• Journal of the Korean Mathematical Society
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• v.54 no.6
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• pp.1683-1698
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• 2017

In this paper, we study the $Carath{\acute{e}}odory$ extremal problems on the Hua domain of the first three types. We give the explicit formula for the $Carath{\acute{e}}odory$ extremal problems between the first three types of Hua domain and the unit ball, which improves the works done on Hua domain and Cartan-egg domain and super-Cartan domain.

• Bulletin of the Korean Mathematical Society
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• v.57 no.3
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• pp.583-595
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• 2020

Let HE_I, HE_II, HE_III and HE_IV be the first, second, third and fourth type Loo-Keng Hua domain respectively, 𝜑 a holomorphic self-map of HE_I, HE_II, HE_III, or HE_IV and u ∈ H(𝓜) the space of all holomorphic functions on 𝓜 ∈ {HE_I, HE_II, HE_III, HE_IV}. In this paper, motivated by the well known Hua's matrix inequality, first some inequalities for the points in the Bers-type spaces of the Loo-Keng Hua domains are obtained, and then the boundedness and compactness of the weighted composition operators W_𝜑,u : f ↦ u · f ◦ 𝜑 on Bers-type spaces of these domains are characterized.

• Journal of the Korean Mathematical Society
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• v.40 no.4
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• pp.609-627
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• 2003

In this paper we describe the Einstein-Kahler metric for the Cartan-Hartogs of the first type which is the special case of the Hua domains. Firstly, we reduce the Monge-Ampere equation for the metric to an ordinary differential equation in the auxiliary function X = X(z, w) = $\midw\mid^2[det(I-ZZ^{T}]^{\frac{1}{K}}$ (see below). This differential equation can be solved to give an implicit function in Χ. Secondly, we get the estimate of the holomorphic section curvature under the complete Einstein-K$\ddot{a}$hler metric on this domain.

• Journal of the Korean Mathematical Society
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• v.49 no.1
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• pp.69-83
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• 2012

In this note, we present certain circular domain, named Forelli-Rudin construction or Hua construction, which is built on Cartan domains. We compute the explicit Bergman kernel for it and get the corresponding weighted Bergman kernel on its base.

• Journal of applied mathematics & informatics
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• v.28 no.1_2
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• pp.49-58
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• 2010

In the present article we consider the diffusive Nicholson's blowflies equation with nonlocal delay incorporated into an integral convolution over all the past time and the whole infinite spatial domain $\mathbb{R}$. When the kernel function takes a special function, we construct a pair of lower and upper solutions of the corresponding travelling wave equation and obtain the existence of travelling fronts according to the existence result of travelling wave front solutions for reaction diffusion systems with nonlocal delays developed by Wang, Li and Ruan (J. Differential Equations, 222(2006), 185-232).

• Proceedings of the Korean Magnestics Society Conference
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• 2008.12a
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• pp.305.2-305.2
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• 2008

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.1
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• pp.5-9
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• 2013

Rhomboids were identified as the first intramembrane serine proteases about 10 years ago. Since then, the study of the rhomboid protease family has blossomed. Rhomboid domain containing 1 (RHBDD1), highly-expressed in human testis, contains a rhomboid domain with unknown function. In the present study, we tested the hypothesis that RHBDD1 was associated with proliferation and apoptosis in hepatocellular carcinoma using recombinant lentivirus-mediated silencing of RHBDD1 in HepG2 cells. Our results showed that down-regulation of RHBDD1 mRNA levels markedly suppressed proliferation and colony formation capacity of HepG2 human hepatoma cancer cells in vitro, and induced cell cycle arrest. We also found that RHBDD1 silencing could obviously trigger HepG2 cell apoptosis. In summary, it was demonstrated that RHBDD1 might be a positive regulator for proliferative and apoptotic characteristics of hepatocellular carcinoma.

• Development and Reproduction
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• v.23 no.3
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• pp.285-295
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• 2019

Junction-mediating and regulatory protein (JMY) is a regulator of both transcription and actin filament assembly. The actin-regulatory activity of JMY is based on a cluster of three actin-binding Wiskott-Aldrich syndrome protein homology 2 (WH2) domains that nucleate actin filaments directly and promote nucleation of the Arp2/3 complex. In addition to these activities, we examined the activity of JMY generation in early embryo of mice carrying mutations in the JMY gene by CRISPR/Cas9 mediated genome engineering. We demonstrated that JMY protein shuttled expression between the cytoplasm and the nucleus. Knockout of exon 2, CA (central domain and Arp2/3-binding acidic domain) and NLS-2 (nuclear localization signal domain) on the JMY gene by CRISPR/Cas9 system was effective and markedly impeded embryonic development. Additionally, it impaired transcription and zygotic genome activation (ZGA)-related genes. These results suggest that JMY acts as a transcription factor, which is essential for the early embryonic development in mice.

• Journal of Computing Science and Engineering
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• v.11 no.4
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• pp.111-120
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• 2017

Post-translational modifications (PTMs) of proteins play substantial roles in the gene regulation of cell physiological functions and in the generation of major diseases. However, the majority of existing studies only explored a certain PTM of proteins, while very few have investigated the PTMs of two or more domains and the effects of their interactions. In this study, after collecting data regarding a large number of breast cancer-related and validated PTMs, a sequence and domain analysis of breast cancer proteins was carried out using bioinformatics methods. Then, protein-protein interaction network-related tools were applied in order to determine the crosstalks between the PTMs of the proteins. Finally, statistical and functional analyses were conducted to identify more modification sites of domains and proteins that may interact with at least two or more PTMs. In addition to exploring the associations between the interactive effects of PTMs, the present study also provides important information that would allow biologists to further explore the regulatory pathways of biological functions and related diseases.

• Molecules and Cells
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• v.27 no.1
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• pp.39-45
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• 2009

Ligand-dependent or independent oligomerization of receptor protein tyrosine kinase (RPTK) is often an essential step for receptor activation and intracellular signaling. The novel oncogene with kinase-domain (NOK) is a unique RPTK that almost completely lacks an ectodomain, expresses intracellularly and activates constitutively. However, it is unknown whether NOK can form oligomer or what function oligomerization would have. In this study, two NOK deletion mutants were generated by either removing the ectodomain ($NOK{\Delta}ECD$) or including the endodomain (NOK-ICD). Co-immunoprecipitation demonstrated that the transmembrane (TM) domain of NOK was essential for its intermolecular interaction. The results further showed that NOK aggregated more closely as lower order oligomers (the dimer- and trimer-sized) than either deletion mutant did since NOK could be crosslinked by both Sulfo-EGS and formaldehyde, whereas either deletion mutant was only sensitive to Sulfo-EGS. Removing the NOK TM domain (NOK-ICD) not only markedly promoted higher order oligomerization, but also altered the subcellular localization of NOK and dramatically elevated the NOK-mediated constitutive activation of extracellular signal-regulated kinase (ERK). Moreover, NOK-ICD but not NOK or $NOK{\Delta}ECD$ was co-localized with the upstream signaling molecule RAS on cell membrane. Thus, TM-mediated intermolecular contacting may be mainly responsible for the constitutive activation of NOK and contribute to the autoinhibitory effect on RAS/MAPK signaling.