• Toxicological Research
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• 제23권4호
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• pp.363-371
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• 2007

Isaria sinelairii (IS) was orally administered at doses of 0, 0.04, 0.2, and 1 g/kg/day over a 13-week period. There were no observed clinical signs or deaths related to treatment in all the groups tested. Therefore, the approximate lethal oral dose of I. sinclairii was considered to be higher than 1 g/kg in rats. Throughout the administration periods, no significant changes in diet consumption, ophthalmologic findings, organ weight, clinical pathology (hematology, clinical chemistry, coagulation, and urinalysis) or gross pathology were detected. Minor changes were found in hematological parameters for the 0.04 g/kg/day and 0.2 g/kg/day IS treated groups (triglyceride reductions of $20.1{\sim}46.6%$ and platelet increases), but all changes were within physiological range. Microscopic examination failed to identify any treatment-related histopathologic changes in the organs of the IS-treated rats other than nuclear enlargement (cellular atypia) of the tubular regions in the medulla of the kidney in the high dose group. From these results, one can conclude that the no-observed effect level (NOAEL) of I. sinclairii is less than 0.04 g/kg/day in rats.

• 한국보육지원학회지
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• 제11권2호
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• pp.283-310
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• 2015

본 연구의 목적은 보육경험과 어머니의 양육행동이 유아의 문제행동에 미치는 주효과와 상호작용 효과를 살펴보는 것이다. 만 3-5세 유아 248명(남아: 112명, 여아: 136명)과 그들의 어머니가 본 연구에 참여하였으며, 어머니들은 보육경험(보육 시작 시기, 1일 평균 보육시간, 주당 평균 보육일, 보육기관 변경횟수), 양육행동, 유아의 문제행동에 관한 문항들이 포함된 질문지에 응답하였다. 본 연구의 주요결과는 다음과 같다. 첫째, 보육경험 중 보육기관 변경횟수가 잦을수록 유아는 공격성을 더 보였다. 둘째, 어머니의 양육행동 중 논리적 설명, 강압, 방임이 유아의 문제행동에 영향을 미쳤다. 마지막으로 보육경험과 어머니의 양육행동은 상호작용하여 유아의 문제행동에 영향을 미쳤다. 이러한 결과는 보육경험이 모든 유아에게 동일한 영향을 미치는 것이 아니며, 어머니의 양육행동에 따라 보육경험의 영향에 차이가 있을 수 있음을 제안한다.

• 생명과학회지
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• 제19권2호
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• pp.198-205
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• 2009

본 연구는 비만 여자중학생을 대상으로 12주간 유산소운동군(AEG), 유산소운동과 생활양식수정 병행 실시군(ALG), 대조군(CG)으로 구분하여 이들의 신체구성과 대사증후군 유병률 및 대사증후군 위험인자에 미치는 효과를 규명하기 위해 실시하였다. 프로그램 실시 전 연구대상자 전체의 대사증후군 유병률이 48.1%로 나타났으나, 프로그램 실시 후 AEG, ALG에서 각각 33.3, 27.8%의 대사증후군 유병률이 개선되었다. 대사증후군 위험인자는 AEG와 ALG에서 허리둘레, TG, 혈당 및 수축기혈압이 CG보다 더 개선되었다. 그러나 HDL-C와 이완기혈압의 변화는 집단간에 차이가 없었다. 또한 대사증후군의 모든 항목의 변화에서 AEG와 ALG간에 차이가 나타나지 않았다. 따라서 유산소운동과 생활양식수정 병행 실시군의 이 같은 긍정적인 변화는 생활양식수정 실시의 추가적인 효과가 나타나지 않았음으로 유산소운동의 단독효과인 것으로 생각된다.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2001년도 추계학술대회 논문집 전력기술부문
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• pp.272-274
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• 2001

This paper presents a model for short-term load forecasting using relationship of temperature and load. We made one-day ahead load forecasting model using hourly normalized load and 11 dummy variables that were classified by day characteristics such as day of the week, holiday, and special holiday.

• Toxicological Research
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• 제14권3호
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• pp.443-452
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• 1998

This sutdy was carried out to investigate the acute toxicity and foru-week intravenous toxicity of the intralipidos in rats and rabbits. The acute toxicity study of Intralipidos was performed in Spragur-Dawley (SD) rats. Intralipidos was administered by intravenous to maximum dose 200 ml/kg. $LD_{50}$ of intralipidos was found 139.5ml/kg and 153.8ml/kg in male female SD rats. Four-week toxicity of intralipidos using New Zealand White Rabbit and SD rats. The Rabbit and Rats were administered by intravenous seven days per week for 28 days, with dosage of 15, 6, 2 ml/kg/day and 20, 6, 2ml/kg/day, respectively. Animals treated with intralipidos did not cause any death and show any clinical signs. They did not show any significant changes of body weight, feed uptake and water consumption. They were not significantly different from the control group in urinalysis, ocular examination hematological, serum biochemical value and histopathological examination. Therefore, Intralipidos was not indicated to have any toxic effect in the Rabbits and Rats, when it was administrated by intravenous below the dosage 15ml/kg/day and 20 ml/kg/day for four weeks.

• Journal of Nutrition and Health
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• 제33권2호
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• pp.193-201
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• 2000

This study was conducted to investigate the effectiveness of nutrition counseling on the dietary intake and nutritional status cancer patients undergoing radiotherapy treatment. The study was conducted over 6 week period and included 104 patients : 66 received nutrition counseling as the variable group of 42 male and 24 female and 38 patients received no counseling as the control group of 19 male and 19 female. Nutrition counseling was accompanied with the radiation therapy and adminstered via counseling session and distribution of printed material during radiation therapy for 6 weeks. Nutrition counseling aimed at maintaining a balanced diet and preventing weight loss of subjects, guideline used for energy and protein intake were 35kcal/kg IBW and 1.5-2.0g/kg IBW, respectively. Over the course of the study, the counseling group increased significantly in comparison to the control group's energy intake, evidenced by the counseling group's initial mean daily energy intake of 1932.0kcal, and 4 and 6 week mean energy intake values of 2046.6kcal, 2066kcal, respectively. But mean energy values of control group was 1614.3kcal at 4 week. Th energy intake per weight values and protein intake per weight values for initial, 4 and 6 week intervals for counseling group were 33.2kcal/kg, 33.7kcal/kg, 34.0kcal/kg, and 1.48g/kg, 1.58g/kg, 1.59g/kg, respectively. Based on results, nutrition counseling had positive effects on both the variety of diet and energy intake of the variable group, mostly due to an increase in dairy product and egg consumption. In addition, the percentage of counseling group patients who consumed all 5 food group increased from 48.5% to 54.5%. Sufficient energy intake and protein consumption seem to be important factors in weight loss prevention, evidenced by weight gain by subjects in the counseling group who had 36.1kcal/kg/day mean energy intake and 1.77g/kg/day mean protein intake after 4 weeks. Counseling group subjects experiencing weight loss had lower intake and 1.77g/kg/day mean protein intake after 3 weeks. Counseling group subjects experiencing weight loss had lower intakes of 29.3kcal/kg/day for energy and 1.33g/kg/day for protein during the same period. Another significant factor in weight loss prevention of the counseling group could be the variety of diet. The dietary variety scores(DVS) of both counseling and control groups differed significantly : the counseling group had a mean score of 34 while the control group of patients. At the end of the study, the mean percentage of subjects within each group having a DDS 5 was higher in the counseling group (54.5% v.s. 24.0%). In this study, nutrition counseling for cancer patients undergoing radiation therapy proved to be effective in preventing weight loss, a major complication during radiotherapy. Nutrition counseling not only increased protein and energy intake, but also had desirable effects on variety or diversity of diet.

• 대한기관식도과학회지
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• 제8권1호
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• pp.29-34
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• 2002

Background and Objectives : Sulfur dioxide gas is one of the major airborne Pollutants noxious to human in industrialized countries. The most vulnerable areas in the human respiratory system were the trachea and main bronchi and a gradient of decreasing damage was observed in the peripheral tracheobronchial tree. Induced functional alteration was increased mucosal permeability, and morphological changes were epithelial sloughing, intracellular edema, mitochondrial swelling, widened intercellular spaces, and ciliary cytoplamic extrusions. The laminins are a family of extracellular matrix glycoproteins localized in the basement membrane. Their primary role is cell-matrix attachment, but many additional biologic activities, including Promoting cell growth and migration, tumor growth and metastasis, wound repair, and graft survival, have been demonstrated. Materials and Methods : Histologic changes and expression of laminin in tracheal mucosa sacrificed at 1 day, 2 day, 3 day, 1 week, 2 weeks, and 3 weeks after continued SO2 exposure of 250 ppm for 30 minutes a day(to 7week) were studied in rats. In this study, mild immune reaction for laminin was noted at the apical cytoplasm of epithelial cells and basement membrane one day after a 7 week $SO_2$ exposure. The cilia and nucleoi of epithelial cells were normal and no immune reaction was noted in Goblet cells. The lamina propria of the tracheal tissue was infiltrated by monocytes and lymphocytes. Results : At 24 hours after exposure, all tracheal cells except Goblet cells revealed a mild immune reaction for laminin. No immune reactions were noted in the basement membrane. At 72 hours after exposure, mild or moderate immune reactions for laminin was seen in the tracheal cell cytoplasm. Irregular faint immune reaction for laminin was noted in the basement membrane. At 1 week after exposure, strong immune reaction for laminin was detected over all tracheal cells, and the basement membrane was seen clearly. At 2~3 weeks after exposure, strong immune reaction for laminin was seen in all tracheal epithelial cells except Goblet cells and a mild immune reaction was partly revealed in the basement membrane. Conclusion : Our study suggests that 502 produces histologic damage on the tracheal mucosa. Longer duration after exposure of $SO_2$ makes more progressive healing on the tracheal mucosa and increased immunoreactivity for laminin.

• 동의생리병리학회지
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• 제18권3호
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• pp.854-856
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• 2004

The purpose of this study was to investigate the effects of Slim Cushion on the decrease of the girth of the lower half of body. We used Slim Cushion for health appliance of woman's hypogastrium. We collected 30 woman patients with obesity and then expremented Slim Cushion 15 mintues × 3 times I day, during 12 weeks. We checked the weight of body, the girth of navel and pelvis and thigh for every week. The results were as follows: The decrease of weight was not significant. The decrease of navel girth was significant change 3, 4, 5, 6, 7, 8 week times (p<0.05) and very significant 9, 10, 11, 12 week times. The decrease of pelvis girth was significant change 4, 5, 6, 7, 8 week times (p<0.05) and very significant 9, 10, 11, 12 week times(p<0.01). The decrease of thigh girth was significant change 6, 7, 8, 9, 10, 11 week times (p<0.05) and very significant 12 week times(p<0.01).

• 한국직업건강간호학회지
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• 제7권1호
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• pp.5-19
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• 1998

This descriptive-correlational study was conducted to identify the major factors affecting health promoting behaviors. 344 workers who employed in four different manutacturing plants in Taegu and Kyungbuk area were selected by convenience sampling method. Data were collected from April let to April 18th, 1998 by ready structured questionaires. The purpose of this study was to offer the basic data for health promotion theory development and health promotion strategy planning. This study was based on Pender's Health Promotion Model and examined three variables health promoting behavior, self-concept and perceived importance of health. The Life Style and Health Habit Assessment scale(LHHA) developed by Pender(1982).The Self-concept scale developed by Choi(1972) and the Health Value scale developed by Wallston, Maides and Wallston(1980) were used for this study. Data was analyzed by percentage, mean. t-test. ANOVA, Pearson Correlation Coefficient, and Stepwise Multiple Regression. The major findings of this study are as follows ; 1. The average level of health promoting behavior practice was 63.2% and possible range was from 62 to 248 point. The mean score of respondent's positive self-concept was 75.8. 81.4% of respondents put a high priority on the importance of health. 2. There was a significant difference between the practice level in the category of general self care and less amount of working hours per day(P=0.000), less amount of working hours per week(P=0.000). There was a significant difference between the practice level in the category of nutrition and age(0.002), marital status(0.000), working hour per day(0.008), working hours per week(0.001), There was a significant difference between the practice level in the category of nutriton and sex(0.000), age(0.000), marital status(0.025), education level(0.000), working hours per day(0.002), working hours per week(0.006). There was a significant difference between the practice level in the category of sleep and rest and age(0.003), marital status(0.002), working hours per day(0.001), working hours per week(0.001). There was a significant difference between the practice level in the category of stress management and working hours per day(0.001), working hours per week(0.002). There was a significant difference between the practice level in the category of self-actualization and working hours per day(0.050). 3. General characteristics influencing the respodent's self-concept were level(P=0.009) and worksite(P=0.001). 4. The results of the hypothesis tests are as follows The first hypothesis, that "The respondent who have more positive self-concept will have higher scores in the practice of health promoting behavior." was supported(r=0.2973, P=0.0001). The second hypothesis that "The respondent who have higher perception level on importance of health will have higher scores in the practice health promoting behavior." was rejected(r=- 0665, P=0.2225). 5. The most important factor that affects health promoting behavior practice was working hours per week(6.0%). The combination of working hours per week, age, education level accounted for 10.0% of the variance in health promoting behavior. In conclusion, the results of this study on industrial workers supported Pender's health promotion model in partial and showed the relatedness between self concept and the practice of health promoting behavior. Further research is required to find factors influencing health promoting behaviors of industrial workers.

• International Journal of Industrial Entomology and Biomaterials
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• 제5권1호
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• pp.109-122
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• 2002

The purpose of this investigation is to evaluate the effects of the Nuegra on enhancement of the masculine and physical activities in general through measuring changes of the testosterone, FSH and subjective symptoms like fatigue, insomnia, urinary stream, muscular weakness, libido and erectile dysfunction. Total 168 male subjects were enrolled from 12 urology, internal medicine clinics and general practitioner, During the 6-week investigational period, 2 capsules of Nuegra were given to the subjects right after meal for 4 weeks, and 1 capsule of Nuegra was added each time in subjects with no or minimal effect. Testoster-one and FSH levels were measured at first visit and last visit, for evaluating masculine activities. To avoid bias and standardize the test results, only one clinic was assigned as a central lab, and all blood samples were transferred. General information and subjective symptoms were evaluated at first visit and at 2 weeks interval, week 2, 4 and 6 using VAS (Visual Analogue Scale). The mean age of the subjects were 51.8${\pm}$8.2 years old (range: 36.1-82.1). Based on the subjects who were tested on testosterone and FSH levels at day l and week 6, the means were 4.4${\pm}$1.4 nmol/L (range: 2.6-7.7), 8.6${\pm}$9.6 mIU/mL (range: 0.3-40.4), respectively at day 1. At week 6, the results were 4.9 ${\pm}$1.6 (2.6-8.9 range), 9.4${\pm}$13.1 (1.0-53.9 range), respectively. Marginally significant difference between pre-dose and post-dose was present. Statistically significant differences were revealed in general assessment for subjective symptoms, fatigue, insomnia, erectile dysfunction, etc. In fatigue, response rates were 39.6, 65.4 and 76.4% at week 2, 4 and 6, respectively (P < 0.0001). Response vates for erectile dysfunction were 13.4, 41.2 and 72.7% at week 2, 4, and 6 (P < 0.0001), respectively, Response rates for libido were 13.6, 51.6 and 73.5% at week 2, 4, and 6 (P < 0.0001), respectively. For urinary stream response rates were 26.9, 44.7 and 66.8% at week 2, 4, and 6 (P < 0.0001), respectively. VAS for muscular weakness did not show significant results that response rates were 40, 60 and 80% at week 2, 4, and 6 from 8.2 (P ＝ 0.24), respectively. Response rates for insomnia were 50, 60, 100% at week 2, 4, and 6 (P < 0.0001), respectively. The results shows that Nuegra tends to enhance masculine activities including libido, erectile dysfunction and urinary stream and also effective for improving general conditions especially insomnia, muscular weakness and fatigue. In conclusion, this investigation has demonstrated that Nuegra does not only have tendency to increase masculine activities through increased secretion of the testosterone and FSH but also improve general conditions such as erectile dysfunction, libido, fatigue and muscular power.