• Journal of Microbiology and Biotechnology
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• 제32권5호
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• pp.645-656
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• 2022

Gossypol, a natural phenolic aldehyde present in cotton plants, was originally used as a means of contraception, but is currently being studied for its anti-proliferative and anti-metastatic effects on various cancers. However, the intracellular mechanism of action regarding the effects of gossypol on pancreatic cancer cells remains unclear. Here, we investigated the anti-cancer effects of gossypol on human pancreatic cancer cells (BxPC-3 and MIA PaCa-2). Cell counting kit-8 assays, annexin V/propidium iodide staining assays, and transmission electron microscopy showed that gossypol induced apoptotic cell death and apoptotic body formation in both cell lines. RNA sequencing analysis also showed that gossypol increased the mRNA levels of CCAAT/enhancer-binding protein homologous protein (CHOP) and activating transcription factor 3 (ATF3) in pancreatic cancer cell lines. In addition, gossypol facilitated the cleavage of caspase-3 via protein kinase RNA-like ER kinase (PERK), CHOP, and Bax/Bcl-2 upregulation in both cells, whereas the upregulation of ATF was limited to BxPC-3 cells. Finally, a three-dimensional culture experiment confirmed the successful suppression of cancer cell spheroids via gossypol treatment. Taken together, our data suggest that gossypol may trigger apoptosis in pancreatic cancer cells via the PERK-CHOP signaling pathway. These findings propose a promising therapeutic approach to pancreatic cancer treatment using gossypol.

• 한국군사과학기술학회지
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• 제24권6호
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• pp.664-675
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• 2021

Air force air-to-air combat tactics are occurring at a high speed in three-dimensional space. The specification of the tactics requires dealing with a quite amount of information, which makes it a challenge to accurately describe the maneuvering procedure of the tactics. The specification of air-to-air tactics using natural languages is not suitable because of the intrinsic ambiguity of natural languages. Therefore, this paper proposes an approach of using UML Sequence Diagram to describe air-to-air combat tactics. Since the current Sequence Diagram notation is not sufficient to express all aspects of the tactics, we extend the syntax of the Sequence Diagram to accommodate the required features of air-to-air combat tactics. We evaluate the applicability of the extended Sequence Diagram to air-to-air combat tactics using a case example, that is the manned-unmanned teaming combat tactic. The result shows that Sequence Diagram specification is more advantageous than natural language specification in terms of readability, conciseness, and accuracy. However, the expressiveness of the Sequence Diagram is evaluated to be less powerful than natural language, requiring further study to address this issue.

• Membrane and Water Treatment
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• 제13권5호
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• pp.235-243
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• 2022

The paper presents the effect of operating temperatures and flow rates on the distillate flux that can be obtained from a hydrophobic membrane having the characteristics: pore size of 0.15 ㎛; thickness of 130 ㎛; and 85% porosity. That membrane in the present investigation could be the direct contact (DCMD) or the air-gap membrane distillation (AGMD). To model numerically the membrane distillation processes, the two-dimensional computational fluid dynamic (CFD) is used for the DCMD and AGMD cases here. In this work, DCMD and AGMD models have been validated with the experimental data using different flows (Parallel and Counter-current flows) in non-steady-state situations. A good agreement is obtained between the present results and those of the experimental data in the literature. The new approach in the present numerical modeling has allowed examining effects of the nature of materials (Polyvinylidene fluoride (PVDF) polymers, copolymers, and blends) used on thermal properties. Moreover, the effect of the area surface of the membrane (0.021 to 3.15 ㎡) is investigated to explore both the laminar and the turbulent flow regimes. The obtained results found that copolymer P(VDF-TrFE) (80/20) is more effective than the other materials of membrane distillation (MD). The mass flux and thermal efficiency reach 193.5 (g/㎡s), and 83.29 % using turbulent flow and an effective area of 3.1 ㎡, respectively. The increase of feed inlet temperatures and its flow rate, with the reduction of cold temperatures and its flow rate are very effective for increasing distillate water flow in MD applications.

• 접착 및 계면
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• 제23권3호
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• pp.75-79
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• 2022

그래핀은 벌집 모양의 sp² 혼성 오비탈 결합으로 이루어진 이차원 탄소 동소체이다. 우수한 전기적, 기계적 특성을 보이며, 차세대 전자소자의 핵심 재료로써 각광을 받고 있다. 그러나, 소자를 구성하는 소재 간의 불안정한 계면 형성으로부터 쉬운 외부 불순물의 침투 혹은 흡착으로 인해 낮은 환경 안정성을 보이고 있다. 따라서 본 연구에서는 고체탄화수소를 그래핀의 전구체로 활용한 직성장을 통해 그래핀 기반 전계효과 트랜지스터의 낮은 환경 안정성을 해결하고자 한다. 직성장으로부터 합성된 그래핀은 이를 활용한 전자소자에서 전하 이동도 및 Dirac 전압의 변화 감소를 통해 높은 구동 안정성을 보였다. 이를 통해 차세대 전자소자의 핵심 재료로써 그래핀을 활용하기 위한 새로운 접근 방법을 제시하였다.

• 한국콘텐츠학회논문지
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• 제22권9호
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• pp.439-450
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• 2022

연구 목적: 가임 여성의 조기진통에 대한 예방적 자가관리 지식(PSMK-PL) 측정도구를 개발하는 것이다. 연구 방법: 연구절차는 1단계 개념 정의(문헌 고찰, 질적 면담), 2단계 문항개발(문항작성, 전문가 내용타당도, 가임 여성의 인지적 면담), 3단계 내용타당도와 신뢰도 검정(250명의 온라인 설문조사 자료 분석)이었다. 문항반응이론을 적용한 내용타당도는 2-모수 로지스틱 모형을 사용하였다. 내적일관성 신뢰도는 Cronbach's α (95% CI)를 확인하였다. 연구 결과: 전문가 내용타당도 검정과 인지적 인터뷰를 통해 수정한 예비 문항 30개 중 적합도, 양류상관계수, 중요도를 고려해 6개를 삭제하였다. 최종 24문항, 하부 범주는 조기진통의 위험요인(10개), 예방적 관리(8개), 조기진통의 증상과 증상관리(6개)였다. 최종 문항 난이도(-2.18~0.90), 변별도(0.80~2.90), 내적합도(0.78~1.14), 양류상관계수(0.42~0.68)는 모두 수용할 만한 수준이었다. Cronbach's α (95% CI)는 .89(.87~.91)였다. 결론: PSMK-PL 측정도구는 가임 여성의 조기진통에 대한 예방적 자가관리지식을 측정할 수 있는 검정된 척도이다.

• Geomechanics and Engineering
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• 제29권2호
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• pp.183-192
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• 2022

Piled raft foundations are widely used and effective in supporting high-rise buildings around the world. In this study, a piled raft system was numerically simulated using PLAXIS 3D. The settlement comparison results between the actual building measurements and the three-dimensional (3D) numerical analysis, were in good agreement, indicating the usefulness of this approach for the evaluation of the feasibility of using a piled raft foundation in Ho Chi Minh City subsoil. The effects were investigated of the number of piles based on pile spacing, pile length, raft embedment on the settlement, load sharing, bending moments, and the shear force of the piled raft foundation in Ho Chi Minh City subsoil. The results indicated that with an increased number of piles, increased pile length, and embedding raft depth, the total and differential settlement decreased. The optimal design consisted of pile numbers of 60-70, corresponding to pile spacings is 5.5-6 times the pile diameter (D_p), in conjunction with a pile length-to-pile diameter ratio of 30. Furthermore, load sharing by the raft, by locating it in the second layer of stiff clay, could achieve 66% of the building load. The proposed model of piled raft foundations could reduce the total foundation cost by 49.61% compared to the conventional design. This research can assist practicing engineers in selecting pile and raft parameters in the design of piled raft foundations to produce an economical design for high-rise buildings in Ho Chi Minh City, Viet Nam, and around the world.

• Clinics in Shoulder and Elbow
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• 제25권1호
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• pp.49-56
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• 2022

Background: The treatment approach for proximal humeral fractures is determined by various factors, including patient age, sex, dominant arm, fracture pattern, presence of osteoporosis, preexisting arthritis, rotator cuff status, and medical comorbidities. However, there is a lack of consensus in the literature regarding the optimal treatment for displaced proximal humeral fractures. This study aimed to assess and quantify the decision-making process for either conservative or surgical treatment and the choice of surgical method among shoulder surgeons when treating proximal humeral fractures. Methods: Forty sets of true anteroposterior view, scapular Y projection view, and three-dimensional computed tomography of proximal humeral fractures were provided to 12 shoulder surgeons along with clinical information. Surveys regarding Neer classification, decisions between conservative and surgical treatments, and chosen methods were conducted twice with an interval of 2 months. The factors affecting the treatment plans were also assessed. Results: The inter-rater agreement was fair for Neer classification (kappa=0.395), moderate for the decision between conservative and surgical treatments (kappa=0.528), and substantial for the chosen method of surgical treatment (kappa=0.740). The percentage of agreement was 71.1% for Neer classification, 84.6% for the decision between conservative and surgical treatment, and 96.4% for the chosen method of surgical treatment. The fracture pattern was the most crucial factor in deciding between conservative and surgical treatments, followed by age and physical activity. Conclusions: The decision between conservative and surgical treatment for proximal humeral fractures showed good agreement, while the chosen method between osteosynthesis and arthroplasty showed substantial agreement among shoulder surgeons.

• 한국보건간호학회지
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• 제36권3호
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• pp.361-374
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• 2022

Purpose: This study applies an ecological model to investigate individual and organizational levels to identify factors influencing the HRQOL of industrial employees. Methods: Totally, 133 industrial workers of a vehicle company were enrolled, who understood the purpose and consented to participate in the study. The collected data were analyzed by frequency, percentage, mean, standard deviation, independent t-test, one-way ANOVA, Scheffe Test and hierarchical regression analysis using the SPSS 20.0 program. Results: Hierarchical regression analysis showed that job Stress(β=-.44, p<.001), and hobbies(β=-.21, p=.013) were the major influencing factors of the Physical Component Summary of HRQOL, which had an additional explanatory power of 11.5%. The influencing factors for the Mental Component Summary of HRQOL were job stress(β=-.43, p<.001), and coronary artery disease(β=.17, p=.034) with an additional explanatory power of 13.5%. Conclusion: Results of this study, reveal that a multidimensional approach based on an ecological model is suitable as a health promotion intervention strategy to improve the HRQOL. We further propose developing a multi-dimensional health promotion program that consider the individual and organizational factors such as job stress, activation of in-house clubs, and assessing and managing of the risk of cerebral and cardiovascular diseases.

• Advances in nano research
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• 제12권2호
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• pp.213-221
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• 2022

Silicon carbide (SiC) is a binary carbon-silicon compound. In its two-dimensional form, monolayer SiC is composed of a monolayer carbon and silicon atoms constructed as a honeycomb lattice. SiC has recently been receiving increasing attention from researchers owing to its intriguing electronic properties. In this present work, SiC nanoribbons (SiCNRs) are modelled and simulated to obtain accurate electronic properties, which can further guide fabrication processes, through bandgap engineering. The primary objective of this work is to obtain the electronic properties of monolayer SiCNRs by applying numerical computation methods using nearest-neighbour tight-binding models. Hamiltonian operator discretization and approximation of plane wave are assumed for the models and simulation by applying the basis function. The computed electronic properties include the band structures and density of states of monolayer SiCNRs of varying width. Furthermore, the properties are compared with those of graphene nanoribbons. The bandgap of ASiCNR as a function of width are also benchmarked with published DFT-GW and DFT-GGA data. Our nearest neighbour tight-binding (NNTB) model predicted data closer to the calculations based on the standard DFT-GGA and underestimated the bandgap values projected from DFT-GW, which takes in account the exchange-correlation energy of many-body effects.

• 한국학교수학회논문집
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• 제25권4호
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• pp.333-352
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• 2022

본고는 초등수학을 기반으로 첨단기술및 ICT교구를활용한 초등융합교육자료의 개발에 대한 사례 연구이다. 본 연구에서는 초등현장 교육전문가 6인이 준비-개발-개선의 PDI 모형에 따라 융합교육 자료를 개발하였고, 개발된 자료는 수학, 과학, 미술, 공학 과목의 교과교육전문가 4인에 의해서 수정·보완하였다. 개발된 융합교육 자료는 초등 3~4학년군에서 활용 가능한 『그래프! 과거, 현재, 미래를 이어주는 다리』 의 1종이고, 5~6학년군은『알쏭달쏭, 같은 듯 다른 너!』 , 『함께 만드는 가상현실 입체 공간』의 2종이며, 초등 3~4학년군과 5~6학년군에서 학년군별로 재구성해 사용 가능한 『그리고 만드는 재미있는 도형 나라』 , 『거북선 지붕을 빈틈없이 덮어라!』 의 2종이었다. 본 개발 연구의 결과를 기반으로 한 제언은 다음과 같다. 초등교육 현장에서 원활한 융합교육을 수행할 수 있도록 다양한 융합교육 자료가 개발 공유되어야 하며, 나아가 앞으로 융합교육의 확산과 정착을 위해서는 현장 초등 교사나 예비 초등 교사들의 융합교육 역량의 함양 및 신장이 절대적인 선결 조건일 것이다.