• BMB Reports
• /
• 제48권7호
• /
• pp.371-372
• /
• 2015

MicroRNAs (miRNAs) can regulate the expression of genes that are involved in multiple cellular pathways. However, their targets and mechanism of action associated with the autophagy pathway are not fully investigated yet. EWSR1 (EWS RNA-Binding Protein 1/Ewing Sarcoma Break Point Region 1) gene encodes a RNA/DNA binding protein that is ubiquitously expressed and plays roles in numerous cellular processes. Recently, our group has shown that EWSR1 deficiency leads to developmental failure and accelerated senescence via processing of miRNAs, but its role in the regulation of autophagy remains elusive. In this context, we further investigated and found that EWSR1 deficiency triggers the activation of the DROSHA-mediated microprocessor complex and increases the levels of miR125a and miR351, which directly target Uvrag. Interestingly, the miR125a- and miR351-targeted reduction of Uvrag led to the inhibition of autophagy in both ewsr1 knockout (KO) MEFs and ewsr1 KO mice. In summary, our study demonstrates that EWSR1 is associated with the posttranscriptional regulation of Uvrag via miRNA processing. The regulation of autophagy pathway in miRNAs-Uvrag-dependent manner provides a novel mechanism of EWSR1 deficiency-related cellular dysfunction. [BMB Reports 2015; 48(7): 371-372]

• 대한산업공학회지
• /
• 제33권3호
• /
• pp.373-380
• /
• 2007

In this paper, we consider a new lot-sizing and scheduling problem (LSSP) that minimizes the sum of production cost, setup cost and inventory cost. Setup carry-over and overlapping as well as demand splitting are considered. Also, maximum number of setups for each time period is not limited. For this LSSP, we have formulated a mixed integer programming (MIP) model, of which the size does not increase even if we divide a time period into a number of micro time periods. Also, we have developed an efficient heuristic algorithm by combining decomposition scheme with local search procedure. Test results show that the developed heuristic algorithm finds good quality (in practice, even better) feasible solutions using far less computation time compared with the CPLEX, a competitive MIP solver.

• 미생물학회지
• /
• 제53권4호
• /
• pp.337-339
• /
• 2017

본 연구에서 남극 킹 조지 섬 인근에서 채집한 지의류 Psoroma 종에서 분리한 Caballeronia sordidicola 균주 PAMC 26633의 초벌 유전체를 분석하였다. 이전의 연구를 통한 극지방의 지의류에 공생하는 Caballeronia 속 세균의 유전체와 마찬가지로 생물공학 및 생태학적으로 활용가능성 있는 다양한 유전자를 발견할 수 있었다. 이는 다양한 대사 관련 유전자를 포함하며, 탄수화물, 아미노산, 질소/황 대사, 스트레스, 세포막 수송체, 항생제 및 중금속 내성에 관련이 있었다. 파아지와 트랜스포존 유전자가 소수 있었으며, CRISPR 관련 유전자 및 서열은 발견되지 않았다.

• 한국어교육
• /
• 제28권1호
• /
• pp.221-250
• /
• 2017

This study aims to discuss the basic foundations to set levels and language skills for developing a Korean Proficiency Test for young and adolescent learners. Recently, there has been an increase in demand regarding young and adolescent learners from multicultural and overseas backgrounds. However, the current Korean Proficiency Test lacks the appropriate means to determine the Korean proficiency of young and adolescent learners with general purposes of language learning. Therefore, there is an urgent need for developing a specialized and new form of language assessment for young and adolescent learners who are exposed to a foreign language or a second language learning environment. The study examines and analyzes cases of foreign language examinations for young & adolescent learners; furthermore, the objectives and target were set based on the results of a needs analysis and in-depth interviews conducted among teachers and education officials in overseas Korean Hangeul Schools, international schools, elementary and secondary schools. Finally, the levels and language skills appropriate for the objectives of a proficiency test and target learners have been suggested.

• 비교문화연구
• /
• 제47권
• /
• pp.27-51
• /
• 2017

본고는 패전 후 일본의 대표적인 문예재판인 '채털리 재판'을 중심으로 평화헌법(신헌법)이 보장하는 인권을 사수하려고 하는 변호인 측과 검찰 사법권으로 대표되는 공권력과의 대립을 판결문을 중심으로 고찰한 것이다. 판결문을 통해서 드러나는 재판소의 외설문서의 판단기준은 '성행위의 비밀성'과 '사회통념'인데, 이들을 판단할 때 재판소는 편파적이고 애매한 기준을 부여하고 있다. 또한 재판소는 이 작품의 예술성과 외설성에 대해서 양자는 전혀 다른 차원의 것임을 인정하면서도 예술성을 공공의 복지를 기준으로 공권력인 재판소가 판단해야 한다고 주장한다. 이에 대항하여 변호인 측은 평화헌법이 보장한 표현의 자유는 무제한적이며, 중요한 것은 작품의 내용이 비인도덕인지 아닌지 라고 역설하였다. 이러한 변호인 측의 주장은 패전 이전의 상황을 연상시키는 공권력에 맞선 것으로, 단지 풍속 단속에 대해서 항의하는 차원이 아닌 과거의 일본을 재현하지 않으려고 한 투쟁이었다고 할 수 있다.

• 산업융합연구
• /
• 제14권1호
• /
• pp.15-25
• /
• 2016

A technopark is an industrial and technological complex where personal, material and technological resources, scattered to businesses, academic institutions, research facilities and governments are gathered into a single place. Technopark's role is facets. The aim of this study is to offer new policy services for firms by utilizing the exploratory methodology for Chungnam Technopark's performance for three year (2011 ~2013). Through the findings, this study suggests that policy support for firm's growth in Chung Nam Region have been effective and fruitful in terms of total sale and increase of employees. But, technological performance measured by patents has not enough to catch the innovation. Chungnam Technopark should be more focused on technological policy supports including R&D as well as commercialization. Ultimately in order to have sustainabilities for own firm's growth, firms should keep going on ceaseless create the new technological performance. In that sense, for regional specific industry Technopark's role has been critical for not only firm's current growth but firm's innovation competency.

• Geomechanics and Engineering
• /
• 제30권3호
• /
• pp.247-258
• /
• 2022

A field velocity resistivity probe (FVRP) can measure compressional waves, shear waves and electrical resistivity in boreholes. The objective of this study is to perform the soil classification through a machine learning technique through elastic wave velocity and electrical resistivity measured by FVRP. Field and laboratory tests are performed, and the measured values are used as input variables to classify silt sand, sand, silty clay, and clay-sand mixture layers. The accuracy of k-nearest neighbors (KNN), naive Bayes (NB), random forest (RF), and support vector machine (SVM), selected to perform classification and optimize the hyperparameters, is evaluated. The accuracies are calculated as 0.76, 0.91, 0.94, and 0.88 for KNN, NB, RF, and SVM algorithms, respectively. To increase the amount of data at each soil layer, the synthetic minority oversampling technique (SMOTE) and conditional tabular generative adversarial network (CTGAN) are applied to overcome imbalance in the dataset. The CTGAN provides improved accuracy in the KNN, NB, RF and SVM algorithms. The results demonstrate that the measured values by FVRP can classify soil layers through three kinds of data with machine learning algorithms.

• 한국산업정보학회논문지
• /
• 제27권4호
• /
• pp.11-18
• /
• 2022

PUF(physically unclonable function)는 회로의 자연적인 변이를 이용하여 복제 불가능한 난수를 생성하는 회로이다. 통제가 어려운 변이를 활용하기 때문에 예측이 불가능하여 완전한 난수를 생성할 수 있지만 환경 변수에 의해 영향을 받는다는 문제가 있다. 본 논문에서는 이를 해결하기 위해 신뢰도 신호를 생성하는 PUF를 제안한다. 두 회로의 시간상수(time constant)의 차이를 이용한 PUF를 설계, 구현하여 서로 다른 PUF에서는 충분히 다른 출력이 나오고 같은 PUF에서는 온도가 변하여도 출력값의 큰 차이가 없음을 검증하였다. 오류정정코드를 사용하는 기존 기술 대비 700배 이상 작은 오버헤드로 동등한 수준의 신뢰도를 보장한다.

• 한국응급구조학회지
• /
• 제26권3호
• /
• pp.93-104
• /
• 2022

Purpose: This study examined the correlation between satisfaction with major, academic self-efficacy, and academic persistence with the general characteristics of students in a health-related field, to determine factors that affect academic persistence. Methods: The study was conducted on third- and fourth-grade health-field students at Daejion. The questionnaire consisted of a self-report, and a URL was sent by text message to students who agreed to participate after reading the purpose and necessity of the study. Results: Major satisfaction was 4.23 on average, academic self-efficacy was 4.15, and academic continuity was 4.25. Grade and school life satisfaction were the factors correlated with a significant difference in academic persistence. Significant positive correlations were seen between satisfaction with major (r=.637, p<.001) and academic self-efficacy (r=.563, p<.001); higher major satisfaction and academic self-efficacy led to higher academic persistence. Conclusion: A more systematic management approach needs to be conducted by developing active learning participation and applying customized counseling management and support programs by grade to improve the academic self-efficacy and academic persistence of students in health-related fields.

• 한국임상수의학회지
• /
• 제39권4호
• /
• pp.173-176
• /
• 2022

Intravenous catheterization is a common procedure in human and veterinary medicine. Occasionally, a catheter might break within the blood vessel, and the fragment may cause embolization, infections, or other severe complications, and therefore must be removed promptly. For a successful and low-risk removal, the fragment should be localized accurately; however, ultrasound may be challenging to perform on small dogs due to inadequate probes. We report the case of a 2-year-old, 2.6 kg, intact female toy poodle that presented to the veterinary medical center owing to a recent onion intake; the owner requested to induce emesis. A 24 gauge peripheral intravenous catheter was inserted into the cephalic vein prior to the emetic injection. When the clinician removed the catheter, a device breakage was observed. A tourniquet was applied immediately proximal to the elbow. Ultrasonography was performed with a high-frequency small-footprint linear array transducer, also called a hockey-stick probe, to localize the fragment. An additional ultrasound was performed before surgery to confirm the location of the catheter piece, which migrated 5 cm proximally. Afterward, a surgical intervention allowed us to retrieve the fragment. This report highlights the effectiveness of a hockey-stick probe to determine the location of a catheter fragment in small breed dogs.