Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.04a
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- Pages.234.2-234.2
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- 2003
Cyclic Aminoalcohols with C-18 Alkenyl Substituents and Their Nanomolar Level-Activities as Tissue Factor Inhibitors
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Yoon, Ung-Chan
(Pusan National University, Department of Chemistry)
;
- Kwon, Hyuk-Chul (Pusan National University, Department of Chemistr) ;
- Cho, Yong-Jin (Pusan National University, Department of Chemistry)
- Published : 2003.04.01
Abstract
Development of new tissue factor (TF) inhibitor is still needed for improved compositions having anticoagulant activity and which can be administed orally or non-intravenously at low doses. Our studies for the development of new TF inhibitors uncovered that aminoalcohols with C-18 alkenyl group, 9-octadecenyl- or 9,12-octadecadienyl groups exhibits in vitro nanomolar level activities. (omitted)
Keywords