• Journal of Family Resource Management and Policy Review
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• v.27 no.2
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• pp.35-47
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• 2023

The purpose of this study was to understand family changes and dynamics of and to suggest institutional/policy-level tasks for coping with them, by paying attention to changing family values of single-person households and their caring work performed in everyday life. This study selected 11 single-person households residing in Ulsan by considering their age and marital status, and analyzed their overall daily lives, family values, and the characteristics of household work and caring. The characteristics of these single-person households in Ulsan, not only showed the coexistence of "simplicity, but instability" when maintaining and living their own lives, but also showed the ambivalent characteristics of family values by showing a gap between the perception and reality of diversity. In regard to family life, the participants complained of difficulties in "caring and relationship of family of origin" and the "economic factors", and notably showed the "dual value system". For a more stable life, the single-person households were forming social networks to relieve a sense of isolation and loneliness, and to recover relationships, instead of limiting themselves to only the traditional method of family formation. Thus, it would be possible to respond to family changes when changes are promoted in each area of "the perception of life", "family life", and the "family & social relationship", and this research suggests policy-level tasks based on the results of this study.

• Korean Journal of Social Welfare
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• v.57 no.2
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• pp.143-164
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• 2005

The study is to analyze support-related issues, particularly associated with elderly and children care, which have been a fundamental agenda of family welfare policy. We are expected for societal-level controversy on the relationship of family support and social security in the near future because of rapid increase in ageing and divorce rate. Accordingly, we need to establish social consensus on the extent to which both family support system and social support system are responsible for the life maintenance of the elderly and the children from divorced family. We also clarify the various characteristics(including scope, degree, period of time, and need/manageability) of support provided by family members. Considering the changes of family structure and population composition, the policy of supporting the old and children should go for social responsibility. Findings show that civil law and social welfare law have unclear application on the relationship between family support and social security, and contents in family support. In particular, public assistance law strongly emphasizes the principle of family support while social insurance laws provide only limited and insufficient family maintenance. The suggestions of further study on support-related issues are given in the rapidly changing society and the increasing economic instability.

• Journal of the Korean Data and Information Science Society
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• v.27 no.5
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• pp.1327-1336
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• 2016

Most cases of child abuse in South Korea are caused by parents in the family home. Currently, these types of incidents are growing. Child abuse creates irreparable damage to a child's development and its effects are prolonged. This damage can create a maladjusted adolescent and adult criminal acts. Because of this damage and the long lasting effects on a person and society as a whole, special attention needs to be paid to this pressing issue. South Korea's rapidly changing social environment has created a variety of new family forms including dual-income families and single-parent families. With the current economic downturn and accompanying employment instability, many families exist in uneasy financial and emotional states. The children in these stressful family environments are the most vulnerable and live in risk of experiencing physical or psychological abuse from their parents. In the context of significant and often difficult social changes, this study identifies the characteristics of child abuse based on family status and parental mental health.

• Journal of the Korean Home Economics Association
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• v.30 no.1
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• pp.283-309
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• 1992

This study examines work and family life of married women employed in a manufacturing industry. Data were gathered from the use of fact-to-face interview method from a sample of 230 married working women. The major findings of this study can be summarized as follows : (1) With high rates of change of job, most of the respondents remain unstable in their working situation. It was shown that the important factors influencing job satisfaction of married women are women's life cycle, degree of contribution of wife's income toward total family income, and husband's attitude toward wife's empolyment. The degree of job satisfaction is also strongly influenced by labor structural factors such as pay, work environment and fringe benefits. (2) The amount of household labor time was limited by job-related factors rather than by family-related factors, because among these working women employment itself is necessarily for their subsistance. (3) It was shown that wives participated more actively in their marital communications than their husbands. Most of the respondents showed the syncratic type of the decision making patterns, but this results does not necessarily mean wives exercised an equal power with their husbands. The economic factors and the emotional instability of the husband are the ones mostly influencing marital conflicts of the employed women. It was found that the respondents easily revealed marital conflicts related to personal problems of their husbands(such as extramarital affairs, gambling and alchoholism). However, they tried to overcome the structural conflicts related to authoritarian attitudes of their husbands or economic problems without any complaints. (4) Mothers have difficulty in controlling their adolescent children, due to the weakening of parental authority. Although most of the respondents perceived their employment as having negative impacts on their children, they still have high expectations toward their children. Inspite of low degree of father role expectations and facther role performance of their husbands, most of the respondents anticipated expressive roles as well as traditionally instrumental role from their husbands. Finally, these findings would help us determine family welfare policies in Korea. Improvements in paid and household labor structure of married women should be accomplished at the national level. Also, the acting programs for parent education, marital councelling services, and law enforcement for equal employment between men and women should be provided in our society.

• Human Ecology Research
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• v.52 no.5
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• pp.541-549
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• 2014

The purpose of this study was to analyze the effects of preschool children's behavioral and emotional regulation on their peer play behavior, focusing on gender differences. A total of 214 4- and 5-year-old children attending a child care center in South Korea participated in this study. The instruments used in this study were the Child Behavior Rating Scale, Emotion Regulation Checklist, and Penn Interactive Peer Play Scale. The collected data were analyzed using a Student's t -test, Pearson's partial correlation, and multiple regressions with the SPSS software ver. 16.0. The main results of this study are as follows: first, there was a significant gender difference in preschool children's behavioral regulation, emotional control, play interaction, and play disruption. However, there was no gender difference in preschool children's play disconnection. Second, preschool children's emotional control and behavioral regulation had positive effects on their play interaction irrespective of gender. Third, preschool children's emotional instability and emotional control had a positive influence on their play disruption irrespective of gender. Finally, the factors of behavioral regulation and emotional instability significantly predicted the boys' play disconnection, while for the girls, the significant predictor was emotional control. Further, implications for the use of early intervention targeting specific behavioral and emotional regulation problems have been discussed.

• Journal of Gastric Cancer
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• v.10 no.4
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• pp.149-154
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• 2010

Purpose: Replication error is an important mechanism in carcinogenesis. The microsatellite instability (MSI-H) of colorectal cancers is associated with the development of multiple cancers. The influence of MSI-H on the development of multiple gastric cancers in sporadic gastric cancer patients has not been defined. This study was performed to reveal the association between the clinicopathologic features and MSI in sporadic gastric cancers. Materials and Methods: Between July 2004 and March 2009, the clinicopathologic characteristics, including MSI status, were evaluated in 128 consecutive patients with sporadic gastric cancers. None of the patients had hereditary non-polyposis colorectal cancer of familial gastric cancer. The markers that were recommended by the NCI to determine the MSI status for colorectal cancers were used Results: MSI-H cancers were found in 10.9% of the patients (14/128). Synchronous gastric cancers were shown in 4 patients (3.1%). Synchronous cancers were found in 2 of 14 patients with MSI-H gastric cancer (14.3%) and 2 of 114 patients with MSS gastric cancer (1.8%; P=0.059, Fisher's exact test). Among the patients with synchronous cancer 50% (2/4) had MSI-H cancer, but 9.7% of the patients (12/124) without synchronous cancer had MSI-H cancer. MSI-H (RR, 24.7; 95% CI, 1.5~398.9; P=0.024) was related with to synchronous gastric cancer, but age, gender, family history, histologic type, location, gross morphology, size, and stage were not related to synchronous gastric cancer. Conclusions: MSI is associated with the intestinal-type gastric cancer and the presence of multiple gastric cancers in patients with sporadic gastric cancer. Special attention to the presence of synchronous and the development of metachronous multiple cancer in patients with MSI-H gastric cancer is needed.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.9
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• pp.4259-4265
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• 2016

Background: Colorectal malignancies with high microsatellite instability (MSI-H), either hereditary (Lynch syndrome) or sporadic, demonstrate better prognosis and altered response to 5FU chemotherapy. It is now recommended to perform MSI testing for all new cases of colorectal cancer regardless of being categorized as hereditary or sporadic. For MSI detection, immunohistochemistry or PCR-based protocols using a cohort of various sets of STR markers are recommended. Here we aimed to evaluate a simplified protocol using just a single STR marker, MT1XT20 mononucleotide repeat, for detection of MSI in Lynch syndrome patients. A Promega five-marker MSI testing panel and immunohistochemistry (IHC) were used as the gold standard in conjunction with MT1XT20. Materials and Methods: Colorectal patients with a positive history of familial cancers were selected by evaluating medical records. Based on Amsterdam II criteria for Lynch syndrome 20 families were short listed. DNA was extracted from formalin fixed paraffin embedded tumour and adjacent normal tissues resected from the index case in each family. Extracted DNA was subjected to MT1XT20 mononucleotide marker analysis and assessment with a commercially available five marker MSI testing kit (Promega, USA). IHC also was performed on tissue sections and the results were compared with PCR based data. Results: Eight (40%), seven (35%) and five (25%) cases were MSI positive using with the Promega kit, IHC and MT1XT20, respectively. Among the markers included in Promega kit, BAT26 marker showed instability in all 8 samples. NR24 and NR21 markers showed instability in 7 (87.5%), and BAT25 and MONO 27 in 6 (75%) and 5 (62.5%). Conclusions: Although MT1XT20 was earlier reported as a valid standalone marker for MSI testing in CRC patients, we could not verify this in our Iranian patients. Instead BAT26 among the markers included in Promega MSI testing kit showed instability in all 8 MSI-H CRC samples. Therefore, it seems BAT26 could act well as a single marker for MSI testing in Iranian CRC patients.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.4
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• pp.1917-1923
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• 2016

Background: Lynch Syndrome (LS) is a familial cancer condition caused by germline mutations in DNA mismatch repair genes. Individuals with LS have a greatly increased risk of developing colorectal cancer (CRC) and it is therefore important to identify mutation carriers so they can undergo regular surveillance. Tumor DNA from LS patients characteristically shows microsatellite instability (MSI). Our aim here was to screen young CRC patients for MSI as a first step in the identification of unrecognized cases of LS in the Saudi population. Materials and Methods: Archival tumor tissue was obtained from 284 CRC patients treated at 4 institutes in Dammam and Riyadh between 2006 and 2015 and aged less than 60 years at diagnosis. MSI screening was performed using the BAT-26 microsatellite marker and positive cases confirmed using the pentaplex MSI analysis system. Positive cases were screened for BRAF mutations to exclude sporadic CRC and were evaluated for loss of expression of 4 DNA mismatch repair proteins using immunohistochemistry. Results: MSI was found in 33/284 (11.6%) cases, of which only one showed a BRAF mutation. Saudi MSI cases showed similar instability in the BAT-26 and BAT-25 markers to Australian MSI cases, but significantly lower frequencies of instability in 3 other microsatellite markers. Conclusions: MSI screening of young Saudi CRC patients reveals that approximately 1 in 9 are candidates for LS. Patients with MSI are strongly recommended to undergo genetic counselling and germline mutation testing for LS. Other affected family members can then be identified and offered regular surveillance for early detection of LS-associated cancers.

• Journal of the Korean housing association
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• v.25 no.6
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• pp.123-132
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• 2014

Proportion of senior population living alone in South Korea has exceeded over 20.2% in 2012, and it is anticipated that the proportion would increase every year. Poverty rate of seniors living alone in Korea is also anticipated to increase the highest rate (76.6%) among OECD countries. In particular, seniors lacking family support are having greater difficulty and isolated due to high housing costs and housing instability. Therefore, they need a new housing alternatives for considering their economical difficulty and lacking family and social support. This study attempted to examine possibility to develop a new housing alternatives for Korean seniors, especially living urban area. For this purpose, this study identified the attitudes and preference for a new house alternatives(Senior Shared House) by Korean seniors living alone. The key findings of this study were as follows: 1) Eighty-five percent of seniors participated in this study responded the senior shared house was needed. 2) It should be developed by utilizing or renovating and renting out existing housing in city areas. 3) Pre-residence checklist can be developed to connect and match prospect residents. 4) Professional workforce (e.g. housing welfare professional) is absolutely necessary to perform the role of coordinator understanding the various characteristics of the seniors, and their living requirements. Recommendations and directions for future development of senior shared house were suggested.

• Molecules and Cells
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• v.22 no.3
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• pp.360-363
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• 2006

Human endogenous retroviruses (HERVs) contribute to various kinds of genomic instability via rearrangement and retrotransposition events. In the present study the formation of a new human-specific solo-LTR belonging to the HERV-H family (AP001667; chromosome 21q21) was detected by a comparative analysis of human chromosome 21 and chimpanzee chromosome 22. The solo-LTR was formed as a result of an equal homologous recombination excision event. Several evolutionary processes have occurred at this locus during primate evolution, indicating that mammalian-wide interspersed repeat (MIR) and full-length HERV-H elements integrated into hominoid genomes after the divergence of Old World monkeys and hominoids, and that the solo-LTR element was created by recombination excision of the HERV-H only in the human genome.