Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.04a
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- Pages.238.1-238.1
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- 2003
Syntheses of Aminoalcohols with Alkenyl Substituents for the Development of Tissue Factor Inhibitors and Their in vitro Nanomolar Level-Activities
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Yoon, Ung-Chan
(Pusan National University, Department of Chemistry) ;
- Kwon, Hyuk-Chul (Pusan National University, Department of Chemistr) ;
- Song, Kyu-Chan (Pusan National University, Department of Chemistry)
- Published : 2003.04.01
Abstract
Tissue Factor (TF), a principal initiator of the veterbrate coagulation cascade is known to to induced in endothelial cells, monocytes and macrophages by inflammetry stimuli and in many pathological conditions. Through our synthetic efforts to develop new TF inhibitors, seventeen N-C-18 alkenyl group (9-octadecenyl or 9,12-octadecadienyl) substituted aminoalcohols (2-aminoethanol, 1-amino-2-propanol and 3-amino-1-propanol) were prepared and their in vitro TF inhibitory activities were examined. (omitted)
Keywords