• 고신대학교 의과대학 학술지
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• 제33권3호
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• pp.347-357
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• 2018

Objectives: Few studies of pediatric Epstein-Barr virus (EBV)-associated infectious mononucleosis (IM) have been conducted in Korea. We evaluated the clinical features of children with IM to define differences according to age. Methods: We conducted retrospective chart reviews of 68 children aged 0 to 15 years who were diagnosed by EBV-associated IM with EBV-Viral Capsid Antigen(VCA) IgM at laboratory test and were admitted between 2010 and 2014. The children were classified into four age groups: aged 0-3, 4-6, 7-9, and 10-15 years. Results: The age distribution of patients was as follows: 19 (27.9%) 0-3, 25 (36.8%) 4-6, 13 (19.1%) 7-9, and 11 (16.2%) 10-15. Fever was the most common presentation regardless of age. It was more common in the 0-3 group than the 4-6 group (P = 0.018). Pharyngitis was more common in the 7-9 group than the 0-3 group (P = 0.048), and myalgia was more common in the 10-15 group than the 0-3 group (P = 0.007). Pharyngitis was accompanied by lymphadenopathy, protracted fever, and rash. In the 0-3 age group, the prevalence of rash was higher while the percentage of atypical lymphocytes was lower, but there was no statistical support for this tendency. There were no differences in the frequency of hepatosplenomegaly or laboratory findings between age groups. Conclusions: IM is not uncommon in young children and its clinical presentation varies with age. Therefore, IM should be suspected in young febrile children with pharyngitis and rash despite low percentages of atypical lymphocytes.

• 한국지형학회지
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• 제23권2호
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• pp.47-59
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• 2016

The formation age and depositional environment of the marine terrace I of the estimated paleoshoreline altitude of 18m in Sanhari of Ulsan coast, southeastern Korea were investigated on the basis of examination of lithofacies and stratigraphy of terrace deposits. Marine deposits of the terrace is composed of rounded boulders(70cm in diameter) and rounded pebbles(1.0cm in diameter) which overlay them. The above rounded boulders which lie on the paleo-shore platform are considered to have been formed by wave abrasion in the same period that the paleo-shore platform was developed. The rounded pebbles which lie on the rounded boulder layer are considered to have been deposited in gravel beach and berm environment, judging from the laminae developed in this layer. The paleo-shore platform and marine rounded gravel layer of the terrace are assumed to have been formed in the large transgression period of the Last Interglacial culmination stage(MIS 5e), judging from the comparision of the formation age of 125ka B.P. of Juckcheon terrace I in the adjacent Pohang coast which was dated by amino acid dating. The terrestrial deposit of this terrace was largely composed of angular and subangular gravel mixed with marine rounded pebble which has been carried away mainly from the deposit of previous marine terraces and redeposited in this terrace. The lowest peat layer of terrastrial deposit was considered to have been deposited during the period from the late MIS 5e which is the estimated finishing time of deposition of the above marine gravels to the early stage of following regression period(MIS 5d) in which the sea level was still high. The sediments of angular and subangular gravel deposit which lie on this peat layer were assumed to have been deposited during the period from the early stage of the first regression period(MIS 5d) of the Last Interglacial to the Last Glacial. The lower part of the angular gravel layer is composed of the deposits of the fluvial and colluvial sediments, whereas most of the upper and middle part of the layer is mainly composed of angular gravels of colluvial sediments formed in the cold environment.

• Journal of Nutrition and Health
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• 제54권5호
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• pp.435-447
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• 2021

Purpose: Body adiposity is negatively correlated with hepatic iron status, and Korean pine nut oil (PNO) has been reported to reduce adiposity. Therefore, we aimed to study the effects of PNO on adiposity, hepatic mineral status, and the expression of genes and proteins involved in iron absorption. Methods: Five-week-old male C57BL/6 mice were fed a control diet containing 10% kcal from PNO (PC) or soybean oil (SBO; SC), or a high-fat diet (HFD) containing 35% kcal from lard and 10% kcal from PNO (PHFD) or SBO (SHFD). Hepatic iron, copper, and zinc content; and expression of genes and proteins related to iron absorption were measured. Results: HFD-fed mice had a higher white fat mass (2-fold; p < 0.001), lower hepatic iron content (25% lower; p < 0.001), and lower hepatic Hamp (p = 0.028) and duodenal Dcytb mRNA levels (p = 0.037) compared to the control diet-fed mice. Hepatic iron status was negatively correlated with body weight (r = -0.607, p < 0.001) and white fat mass (r = -0.745, p < 0.001). Although the PHFD group gained less body weight (18% less; p < 0.05) and white fat mass (18% less; p < 0.05) than the SHFD group, the hepatic iron status impaired by the HFD feeding did not improve. The expression of hepatic and duodenal ferroportin protein was not affected by the fat amount or the oil type. PNO-fed mice had significantly lower Slc11a2 (p = 0.022) and Slc40a1 expression (p = 0.027) compared to SBO-fed mice. However, the PC group had a higher Heph expression than the SC group (p < 0.05). The hepatic copper and zinc content did not differ between the four diet groups, but hepatic copper content adjusted by body weight was significantly lower in the HFD-fed mice compared to the control diet-fed mice. Conclusion: HFD-induced obesity decreased hepatic iron storage by affecting the regulation of genes related to iron absorption; however, the 18% less white fat mass in the PHFD group was not enough to improve the iron status compared to the SHFD group. The hepatic copper and zinc status was not altered by the fat amount or the oil type.

• 한국응용과학기술학회지
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• 제38권5호
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• pp.1302-1313
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• 2021

본 연구는 가미수미원(백하수오 10 g,; 당귀 6 g; 구기자 8 g; 화피 6 g; 선태 3 g; 홍화 2 g)에 방기(Sinomenium acutum R.) 4 g의 첨가 여부에 따라 각각 열수추출물은 GS±SC(DW), 80% 에탄올 추출물은 GS±SC(EtOH)로 표기 하였다. 각 추출물은 항산화를 측정하기 위해 다음과 같은 연구를 수행하였다. HPLC를 통한 방기 지표물질 함량측정, 중금속 검사 기준 측정, ABTS/DPPH 라디칼 소거능 측정, SOD 유사 활성능 측정, ROS 및 NO 생성량을 측정하였다. 방기 지표물질 중 sinomenine의 함량은 열수 추출물에서, decursin은 에탄올 추출물에서 더 높게 확인되었다. 중금속 측정 결과 기준치 적합으로 확인되었다. ABTS/DPPD 라디칼 소거능을 측정한 결과 GS+SC(EtOH)의 소거능이 가장 높게 나왔으며, 상대적으로 열수보다 에탄올 추출이 라디칼 소거율이 높게 확인되었다. 그러나 SOD의 경우 열수 추출에서 상대적으로 유사 활성능이 높게 확인되었다. ROS 생성의 경우 열수 추출물이 에탄올 추출에 비해 유의하게 감소시켰으며, NO의 생성은 에탄올 추출물이 상대적으로 더 유의하게 감소시키는 것을 확인하였다. 본 연구 결과에서 GS+SC(EtOH)이 라디컬 소거능 및 NO 감소를 높게 나타낸 것으로 확인되어 산화적스트레스 후, 생성된 활성산소의 제거에 좀 더 영향을 미치는 것으로 판단된다. 향 후 지속적인 효능 심화 연구를 통해 조성물을 활용한 화장품 및 기능성 원료의 소재로서의 가능성이 높을 것으로 사료된다.

• 한국정보통신학회논문지
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• 제24권12호
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• pp.1704-1710
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• 2020

컨테이너 검색을 위해 사용되는 고에너지 X-선 영상획득용 검출기는 입사되는 고에너지 X-선을 효과적으로 획득하기 위하여 MeV X-선 수집이 충분히 수행될 수 있는 두께의 섬광체를 사용한다. 컨테이너 검색기에서는 섬광체에 입사되는 X-선의 에너지는 일반적으로 최대 9MeV의 X-선이 사용된다. 그러므로 고에너지 X-선 광자를 효과적으로 수집하기 위해서는 수 cm 두께의 섬광체가 이용되어야 하며 섬광체의 두께는 신호의 수집효율에 영향을 미치게 된다. 본 연구에서는 컨테이너 검색에 사용되는 CdWO4 섬광체와 소면적의 센서를 활용한 영상검출기의 설계조건에 대한 연구를 기술하고 있다. 이를 위하여 본연구에서는 섬광체의 적절한 두께와 섬광체 표면의 반사율에 따른 빛 수집효율을 계산하기 위하여 MCNP6와 DETECT2000을 활용하여 다양한 조건에서 X-선 거동과 빛의 거동에 대한 모사를 수행하였다. 빛 수집효율 계산결과 섬광체 표면의 반사율이 낮은 경우 대략 15 ~ 20mm 두께의 섬광체를 선정하는 것이 적합하였으나 반사율이 높아짐에 따라 대략 25 ~ 30mm 두께의 CdWO4 섬광체를 선정하는 것이 적합한 것으로 확인되었다.

• Molecules and Cells
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• 제44권1호
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• pp.26-37
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• 2021

Human papillomaviruses (HPVs) cause cellular hyperproliferation-associated abnormalities including cervical cancer. The HPV genome encodes two major viral oncoproteins, E6 and E7, which recruit various host proteins by direct interaction for proteasomal degradation. Recently, we reported the structure of HPV18 E7 conserved region 3 (CR3) bound to the protein tyrosine phosphatase (PTP) domain of PTPN14, a well-defined tumor suppressor, and found that this intermolecular interaction plays a key role in E7-driven transformation and tumorigenesis. In this study, we carried out a molecular analysis of the interaction between CR3 of HPV18 E7 and the PTP domain of PTPN21, a PTP protein that shares high sequence homology with PTPN14 but is putatively oncogenic rather than tumor-suppressive. Through the combined use of biochemical tools, we verified that HPV18 E7 and PTPN21 form a 2:2 complex, with a dissociation constant of 5 nM and a nearly identical binding manner with the HPV18 E7 and PTPN14 complex. Nevertheless, despite the structural similarities, the biological consequences of the E7 interaction were found to differ between the two PTP proteins. Unlike PTPN14, PTPN21 did not appear to be subjected to proteasomal degradation in HPV18-positive HeLa cervical cancer cells. Moreover, knockdown of PTPN21 led to retardation of the migration/invasion of HeLa cells and HPV18 E7-expressing HaCaT keratinocytes, which reflects its protumor activity. In conclusion, the associations of the viral oncoprotein E7 with PTPN14 and PTPN21 are similar at the molecular level but play different physiological roles.

• 한국동물위생학회지
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• 제43권4호
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• pp.227-236
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• 2020

In this study, we have developed 3D8 scFv transgenic pig (TG) by microinjection of fertilized one-cell pig zygotes (2.17%). The effect of 3D8 scFv TG on porcine reproductive and respiratory syndrome virus (PRRSV) resistance were evaluated through PRRSV VR2332 (1×103 TCID50/mL) challenge and transmission experiments. As a result, the average daily weight gain (ADWG) of TG increased compared to the wild type pigs (WT) in PRRSV challenge groups and the serum viremia levels of the TG was significantly lower than of WT on the 7 day and 21 day after infection, meaning that the viral shedding was suppressed by 3D8 scFv expression. These results suggest that the expression of 3D8 scFv in pig could suppress spreading of infected virus to pigs sharing a room.

• 천문학회지
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• 제54권3호
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• pp.89-102
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• 2021

Even in an era where 8-meter class telescopes are common, small telescopes are considered very valuable research facilities since they are available for rapid follow-up or long term monitoring observations. To maximize the usefulness of small telescopes in Korea, we established the SomangNet, a network of 0.4-1.0 m class optical telescopes operated by Korean institutions, in 2020. Here, we give an overview of the project, describing the current participating telescopes, its scientific scope and operation mode, and the prospects for future activities. SomangNet currently includes 10 telescopes that are located in Australia, USA, and Chile as well as in Korea. The operation of many of these telescopes currently relies on operators, and we plan to upgrade them for remote or robotic operation. The latest SomangNet science projects include monitoring and follow-up observational studies of galaxies, supernovae, active galactic nuclei, symbiotic stars, solar system objects, neutrino/gravitational-wave sources, and exoplanets.

• 한국균학회지
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• 제49권1호
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• pp.67-79
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• 2021

금강 상류와 태안, 순천만 등 해안주변환경의 야생효모들의 효모 종 분포특성을 조사하고 국내 미발표된 효모들을 선별하여 이들의 균학적 특성들을 알아보고자 금강 상류인 충남 금산의 천내강과 서해안에 있는 청포대 해수욕장 및 순천만 습지대 주변의 물과 토양들로부터 야생효모들을 분리, 동정하였고 이들 중 국내 미기록 효모들을 선별하여 이들의 균학적 특성을 조사하였다. 금산의 천내강 주변 물과 토양 40점에서 49종의 야생효모들을 분리, 동정하였고, 태안의 청포대 해수욕장과 순천만 습지대 주변 물과 식물체 부식물 및 토양 80점에서 각각 56종, 36종의 야생효모 들을 분리, 동정하였다. 이들지역에서분리, 동정한야생효모들중C. michaelii NNIBRFG28278, Sp. japonicus NNIBRFG28271, D. buhagiarii NNIBRFG28279, U. spermophora NNIBRFG28273, N. pomicola NNIBRFG31590, C. natalensis NNIBRFG31591, C. pseudorhagii NNIBRFG31592, C. santamariae NNIBRFG31593, Cu. terricola NNIBRFG31594, M. nashicola NNIBRFG31595등 10균주들이 국내 미기록 야생효모들로 최종 선별되었다. 이들 미기록 효모들은C. pseudorhagii NNIBRFG31592과 Cu. terricola NNIBRFG31594 만이 구형이고 나머지 균들은 난형으로 Sp. japonicus NNIBRFG28271와 C. natalensis NNIBRFG31591 두 균주만이 포자를 생성하였다. U. spermophora NNIBRFG28273균주는 vitamin-free배지에서도 생육이 아주 양호하였고 Sp. japonicus NNIBRFG28271균주는 15% NaCl을 함유한 YPD배지에서도 생육이 양호한 호염성균이었다.

• 국제지역연구
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• 제21권4호
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• pp.195-222
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• 2017

본고는 글로벌 경쟁 속에서 지역의 성장과 발전을 도모하기 위한 연구로서 지역의 경쟁우위를 결정하는 요인, 원천 및 효과에 대해 분석하였다. 포터의 국가경쟁력 모델을 원용한 3중 다이아몬드 모델에 의거 제주관광산업을 사례연구하였다. 분석 결과 제주관광산업은 뛰어난 자연경관, 도외 관광전문인력, 공항과 항구 등의 사회간접자본, 대규모 외래관광객, 쇼핑센터와 카지노 등의 관련산업의 성장, 올레길 조성과 중국정부의 해외여행자유화 조치 등의 우연한 사건 등의 경쟁우위 요인들을 기반으로 2013년부터 1천만 관광객을 맞이하게 되었다. 이들 경쟁우위 요인들은 도내, 국내 및 해외지역에서 유래하는 경영자원에 그 기반을 두고 있기 때문에 이들 자원을 확보 및 활용하는 제주관광업체들의 경영역량이 지역 경쟁우위 제고에서 중요하다는 점을 제시하였다. 제주관광산업은 지난 5년 동안 경쟁우위가 향상되고 있으나 지역경제와의 유기적 관계 부족으로 인해 그 효과가 크지 않은 것으로 분석되어 도민들의 생활의 질을 향상시키기 위한 노력이 요구되고 있다. 본고는 산업연구를 바탕으로 국가단위의 경쟁우위를 분석한 기존 연구와 달리 지역단위의 경쟁우위 요인과 함께 이들 요인들이 지역, 국내 및 해외 등 어디에서 유래하는가를 분석한 다음 경쟁우위 요인의 특성과 원천이 지역경제에 주는 효과를 분석하였다. 이를 통해 포터의 국가경쟁우위 분석 틀을 지역경쟁우위 분석 틀로 확장하고 이를 사례분석을 통해 검증하였다. 또한 매력도를 바탕으로 관광목적지의 경쟁력을 주로 연구한 기존 연구와 달리 다양한 경쟁우위 요인을 체계적으로 분석하여 지역의 경쟁우위를 연구하였다.