• 공업화학
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• 제20권6호
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• pp.632-637
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• 2009

Pluronic F127을 함유한 poly(${\varepsilon}-caprolacton$) / ethyl cellulose (PCL/EC) 마이크로 캡슐을 분무건조법으로 제조하였다. 20% (w/v)의 pluronic F127 수용액을 수상으로, 5% (w/w)의 PCL/EC이 녹아있는 디클로로메탄(dichloromethane)을 유기상으로 이용하여 water-in-oil (W/O) 에멀젼을 제조하였고, 이를 분무건조하여 마이크로 캡슐을 얻어낼 수 있었다. 주사전자현미경과 입도분석기로 분석한 결과, 수 마이크로부터 수십 마이크로 크기의 마이크로 캡슐이 형성을 확인되었다. 시차주사열량측정기로 마이크로 캡슐의 상전이 온도를 조사한 결과, 마이크로 캡슐 제조 시 사용된 고분자들의 상전이 온도가 관찰되었다. 마이크로 캡슐의 온도 의존적 방출 특성은 $30{\sim}45^{\circ}C$에서 관찰하였으며, 수용성 염료인 fluorescein isothiocyanate-dextran (FITC-dextran)과 blue dextran을 방출모델시약으로 하였다. 온도가 증가할수록 마이크로 캡슐로부터 방출되는 양이 증가하였으며, 방출모델시약의 분자량이 작을수록 더 많이 방출되었다.

• 충청수학회지
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• 제28권1호
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• pp.127-138
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• 2015

In this paper, we introduce the notion of f-derivation in a BE-algebra, and consider the properties of f-derivations. Also, we characterize the fixed set $Fix_d(X)$ and Kerd by f-derivations. Moreover, we prove that if d is a f-derivation of a BE-algebra, every f-filter F is a a d-invariant.

• 충청수학회지
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• 제32권1호
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• pp.127-138
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• 2019

In this paper, I investigate a stability of the following set-valued functional equation $$f(x+3y){\oplus}10f(x+y){\oplus}7f(-x){\oplus}5f(x-y)=5f(x+2y){\oplus}f(x){\oplus}f(2x){\oplus}f(x-2y)$$ in the sense of P. $G{\check{a}}vruta$.

• Journal of Pharmaceutical Investigation
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• 제31권1호
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• pp.1-5
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• 2001

The aggregation behavior of nystatin (NYS) in the presence of pluronic F127, triblock copolymer of poly (ethylene oxide) (PEO) and poly (propylene oxide) (PPO), was measured and correlated with hemolytic activity. Antifungal activity was also studied using Saccharomyces cerevisiae as a model strain. The critical aggregation concentrations (CAC) of the drug were 50.1, 108.0, 134.2, 154.3, and $217.9\;{\mu}M$ at 0.1%, 0.5%, 1.0%, 1.5%, and 2.0% pluronic F127 solution, respectively. The levels of NYS required to start lysis of erythrocytes were about 80, 100, 125, 150, and $200\;{\mu}M$ at 0.1%, 0.5%, 1.0%, 1.5%, and 2.0% pluronic F127 solution, respectively. It was $50\;{\mu}M$ in the absence of the polymer. Minimal inhibitory concentration (MIC) and minimal fungicidal concentration (MFC) of NYS-pluronic F127 lyophilizate were same at $3\;{\mu}g/ml$, while MIC and MFC of pure NYS are $3\;{\mu}g/ml$ and $12\;{\mu}g/ml$, respectively. By modulating the aggregation behavior of NYS, pluronic F127 was able to reduce the toxicity of the drug without compromising the MIC and MFC.

• Journal of Pharmaceutical Investigation
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• 제20권3호
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• pp.121-127
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• 1990

Mefenamic acid has been widely used clinically as an anti-inflammatory analgesic. It has poor solubility in water $(41\;{\mu}g/ml)$ and there is the difficulty of dissolution in the mefenamic acid capsules. A study was made to investigate the effect of various surfactants on the dissolution of mefenamic acid capsules. The surfactants used were sodium lauryl sulfate (SLS), Pluronic F-68, F-77, and F-127. Mefenamic acid capsule containing surfactant showed significantly improved dissolution characteristics. The dissolution rate was fast in the order of SLS > F-77 > F-68 > F-127 in mefenamic acid capsules containing 0.2 w/w % surfactant. SLS was selected for further study on the bioavailability in rabbits. The area under the plasma concentration-time curve $(AUC_{0-24})$ of mefenamic acid capsule containing SLS was higher than one of mefenamic acid capsule not containing surfactant.

• 대한수학회논문집
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• 제24권1호
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• pp.127-144
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• 2009

Let f be a diffeomorphism of a compact $C^{\infty}$ manifold, and let p be a hyperbolic periodic point of f. In this paper we introduce the notion of $C^1$-stable inverse shadowing for a closed f-invariant set, and prove that (i) the chain recurrent set $\cal{R}(f)$ of f has $C^1$-stable inverse shadowing property if and only if f satisfies both Axiom A and no-cycle condition, (ii) $C^1$-generically, the chain component $C_f(p)$ of f associated to p is hyperbolic if and only if $C_f(p)$ has the $C^1$-stable inverse shadowing property.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제34권6호
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• pp.384-390
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• 2012

Purpose: The purpose of this study is to examine in vivo osteogenesis of cultured human periosteal-derived cells and polydioxanone/pluronic F127 scaffold. Methods: Two one-year-old miniature pigs were used in this study. $2{\times}10^6$ periosteal-derived cells in 1 mL medium were seeded by dropping the cell suspension into the polydioxanone/pluronic F127 scaffold. These cell-scaffold constructs were cultured in osteogenic Dulbecco's modified Eagle's medium for 7 days. Under general anesthesia with azaperone and tiletamine-zolazepam, the mandibular body and ramus of the pigs were exposed. Three bony defects were created. Polydioxanone/pluronic F127 scaffold with periosteal-derived cells and the scaffold only were implanted into each defect. Another defect was left empty. Twelve weeks after implantation, the animals were sacrificed. Results: New bone formation was clearly observed in the polydioxanone/pluronic F127 scaffold with periosteal-derived cells. Newly generated bone was also observed in the scaffold without periosteal-derived osteoblasts and empty defect, but was mostly limited to the periphery. Conclusion: These results suggest that cultured human periosteal-derived cells have good osteogenic capacity in a polydioxanone/pluronic F127 scaffold, which provides a proper environment for the osteoblastic differentiation of these cells.

• 공업화학
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• 제32권2호
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• pp.219-223
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• 2021

Considering the current COVID 19 pandemic, herein, we developed a material that can be used to fabricate a device for checking the body temperature of a person who has been exposed to influenza or corona virus. This material was formed by mixing pluronic F127 (F127) with a polydiacetylene (PDA) vesicle, which was formed with 10,12-pentacosadiynoic acid. The color of the system started to change from blue to light purple at 37 ℃, finally turning reddish at 40 ℃. Thus, the developed material can be used to detect changes in body temperature, and thus, detect signs of fever. The mixing ratio of the PDA vesicle and F127 was an important factor for controlling the temperature at which the color change started. The results showed that the color change accompanied by the separation of the PDA vesicle with F127. We believe that this phenomenon plays an important role in reducing the conjugation length in the double and triple bond of PDA.

• 한국작물학회지
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• 제27권2호
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• pp.107-110
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• 1982

일수립수가 보통소맥보다 월등히 많은 분지성소맥의 분지성과 부모용의 유전현상을 구명하고자 분지성 소맥 $\overline{PH}$ 및 PH127에 올밀과 중국 8001를 교배하여 얻은 4개 조합의 $F_1, $F_14, 가 집단과 양친을 고온단일 및 고온장일하에서 시험한 결과를 요약하면 다음과 같다. 1. 공시된 전조합에서 $F_1$이 정상수로 나타나 분지성에 관여하는 유전자는 열성인 것으로 판명되었다. 2. 분지성의 유전양식은 쓰여진 재료에 따라 차이가 있어서 PH127은 2쌍의 열성유전자에 의하여 PH119은 3쌍의 열성유전자에 의하여 표현되는 것으로 나타났다. 3. 분지성의 표현은 일장에 의하여 그 분리비가 변하지 않았으나 단일조건에서 분지의 발육이 왕성한 편이었다. 4. PH127 및 PH119의 부모용은 단순우성유전자에 의하여 지배되는 것으로 나타났으며 부모용은 PH119\times중국8001에서 분지성과 독립인 것으로 그러나 PH 119$\times$올밀에서는 관련이 있는 것으로 나타났다.

• 융합정보논문지
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• 제8권3호
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• pp.127-136
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• 2018

본 연구는 G, J 지역의 치위생(학)과 학생들을 대상으로 임상실습만족도에 영향을 미치는 요인을 조사하기 위해 시행되었다. 수집된 자료는 SPSS 21.0 프로그램을 이용하여 t-검정, 일원분산분석을 사용하였고, 상관관계는 피어슨 상관계수로 임상실습만족도에 영향을 미치는 요인은 다중회귀분석을 사용하였다. 대상자의 일반적인 특성에 따른 임상실습만족도의 차이는 건강상태(F=8.108, p<.001), 학과만족도(F=16.372, p<.001), 교우관계(F=8.198, p<.001)에서 통계적으로 유의하게 나타났다. 대상자의 교우관계와 학업성적(r=.277, p=.01), 건강상태와 교우관계에서도 정적상관관계(r=.327, p=.01)를 보였다. 또한 임상실습만족도와 학업성적(r=.127, p=.05), 건강상태(r=.226, p=.01), 교우관계(r=.240, p=.01)에서도 상관관계를 나타내었다. 본 연구 대상자의 임상실습만족도에 영향을 미치는 요인은 교우관계, 학과 만족도, 건강상태로 나타났고, 본 연구결과를 통하여 치위생(학)과 학생들을 대상으로 임상실습만족도를 향상시킬 수 있는 프로그램 개발이 필요하다.