• Molecules and Cells
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• 제26권3호
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• pp.243-249
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• 2008

Corticotropin releasing factor (CRF) mediates various responses to stress through CRF receptors 1 and 2. CRF receptor 2 has two forms, $2{\alpha}$ and $2{\beta}$ each of which appears to have distinct roles. Here we used dopaminergic neuron-derived MN9D cells to investigate the function of CRF receptor 2 in dopamine neurons. We found that n-butyrate, a histone deacetylase inhibitor, induced MN9D cell differentiation and increased gene expression of all CRF receptors. CRF receptor $2{\beta}$ was minimally expressed in MN9D cells; however, its expression dramatically increased during differentiation. CRF receptor $2{\beta}$ expression levels appeared to correlate with neurite outgrowth, suggesting CRF receptor $2{\beta}$ involvement in neuronal differentiation. To validate this statement, we made a CRF receptor $2{\beta}$-overexpressing $MN9D/CRFR2{\beta}$ stable cell line. This cell line showed robust neurite outgrowth and GAP43 overexpression, together with MEK and ERK activation, suggesting MN9D cell neuronal differentiation. From these results, we conclude that CRF receptor $2{\beta}$ plays an important role in MN9D cell differentiation by activating the MEK/ERK signaling pathway.

• 농업생명과학연구
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• 제45권1호
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• pp.15-20
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• 2011

본 연구는 전북 무주지역 36년생 리기다소나무 임분을 대상으로 지상부 바이오매스 추정식을 개발하고, 줄기밀도와 바이오매스 확장계수를 산출하고자 하였다. 리기다소나무의 흉고직경을 독립변수로 하고 바이오매스를 종속변수로 하는 상대생장식을 추정한 결과, 잎 (78%)과 가지 (83%)를 제외하면 모든 부위에서 결정계수가 95% 이상의 높은 설명력을 나타냈다. 리기다소나무의 바이오매스량은 줄기 목질부 $65.9 Mg\;ha^{-1}$, 줄기 수피 $9.5Mg\;ha^{-1}$, 가지 $19.6Mg\;ha^{-1}$, 잎 $7.0Mg\;ha^{-1}$, 전체 $102Mg\;ha^{-1}$로 나타났으며, 바이오매스 구성비는 줄기목질부 (64.6%) > 가지 (19.2%) > 줄기 수피 (9.3%) > 잎 (6.9%) 순으로 나타났다. 리기다소나무의 줄기밀도 $(g/cm^{3})$는 0.453으로 나타났고, 바이오매스 확장계수는 1.344로 나타났다.

• Perinatology
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• 제29권4호
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• pp.170-174
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• 2018

Objective: Progesterone is used to prevent recurrent preterm delivery, however the molecular mechanisms of its effect are incompletely understood. The objective of this study was to determine the effect of progesterone on tumor necrosis factor $(TNF)-{\alpha}$-induced matrix metalloproteinase (MMP)-9 activity in human choriodecidual (CD) membranes. Methods: We collected CD membranes from women with uncomplicated term pregnancies who were scheduled for elective cesarean delivery (n=10). CD membranes ($1{\times}1cm$) were incubated in tissue culture media at $37^{\circ}C$. We pre-treated the CD membranes with progesterone (P4), $17{\alpha}$-hydroxyprogesterone caproate (17P), promegestone (R5020), or vehicle (ethanol) for 24 hours. The CD membranes were subsequently treated with $TNF-{\alpha}$ (with continued progesterone treatment) for 48 hours, then media was harvested for measuring MMP-9 activity by zymography and total protein was isolated from CD membrane tissues for MMP-9 expression by western blot analysis. Results: P4, 17P, and R5020 significantly reduced $TNF-{\alpha}$-induced MMP-9 activity in fetal membrane tissue samples (P=0.0078, P=0.0156, and P=0.0391, respectively) by zymography. Western blot analysis also showed decreased expression of MMP-9 in progesterone pretreated groups (P=0.0313). Conclusion: Progesterone reduces $TNF-{\alpha}$-induced MMP-9 activity in human CD membranes. These findings may provide further support for the role of progesterone in preventing preterm birth.

• 한국게임학회 논문지
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• 제17권3호
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• pp.63-70
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• 2017

인공지능 연구에서 바둑은 위치평가의 어려움과 엄청난 분기수로 인해 가장 도전적인 보드게임으로 여겨지고 있다. 몬테카를로 트리탐색은 이러한 문제점을 극복할 수 있는 고무적인 돌파구이다. 알파고의 숨겨진 아이디어는 주어진 위치에서의 승률을 예상하여 깊은 탐색을 유도한 후 가장 고무적인 착수를 찾아내는 것이었다. 본 논문에서는 무전략 MCTS를 활용하여 9줄바둑에서 프로기사들이 최상의 첫수로 여기는 천원점이 옳다는 것을 확인했으며, 또한 가장 유행하는 첫 수들의 평균승률을 비교했다.

• 대한약학회:학술대회논문집
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• 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.1
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• pp.234.2-234.2
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• 2003

Development of new tissue factor (TF) inhibitor is still needed for improved compositions having anticoagulant activity and which can be administed orally or non-intravenously at low doses. Our studies for the development of new TF inhibitors uncovered that aminoalcohols with C-18 alkenyl group, 9-octadecenyl- or 9,12-octadecadienyl groups exhibits in vitro nanomolar level activities. (omitted)

• 대한약학회:학술대회논문집
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• 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.1
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• pp.238.1-238.1
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• 2003

Tissue Factor (TF), a principal initiator of the veterbrate coagulation cascade is known to to induced in endothelial cells, monocytes and macrophages by inflammetry stimuli and in many pathological conditions. Through our synthetic efforts to develop new TF inhibitors, seventeen N-C-18 alkenyl group (9-octadecenyl or 9,12-octadecadienyl) substituted aminoalcohols (2-aminoethanol, 1-amino-2-propanol and 3-amino-1-propanol) were prepared and their in vitro TF inhibitory activities were examined. (omitted)

• 한국통신학회논문지
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• 제40권9호
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• pp.1793-1801
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• 2015

최근 KRLS-T라고 하는 커널 기반의 RLS 알고리즘이 제안되었다. 이 알고리즘은 비정재 환경에서 베이지안 이론에 기반한 망각 기저를 사용하고 있다. 이런 망각 기저의 핵심은 고정 망각인자를 사용하는 것이다. 그러나 실제 환경에서는 시스템의 비정재 정도까지도 시변인 경우가 많다. 이 경우 고정 망각인자로는 시스템의 바른 추정이 불가하다. 본 논문에서는 가변 망각인자를 사용한 KRLS-T를 제안한다. 그리고 모의 실험에서 가변 망각인자를 가진 KRLS-T가 시변 시스템의 추정에 더 효과적임을 보인다.

• 대한방사선기술학회지:방사선기술과학
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• 제31권1호
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• pp.89-95
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• 2008

국제원자력기구의 TRS-398 측정 프로토콜을 임상에 적용하기 위해서는 사용하는 빔과 전리함에 대한 선질 보정인자가 필요하다. 본 연구에서는 몬테칼로 계산코드(DOSRZnrc/EGSnrc)를 사용하여 상용의 평판형전리함에 대한 고에너지 전자선($4{\sim}20\;MeV$)에서의 선질보정인자를 계산하였다. 계산결과를 프로토콜에서 제시하는 값과 비교한 결과 $5{\sim}20\;MeV$에서 약 1% 이내로 일치하였으며 4 MeV의 경우에는 약 1.9% 차이를 보였다. 본 연구 방법은 선질보정인자를 독립적으로 결정하는 방법의 하나로서 프로토콜에서 주어진 값들의 확인이 필요하거나 또는 새로운 모델의 전리함을 사용하는 경우에 응용될 수 있다.

• 한국항만학회지
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• 제14권1호
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• pp.57-64
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• 2000

For composing the structure model of national maritime power system by system structural modeling, in this study, the 50 basic factors are selected by survey of the extensive and through literatures on maritime, sea, maritime power and sea power. And the basic factors are classified into 36 component factors by cluster method. The 9 attributes are extracted by the application of the principle component analysis method, one of the factor analysis method in system engineering, to component factors. In this study, we define the attributes composing the national maritime power system by integrating the result of this study and existed our studies relating to this topic. Which are showed in Table 2. and we show the structure model of national maritime power system in Fig. 3. In Table 2, the 9 attributes are as follows : the fundamental power of maritime, shipping and port power, naval power, fishing power, shipbuilding power, the power of ocean research and development, dependency on seaborne trade, the protection power of ocean environment and the will and inclination of govemment. Also, in the case of evaluating this system, we conform the importance of considering the interactions among the attributes which have strong interactions in structure model of national maritime power system.

• 전기학회논문지
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• 제65권9호
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• pp.1626-1631
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• 2016

Generally, the low-voltage customer has been used with a linear load and nonlinear load in the 3-phase 4-wire distribution system. Linear load has usually configured the resistance and inductance, current phase is slower than the voltage phase, so power factor is low. It is required for the power factor correction device prior to the phase of the current than the voltage. The capacitor is connected in parallel to the load in order to ensure a low power factor. Power converter such as an inverter is a typical non-linear load. Non-linear load generates harmonic currents in the energy conversion process. Many electrical equipment may be adversely affected by the harmonic current. There, passive or active filter have been used to reduce these harmonics current. Passive filter consisting of inductor and capacitor generates a reactive power. According to the combination of filter inductor and capacitor, reactive power can be adjusted. In this paper, we analyzed how the combination of inductor and capacitor affects the overall power factor by simulation and measurement.