국전력공사 서울연수원; 17-18 Oct. 1997
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• pp.40-43
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• 1997

This paper presents a 3D object recognition method for generation of 3D environmental map or obstacle recognition of mobile robots. An active light source projects a stripe pattern of light onto the object surface, while the camera observes the projected pattern from its offset point. The system consists of a laser unit and a camera on a pan/tilt device. The line segment in 2D camera image implies an object surface plane. The scaling, filtering, edge extraction, object extraction and line thinning are used for the enhancement of the light stripe image. We can get faithful depth informations of the object surface from the line segment interpretation. The performance of the proposed method has demonstrated in detail through the experiments for varies type objects. Experimental results show that the method has a good position accuracy, effectively eliminates optical noises in the image, greatly reduces memory requirement, and also greatly cut down the image processing time for the 3D object recognition compared to the conventional object recognition.

• Journal of Radiation Protection and Research
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• 제37권3호
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• pp.123-128
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• 2012

방사선 노출은 해마 기능이상으로 인한 인지장애와 기억력 감퇴가 나타난다. 본 연구에서는 마우스에 방사선 노출(감마선 0.5 또는 2 Gy) 후 passive avoidance 및 object recognition test를 적용한 행동이상, apoptosis 측정 및 신경발생 관찰지표로서 Kiel 67 (Ki-67) 및 doublecortin (DCX)에 대한 면역염색 방법을 적용하여 diethyldithiocarbamate(DDC)의 학습기억 장애 경감효과를 관찰하였다. DDC는 방사선 조사 30분 전에 1회(체중 kg당 1,000 mg) 복강 내 주사하였다. Passive avoidance 및 object recognition test 결과, 정상대조군에 비해 방사선 단독조사군(2 Gy)에서 유의성 있는 학습기억 장애를 나타냈으며, 방사선 조사 후 12시간에 치아이랑 부위의 apoptosis 발생세포의 수가 증가하였고, Ki-67 및 DCX 양성세포의 수는 현저히 감소하였다. 방사선 노출 전 DDC 처리군에서는 유의성 있는 행동장애 완화, apoptosis 발생 감소가 관찰되었고, 평균치를 기준으로 Ki-67 및 DCX 양성세포의 수도 약간 증가하였다. DDC는 성숙마우스에서 방사선에 의한 해마 신경세포발생 및 학습기억 장애 개선효과가 있는 것으로 사료된다.