• Molecules and Cells
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• 제28권2호
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• pp.111-117
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• 2009

The CHRM3 gene is a member of the muscarinic acetylcholine receptor family that plays important roles in the regulation of fundamental physiological functions. The evolutionary mechanism of exon-acquisition and alternative splicing of the CHRM3 gene in relation to transposable elements (TEs) were analyzed using experimental approaches and in silico analysis. Five different transcript variants (T1, T2, T3, T3-1, and T4) derived from three distinct promoter regions (T1: L1HS, T2, T4: original, T3, T3-1: THE1C) were identified. A placenta (T1) and testis (T3 and T3-1)-dominated expression pattern appeared to be controlled by different TEs (L1HS and THE1C) that were integrated into the common ancestor genome during primate evolution. Remarkably, the T1 transcript was formed by the integration event of the human specific L1HS element. Among the 12 different brain regions, the brain stem, olfactory region, and cerebellum showed decreased expression patterns. Evolutionary analysis of splicing sites and alternative splicing suggested that the exon-acquisition event was determined by a selection and conservation mechanism. Furthermore, continuous integration events of transposable elements could produce lineage specific alternative transcripts by providing novel promoters and splicing sites. Taken together, exon-acquisition and alternative splicing events of CHRM3 genes were shown to have occurred through the continuous integration of transposable elements following conservation.

• 한국항공우주학회지
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• 제34권2호
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• pp.56-67
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• 2006

위성개발 시 비용의 절감과 효율적인 설계 보장을 위해 신뢰성과 고장모드 분석이 필요하지만, COTS 소자를 사용하는 소형위성의 경우 통상 제작자로부터 소자에 대한 실패율이 제공되지 않기 때문에 신뢰성 계산이 어렵다. 이 논문에서는 실패율 예측을 위해 MIL-HDBK-217F의 시험적/경험적 데이터에 기초한 방법을 사용하였고, MIL-HDBK -217F에서 고려되지 않은 방사능 환경을 실패율 예측에 반영하기 위해 방사능 효과들 중 신뢰도에 영향을 미칠 수 있는 $10^-9$failures/device/$10^6$hours 이상의 발생확률을 갖는 SEL 발생확률을 실패율 예측 결과에 추가로 반영하였다. 결국 본 논문은 실패율이 제공되지 않는 COTS 소자를 사용하는 저가 소형위성에 대해 통계적 기법을 이용한 새로운 신뢰성 해석 방법을 제안하고, 현재 개발 중인 25kg급의 초소형위성인 HAUSAT-2에 이 방법을 적용하여 분석한 결과를 보여준다.

• 디지털융복합연구
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• 제20권4호
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• pp.119-126
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• 2022

"인터넷+" 경제 모델의 부상과 급속한 발전으로 인터넷은 사회 경제와 깊이 통합되어 삶의 구석구석을 파고든다. 전자상거래 기업은 내부 투자나 자본 축적을 통한 사업 규모 확대에 비해 효율적인 인수합병(M&A)을 통해 직접 타사를 지배하려는 경향이 강하다. 본 연구의 목적은 인터넷 시대 중국 최대 전자상거래기업인 알리바바의 M&A를 중심으로 M&A 전후의 재무실적 변화를 분석하고자 한다. 본 연구는 M&A가 알리바바의 주가와 주주 재산에 미치는 영향을 보다 직관적으로 제시하기 위해 사건연구 방식으로 시장모델을 선정해 비정상수익률을 측정했다. 연구결과 M&A 이벤트는 단기적으로 알리바바의 주주재산 감소로 이어졌음을 보여준다. 본 연구는 전자상거래기업들의 M&A성과에 대한 이론적 근거를 제시하고 있다.

• BMB Reports
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• 제44권8호
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• pp.529-534
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• 2011

Ribosomal protein S3 (rpS3) is a multifunctional protein involved in translation, DNA repair, and apoptosis. The relationship between rpS3 and cyclin-dependent kinases (Cdks) involved in cell cycle regulation is not yet known. Here, we show that rpS3 is phosphorylated by Cdk1 in G2/M phase. Co-immunoprecipitation and GST pull-down assays revealed that Cdk1 interacted with rpS3. An in vitro kinase assay showed that Cdk1 phosphorylated rpS3 protein. Phosphorylation of rpS3 increased in nocodazole-arrested mitotic cells; however, treatment with Cdk1 inhibitor or Cdk1 siRNA significantly attenuated this phosphorylation event. The phosphorylation of a mutant form of rpS3, T221A, was significantly reduced compared with wild-type rpS3. Decreased phosphorylation and nuclear accumulation of T221A was much more pronounced in G2/M phase. These results suggest that the phosphorylation of rpS3 by Cdk1 occurs at Thr221 during G2/M phase and, moreover, that this event is important for nuclear accumulation of rpS3.

• 한국물환경학회지
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• 제26권6호
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• pp.954-962
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• 2010

The objective of this study was to develop automatic event detection algorithm for groundwater level rise. The groundwater level data and rainfall data in July and August at 37 locations nationwide were analyzed to develop the algorithm for groundwater level rise due to rainfall. In addition, the algorithm for groundwater level rise by ice melting and ground freezing was developed through the analysis of groundwater level data in January. The algorithm for groundwater level rise by rainfall was composed of three parts, including correlation between previous rainfall and groundwater level, simple linear regression analysis between previous rainfall and groundwater level, and diagnosis of groundwater level rise due to new rainfall. About 49% of the analyzed data was successfully simulated for groundwater level rise by rainfall. The algorithm for groundwater level rise due to ice melting and ground freezing included graphic analysis for groundwater level versus time (day), simple linear regression analysis for groundwater level versus time, and diagnosis of groundwater level rise by new ice melting and ground freezing. Around 37% of the analyzed data was successfully simulated for groundwater level rise due to ice melting and ground freezing. The algorithms from this study would help develop strategies for sustainable development and conservation of groundwater resources.

• 감성과학
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• 제11권3호
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• pp.397-418
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• 2008

본 연구는 주관적 안녕감이 긍정적인 사건을 인식하는 비율과 나아가 기억을 재구성하는 인지적 과정에 있어서 어떠한 영향을 미치는지 알아보기 위해 시행되었다. 199명의 학부생들이 일상적으로 일어날법한 긍정적인 사건과 부정적인 사건 40개를 기술한 문장들을 본 후 이에 대한 회상 과제와 재인 과제를 수행하였다. 먼저 사건을 기술한 문장을 본 후 긍정적인 사건과 부정적인 사건에 대한 비율을 응답하게 한 결과, 삶에 대한 만족도가 높은 참가자들이 긍정적인 문장의 비율이 월등히 높은 조건에서 긍정적인 사건의 비율을 실제보다 더 높게 보고하였으며, 또한 긍정적인 비율이 높은 조건에서 주관적 안녕감이 높은 참가자들은 긍정적인 문장을 더 많이 회상했다. 참가자들이 처음 보고한 긍정적인 사건의 비율과 실제 회상한 기억들 중 긍정적인 사건의 비율은 정적인 상관을 가졌다. 그러나 예상과는 달리 재인 과제에서는 참가자들은 주관적 안녕감 수준에 따라 유의미하게 차이나는 오류를 보이지 않았다. 마지막으로 이 연구의 이론적 함의와 후속 연구를 위한 제언이 논의되었다.

• 식물분류학회지
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• 제42권1호
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• pp.13-23
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• 2012

trnL-F 지역은 엽록체 게놈 large single-copy 지역에 위치하며, trnL gene, trnL intron, trnL-F IGS로 구성된다. 본 연구는 한국산 꿩의다리속 내에서 trnL-F 지역의 분자진화와 유연관계를 분석하였다. 갭형질을 이용한 자료의 베이시안과 파시모니 분석에서 몇몇 indels evolution는 분계조를 지지하여 해상력이 좋은 계통수가 나타났다. 한국산 꿩의다리속 내에 cpDNA trnL-F 지역의 indel events는 계통학적으로 유용한 정보를 가지고 있는 것으로 판단된다. 산꿩의다리절(그늘꿩의다리 제외)은 속내에서 가장 먼저 분기한 것으로 나타났고, 나머지 절은 강하게 분계조를 형성하며 분기하였다. 한국산 꿩의다리속 내에 trnL-F 지역은 뉴클레오티드의 다양한 공간적 분포 변이와 주로 transversion에 따른 염기치환 등 다양한 진화적 패턴을 가지고 있었다.

• 성인간호학회지
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• 제17권4호
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• pp.668-678
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• 2005

Purpose: The purpose of this study was to provide the basic data of a comprehensive counter-plan to promote health for people by comparing various factors related to cancer outbreak factors including general characteristics, health-related lifestyles, health promoting behaviors, perceived healthy status, life event stress and health care seeking behaviors with cancer patients and health people. Method: The study was designed to be a retrospective-comparison-survey-study and its data was collected through 5 types of questionnaires from September 2003 to December 2003. Results: Cancer patients had lower education and household income, and many of them had no occupation. Cancer patients had a higher rate of smoking and drinking periods. Exercise level was higher in healthy people. However, Cancer patients were better in sleep and rest. In comparison with health promoting behaviors, it was higher in healthy people than in cancer patients but the two groups had no significant differences statistically. The perceived health status was higher in healthy people than in cancer patients. The health care seeking behaviors were higher in healthy people than in cancer patients. Cancer patients and healthy people's life event stress had no significant differences statistically. Conclusion: As a result of comparative analysis of cancer patients and healthy people's health risk factors, smoking, drinking period, regular exercise and health care seeking behaviors were suggested as direct or indirect risk factors for cancer patients. These finding can be applied to health promoting behavior programs to keep and promote optimal health status as well as to prevent cancer disease.

• 기록학연구
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• 제66호
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• pp.37-67
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• 2020

최근 산업유산은 도시재생 바람을 타고 문화시설로 변형되며 관심을 받고 있다. 이러한 관심은 주로 외관에 집중되어 있으며 설명 역시 거대서사로 축약된 경우가 많으며, 장소성은 충분히 전승되지 못하고 있다. 산업유산이 가진 장소성은 역사적 기억 뿐 아니라 개인의 기억을 포함하고 있다. 정체성의 근원이 될 수 있는 장소성이 보존되고 활용되기 위해서는 장소기억이 수집되어 관리되어야 한다. 본 연구는 이를 위해 개인의 생애서사를 중심으로 장소기억을 수집하는 방안을 제시하였다. 안동역과 청주연초제조창 수집사례를 이용하여 생애서사를 사건으로 분해하였으며, 이를 장소기억으로 재해석하는 과정을 통해 산업유산 장소 아카이빙 실행을 제안하였다. 이러한 방법론은 기존의 방법론을 보완할 수 있다는데 의미를 가진다.

• 한국수자원학회:학술대회논문집
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• 한국수자원학회 2015년도 학술발표회
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• pp.236-236
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• 2015

Flood is one of the major natural disasters affecting millions of people. Thailand also, frequently faces with this type of disaster. Especially, 2011 mega flood in Central Thailand, inundated highway severely attributed to the failure of national economic and risk to life. Lesson learned from such an extreme event caused flood monitoring and warning becomes one of the sound mitigations. The highway flood hazard mapping accomplished in this research is one of the strategies. This is due to highway flood is the potential risk to life and limb, and potential damage to property. Monitoring and warning therefore help reducing live and property losses. In this study, degree of highway flood hazard was assessed by weighting factors for each cause of the highway flood using Multi Criteria Analysis (MCA) based Analytic Hierarchy Process (AHP). These weighting factors are the essential information to classify the degree of highway flood hazard to enable pinpoint on flood monitoring and flood warning in hazard areas. The highway flood causes were then investigated. It was found that three major factors influence to the highway flood are namely the highway characteristics, the hydrological characteristics and the land topography characteristics. The weight of importance for each cause of the highway flood in the whole country was assessed by weighting 3 major factors influence to the highway flood. According to the result of MCA analysis, the highway, the hydrological and the land topography characteristics were respectively weighted as 35, 35 and 30 percent influence to the cause of highway flood. These weighting factors were further utilized to classify the degree of highway flood hazard. The Weight Linear Combination (WLC) method was used to compute the total score of all highways according to each factor. This score was later used to categorize highway flood as high, moderate and low degree of hazard levels. Highway flood hazard map accomplished in this research study is applicable to serve as the handy tool for highway flood warning. However, to complete the whole warning process, flood water level monitoring system for example the camera gauge should be installed in the hazard highway. This is expected to serve as a simple flood monitor as part of the warning system during such extreme or critical event.