• Korean Journal of Oriental Medicine
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• v.2 no.1
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• pp.314-326
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• 1996

Experimental studies were done to research the clinical effect of Insamyunpye-H wan on viscousity of mucin solution, pulmonary thromboembolism, oxygen consumption in $O_3$-exposed and Lung TBA in rats and mice. The result was obtained as follows : 1. In the effect of viscosity sampled from mucin, Insamyunpye-Hwan was revealed to have a significant effect of decrease in the rate of viscousity (p<0.01). 2. In the effect of sodium aracdonic acid induced pulmonary thromboembolism, I samyunpye-Hwan was revealed to have an effect of increasing the number of survival, but were not significant 3. In the effect of ADP induced pulmonary thrornboembolism, Insamyunpye-Hw an was revealed to have an effect of increasing the number of survival, but were not significant 4. In the effect of oxygen cansumption values in rats exposed-$O_3$, Insarnyunpye-Hwan was revealed to have a significant effect (p<0.05). 5. In the effect of the lung TBA values in rats exposed-$O_3$, Isamyunpye-Hwan was revealed to have a significant effect (p<0.05). In connection with the results of the studies, Insamyunpye-Hwan is concluded to be effective on the treatment of cough and lung and respiratory organ damages.

• The Journal of Korean Medicine
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• v.15 no.2 s.28
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• pp.173-183
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• 1994

The results about effects of Maecmoondongtang on the pulmonary function of $SO_2$ exposed rats were summerized as follows: 1. Maecmoondongtang reavealed significant effect on decrease of the lung weight in pulmomary edema of rats. 2. Maecmoondongtang reavealed very significant effect on decrease of the TBA value of lung. 3. It was recognized Maecmoondongtang had signiftcant effect on decrease of glycoprotein contents in trachea. 4. It was recognized maecmoondongtang had significant effect on decrease of mucos area in tracheal epithelium. 5. Maecmoondongtang had effects on recovery of the cillia cells of tracheal epithelium and inhibition of mucous secretion. According to the above result. it was recognized Gamimaecdongtang had significant effect on decrease of lung weight in pulmonary edema. the TBA value. glycoprotein contents in trachea. and mucous area in tracheal epithelium. and recovery of the cillia cells of tracheal epithelium. and inhibition of mucous secretion. So I think we can take advantage of this medicine very usefully for treatment of pulmonary edema. pheumonia. acute and chronic bronchitis etc.

• The Journal of Internal Korean Medicine
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• v.15 no.2
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• pp.260-273
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• 1994

This study attempted to investigate the effects of Sojagangkitang and Gamisojagangkitang on the variation of lung thiobarbituric acid(TBA) value, tracheal glycoprotein, serum sodium ion$(Na^+)$ contents, serum potassium ion$(K^+)$ contents ; immediatly type allergy reaction, delayed type allergy reaction in rats and mice. The results were as follows: 1. Sojagangkitang and Gami-sojagangkitang revealed significant effect on immediatly type hypersensitivity responds to histamine. 2. Sojagangkitang and Gami-sojagangkitang revealed significant effect on delayed type hypersensitivity responds to picryl chloride. 3. Sojagangkitang and Gami-sojagangkitang revealed significant effect on delayed type hypersensitivity responds to SRBC, effect of Gami-sojagangkitang was outstanding. 4. Lung thiobarbituric acid(TBA) value was decreased with statistical significance. 5. Sojagangkitang and Gami-sojagangkitang revealed decreasing effect on Tracheal glycoprotein contents, effect of Gami-sojagangkitang was outstanding. 6. Sojagangkitang and Gami-sojagangkitang revealed decreasing effect on phenol red excretion of respiratory tract. 7. Viscosity of mucine solution was decreased in proportion to increasing dosage of the Sample. 8. Serum $Na^+$ contents was not recognized significance. 9. Sojagangkitang and Gami-sojagangkitang revealed decreasing effect on Serum $K^+$ contents, effect of Gami-sojagangkitang were outstanding. According to the above results, it seems that Sojagangkitang and Gami-sojagangkitang can be applied for asthma, chronic obstructive pulmonary diseases, allergic respiratory diseases.

• The Journal of Korean Medicine
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• v.17 no.2 s.32
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• pp.203-213
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• 1996

Experimental studies were done to research the clinical effect of Insamyounpaesan and Insamyounpaesangamibang on viscousity of mucin solution, pulmonary thromboembolism, oxygen consumption in $O_3$ - exposed and Lung TBA in rats and mice. The result was obtained as follows: 1. In the effect of Insamyounpaesan and I nsamyounpaesangami-bang on the rate of viscousity sampled from mucin, Insam-younpaesan and Insamyounpaesangamibang were revealed to have a significant effect of decreasinf the rate of viscousity (p<0.05). 2. In the effect of Insamyounpaesan and Insamyounpaesangami-bang on sodium arachidonic acid induced pulmonary thrombo-embolism, Insamyounpaesan and Insamyounpaesangarnibang were revealed to have an effect of increasing the number of survival(p<0,05), but were not significant. 3. In the effect of Insamyounpaesan and Insamyounpaesangami-bang on ADP induced pulmonary thromboembolism, Insam-younpaesangamibang were revealed to have an effect of increasing the number of survival(p<0.05), but were not significant. 4. In the effect of Insamyounpaesan and Insamyounpaesangami-bang on oxygen cansumption values in rats exposed, Insamyounpaesan and Insamyounpaesangamibang were revealed to have a significant effect on the care of lung damages (p<0.05), but were not significant by Duncan's multiple comparision test. 5. In the effect of Insamyounpaesan and Insamyounpaesangami-bang on the lung TBA values in rats exposed $-O_3$, Insam-younpaesangamibang were revealed to have a significant effect (p<0.05) on the care of lung damages. In connection with the results of the studies, Insamyounpaesan and Insamyounpaesangamibang are concluded to be effective on the treatment of cough and lung and respiratory organ damages.

• Journal of Physiology & Pathology in Korean Medicine
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• v.16 no.3
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• pp.577-583
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• 2002

Experimental studies were done to research the Clinical effects of Insambakhab-tang on the Anti-allergic effect and pulmonary function of O₃ intoxicated Mice. Anti-allergic effect experiment consisted of vascular permeability responses to intradermal histamine and serotonin, 48hrs homologous passive cutaneous anaphylaxis provoked by the IgE-like antibody against egg white albumin, and delayed type hypersensitivity responses to Picryl Chloride and SRBC. Pulmonary function of O₃ intoxicated Mice experimental consisted of pulmonary thromboembolism (Sodium Arachidonate-induced and ADP-induced), lung TBA value, and serum Na/sup +/, K/sup +/, Cl/sup +/ level. The results obtained as follows; 1. In the effects of Insambakhab-tang on the pulmonary thromboembolism by Sodium Arachidonic acid and ADP, Insambakhab-tang group revealed significant effect. 2. In the effects of Insambakhab-tang on the vascular permeability responses to intradermal histamine, Insambakhab-tang group revealed significant effect. 3. In the effects of Insambakhab-tang on the vascular permeability responses to intradermal serotonine, Insambakhab-tang group revealed significant effect. 4. In the 48hrs homologous passive cutaneous anaphylaxis provoked by the IgE-like antibody against egg white albumin, Insambakhab-tang group revealed significant effect. 5. In the delayed type hypersensitivity responses to Picryl Chloride, Insambakhab-tang group revealed significant effect. 6. Insambakhab-tang group revealed significant effect on decrease of the lung TBA value of lung. 7. In the effects of Insambakhab-tang on Serum Na/sup +/, K/sup +/ Level in O₃-intoxicated Mice. Insambakhab-tang group revealed none significant effect, but In the effects of Insambakhab-tang on Serum Cl/sup +/ Level in O₃-intoxicated Mice, Insambakhab-tang group revealed significant effect.

• The Journal of Korean Medicine
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• v.18 no.1
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• pp.208-217
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• 1997

Experimental studies were done to research the clinical effect of Banhaonpyetang and Banhaonpyetanggarnibang estimated the level of $pO_2,\;pCO_2$, and pH, the concentration of $HCO_{3}-ion$, the lung TBA(thiobarbituric acid) values in blood and oxygen consumption values in blood in $O_{3}-intoxicated$ rats. The results were obtained as follows. 1. Both Banhaonpyetang and Banhaonpyetanggamibang revealed the increasing effect with statistically significant on the blood $pO_2$ level in $O_{3}-intoxicated$ rats 2. Both Banhaonpytang and Banhaonpyetanggarnibang revealed the decreasing effect with statistically significant on the blood $pO_2$ level in $O_{3}-intoxicated$ rats 3. Both Banhaonpyetang and Banhaonphetanggarnibang revealed the decreasing effects with statistically significant on the blood $HCO_{3}level$ in $O_{3}-intoxicated$ rats. 4. Both Banhaonpyetang and Banhaonpyetanggamibang revealed the increasing effects with statistically significant on the blood pH level in. $O_{3}-intoxicated$ rats. 5. Both Banhaonpyetang and Banhaonpyetanggamibang revealed the decreasing effects with statistically significant on the Oxygen consumption values in $O_{3}-intoxicated$ rats. 6. Both Banhaonpyetang and Banhaonpyetanggamibang revealed the decreasing effects with statistically significant on the Lung TBA values in $O_{3}-intoxicated$ rats. According to the above findings, it is suggested that Banhaonpyetang and Banhaonpyetanggamibang retain effectiveness on the lung damages and can be used for treatment of respiratory disease.

• The Journal of Pediatrics of Korean Medicine
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• v.12 no.1
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• pp.231-256
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• 1998

Experimental studies were done to research the clinical effects of Chihyosan and Chihyosangamibang on the Anti-allergic effect and pulmonary function of $O_3$ intoxicated Rats. Anti-allergic effect experiment consisted of vascular permeability responses to intradermal histamine and serotonin, 48hrs homologous passive cutaneous anaphylaxis provoked by the IgE-like antibody against egg white albumin, and delayed type hypersensitivity responses to Picryl Chloride and SRBC. Pulmonary function of $O_3$ intoxicated Rats experiment consisted of lung TBA value, water Contents of the lung, oxygen consumption time, and arterial blood $pCO_2,\;pO_2,\;HCO_3^-$, pH level. The results obtained as follows; 1. In the effects of Chihyosan and Chihyosangamibang on vascular permeability responses to intradermal histamine, both of chihyosan and Chihyosangamibang group revealed significant effect. 2. In the effects of Chihyosan and Chihyosangamibang on vascular permeability responses to intradermal serotonin, both of chihyosan and Chihyosangamibang group revealed significant effect. 3. In the 48hrs homologous passive cutaneous anaphylaxis provoked by the IgE-like antibody against egg white albumin, Chihyosan groups revealed significant effect, but Chihyosangamibang groups revealed none significant effect. 4. In the delayed type hypersensitivity responses to Picryl Chloride, Chihyosan and Chihyosangamibang groups revealed none significant effect. 5. In the delayed type hypersensitivity responses to. SRBC, Chihyosan revealed none significant effect, but Chihyosankamibang revealed significant effect. 6. Both of Chihyosan and Chihyosangamibang groups revealed significant effect on decrease of the lung TBA value of lung. 7. Both of Chihyosan and Chihyosangamibang groups revealed significant effect on decrease of the water contents of right and left lung. 8. Both of Chihyosan and Chihyosangamibang groups revealed significant effect on decrease of oxygen consumption time. 9. In the decrease effect of arterial blood $pCO_2$ level, both of Chihyosan and Chihyosangamibang groups revealed none significant effect. 10. In the increase effect of arterial blood $pO_2$ level, both of Chihyosan and Chihyosangamibang groups revealed none significant effect. 1. In the decrease effect of arterial blood $HCO_3^-$ level, both of Chihyosan and Chihyosangamibang groups revealed significant effect. 12. In the increase of arterial blood pH level, Chihyosangamibang groups revealed none significant effect, but Chihyosan groups revealed significant effect. According to above stated results, both of Chihyosan and Chihyosangamibang are very usefully for treatment of cough, asthma, chronic obstructive pulmonary diseases and allergic pulmonary diseases.

• The Journal of Korean Medicine
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• v.16 no.2 s.30
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• pp.271-280
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• 1995

The experimental studies were done to research the clinical effects of lnsambaekhabtang and Insambaekhabtanggamibang on the xylene-poisoned-lung damage and hypoprothrombinemia induced by warfarin injection in rats and mice. The results are as follows: 1. As to the hemostatic time in mice, lnsambaekhabtang was recongnized no significance but Insambaekhabtanggamibang was recognized significance( P<0.02 ). 2. As to the prothrombine time in rats. lnsambaekhabtang and lnsambaekhabtanggamibang Were recognized significance ( P<0.05, P<0.05 ). 3. As to the recalcification in rats, Insambaekhabtang and lnsambaekhabtanggamibang Were recognized significance ( P<0.05, P<0.02). 4. As to the lung TBA values in Xylene intoxicated rats, Insambaekhabtang was recognized significance but Insambaekhabtanggamibang was no recognized significance ( P<0.05). 5. As to the oxygen consumption in Xylene intoxicated rats, Insambaekhabtang and lnsambaekhabtanggamibang were no recognized significance. According to the above findings, it is suggested that the solid extract of Insambaekhabtang and Insambaekhabtanggamibang revealed effects on the xylene-poisoned-Iung damage and hypoprothrombinemia induced by warfarin injection in rats and mice.

• The Journal of Korean Medicine
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• v.17 no.2 s.32
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• pp.178-190
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• 1996

This experiment was performed in order to study the effects of Haepyoyijintang on the pulmonary injury caused by $SO_2$. Healthy adult male rats weighting about 250g were divided into 4 groups- the Normal group, the Control group, the group of Haepyoyijintang administration for 5 days after $SO_2$ gas exposure (Sample I ), and the group of Haepyoyijintang administration for 10 days before and for 5 days after $SO_2$ gas exposure (SampleⅡ). The results were obtained as follows; 1. In the total number of leucocyte, Sample I and Sample II decreased significantly compared with Control group. 2. In the erythrocyte sedimentation rate, Sample I and Sample Ⅱ decreased significantly compared with Control group. 3. In the lung weight, Sample I and Sample II decreased significantly compared with Control group. 4. In the lung TBA level, only Sample II decreased significantly compared with Control group. 5. In the tracheal glycoprotein level, Sample I and Sample II decreased significantly compared with Control group. According to the above results, Haepyoyijintang has significant effects on the pulmonary injury caused by $SO_2$ in rats.

• The Journal of Korean Medicine
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• v.18 no.1
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• pp.344-356
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• 1997

This experiment was performed in order to study the clinical effect of Sojadodamgangkitang on the pulmonary injury caused by $SO_2$. Healthy adult male rats weighing about 250g were divided into 4 groups-the Normal group, the Control group, the group of Sojadodamgangkitang administration for 5 days after $SO_2$ gas exposure(Sample I), and the group of Sojadodamgangkitang administration for 10 days before and for 5days after $SO_2$ gas exposure(Sample II). The results were obtained as. follows; 1. In comparison with Control group, Sample I and Sample II were revealed significant effect on the total number of leucocyte. 2. In comparison with Control group, Sample I and Sample II were revealed significant effect on. the erythrocyte sedimentation rate. 3. In the effect on the lung weight, Sample I and Sample II were revealed significantly. 4. In the effect on the lung TBA level, only Sample II was revealed significantly. 5. In the effect on the tracheal glycoprotein level, Sample I and Sample II were revealed significantly. According to above results, Sojadodamgangkitang had significant effect on the pulmonary injury caused by $SO_2$ in rats.