• Proceedings of the Korean Powder Metallurgy Institute Conference
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• 2006.09a
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• pp.34-35
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• 2006

The development of Micro MIM as a new manufacturing process for metallic micro parts made of advanced functional materials has been the subject of considerable research over the last years. This paper addresses important quality aspects on processing of new materials by Micro-MIM. Three examples of new functional materials that can be processed are reviewed in this paper. The first example is two-component-Micro-MIM to obtain multi-functional devices. A micro positioning encoder consisting of a magnetic / non-magnetic material combination is presented. The second issue is series production of the replicate of the smallest human bone in the ear (stapes) from Titanium as an example of medical application. Quality assurance and reproducibility in terms of injection moulding parameters are addressed. In the third part, first results on the processing of the shape memory alloy NiTi by Micro-MIM are presented. Potential applications include biocompatible devices and transportation, for example automotive and aerospace. Processing routes and initial microstructures obtained are discussed.

• International conference on construction engineering and project management
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• 2020.12a
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• pp.353-358
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• 2020

Recent efforts to develop a common standard for nuclear power plants (NPPs) with the aim of creating (1) a digital environment for a better understanding of NPPs life-cycle management aspect and (2) engineering data interoperability by using existing standards among different unspecified project participants (e.g., owners/operators, engineers, contractors, equipment suppliers) during plants' life cycle process (EPC, O&M, and decommissioning). In order to meet this goal, there is a need for formulating a standardized high-level physical breakdown structure (PBS) for NPPs project management office (PMO). However, high-level PBS must be comprehensive enough and able to represent the different types of plants and the new trends of technologies in the industry. This has triggered the need for addressing the issues of the recent operational NPPs and future technologies' ramification for evaluating the changes in the NPPs physical components in terms of structure, system, and component (SSC) configuration. In this context, this ongoing study examines the recent conventional NPPs and technological trends in the development of future NPPs facilities. New reactor models regarding the overlap of variant issues of nuclear technology were explored. Finally, issues on PBS for project management are explored by the examination of the configuration of NPPs primary system. The primary systems' configuration of different reactor models is assessed in order to clarify the need for analyzing the new trends in nuclear technology and to formulate a common high-level PBS. Findings and implications are discussed for further studies.

• Tunnel and Underground Space
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• v.25 no.3
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• pp.293-302
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• 2015

Thin Spray-on Liner (TSL) has been considered as a new rock support to replace shotcrete as well as wire mesh. However, the development of its original production technology is highly in demand since it is not open to the public. Therefore, two kinds of powder-type TSL prototypes were developed as the first development stage. Then, their mechanical properties were experimentally compared with those of a two-component foreign TSL material including both of liquid and powder components. From a series of experiments, the first TSL prototype mixing condition satisfied every TSL performance requirements specified by EFNRAC (2008), and showed much higher tensile and bond strengths than those of the two-component foreign TSL, even though the other TSL prototype cannot be used as a support member since its elongation at break is much lower than its corresponding EFNARC (2008) performance criterion. In addition, a further study to increase the ductility of the first TSL prototype might be necessary to guarantee its higher applicability to field conditions.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.34 no.10
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• pp.947-955
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• 2010

Most oil and gas reservoirs, which have some light hydrocarbon components, show sensitive phase behavior in response to changes in the composition of the internal fluid. When evaluating and developing plans for oil and gas fields, flash calculation, PVT analysis, and saturation-property calculation are necessary for analyzing reservoir characteristics and pipeline flows. In general, the determination of saturation properties such as dew point and bubble point is considered a difficult task because of the poor convergence of the calculation methods. In this study, several new initial-value-guessing methods and root-finding methods are proposed; parametric analysis were carried out to verify the improvement in convergence. Finally, these new ideas and methods were successfully applied to the new GUI based multi-phase behavior simulator.

• Journal of Environmental Impact Assessment
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• v.20 no.3
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• pp.337-348
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• 2011

Urban environmental problem became one of major issues during its urbanization processes. Environmental impacts are assessed during recent urban planning and development. Though the environmental impact assessment considers meteorological impact as a minor component, changes in wind environment during development can largely affect the distribution pattern of air temperature, humidity, and pollutants. Impact assessment of local wind is, therefore, a major element for impact assessment prior to any other meteorological impact assessment. Computational Fluid Dynamics (CFD) models are utilized in various fields such as in wind field assessment during a construction of a new building and in post analysis of a fire event over a mountain. CFD models require specially formatted input data and produce specific output files, which can be analyzed using special programs. CFD's huge requirement in computing power is another hurdle in practical use. In this study, a CFD model and related software processors were automated and integrated as a microscale wind environmental impact assessment system. A supercomputer system was used to reduce the running hours of the model. Input data processor ingests development plans in CAD or GIS formatted files and produces input data files for the CFD model. Output data processor produces various analytical graphs upon user requests. The system was used in assessing the impacts of a new building near an observatory on wind fields and showed the changes by the construction visually and quantitatively. The microscale wind assessment system will evolve, of course, incorporating new improvement of the models and processors. Nevertheless the framework suggested here can be utilized as a basic system for the assessment.

• Biomolecules & Therapeutics
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• v.31 no.2
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• pp.219-226
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• 2023

Furanocoumarin 8-methoxypsoralen (8-MOP) is the parent compound that naturally occurs in traditional medicinal plants used historically. 8-MOP has been employed as a photochemotherapeutic component of Psoralen + Ultraviolet A (PUVA) therapy for the treatment of vitiligo and psoriasis. Although the role of 8-MOP in PUVA therapy has been studied, little is known about the effects of 8-MOP alone on human gastric cancer cells. In this study, we observed anti-proliferative effect of 8-MOP in several human cancer cell lines. Among these, the human gastric cancer cell line SNU1 is the most sensitive to 8-MOP. 8-MOP treated SNU1 cells showed G1-arrest by upregulating p53 and apoptosis by activating caspase-3 in a dose-dependent manner, which was confirmed by loss-of-function analysis through the knockdown of p53-siRNA and inhibition of apoptosis by Z-VAD-FMK. Moreover, 8-MOP-induced apoptosis is not associated with autophagy or necrosis. The signaling pathway responsible for the effect of 8-MOP on SNU1 cells was confirmed to be related to phosphorylated PI3K, ERK2, and STAT3. In contrast, 8-MOP treatment decreased the expression of the typical metastasis-related proteins MMP-2, MMP-9, and Snail in a p53-independent manner. In accordance with the serendipitous findings, treatment with 8-MOP decreased the wound healing, migration, and invasion ability of cells in a dose-dependent manner. In addition, combination treatment with 8-MOP and gemcitabine was effective at the lowest concentrations. Overall, our findings indicate that oral 8-MOP has the potential to treat early human gastric cancer, with fewer side effects.

• Journal of Environmental Science International
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• v.24 no.5
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• pp.623-631
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• 2015

Microarray technology provides a unique tool for the determination of gene expression at the level of messenger RNA (mRNA). This study, the mRNA expression profiles provide insight into the mechanism of action of cadmium in Fleshy shrimp (Fenneropenaeus chinensis). The ability of genomic technologies was contributed decisively to development of new molecular biomarkers and to the determination of new possible gene targets. Also, it can be approach for monitoring of trace metal using oligo-chip microarray-based in potential model marine user level organisms. 15K oligo-chip for F. chinensis that include mostly unique sets of genes from cDNA sequences was developed. A total of 13,971 spots (1,181 mRNAs up- regulated and 996 down regulated) were identified to be significantly expressed on microarray by hierarchical clustering of genes after exposure to cadmium for different conditions (Cd24-5000 and Cd48-1000). Most of the changes of mRNA expression were observed at the long time and low concentration exposure of Cd48-1000. But, gene ontology analysis (GO annotation) were no significant different between experiments groups. It was observed that mRNA expression of main genes involved in metabolism, cell component, molecular binding and catalytic function. It was suggested that cadmium inhibited metabolism and growth of F. chinensis.

• Journal of Physiology & Pathology in Korean Medicine
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• v.30 no.6
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• pp.385-396
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• 2016

It is a fact that the existing pharmacological research method is difficult to explain the effect and mechanism of action of herbal formula of Korean medicine. We are now very pleased with the development of modern science and the development of a methodology for studying herbal formula characterized by network targets and multi-component therapeutics over the human body. In this review, systems pharmacology or network pharmacology is demonstrated how these are applied to explain the effectiveness of herbal medicine. The post-genomic era provides a unique opportunity for the two fields to understand and benefit from each other. In particular, recent research trends, research methodology, useful databases and results of research on herbal formula are introduced. China already has a policy of scientific development of traditional chinese medicine (TCM) and the development of Chinese medicine industry with a focus on herbal formula research at national level, and in Korea, it is urgent to support and nurture the methodology appropriate to the characteristics of the herbal formula in order to study the safety and efficacy of Korean medicine.

• The Journal of the Korea institute of electronic communication sciences
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• v.1 no.1
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• pp.87-93
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• 2006

This is paper, with the development of computer and network communications technology, the technology of digital computer and modern communications has integrated into the field of intelligent home appliances, making them intelligentize with the function of a network information terminal. The paper introduces the Bluetooth SIG(Special Interesting Group) and the development of the standard of the Bluetooth. Researches the application model and the practical application of the Bluetooth technology, and the component elements of the Bluetooth. Finally deals with the outlook for the development of the Bluetooth technology.

• International Journal of Naval Architecture and Ocean Engineering
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• v.10 no.6
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• pp.741-761
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• 2018

A shipyard is an Engineer To Order (ETO) company that designs and manufactures new products when orders are placed. Various tasks are concurrently performed, thereby making process management considerably important. It is particularly important to plan and control production activities because production constitutes the largest part of the overall process. Therefore, this study focuses on the development of a production planning system based on an Advanced Planning System (APS). An APS is an integrated planning system that targets supply chain processes in accordance with the principles of hierarchical planning. In this study, a Supply Chain Planning Matrix (SCP-Matrix), which is used as a guideline for APS development, is designed through analysis of shipyard cases. Then, we define the process in detail, starting from long-term production plan as the initial application, and design and implement a long-term production planning system using a component-based development.